Not found

Keith A. Youker,

Houston Methodist


Areas Of Expertise

Immunology Cardiac Transplantation LVAD Heart Failure
Publications

Macrophage bone morphogenic protein receptor 2 depletion in idiopathic pulmonary fibrosis and Group III pulmonary hypertension
Chen, NY, Collum, SD, Luo, F, Weng, T, Le, TT, Hernandez, AM, Philip, K, Molina, JG, Garcia-Morales, LJ, Cao, Y, Ko, TC, Amione-Guerra, J, Al-Jabbari, O, Bunge, RR, Youker, K, Bruckner, BA, Hamid, R, Davies, J, Sinha, N & Karmouty-Quintana, H 2016, American Journal of Physiology - Lung Cellular and Molecular Physiology, vol 311, no. 2, pp. 238-254. DOI:

MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1
Jeyabal, P, Thandavarayan, RA, Joladarashi, D, Suresh Babu, S, Krishnamurthy, S, Bhimaraj, A, Youker, KA, Kishore, R & Krishnamurthy, P 2016, Biochemical and Biophysical Research Communications, vol 471, no. 4, pp. 423-429. DOI:

Combination of angiotensin II and l-NG-nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure
Hamilton, DJ, Zhang, A, Li, S, Cao, TN, Smith, JA, Vedula, I, Cordero-Reyes, AM, Youker, KA, Torre-Amione, G & Gupte, AA 2016, American Journal of Physiology - Heart and Circulatory Physiology, vol 310, no. 6, pp. H667-H680.

Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1a/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1a and Regulates Responsive Cardiac Angiogenesis
Yue, X, Lin, X, Yang, T, Yang, X, Yi, X, Jiang, X, Li, X, Li, T, Guo, J, Dai, Y, Shi, J, Wei, L, Youker, KA, Torre-Amione, G, Yu, Y, Andrade, KC & Chang, J 2016, Hypertension, vol 67, no. 3, pp. 597-605. DOI:

A specifically designed nanoconstruct associates, internalizes, traffics in cardiovascular cells, and accumulates in failing myocardium: A new strategy for heart failure diagnostics and therapeutics
Ruiz-Esparza, GU, Segura-Ibarra, V, Cordero-Reyes, AM, Youker, KA, Serda, RE, Cruz-Solbes, AS, Amione-Guerra, J, Yokoi, K, Kirui, DK, Cara, FE, Paez-Mayorga, J, Flores-Arredondo, JH, Guerrero-Beltrán, CE, Garcia-Rivas, G, Ferrari, M, Blanco, E & Torre-Amione, G 2016, European Journal of Heart Failure, vol 18, no. 2, pp. 169-178. DOI:

Combination of Angiotensin II and L-NG-Nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure
Hamilton, DJ, Zhang, A, Li, S, Cao, TN, Smith, JA, Vedula, I, Cordero-Reyes, AM, Youker, KA, Torre-Amione, G & Gupte, AA 2016, American Journal of Physiology - Heart and Circulatory Physiology, pp. ajpheart.00746.2015.

Combination of angiotensin II and l-NG-nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure
Hamilton, DJ, Zhang, A, Li, S, Cao, TN, Smith, JA, Vedula, I, Cordero-Reyes, AM, Youker, KA, Torre-Amione, G & Gupte, AA 2016, American Journal of Physiology - Heart and Circulatory Physiology, vol 310, no. 6, pp. H667-H680. DOI:

Full Expression of Cardiomyopathy Is Partly Dependent on B-Cells: A Pathway That Involves Cytokine Activation, Immunoglobulin Deposition, and Activation of Apoptosis
Cordero-Reyes, AM, Youker, KA, Trevino, AR, Celis, R, Hamilton, DJ, Flores-Arredondo, JH, Orrego, CM, Bhimaraj, A, Estep, JD & Torre-Amione, G 2016, Journal of the American Heart Association, vol 5, no. 1. DOI:

Enhanced Cardiac Regenerative Ability of Stem Cells After Ischemia-Reperfusion Injury: Role of Human CD34(+) Cells Deficient in MicroRNA-377
Joladarashi, D, Srikanth Garikipati, VN, Thandavarayan, RA, Verma, SK, Mackie, AR, Khan, M, Gumpert, AM, Bhimaraj, A, Youker, KA, Uribe, C, Suresh Babu, S, Jeyabal, P, Kishore, R & Krishnamurthy, P 2015, Journal of the American College of Cardiology, vol 66, no. 20, pp. 2214-2226. DOI:

Standardized extracts from black bean coats (Phaseolus vulgaris L.) prevent adverse cardiac remodeling in a murine model of non-ischemic cardiomyopathy
García-Rivas, G, Youker, KA, Orrego, C, Flores-Arredondo, J, Guerrero-Beltrán, CE, Cordero-Reyes, A, Gutiérrez-Uribe, JA, García, M, Serna-Saldivar, SO & Torre-Amione, G 2015, RSC Advances, vol 5, no. 110, pp. 90858-90865. DOI:

Differential mitochondrial function in remodeled right and non-remodeled left ventricles in pulmonary hypertension.
Gupte, AA, Cordero-Reyes, AM, Youker, K, Matsunami, RK, Engler, DA, Loebe, M, Ashrith, G, Torre, G & Hamilton, DJ 2015, Journal of Cardiac Failure, pp. Epub.

Cardiac mitochondrial function in a non-ischemic mouse model of heart failure.
Gupte, AA, Cao, TN, Li, S, Zhang, A, Cordero-Reyes, AM, Youker, K, Torre, G & Hamilton, DJ 2015, Keystone symposia: Mitochondria, Metabolism and Heart Failure (J5), Santa Fe, United States, 1/27/15 - 2/1/15, .

High proportion of patients with end-stage heart failure regardless of aetiology demonstrates anti-cardiac antibody deposition in failing myocardium: Humoral activation, a potential contributor of disease progression
Youker, KA, Assad-Kottner, C, Cordero-Reyes, AM, Trevino, AR, Flores-Arredondo, JH, Barrios, R, Fernandez-Sada, E, Estep, JD, Bhimaraj, A & Torre-Amione, G 2014, European Heart Journal, vol 35, no. 16, pp. 1061-1068. DOI:

Freshly isolated mitochondria from failing human hearts exhibit preserved respiratory function
Cordero-Reyes, AM, Gupte, AA, Youker, KA, Loebe, M, Hsueh, WA, Torre-Amione, G, Taegtmeyer, H & Hamilton, DJ 2014, Journal of Molecular and Cellular Cardiology, vol 68, pp. 98-105. DOI:

Molecular and cellular correlates of cardiac function in end-stage DCM: A study using speckle tracking echocardiography
Cordero-Reyes, AM, Youker, K, Estep, JD, Torre-Amione, G & Nagueh, SF 2014, JACC: Cardiovascular Imaging, vol 7, no. 5, pp. 441-452. DOI:

Mechanical unloading promotes myocardial energy recovery in human heart failure
Gupte, AA , Hamilton, DJ, Cordero-Reyes, AM, Youker, KA, Yin, Z, Estep, JD, Stevens, RD, Wenner, B, Ilkayeva, O, Loebe, M, Peterson, LE, Lyon, CJ, Wong, STC, Newgard, CB, Torre-Amione, G, Taegtmeyer, H & Hsueh, WA 2014, Circulation: Cardiovascular Genetics, vol 7, no. 3, pp. 266-276. DOI:

The role of B-cells in heart failure.
Cordero-Reyes, AM, Youker, KA & Torre-Amione, G 2013, Houston Methodist DeBakey Cardiovascular Journal, vol 9, no. 1, pp. 15-19.

Molecular, cellular, and functional characterization of myocardial regions in hypertrophic cardiomyopathy
Cordero-Reyes, AM, Youker, K, Hamilton, DJ, Torre-Amione, G, Marian, AJ & Nagueh, SF 2012, Circulation: Cardiovascular Imaging, vol 5, no. 3, pp. 419-422. DOI:

Erratum: Neovascularization and remodeling in patients injected with autologous bone marrow cells (ASAIO Journal 57:2 (103))
Bruckner, BA, Garcia-Morales, LJ, Youker, K, Motomura, T, Bunge, RR, Ramlawi, B, Estep, J & Loebe, M 2011, ASAIO Journal, vol 57, no. 4. DOI:

Cellular Evidence of Reverse Cardiac Remodeling Induced by Cardiac Resynchronization Therapy
Orrego, CM, Nasir, N, Oliveira, GH, Flores-Arredondo, JH, Cordero-Reyes, AM, Loebe, M, Youker, KA & Torre-Amione, G 2011, Congestive Heart Failure, vol 17, no. 3, pp. 140-146. DOI: