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Longhou Fang, PhD

Assistant Professor of Cardiovascular Sciences, Institute for Academic Medicine
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College

my lab home page


The Fang lab employ zebrafish and mouse models to studying the role of lipid metabolism in angiogenesis and lymphangiogenesis. During his Ph.D studies at UC San Diego, Dr. Fang discovered that apolipoprotein (apoA-I) binding protein (AIBP) controls angiogenesis via regulation of cholesterol homeostasis.Based upon the findings, the Fang laboratory will be focusing on the role of AIBP-regulated lipid metabolism in angiogenesis and lymphangiogenesis. We will use a plethora of disease models such as heart hypertrophy, heart ischemia and reperfusion, peripheral artery ischemia and reperfusion, corneal angiogenesis, and tumorigenesis in mice as well as in zebrafish heart regeneration. Both zebrafish and mouse model will be used to study the role of AIBP in lymphangiogenesis.

Areas Of Expertise

Angiogenesis Lymphangiogenesis hematopoiesis cholesterol metabolism
Education & Training


AIBP Limits Angiogenesis Thorough ?-Secretase-Mediated Upregulation of Notch Signaling
Mao, R, Meng, S, Gu, Q, Araujo-Gutierrez, R, Kumar, S, Yan, Q, Almazan, F, Youker, KA, Fu, Y, Pownall, HJ, Cooke, JP, Miller, YI & Fang, L 2017, Circulation Research. DOI:

AIBP: A Novel Molecule at the Interface of Cholesterol Transport, Angiogenesis, and Atherosclerosis: A Novel Molecule at the Interface of Cholesterol Transport, Angiogenesis, and Atherosclerosis
Fang, L & Zhu, L 2015, Methodist DeBakey Cardiovascular Journal, vol 11, no. 3, 26634023 , pp. 160-5. DOI:

Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development
Yang, H, Fang, L, Zhan, R, Hegarty, JM, Ren, J, Hsiai, TK, Gleeson, JG, Miller, YI, Trejo, J & Chi, NC 2015, Developmental Biology, vol 404, no. 2, pp. 49-60. DOI:

Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia
Liu, C, Gates, KP, Fang, L, Amar, MJ, Schneider, DA, Geng, H, Huang, W, Kim, J, Pattison, J, Zhang, J, Witztum, JL, Remaley, AT, Dong, PD & Miller, YI 2015, Disease models & mechanisms, vol 8, no. 8, pp. 989-998. DOI:

Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of MicroRNA-92a
Chen, Z, Wen, L, Martin, M, Hsu, CY, Fang, L, Lin, FM, Lin, TY, Geary, MJ, Geary, GG, Zhao, Y, Johnson, DA, Chen, JW, Lin, SJ, Chien, S, Huang, HD, Miller, YI, Huang, PH & Shyy, JYJ 2015, Circulation, vol 131, no. 9, pp. 805-814. DOI:

Zebrafish models of dyslipidemia: Relevance to atherosclerosis and angiogenesis
Fang, L, Liu, C & Miller, YI 2014, Translational Research, vol 163, no. 2, pp. 99-108. DOI:

Targeted cholesterol efflux
Fang, L & Miller, YI 2013, Cell Cycle, vol 12, no. 21, pp. 3345-3346. DOI:

Control of angiogenesis by AIBP-mediated cholesterol efflux
Fang, L, Choi, SH, Baek, JS, Liu, C, Almazan, F, Ulrich, F, Wiesner, P, Taleb, A, Deer, E, Pattison, J, Torres-Vázquez, J, Li, AC & Miller, YI 2013, Nature, vol 498, no. 7452, pp. 118-122. DOI:

Emerging applications for zebrafish as a model organism to study oxidative mechanisms and their roles in inflammation and vascular accumulation of oxidized lipids
Fang, L & Miller, YI 2012, Free Radical Biology and Medicine, vol 53, no. 7, pp. 1411-1420. DOI:

Ezetimibe and simvastatin reduce cholesterol levels in zebrafish larvae fed a high-cholesterol diet
Baek, JS, Fang, L, Li, AC & Miller, YI 2012, Cholesterol, vol 2012, 564705. DOI:

In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish
Fang, L, Green, SR, Baek, JS, Lee, SH, Ellett, F, Deer, E, Lieschke, GJ, Witztum, JL, Tsimikas, S & Miller, YI 2011, Journal of Clinical Investigation, vol 121, no. 12, pp. 4861-4869. DOI:

Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity
Miller, YI, Choi, SH, Wiesner, P, Fang, L, Harkewicz, R, Hartvigsen, K, Boullier, A, Gonen, A, Diehl, CJ, Que, X, Montano, E, Shaw, PX, Tsimikas, S, Binder, CJ & Witztum, JL 2011, Circulation Research, vol 108, no. 2, pp. 235-248. DOI:

Oxidized cholesteryl esters and phospholipids in zebrafish larvae fed a high cholesterol diet: Macrophage binding and activation
Fang, L, Harkewicz, R, Hartvigsen, K, Wiesner, P, Choi, SH, Almazan, F, Pattison, J, Deer, E, Sayaphupha, T, Dennis, EA, Witztum, JL, Tsimikas, S & Miller, YI 2010, Journal of Biological Chemistry, vol 285, no. 42, pp. 32343-32351. DOI:

Lipoprotein modification and macrophage uptake: Role of pathologic cholesterol transport in atherogenesis
Miller, YI, Choi, SH, Fang, L & Tsimikas, S 2010, Sub-cellular biochemistry, vol 51, pp. 229-251. DOI:

Proteomic, functional and motif-based analysis of C-terminal Src kinase-interacting proteins
Yang, G, Li, Q, Ren, S, Lu, X, Fang, L, Zhou, W, Zhang, F, Xu, F, Zhang, Z, Zeng, R, Lottspeich, F & Chen, Z 2009, Proteomics, vol 9, no. 21, pp. 4944-4961. DOI:

Toll-Like Receptor-4 and Lipoprotein Accumulation in Macrophages
Miller, YI, Choi, SH, Fang, L & Harkewicz, R 2009, Trends in Cardiovascular Medicine, vol 19, no. 7, pp. 227-232. DOI:

Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish
Stoletov, K, Fang, L, Choi, SH, Hartvigsen, K, Hansen, LF, Hall, C, Pattison, J, Juliano, J, Miller, ER, Almazan, F, Crosier, P, Witztum, JL, Klemke, RL & Miller, YI 2009, Circulation Research, vol 104, no. 8, pp. 952-960. DOI:

Proteome identification of binding-partners interacting with cell polarity protein Par3 in Jurkat cells
Zhou, Y, Fang, L, Du, D, Zhou, W, Feng, X, Chen, J, Zhang, Z & Chen, Z 2008, Acta Biochimica et Biophysica Sinica, vol 40, no. 8, pp. 729-739. DOI:

Erratum: Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair (Cell Research (2007) 17 (100-116) DOI:10.1038/
Fang, L, Wang, Y, Du, D, Yang, G, Kwok, TT, Kong, SK, Chen, B, Chen, DJ & Chen, Z 2007, Cell Research, vol 17, no. 6, pp. 572-574. DOI:

Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair
Fang, L, Wang, Y, Du, D, Yang, G, Tak Kwok, T, Kai Kong, S, Chen, B, Chen, DJ & Chen, Z 2007, Cell Research, vol 17, no. 2, pp. 100-116. DOI: