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Kelvin Wong, PhD

Associate Research Professor of Systems Medicine and Bioengineering, Institute for Academic Medicine
Associate Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


kwong@houstonmethodist.org
Biography

Dr. Wong is a biomedical engineer who specializes in developing new imaging systems for the visualization of human disease. He received his Magnetic Resonance (MR) physics training at Columbia University in New York City, and in 2005, he joined the Functional and Molecular Imaging Center of the Brigham and Women’s Hospital and the HCNR Center of Bioinformatics in the Harvard Medical School as a Postdoctoral Fellow. In 2007, he left Harvard and joined the Methodist Hospital Research Institute to direct the Translational Multimodality Optical Imaging laboratory.

Description of Research

Dr. Wong’s current research interests focus on clinical and preclinical MR imaging research. In addition to establishing the advanced neuroimaging capabilities at TT and WF Chao Center for BRAIN for neurological disorders, his laboratory focuses on image-guided optical imaging for cellular and molecular imaging for glioblastoma and lung cancer diagnosis. He also combines his expertise in small animal MRI and optical imaging to investigate the tumor vasculature microenvironment using multimodality multiscale image-based modeling. His current projects include:

-Image Guided Optical Molecular Imaging in Lung Cancer Diagnosis
-MR Perfusion derived Tissue Residual Function Analysis of Glioblastoma undergoing Anti-angiogenic/Anti-vascular Therapy
-Multimodailty Multiscale Image-based Modeling of Glioblastoma

Areas Of Expertise

Cancer imaging Image-guided intervention Molecular imaging
Education & Training

Postdoctoral Fellowship , HCNR Center of Bioinformatics, Harvard Medical School, Boston, MA
M Phil , University of Hong Kong
PhD , University of Hong Kong
Publications

Magnetic Resonance Elastography Measured Shear Stiffness as a Biomarker of Fibrosis in Pediatric Nonalcoholic Fatty Liver Disease
Schwimmer, JB, behling, C, Angeles, JE, Paiz, M, Durelle, J, Africa, J, Newton, KP, Brunt, EM, Lavine, JE, Abrams, SH, Massand, P, Krishnamurthy, R, Wong, K, Ehman, RL, Yin, M, Glaser, KJ, Dzyubak, B, Wolfson, T, Hooker, J, Haufe, W, Schlein, A, Hamilton, G, Middleton, MS & Sirlin, CB 2017, Hepatology. DOI: 10.1002/hep.29241

Subarachnoid hemorrhage - Induced block of cerebrospinal fluid flow: Role of brain coagulation factor III (tissue factor)
Golanov, EV, Bovshik, E, Wong, K, Pautler, RG, Foster, C, Federley, R, Zhang, YJ, Mancuso, J, Wong, ST & Britz, GW 2017, Journal of Cerebral Blood Flow and Metabolism. DOI: 10.1177/0271678X17701157

Technical pitfalls of signal truncation in perfusion MRI of glioblastoma
Wong, KK , Fung, SH , New, PZ & Wong, STC 2016, Frontiers in Neurology, vol 7, no. AUG, 121, pp. 121. DOI: 10.3389/fneur.2016.00121

Dual CARS and SHG image acquisition scheme that combines single central fiber and multimode fiber bundle to collect and differentiate backward and forward generated photons
Weng, S, Chen, X, Xu, X, Wong, KK & Wong, STC 2016, Biomedical Optics Express, vol 7, no. 6, pp. 2202-2218. DOI: 10.1364/BOE.7.002202

Multimodal nonlinear endo-microscopy probe design for high resolution, label-free intraoperative imaging
Chen, X, Xu, X, McCormick, DT, Wong, K & Wong, STC 2015, Biomedical Optics Express, vol 6, no. 7, A001, pp. 2283-2293. DOI: 10.1364/BOE.6.002283

Functional brain interactions during reflexive micturition are absent from spinal cord injured rats with neurogenic bladder
Wong, K , Boone, TB , Wong, STC & Munoz, A 2015, Neurourology and Urodynamics, vol 34, no. 5, pp. 469-474. DOI: 10.1002/nau.22596

Effects of glioma presence during radiotherapy on tissue damage
Zawaski, JA, Sabek, O, Wong, K & Gaber, MW 2015, Cancer Research, vol 75, no. 15, 3321. DOI: 10.1158/1538-7445.AM2015-3321

Radiomics Report 2015
Wong, K 2015, . in Radiomics Report 2015.

Novel Method for Automatic Segmentation of Infiltrative Glioblastoma
Wong, K & Wong, ST 2015, . in Proceeding of International Society of Magnetic Resonance in Medicine., 2250.

Prognostic biomarkers for progression-free survival in glioblastoma multiforme: quantitative imaging and gene expressions
Wong, K & Wong, ST 2015, Cancer Research, vol 75, 5281. DOI: 10.1158/1538-7445.AM2015-5281

Predictors for cortical gray matter volume in stroke patients with confluent white matter changes
Xiong, Y, Wong, A, Wong, K, Chu, WCW, Hu, X, Chen, X, Wong, KS, Wong, STC, Liu, X & Mok, V 2014, Journal of the Neurological Sciences, vol 338, no. 1-2, pp. 169-173. DOI: 10.1016/j.jns.2013.12.044

Fiber bundle based endomicroscopy prototype with two collection channels for simultaneous coherent anti-Stokes Raman scattering and second harmonic generation imaging
Liu, Z, Satira, ZA, Wang, X, Xu, X, Chen, X, Wong, K, Chen, S, Xin, J & Wong, STC 2014, . in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8948, 894814, SPIE, Multiphoton Microscopy in the Biomedical Sciences XIV, San Francisco, CA, United States, 2-4 February. DOI: 10.1117/12.2039559

Transcriptional signaling pathways inversely regulated in Alzheimer's disease and glioblastoma multiform
Liu, T, Ren, D, Zhu, X, Yin, Z, Jin, G, Zhao, Z, Robinson, D, Li, X, Wong, K, Cui, K, Zhao, H & Wong, STC 2013, Scientific Reports, vol 3, 3467. DOI: 10.1038/srep03467

Nonlinear motion compensation using cubature Kalman filter for in vivo fluorescence microendoscopy in peripheral lung cancer intervention
He, T, Xue, Z, Alvarado, MVY, Wong, KK, Xie, W & Wong, STC 2013, Journal of Biomedical Optics, vol 18, no. 1, 016008. DOI: 10.1117/1.JBO.18.1.016008

Predictors for cognitive decline in patients with confluent white matter hyperintensities
Mok, V, Xiong, Y, Wong, KK, Wong, A, Schmidt, R, Chu, WWC, Hu, X, Lung Leung, EY, Chen, S, Chen, Y, Tang, WK, Chen, X, Ho, CL, Wong, KS & Wong, STC 2012, Alzheimers and Dementia, vol 8, no. SUPPL. 5. DOI: 10.1016/j.jalz.2011.10.004

The degradation and clearance of Poly(N-hydroxypropyl-l-glutamine)-DTPA-Gd as a blood pool MRI contrast agent
Zhang, G, Zhang, R, Melancon, MP, Wong, K, You, J, Huang, Q, Bankson, J, Liang, D & Li, C 2012, Biomaterials, vol 33, no. 21, pp. 5376-5383. DOI: 10.1016/j.biomaterials.2012.03.081

A minimally invasive multimodality image-guided (MIMIG) system for peripheral lung cancer intervention and diagnosis
He, T, Xue, Z, Lu, K, Valdivia y Alvarado, M, Wong, KK, Xie, W & Wong, ST 2012, Computerized Medical Imaging and Graphics, vol 36, no. 5, pp. 345-355. DOI: 10.1016/j.compmedimag.2012.03.002

Motion correction for cellular-resolution multi-photon fluorescence microscopy imaging of awake head-restrained mice using speed embedded HMM
Chen, T, Xue, Z, Wang, C, Qu, Z, Wong, KK & Wong, STC 2012, Computerized Medical Imaging and Graphics, vol 36, no. 3, pp. 171-182. DOI: 10.1016/j.compmedimag.2011.08.002

Image-guided fiberoptic molecular imaging in a VX2 rabbit lung tumor model
Valdivia Y Alvarado, M , Wong, K, Cheng He, T, Xue, Z & Wong, ST 2011, Journal of Vascular and Interventional Radiology, vol 22, no. 12, pp. 1758-1764. DOI: 10.1016/j.jvir.2011.08.025

Characterization of a human tumorsphere glioma orthotopic model using magnetic resonance imaging
Wong, K, Young, GS, Makale, M, Hu, X, Yildirim, N, Cui, K, Wong, STC & Kesari, S 2011, Journal of Neuro-Oncology, vol 104, no. 2, pp. 473-481. DOI: 10.1007/s11060-010-0517-x