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Joy Wolfram, PhD

Assistant Affiliate Member, Research Institute
Houston Methodist


wolfram.joy@mayo.edu
Biography

Dr. Joy Wolfram is an Assistant Professor of Medicine at the Mayo Clinic in Florida, where she leads the Wolfram Lab for Nanomedicine and Extracellular Vesicles. She also holds affiliate faculty positions in the Department of Nanomedicine at the Houston Methodist Hospital in Texas and in the Department of Biology at the University of North Florida. She received her bachelor’s and master’s degrees in biology from the University of Helsinki in Finland. In 2016, she completed her Ph.D. in Nanoscience and Technology at the University of Chinese Academy of Sciences in Beijing, China. She has authored 40 publications and received more than 25 scientific awards from seven different countries. She was included in the Amgen Scholars Ten to Watch List, which highlights the best and brightest up-and-comers in science and medicine across 42 countries. She has developed several nanoparticles for the treatment of various diseases, including cancer. Her goal is to bring new nanomedicines with increased therapeutic efficacy and safety to the clinic. Her mission is also to inspire and support underrepresented minorities in science. She is actively involved in community outreach and scientific education.

Description of Research

The focus of Dr. Wolfram's research is on the development of synthetic and biological nanotherapeutics for the treatment of life-threatening diseases, such as cancer and tissue injury.

Areas Of Expertise

Extracellular vesicles Nanomedicine Cancer Tissue injury
Education & Training

PhD , University of Chinese Academy of Sciences
MS , University of Helsinki
BS , University of Helsinki
Publications

A novel DNA aptamer for dual targeting of polymorphonuclear myeloid-derived suppressor cells and tumor cells
Liu, H, Mai, J, Shen, J, Wolfram, J, Li, Z, Zhang, G, Xu, R, Li, Y, Mu, C, Zu, Y, Li, X, Lokesh, GL, Thiviyanathan, V, Volk, DE, Gorenstein, DG, Ferrari, M, Hu, Z & Shen, H 2018, Theranostics, vol 8, no. 1, pp. 31-44. DOI: 10.7150/thno.21342

A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery
Wolfram, J, Nizzero, S, Liu, H, Li, F, Zhang, G, Li, Z, Shen, H, Blanco, E & Ferrari, M 2017, Scientific Reports, vol 7, no. 1, pp. 13738. DOI: 10.1038/s41598-017-14221-2

Contribution of Kupffer cells to liposome accumulation in the liver
Samuelsson, E, Shen, H, Blanco, E, Ferrari, M & Wolfram, J 2017, Colloids and Surfaces B: Biointerfaces, vol 158, pp. 356-362. DOI: 10.1016/j.colsurfb.2017.07.014

A Liposome Encapsulated Ruthenium Polypyridine Complex as a Theranostic Platform for Triple-Negative Breast Cancer
Shen, J, Kim, HC, Wolfram, J, Mu, C, Zhang, W, Liu, H, Xie, Y, Mai, J, Zhang, H, Li, Z, Guevara, M, Mao, ZW & Shen, H 2017, Nano Letters, vol 17, no. 5, pp. 2913-2920. DOI: 10.1021/acs.nanolett.7b00132

Multi-step encapsulation of chemotherapy and gene silencing agents in functionalized mesoporous silica nanoparticles
Shen, J, Liu, H, Mu, C, Wolfram, J, Zhang, W, Kim, HC, Zhu, G, Hu, Z, Ji, LN, Liu, X, Ferrari, M, Mao, ZW & Shen, H 2017, Nanoscale, vol 9, no. 16, pp. 5329-5341. DOI: 10.1039/c7nr00377c

Taking the vehicle out of drug delivery
Shen, J, Wolfram, J, Ferrari, M & Shen, H 2017, Materials Today. DOI: 10.1016/j.mattod.2017.01.013

Post-nano strategies for drug delivery: multistage porous silicon microvectors
Venuta, A, Wolfram, J, Shen, H & Ferrari, M 2017, Journal of Materials Chemistry B, vol 5, no. 2, pp. 207-219. DOI: 10.1039/C6TB01978A

Enzyme-responsive multistage vector for drug delivery to tumor tissue
Mi, Y, Wolfram, J, Mu, C, Liu, X, Blanco, E, Shen, H & Ferrari, M 2016, Pharmacological Research, vol 113, pp. 92-99. DOI: 10.1016/j.phrs.2016.08.024

Strategies for improving drug delivery: nanocarriers and microenvironmental priming
Khalid, A, Persano, S, Shen, H, Zhao, Y, Blanco, E, Ferrari, M & Wolfram, J 2016, Expert Opinion on Drug Delivery, pp. 1-13. DOI: 10.1080/17425247.2017.1243527

Label-Free Isothermal Amplification Assay for Specific and Highly Sensitive Colorimetric miRNA Detection
Persano, S, Guevara, ML, Wolfram, J, Blanco, E, Shen, H, Ferrari, M & Pompa, PP 2016, ACS Omega, vol 1, no. 3, pp. 448-455. DOI: 10.1021/acsomega.6b00109

Label-Free Isothermal Amplification Assay for Specific and Highly Sensitive Colorimetric miRNA Detection
Persano, S, Guevara, ML, Wolfram, J, Blanco, E, Shen, H, Ferrari, M & Pompa, PP 2016, ACS Omega, vol 1, no. 3, pp. 448-455. DOI: 10.1021/acsomega.6b00109

A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells
Scott, B, Shen, J, Nizzero, S, Boom, K, Persano, S, Mi, Y, Liu, X, Zhao, Y, Blanco, E, Shen, H, Ferrari, M & Wolfram, J 2016, Pharmacological Research, vol 111, pp. 413-421. DOI: 10.1016/j.phrs.2016.07.005

A Micro/Nano Composite for Combination Treatment of Melanoma Lung Metastasis
Mi, Y, Mu, C, Wolfram, J, Deng, Z, Hu, T, Liu, X, Blanco, E, Shen, H & Ferrari, M 2016, Advanced Healthcare Materials, vol 5, no. 8, pp. 936-46. DOI: 10.1002/adhm.201500910

Nanomedicine Activities in the United States and Worldwide
Wolfram, J, Borsoi, C & Ferrari, M 2016, . in B Muller & M Van de Voorde (eds), Nanoscience and Nanotechnology for Human Health. Wiley-VCH, pp. 21-50.

Multistage vector (MSV) therapeutics
Wolfram, J , Shen, H & Ferrari, M 2015, Journal of Controlled Release, vol 219, pp. 406-415. DOI: 10.1016/j.jconrel.2015.08.010

Multistage vector delivery of sulindac and silymarin for prevention of colon cancer
Scavo, MP, Gentile, E, Wolfram, J, Gu, J, Barone, M, Evangelopoulos, M, Martinez, JO, Liu, X, Celia, C, Tasciotti, E, Vilar, E & Shen, H 2015, Colloids and Surfaces B: Biointerfaces, vol 136, pp. 694-703. DOI: 10.1016/j.colsurfb.2015.10.005

Hesperetin liposomes for cancer therapy
Wolfram, J, Scott, B, Boom, K, Shen, J, Borsoi, C, Suri, K, Grande, R, Fresta, M, Celia, C, Zhao, Y, Shen, H & Ferrari, M 2016, Current Drug Delivery, vol 13, no. 5, pp. 711-719.

Connective tissue growth factor stimulates the proliferation, migration and differentiation of lung fibroblasts during paraquat-induced pulmonary fibrosis
Yang, Z, Sun, Z, Liu, H, Ren, Y, Shao, D, Zhang, W, Lin, J, Wolfram, J, Wang, F & Nie, S 2015, Molecular Medicine Reports, vol 12, no. 1, pp. 1091-7. DOI: 10.3892/mmr.2015.3537

Protective effects of intestinal trefoil factor (ITF) on gastric mucosal epithelium through activation of extracellular signal-regulated kinase 1/2 (ERK1/2)
Lin, J, Sun, Z, Zhang, W, Liu, H, Shao, D, Ren, Y, Wen, Y, Cao, L, Wolfram, J, Yang, Z & Nie, S 2015, Molecular and Cellular Biochemistry, vol 404, no. 1-2, pp. 263-70. DOI: 10.1007/s11010-015-2386-2

Polyethylene glycol (PEG)-dendron phospholipids as innovative constructs for the preparation of super stealth liposomes for anticancer therapy
Pasut, G, Paolino, D, Celia, C, Mero, A, Joseph, AS, Wolfram, J, Cosco, D, Schiavon, O, Shen, H & Fresta, M 2015, Journal of Controlled Release, vol 199, pp. 106-113. DOI: 10.1016/j.jconrel.2014.12.008