John J. Mahmarian, MD

Professor of Cardiology, Institute for Academic Medicine
Full Clinical Member, Research Institute
Professor, Department of Cardiology
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Mahmarian received his first faculty appointment in 1987 as an Instructor of Medicine at the Baylor College of Medicine in Houston, Texas. He quickly established himself as a leader in nuclear cardiology research and was promoted to full Professor in 2005 just prior to joining the Houston Methodist Specialty Physician Group and the faculty of the Weill Medical College of Cornell University.

Description of Research

Dr. Mahmarian´s early research efforts focused on quantification of ischemia as measured by SPECT sestimibi, thereby laying the groundwork for the use of this technique in international trials of ischemia. His current research is focused on combining the results of CT acquired coronary angiography with SPECT results (fusion imaging), as well as testing new agents for pharmacologic stress testing and imaging modalities (e.g. "hot spot" imaging).

Areas Of Expertise

Nuclear cardiology Ischemia Imaging CT SPECT Stress testing
Education & Training

Clinical Fellowship , Baylor College of Medicine
Residency , Baylor College of Medicine
MD , New York Medical College
Publications

Nuclear Cardiology Practice in Asia: Analysis of Radiation Exposure and Best Practice for Myocardial Perfusion Imaging - Results From the IAEA Nuclear Cardiology Protocols Cross-Sectional Study (INCAPS)
Pascual, TNB, Mercuri, M, El-Haj, N, Bom, HH-S, Lele, V, Al-Mallah, MH, Luxenburg, O, Karthikeyan, G, Vitola, J, Mahmarian, JJ, Better, N, Shaw, LJ, Rehani, MM, Kashyap, R, Paez, D, Dondi, M, Einstein, AJ & INCAPS Investigators Group 2017, Circulation Journal, vol 81, no. 4, pp. 501-510. DOI:

Coronary artery calcium score as a predictor for incident stroke: Systematic review and meta-analysis
Chaikriangkrai, K, Jhun, HY, Palamaner Subash Shantha, G, Bin Abdulhak, A, Sigurdsson, G, Nabi, F, Mahmarian, JJ & Chang, SM 2017, International Journal of Cardiology. DOI:

Prognostic Value of Coronary Artery Calcium Score in Acute Chest Pain Patients Without Known Coronary Artery Disease: Systematic Review and Meta-analysis
Chaikriangkrai, K, Palamaner Subash Shantha, G, Jhun, HY, Ungprasert, P, Sigurdsson, G, Nabi, F, Mahmarian, JJ & Chang, SM 2016, Annals of Emergency Medicine, vol 68, no. 6, pp. 659-670. DOI:

CMR First-Pass Perfusion for Suspected Inducible Myocardial Ischemia
Hendel, RC, Friedrich, MG, Schulz-Menger, J, Zemmrich, C, Bengel, F, Berman, DS, Camici, PG, Flamm, SD, Le Guludec, D, Kim, R, Lombardi, M, Mahmarian, J, Sechtem, U & Nagel, E 2016, JACC: Cardiovascular Imaging, vol 9, no. 11, pp. 1338-1348. DOI:

Gender Differences in Radiation Dose from Nuclear Cardiology Studies Across the World Findings from the INCAPS Registry
Shi, L, Dorbala, S, Paez, D, Shaw, LJ, Zukotynski, KA, Pascual, TNB, Karthikeyan, G, Vitola, JV, Better, N, Bokhari, N, Rehani, MM, Kashyap, R, Dondi, M, Mercuri, M, Einstein, AJ, Einstein, AJ, Pascual, TNB, Paez, D, Dondi, M, Better, N, Bouyoucef, SE, Karthikeyan, G, Kashyap, R, Lele, V, Magboo, VPC, Mahmarian, JJ, Meeks, JB, Mercuri, M, Mut, F, Rehani, MM, Vitola, JV, Alexanderson, E, Allam, A, Al-Mallah, MH, Better, N, Bouyoucef, SE, Bom, H, Flotats, A, Jerome, S, Kaufmann, PA, Lele, V, Luxenburg, O, Mahmarian, J, Shaw, LJ, Underwood, SR, Vitola, J, Amouri, W, Essabbah, H, Gassama, SS, Makhdomi, KB, El Mustapha, GIE, El Ouchdi, N, Qaïs, N, Soni, N, Vangu, W, Abazid, RM, Adams, B, Agarwal, V, Alfeeli, MA, Alnafisi, N, Bernabe, L, Bural, GG, Chaiwatanarat, T, Chandraguptha, JM, Cheon, GJ, Cho, I, Dogan, AS, Eftekhari, M, Frenkel, A, Garty, I, George, S, Geramifar, P, Golan, H, Habib, S, Hussain, R, Im, H, Jeon, HJ, Kalawat, T, Kang, WJ, Keng, F, Klaipetch, A, Kumar, PG, Lee, J, Lee, WW, Lim, I, Macaisa, CMM, Malhotra, G, Mittal, BR, Mohammad, MH, Mohan, P, Mulyanto, ID, Nariman, D, Nayak, UN, Niaz, K, Nikolov, G, Obaldo, JM, Ozturk, E, Park, JM, Park, S, Patel, CD, Phuong, HK, Quinon, AP, Rajini, TR, Saengsuda, Y, Santiago, J, Sayman, HB, Shinto, AS, Sivasubramaniyan, V, Son, MH, Sudhakar, P, Syed, GMS, Tamaki, N, Thamnirat, K, Thientunyakit, T, Thongmak, S, Velasco, DN, Verma, A, Vutrapongwatana, U, Wang, Y, Won, KS, Yao, Z, Yingsa-Nga, T, Yudistiro, R, Yue, KT, Zafrir, N, Adrian, SC, Agostini, D, Aguadé, S, Armitage, G, Backlund, M, Backman, M, Baker, M, Balducci, MT, Bavelaar, C, Berovic, M, Bertagna, F, Beuchel, R, Biggi, A, Bisi, G, Bonini, R, Bradley, A, Brudin, L, Bruno, I, Busnardo, E, Casoni, R, Choudhri, A, Cittanti, C, Clauss, R, Costa, DC, Costa, M, Dixon, K, Dziuk, M, Egelic, N, Eriksson, I, Fagioli, G, De Faria, DB, Florimonte, L, Francini, A, French, M, Gallagher, E, Garai, I, Geatti, O, Genovesi, D, Gianolli, L, Gimelli, A, Del Giudice, E, Halliwell, S, Hansson, MJ, Harrison, C, Homans, F, Horton, F, J?drzejuk, D, Jogi, J, Johansen, A, Johansson, H, Kalnina, M, Kaminek, M, Kiss, A, Kobylecka, M, Kostkiewicz, M, Kropp, J, Kullenberg, R, Lahoutte, T, Lang, O, Larsson, YH, Lázár, M, Leccisotti, L, Leners, N, Lindner, O, Lipp, RW, Maenhout, A, Maffioli, L, Marcassa, C, Martins, B, Marzullo, P, Medolago, G, Mendiguchía, CG, Mirzaei, S, Mori, M, Nardi, B, Nazarenko, S, Nikoletic, K, Oleksa, R, Parviainen, T, Patrina, J, Peace, R, Pirich, C, Piwowarska-Bilska, H, Popa, S, Prakash, V, Pubul, V, Puklavec, L, Rac, S, Ratniece, M, Rogan, SA, Romeo, A, Rossi, M, Ruiz, D, Sabharwal, N, Salobir, BG, Santos, AI, Saranovic, S, Sarkozi, A, Schneider, RP, Sciagra, R, Scotti, S, Servini, Z, Setti, LR, Starck, SA, Vajauskas, D, Veselý, J, Vieni, A, Vignati, A, Vito, IM, Weiss, K, Wild, D, Zdraveska-Kochovska, M, Agüro, RN, Alvarado, N, Barral, CM, Beretta, M, Berrocal, I, Batista Cuellar, JF, Cabral Chang, TM, Cabrera Rodríguez, LO, Canessa, J, Castro Mora, G, Claudia, AC, Clavelo, GF, Cruz Júnior, AF, Faccio, FF, Fernández, KM, Gomez Garibo, JR, Gonzalez, U, González, EP, Guzzo, MA, Jofre, J, Kapitán, M, Kempfer, G, Lopez, JL, Massardo, VT, Medeiros Colaco, I, Mesquita, CT, Montecinos, M, Neubauer, S, Pabon, LM, Puente, A, Rochela Vazquez, LM, Serna Macias, JA, Silva Pino, AG, Tártari Huber, FZ, Tovar, AP, Vargas, L, Wiefels, C, Aljizeeri, A, Alvarez, RJ, Barger, D, Beardwood, W, Behrens, J, Brann, L, Brown, D, Carr, H, Churchwell, K, Comingore, GA, Corbett, J, Costello, M, Cruz, F, Depinet, T, Dorbala, S, Earles, M, Esteves, FP, Etherton, E, Fanning, RJ, Fornace, J, Franks, L, Gewirtz, H, Gulanchyn, K, Hannah, CL, Hays, J, Hendrickson, J, Hester, J, Holmes, K, Jerome, S, Johnson, A, Jopek, C, Lewin, H, Lyons, J, Manley, C, Meden, J, Moore, S, Moore, WH, Murthy, V, Nace, R, Neely, D, Nelson, L, Niedermaier, O, Rice, D, Rigs, R, Schiffer, K, Schockling, E, Schultz, T, Schumacker, T, Sheesley, B, Sheikh, A, Siegel, B, Slim, AM, Smith, J, Szulc, M, Tanskersley, N, Tilkemeier, P, Valdez, GD, Vrooman, R, Wawrowicz, D, Winchester, DE, Alcheikh, A, Allen, B, Atkins, E, Bevan, J, Bonomini, C, Christiansen, J, Clack, L, Craig, E, Dixson, H, Duncan, I, Fredericks, S, Gales, S, Hampson, R, Hanley, T, Hartcher, K, Hassall, J, Kelley, B, Kelly, S, Kidd, T, De Kort, T, Larcos, G, Macdonald, W, McGrath, C, Murdoch, E, OMalley, S, ORourke, M, Pack, M, Pearce, R, Praehofer, R, Ramsay, S, Scarlett, L, Smidt, K, Souvannavong, F, Taubman, K, Taylor, G, Tse, K, Unger, S & Weale, J 2016, JACC: Cardiovascular Imaging, vol 9, no. 4, pp. 376-384. DOI:

Nuclear cardiology practice and associated radiation doses in Europe: results of the IAEA Nuclear Cardiology Protocols Study (INCAPS) for the 27 European countries
Lindner, O, Pascual, TNB, Mercuri, M, Acampa, W, Burchert, W, Flotats, A, Kaufmann, PA, Kitsiou, A, Knuuti, J, Underwood, SR, Vitola, JV, Mahmarian, JJ, Karthikeyan, G, Better, N, Rehani, MM, Kashyap, R, Dondi, M, Paez, D & Einstein, AJ 2016, European Journal of Nuclear Medicine and Molecular Imaging, vol 43, no. 4, pp. 718-728. DOI:

Optimizing evaluation of patients with low-to-intermediate-risk acute chest pain: A randomized study comparing stress myocardial perfusion tomography incorporating stress-only imaging versus cardiac CT
Nabi, F, Kassi, M, Muhyieddeen, K, Chang, SM, Xu, J, Peterson, L, Wray, N, Shirkey, B, Ashton, C & Mahmarian, J 2016, Journal of Nuclear Medicine, vol 57, no. 3, pp. 378-384. DOI:

Nuclear Cardiology Practices and Radiation Exposure in the Oceania Region: Results From the IAEA Nuclear Cardiology Protocols Study (INCAPS)
Biswas, S, Better, N, Pascual, TNB, Mercuri, M, Vitola, JV, Karthikeyan, G, Westcott, J, Alexánderson, E, Allam, AH, Al-Mallah, MH, Bom, HHS, Bouyoucef, SE, Flotats, A, Jerome, S, Kaufman, PA, Lele, V, Luxenburg, O, Mahmarian, JJ, Shaw, LJ, Underwood, SR, Rehani, M, Kashyap, R, Dondi, M, Paez, D & Einstein, AJ 2017, Heart Lung and Circulation, vol 26, no. 1, pp. 25–34. DOI:

Clinical Utility of Multidetector Computed Tomography in Redo Valve Procedures
Chaikriangkrai, K, Maragiannis, D, Belousova, T, Little, S, Nabi, F, Mahmarian, J & Chang, SM 2016, Journal of Cardiac Surgery, pp. 139-46. DOI:

Additive prognostic value of coronary artery calcium score and renal function in patients with acute chest pain without known coronary artery disease: up to 5-year follow-up
Chaikriangkrai, K, Nabi, F, Mahmarian, JJ & Chang, SM 2015, International Journal of Cardiovascular Imaging, vol 31, no. 8, pp. 1619-1626. DOI:

Prevalence and implications of subclinical coronary artery disease in patients with atrial fibrillation
Chaikriangkrai, K, Valderrabano, M, Bala, SK, Alchalabi, S, Graviss, EA, Nabi, F, Mahmarian, J & Chang, SM 2015, American Journal of Cardiology, vol 116, no. 8, pp. 1219-1223. DOI:

Abstract 491: Detection of Subclinical Coronary Artery Disease by Calcium Score in Patients With Atrial Fibrillation: Potential Clinical Implications
Chaikriangkrai, K, Valderrabano, M, Khaleel Bala, S, Alchalabi, S, Graviss, E, Nabi, F, Mahmarian, J & Chang, SM 2015, Arteriosclerosis, Thrombosis, and Vascular Biology, vol 35, no. Suppl 1, pp. A491.

ImageGuide™ Update
Tilkemeier, PL, Mahmarian, JJ, Wolinsky, DG & Denton, EA 2015, Journal of Nuclear Cardiology, vol 22, no. 5, pp. 994-997. DOI:

Current worldwide nuclear cardiology practices and radiation exposure: results from the 65 country IAEA Nuclear Cardiology Protocols Cross-Sectional Study (INCAPS)
Einstein, AJ, Pascual, TNB, Mercuri, M, Karthikeyan, G, Vitola, JV, Mahmarian, JJ, Better, N, Bouyoucef, SE, Hee-Seung Bom, H, Lele, V, Magboo, VPC, Alexánderson, E, Allam, AH, Al-Mallah, MH, Flotats, A, Jerome, S, Kaufmann, PA, Luxenburg, O, Shaw, LJ, Underwood, SR, Rehani, MM, Kashyap, R, Paez, D, Dondi, M & INCAPS Investigators Group 2015, European Heart Journal, vol 36, no. 26, pp. 1689-96. DOI:

Value of CACS compared with ETT and myocardial perfusion imaging for predicting long-term cardiac outcome in asymptomatic and symptomatic patients at low risk for coronary disease: Clinical implications in a multimodality imaging world
Chang, SM , Nabi, F , Xu, J , Pratt, CM, Mahmarian, AC, Frias, ME & Mahmarian, JJ 2015, JACC: Cardiovascular Imaging, vol 8, no. 2, pp. 134-144. DOI:

Nuclear cardiology: 2014 innovations and developments
Mahmarian, JJ, Chang, S & Nabi, F 2015, Houston Methodist DeBakey Cardiovascular Journal, vol 10, no. 3, pp. 163-71. DOI:

Current worldwide nuclear cardiology practices andradiationexposure: Results from the 65country IAEA nuclear cardiology protocols cross-sectional study (INCAPS)
Einstein, AJ, Pascual, TB, Mercuri, M, Karthikeyan, G, Vitola, JV, Mahmarian, JJ, Better, N, Bouyoucef, SE, Bom, HS, Lele, V, Magboo, VPC, Alexánderson, E, Allam, AH, Al-Mallah, MH, Flotats, A, Jerome, S, Kaufmann, PA, Luxenburg, O, Shaw, LJ, Richard Underwood, S, Rehani, MM, Kashyap, R, Paez, D & Dondi, M 2015, European Heart Journal, vol 36, no. 26, pp. 1689-1696. DOI:

MDCT assessment of mechanical circulatory support device complications
Vivo, RP, Kassi, M, Estep, JD, Bhimaraj, A, Trachtenberg, BH, Orrego, CM, Loebe, M, Bruckner, BA, Nabi, F, Mahmarian, JJ, Zoghbi, WA & Chang, SM 2015, JACC: Cardiovascular Imaging, vol 8, no. 1, pp. 100-102. DOI:

Estimating the reduction in the radiation burden from nuclear cardiology through use of stress-only imaging in the United States and worldwide
Mercuri, M, Pascual, TNB, Mahmarian, JJ, Shaw, LJ, Dondi, M, Paez, D & Einstein, AJ 2016, JAMA Internal Medicine, vol 176, no. 2, pp. 269-273. DOI:

Comparison of Radiation Doses and Best-Practice Use for Myocardial Perfusion Imaging in US and Non-US Laboratories: Findings From the IAEA (International Atomic Energy Agency) Nuclear Cardiology Protocols Study
Mercuri, M, Pascual, TNB, Mahmarian, JJ, Shaw, LJ, Rehani, MM, Paez, D & Einstein, AJ 2016, JAMA Internal Medicine, vol 176, no. 2, pp. 266-269. DOI: