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Kalpana Mujoo,

Houston Methodist
Weill Cornell Medical College

Areas Of Expertise

Stem cells, DNA damage, Nitric oxide, cyclic GMP, signal transduction, HER3 Signal transduction Stem cells DNA damage Nitric oxide Cyclic GMP HER3

MCL-1 depletion impairs DNA DSB repair and re-initiation of stalled DNA replication forks
Mattoo, AR, Pandita, RK, Chakraborty, S, Charaka, V, Mujoo, K, Hunt, CR & Pandita, TK 2016, Molecular and Cellular Biology. DOI:

Novel association of DJ-1 with HER3 potentiates HER3 activation and signaling in cancer
Zhang, S, Mukherjee, S, Fan, X, Salameh, A, Mujoo, K, Huang, Z, Li, L, Salazar, GT, Zhang, N & An, Z 2016, Oncotarget. DOI:

Pluripotent stem cells and DNA damage response to ionizing radiations
Mujoo, K , Butler, EB, Pandita, RK, Hunt, CR & Pandita, TK 2016, Radiation Research, vol 186, no. 1, pp. 17-26. DOI:

ß2-spectrin depletion impairs DNA damage repair
Horikoshi, N, Pandita, RK, Mujoo, K, Hambarde, S, Sharma, D, Mattoo, AR, Chakraborty, S, Charaka, V, Hunt, CR & Pandita, TK 2016, Oncotarget, vol 7, no. 23, pp. 33557-33570. DOI:

A multifaceted role for MOF histone modifying factor in genome maintenance
Mujoo, K, Hunt, CR, Horikoshi, N & Pandita, TK 2016, Mechanisms of Ageing and Development. DOI:

Crk II silencing down-regulates IGF-IR and inhibits migration and invasion of prostate cancer cells
Mujoo, K 2016, Biochemistry and Biophysics Reports, vol 8, 2405-5808, pp. 382-388. DOI:

The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling
Huang, Z, Choi, BK, Mujoo, K, Fan, X, Fa, M, Mukherjee, S, Owiti, N, Zhang, N & An, Z 2015, Oncogene, vol 34, no. 9, pp. 1105-1115. DOI:

Role of the exocyst complex component Sec6/8 in genomic stability
Torres, MJ, Pandita, RK, Kulak, O, Kumar, R, Formstecher, E, Horikoshi, N, Mujoo, K, Hunt, CR, Zhao, Y, Lum, L, Zaman, A, Yeaman, C, White, MA & Pandita, TK 2015, Molecular and Cellular Biology, vol 35, no. 21, pp. 3633-3645. DOI:

Regulation of ERBB3/HER3 signaling in cancer
Mujoo, K, Choi, BK, Huang, Z, Zhang, N & An, Z 2014, Oncotarget, vol 5, no. 21, pp. 10222-10236.

Curcumin induces differentiation of embryonic stem cells through possible modulation of nitric oxide-cyclic GMP pathway
Mujoo, K, Nikonoff, LE, Sharin, VG, Bryan, NS, Kots, AY & Murad, F 2012, Protein and Cell, vol 3, no. 7, pp. 535-544. DOI:

Nitric oxide-cyclic GMP signaling in stem cell differentiation
Mujoo, K, Krumenacker, JS & Murad, F 2011, Free Radical Biology and Medicine, vol 51, no. 12, pp. 2150-2157. DOI:

Nitric oxide receptor soluble guanylyl cyclase undergoes splicing regulation in differentiating human embryonic cells
Sharin, VG, Mujoo, K, Kots, AY, Martin, E, Murad, F & Sharina, IG 2011, Stem Cells and Development, vol 20, no. 7, pp. 1287-1293. DOI:

Role of soluble guanylyl cyclase-cyclic GMP signaling in tumor cell proliferation
Mujoo, K, Sharin, VG, Martin, E, Choi, BK, Sloan, C, Nikonoff, LE, Kots, AY & Murad, F 2010, Nitric Oxide - Biology and Chemistry, vol 22, no. 1, pp. 43-50. DOI:

Role of nitric oxide signaling components in differentiation of embryonic stem cells into myocardial cells
Mujoo, K, Sharin, VG, Bryan, NS, Krumenacker, JS, Sloan, C, Parveen, S, Nikonoff, LE, Kots, AY & Murad, F 2008, Proceedings of the National Academy of Sciences of the United States of America, vol 105, no. 48, pp. 18924-18929. DOI:

Differential expression of nitric oxide signaling components in undifferentiated and differentiated human embryonic stem cells
Mujoo, K, Krumenacker, JS, Wada, Y & Murad, F 2006, Stem Cells and Development, vol 15, no. 6, pp. 779-787. DOI:

Increased sensitivity of a metastatic model of prostate cancer to a novel tetravalent platinum analog
Mujoo, K, Watanabe, M, Khokhar, AR & Siddik, ZH 2005, Prostate, vol 62, no. 1, pp. 91-100. DOI:

Status of p53 phosphorylation and function in sensitive and resistant human cancer models exposed to platinum-based DNA damaging agents
Mujoo, K, Watanabe, M, Nakamura, J, Khokhar, AR & Siddik, ZH 2003, Journal of Cancer Research and Clinical Oncology, vol 129, no. 12, pp. 709-718. DOI:

Triterpenoid saponins from Acacia victoriae (Bentham) decrease tumor cell proliferation and induce apoptosis
Mujoo, K, Haridas, V, Hoffmann, JJ, Wächter, GA, Hutter, LK, Lu, Y, Blake, ME, Jayatilake, GS, Bailey, D, Mills, GB & Gutterman, JU 2001, Cancer Research, vol 61, no. 14, pp. 5486-5490.

Avicins: Triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbation
Haridas, V, Higuchi, M, Jayatilake, GS, Bailey, D, Mujoo, K, Blake, ME, Arntzen, CJ & Gutterman, JU 2001, Proceedings of the National Academy of Sciences of the United States of America, vol 98, no. 10, pp. 5821-5826. DOI:

Emergence of cisplatin-resistant cells from the OVCAR-3 ovarian carcinoma cell line with p53 mutations, altered tumorigenicity, and increased apoptotic sensitivity to p53 gene replacement
Mujoo, K, Zhang, L, Klostergaard, J & Donato, NJ 2000, International Journal of Gynecological Cancer, vol 10, no. 2, pp. 105-114. DOI: