John J. Mahmarian, MD

Professor of Cardiology, Institute for Academic Medicine
Full Clinical Member, Research Institute
Professor, Department of Cardiology
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Mahmarian received his first faculty appointment in 1987 as an Instructor of Medicine at the Baylor College of Medicine in Houston, Texas. He quickly established himself as a leader in nuclear cardiology research and was promoted to full Professor in 2005 just prior to joining the Houston Methodist Specialty Physician Group and the faculty of the Weill Medical College of Cornell University.

Description of Research

Dr. Mahmarian´s early research efforts focused on quantification of ischemia as measured by SPECT sestimibi, thereby laying the groundwork for the use of this technique in international trials of ischemia. His current research is focused on combining the results of CT acquired coronary angiography with SPECT results (fusion imaging), as well as testing new agents for pharmacologic stress testing and imaging modalities (e.g. "hot spot" imaging).

Areas Of Expertise

Nuclear cardiology Ischemia Imaging CT SPECT Stress testing
Education & Training

, Baylor College of Medicine
, New York Medical College
Publications

Prognostic Value of Coronary Artery Calcium Score in Acute Chest Pain Patients Without Known Coronary Artery Disease: Systematic Review and Meta-analysis
Chaikriangkrai, K, Palamaner Subash Shantha, G, Jhun, HY, Ungprasert, P, Sigurdsson, G, Nabi, F, Mahmarian, JJ & Chang, SM 2016, Annals of Emergency Medicine. DOI:

Coronary Artery Calcium Score as a Preditor for Incident Ischemic Stroke: Systematic Review and Meta-Analysis
Chaikriangkrai, K, Ungprasert, P, Sunkara, A, Nabi, F, Mahmarian, JJ & Chang, S-M 2016, American College of Cardiology (ACC) 2016, Chicago, United Kingdom, 4/2/16 - 4/4/16, .

Prognostic Accuracy of Coronary Artery Calcium Score in Acute Chest Pain Patients without Known Coronary Artery Disease in Emergency Department: Systemic Review and Meta-Analysis
Chaikriangkrai, K, Ungprasert, P, Jhun, HY, Nabi, F, Mahmarian, JJ & Chang, S-M 2016, American College of Cardiology (ACC) 2016, Chicago, United Kingdom, 4/2/16 - 4/4/16, .

Nuclear cardiology practice and associated radiation doses in Europe: results of the IAEA Nuclear Cardiology Protocols Study (INCAPS) for the 27 European countries
Lindner, O, Pascual, TNB, Mercuri, M, Acampa, W, Burchert, W, Flotats, A, Kaufmann, PA, Kitsiou, A, Knuuti, J, Underwood, SR, Vitola, JV, Mahmarian, JJ, Karthikeyan, G, Better, N, Rehani, MM, Kashyap, R, Dondi, M, Paez, D & Einstein, AJ 2016, European Journal of Nuclear Medicine and Molecular Imaging, vol 43, no. 4, pp. 718-728. DOI:

Gender Differences in Radiation Dose from Nuclear Cardiology Studies Across the World Findings from the INCAPS Registry
Shi, L, Dorbala, S, Paez, D, Shaw, LJ, Zukotynski, KA, Pascual, TNB, Karthikeyan, G, Vitola, JV, Better, N, Bokhari, N, Rehani, MM, Kashyap, R, Dondi, M, Mercuri, M, Einstein, AJ, Einstein, AJ, Pascual, TNB, Paez, D, Dondi, M, Better, N, Bouyoucef, SE, Karthikeyan, G, Kashyap, R, Lele, V, Magboo, VPC, Mahmarian, JJ, Meeks, JB, Mercuri, M, Mut, F, Rehani, MM, Vitola, JV, Alexanderson, E, Allam, A, Al-Mallah, MH, Better, N, Bouyoucef, SE, Bom, H, Flotats, A, Jerome, S, Kaufmann, PA, Lele, V, Luxenburg, O, Mahmarian, J, Shaw, LJ, Underwood, SR, Vitola, J, Amouri, W, Essabbah, H, Gassama, SS, Makhdomi, KB, El Mustapha, GIE, El Ouchdi, N, Qaïs, N, Soni, N, Vangu, W, Abazid, RM, Adams, B, Agarwal, V, Alfeeli, MA, Alnafisi, N, Bernabe, L, Bural, GG, Chaiwatanarat, T, Chandraguptha, JM, Cheon, GJ, Cho, I, Dogan, AS, Eftekhari, M, Frenkel, A, Garty, I, George, S, Geramifar, P, Golan, H, Habib, S, Hussain, R, Im, H, Jeon, HJ, Kalawat, T, Kang, WJ, Keng, F, Klaipetch, A, Kumar, PG, Lee, J, Lee, WW, Lim, I, Macaisa, CMM, Malhotra, G, Mittal, BR, Mohammad, MH, Mohan, P, Mulyanto, ID, Nariman, D, Nayak, UN, Niaz, K, Nikolov, G, Obaldo, JM, Ozturk, E, Park, JM, Park, S, Patel, CD, Phuong, HK, Quinon, AP, Rajini, TR, Saengsuda, Y, Santiago, J, Sayman, HB, Shinto, AS, Sivasubramaniyan, V, Son, MH, Sudhakar, P, Syed, GMS, Tamaki, N, Thamnirat, K, Thientunyakit, T, Thongmak, S, Velasco, DN, Verma, A, Vutrapongwatana, U, Wang, Y, Won, KS, Yao, Z, Yingsa-Nga, T, Yudistiro, R, Yue, KT, Zafrir, N, Adrian, SC, Agostini, D, Aguadé, S, Armitage, G, Backlund, M, Backman, M, Baker, M, Balducci, MT, Bavelaar, C, Berovic, M, Bertagna, F, Beuchel, R, Biggi, A, Bisi, G, Bonini, R, Bradley, A, Brudin, L, Bruno, I, Busnardo, E, Casoni, R, Choudhri, A, Cittanti, C, Clauss, R, Costa, DC, Costa, M, Dixon, K, Dziuk, M, Egelic, N, Eriksson, I, Fagioli, G, De Faria, DB, Florimonte, L, Francini, A, French, M, Gallagher, E, Garai, I, Geatti, O, Genovesi, D, Gianolli, L, Gimelli, A, Del Giudice, E, Halliwell, S, Hansson, MJ, Harrison, C, Homans, F, Horton, F, J?drzejuk, D, Jogi, J, Johansen, A, Johansson, H, Kalnina, M, Kaminek, M, Kiss, A, Kobylecka, M, Kostkiewicz, M, Kropp, J, Kullenberg, R, Lahoutte, T, Lang, O, Larsson, YH, Lázár, M, Leccisotti, L, Leners, N, Lindner, O, Lipp, RW, Maenhout, A, Maffioli, L, Marcassa, C, Martins, B, Marzullo, P, Medolago, G, Mendiguchía, CG, Mirzaei, S, Mori, M, Nardi, B, Nazarenko, S, Nikoletic, K, Oleksa, R, Parviainen, T, Patrina, J, Peace, R, Pirich, C, Piwowarska-Bilska, H, Popa, S, Prakash, V, Pubul, V, Puklavec, L, Rac, S, Ratniece, M, Rogan, SA, Romeo, A, Rossi, M, Ruiz, D, Sabharwal, N, Salobir, BG, Santos, AI, Saranovic, S, Sarkozi, A, Schneider, RP, Sciagra, R, Scotti, S, Servini, Z, Setti, LR, Starck, SA, Vajauskas, D, Veselý, J, Vieni, A, Vignati, A, Vito, IM, Weiss, K, Wild, D, Zdraveska-Kochovska, M, Agüro, RN, Alvarado, N, Barral, CM, Beretta, M, Berrocal, I, Batista Cuellar, JF, Cabral Chang, TM, Cabrera Rodríguez, LO, Canessa, J, Castro Mora, G, Claudia, AC, Clavelo, GF, Cruz Júnior, AF, Faccio, FF, Fernández, KM, Gomez Garibo, JR, Gonzalez, U, González, EP, Guzzo, MA, Jofre, J, Kapitán, M, Kempfer, G, Lopez, JL, Massardo, VT, Medeiros Colaco, I, Mesquita, CT, Montecinos, M, Neubauer, S, Pabon, LM, Puente, A, Rochela Vazquez, LM, Serna Macias, JA, Silva Pino, AG, Tártari Huber, FZ, Tovar, AP, Vargas, L, Wiefels, C, Aljizeeri, A, Alvarez, RJ, Barger, D, Beardwood, W, Behrens, J, Brann, L, Brown, D, Carr, H, Churchwell, K, Comingore, GA, Corbett, J, Costello, M, Cruz, F, Depinet, T, Dorbala, S, Earles, M, Esteves, FP, Etherton, E, Fanning, RJ, Fornace, J, Franks, L, Gewirtz, H, Gulanchyn, K, Hannah, CL, Hays, J, Hendrickson, J, Hester, J, Holmes, K, Jerome, S, Johnson, A, Jopek, C, Lewin, H, Lyons, J, Manley, C, Meden, J, Moore, S, Moore, WH, Murthy, V, Nace, R, Neely, D, Nelson, L, Niedermaier, O, Rice, D, Rigs, R, Schiffer, K, Schockling, E, Schultz, T, Schumacker, T, Sheesley, B, Sheikh, A, Siegel, B, Slim, AM, Smith, J, Szulc, M, Tanskersley, N, Tilkemeier, P, Valdez, GD, Vrooman, R, Wawrowicz, D, Winchester, DE, Alcheikh, A, Allen, B, Atkins, E, Bevan, J, Bonomini, C, Christiansen, J, Clack, L, Craig, E, Dixson, H, Duncan, I, Fredericks, S, Gales, S, Hampson, R, Hanley, T, Hartcher, K, Hassall, J, Kelley, B, Kelly, S, Kidd, T, De Kort, T, Larcos, G, Macdonald, W, McGrath, C, Murdoch, E, OMalley, S, ORourke, M, Pack, M, Pearce, R, Praehofer, R, Ramsay, S, Scarlett, L, Smidt, K, Souvannavong, F, Taubman, K, Taylor, G, Tse, K, Unger, S & Weale, J 2016, JACC: Cardiovascular Imaging, vol 9, no. 4, pp. 376-384. DOI:

Optimizing evaluation of patients with low-to-intermediate-risk acute chest pain: A randomized study comparing stress myocardial perfusion tomography incorporating stress-only imaging versus cardiac CT
Nabi, F, Kassi, M, Muhyieddeen, K, Chang, SM, Xu, J, Peterson, L, Wray, N, Shirkey, B, Ashton, C & Mahmarian, J 2016, Journal of Nuclear Medicine, vol 57, no. 3, pp. 378-384. DOI:

Nuclear Cardiology Practices and Radiation Exposure in the Oceania Region: Results From the IAEA Nuclear Cardiology Protocols Study (INCAPS)
Biswas, S, Better, N, Pascual, TNB, Mercuri, M, Vitola, JV, Karthikeyan, G, Westcott, J, Alexánderson, E, Allam, AH, Al-Mallah, MH, Bom, HHS, Bouyoucef, SE, Flotats, A, Jerome, S, Kaufman, PA, Lele, V, Luxenburg, O, Mahmarian, JJ, Shaw, LJ, Underwood, SR, Rehani, M, Kashyap, R, Dondi, M, Paez, D & Einstein, AJ 2016, Heart Lung and Circulation. DOI:

2015 ACR/ACC/AHA/AATS/ACEP/ASNC/NASCI/SAEM/SCCT/SCMR/SCPC/SNMMI/STR/STS Appropriate Utilization of Cardiovascular Imaging in Emergency Department Patients With Chest Pain. A Joint Document of the American College of Radiology Appropriateness Criteria Committee and the American College of Cardiology Appropriate Use Criteria Task Force
Rybicki, FJ, Udelson, JE, Peacock, WF, Goldhaber, SZ, Isselbacher, EM, Kazerooni, E, Kontos, MC, Litt, H, Woodard, PK, Alpert, JS, Andrews, GA, Chen, EP, Cooke, DT, Cury, RC, Edmundowicz, D, Ferrari, V, Graff, LG, Hollander, JE, Klein, LW, Leipsic, J, Levy, PD, Mahmarian, JJ, Rosenberg, C, Rubin, G, Ward, RP, White, C, Yucel, EK, Carr, JJ, Rybicki, FJ, White, RD, Woodard, PK, Patel, M, Douglas, P, Hendel, RC, Kramer, C & Doherty, J 2016, Journal of the American College of Radiology. DOI:

Additive prognostic value of coronary artery calcium score and renal function in patients with acute chest pain without known coronary artery disease: up to 5-year follow-up
Chaikriangkrai, K, Nabi, F, Mahmarian, JJ & Chang, SM 2015, International Journal of Cardiovascular Imaging, vol 31, no. 8, pp. 1619-1626. DOI:

Prevalence and implications of subclinical coronary artery disease in patients with atrial fibrillation
Chaikriangkrai, K, Valderrabano, M, Bala, SK, Alchalabi, S, Graviss, EA, Nabi, F, Mahmarian, J & Chang, SM 2015, American Journal of Cardiology, vol 116, no. 8, pp. 1219-1223. DOI:

Abstract 491: Detection of Subclinical Coronary Artery Disease by Calcium Score in Patients With Atrial Fibrillation: Potential Clinical Implications
Chaikriangkrai, K, Valderrabano, M, Khaleel Bala, S, Alchalabi, S, Graviss, E, Nabi, F, Mahmarian, J & Chang, SM 2015, Arteriosclerosis, Thrombosis, and Vascular Biology, vol 35, no. Suppl 1, pp. A491.

ImageGuide™ Update
Tilkemeier, PL, Mahmarian, JJ, Wolinsky, DG & Denton, EA 2015, Journal of Nuclear Cardiology, vol 22, no. 5, pp. 994-997. DOI:

Subclinical coronary artery disease in patients with atrial fibrillation: prevalence and clinical implications.
Kongiat Chaikriangkrai, Bala S Khaleel, S Alchalabi, EA Graviss, Nabi, F & Chang, S-M 2015, American Heart Association (AHA): Arteriosclerosis, Thrombosis and Vascular Biology 2015 Scientific Sessions, San Francisco, United States, 5/7/15 - 5/9/15, .

Complementary Prognostic Value of Renal Function and Coronary Artery Calcium Score in Patients Without Known Coronary Artery Disease: Up to 5-Year Follow-up.
Chaikraingkrai K, Trevino A, Anwar N & Forouzandeh F 2015, American College of Cardiology (ACC) 64th annual scientific sessions, San Diego, CA, United States, 3/14/15 - 3/16/15, .

Value of CACS compared with ETT and myocardial perfusion imaging for predicting long-term cardiac outcome in asymptomatic and symptomatic patients at low risk for coronary disease: Clinical implications in a multimodality imaging world
Chang, SM , Nabi, F , Xu, J , Pratt, CM, Mahmarian, AC, Frias, ME & Mahmarian, JJ 2015, JACC: Cardiovascular Imaging, vol 8, no. 2, pp. 134-144. DOI:

Nuclear cardiology: 2014 innovations and developments
Mahmarian, JJ, Chang, S & Nabi, F 2015, Houston Methodist DeBakey Cardiovascular Journal, vol 10, no. 3, pp. 163-71. DOI:

Estimating the reduction in the radiation burden from nuclear cardiology through use of stress-only imaging in the United States and worldwide
Mercuri, M, Pascual, TNB, Mahmarian, JJ, Shaw, LJ, Dondi, M, Paez, D & Einstein, AJ 2016, JAMA Internal Medicine, vol 176, no. 2, pp. 269-273. DOI:

Comparison of Radiation Doses and Best-Practice Use for Myocardial Perfusion Imaging in US and Non-US Laboratories: Findings From the IAEA (International Atomic Energy Agency) Nuclear Cardiology Protocols Study
Mercuri, M, Pascual, TNB, Mahmarian, JJ, Shaw, LJ, Rehani, MM, Paez, D & Einstein, AJ 2016, JAMA Internal Medicine, vol 176, no. 2, pp. 266-269. DOI:

Current worldwide nuclear cardiology practices andradiationexposure: Results from the 65country IAEA nuclear cardiology protocols cross-sectional study (INCAPS)
Einstein, AJ, Pascual, TB, Mercuri, M, Karthikeyan, G, Vitola, JV, Mahmarian, JJ, Better, N, Bouyoucef, SE, Bom, HS, Lele, V, Magboo, VPC, Alexánderson, E, Allam, AH, Al-Mallah, MH, Flotats, A, Jerome, S, Kaufmann, PA, Luxenburg, O, Shaw, LJ, Richard Underwood, S, Rehani, MM, Kashyap, R, Paez, D & Dondi, M 2015, European Heart Journal, vol 36, no. 26, pp. 1689-1696. DOI:

MDCT assessment of mechanical circulatory support device complications
Vivo, RP, Kassi, M, Estep, JD, Bhimaraj, A, Trachtenberg, BH, Orrego, CM, Loebe, M, Bruckner, BA, Nabi, F, Mahmarian, JJ, Zoghbi, WA & Chang, SM 2015, JACC: Cardiovascular Imaging, vol 8, no. 1, pp. 100-102. DOI: