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James Mancuso, PhD

Instructor in Systems Medicine and Bioengineering, Institute for Academic Medicine
Instructor, Research Institute
Houston Methodist


jjmancuso@houstonmethodist.org
Publications

Deep learning analytics for diagnostic support of breast cancer disease management
He, T, Puppala, M, Ogunti, R, Mancuso, JJ, Yu, X, Chen, S, Chang, JC, Patel, TA & Wong, STC 2017, . in 2017 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2017., 7897281, IEEE, pp. 365-368, 4th IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2017, Orlando, United States, 16-19 February. DOI:

Subarachnoid hemorrhage - Induced block of cerebrospinal fluid flow: Role of brain coagulation factor III (tissue factor)
Golanov, EV, Bovshik, E, Wong, K, Pautler, RG, Foster, C, Federley, R, Zhang, YJ, Mancuso, J, Wong, ST & Britz, GW 2017, Journal of Cerebral Blood Flow and Metabolism. DOI:

DrugMoaMiner: A computational tool for mechanism of action discovery and personalized drug sensitivity prediction
Li, F, Wang, L, Kong, R, Sheng, J, Cao, H, Mancuso, J, Xia, X, Stephan, C & Wong, STC 2016, . in 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016., 7455911, IEEE, pp. 368-371, 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016, Las Vegas, United States, 24-27 February. DOI:

A smartphone app framework for segmented cancer care coordination
He, T, Ogunti, R, Puppala, M, Chen, S, Yu, X, Mancuso, JJ & Wong, STC 2016, . in 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016., 7455912, IEEE, pp. 372-375, 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016, Las Vegas, United States, 24-27 February. DOI:

In Vivo Visualization and Characterization of Epithelial-Mesenchymal Transition in Breast Tumors
Zhao, Z, Zhu, X, Cui, K, Mancuso, J, Federley, R, Fischer, K, Teng, GJ, Mittal, V, Gao, D, Zhao, H & Wong, STC 2016, Cancer Research, vol 76, no. 8, pp. 2094-2104. DOI:

STIM2 regulates PKA-dependent phosphorylation and trafficking of AMPARs
Garcia-Alvarez, G, Lu, B, Yap, KAF, Wong, LC, Thevathasan, JV, Lim, L, Ji, F, Tan, KW, Mancuso, JJ, Tang, W, Poon, SY, Augustine, GJ & Fivaz, M 2015, Molecular Biology of the Cell, vol 26, no. 6, pp. 1141-1159. DOI:

Integration of multiscale dendritic spine structure and function data into systems biology models
Mancuso, JJ, Cheng, J, Yin, Z, Gilliam, JC, Xia, X, Li, X & Wong, STC 2014, Frontiers in Neuroanatomy, vol 8, no. November, 130. DOI:

Genomics-Based Cancer Theranostics
Yin, Z , Mancuso, JJ , Li, F & Wong, STC 2014, . in Cancer Theranostics. Elsevier, pp. 9-20. DOI:

Vasodilation by in vivo activation of astrocyte endfeet via two-photon calcium uncaging as a strategy to prevent brain ischemia
Chen, Y, Mancuso, J, Zhao, Z, Li, X, Cheng, J, Roman, G & Wong, STC 2013, Journal of Biomedical Optics, vol 18, no. 12, 126012. DOI:

Next-generation transgenic mice for optogenetic analysis of neural circuits
Asrican, B, Augustine, GJ, Berglund, K, Chen, S, Chow, N, Deisseroth, K, Feng, G, Gloss, B, Hira, R, Hoffmann, C, Kasai, H, Katarya, M, Kim, J, Kudolo, J, Lee, LM, Lo, SQ, Mancuso, J, Matsuzaki, M, Nakajima, R, Qiu, L, Tan, G, Tang, Y, Ting, JT, Tsuda, S, Wen, L, Zhang, X & Zhao, S 2013, Frontiers in Neural Circuits, vol 7, no. NOV, 160. DOI:

Methods of dendritic spine detection: From Golgi to high-resolution optical imaging
Mancuso, JJ, Chen, Y, Li, X, Xue, Z & Wong, STC 2013, Neuroscience, vol 251, pp. 129-140. DOI:

Optogenetic stimulation of cholinergic projection neurons as an alternative for deep brain stimulation for Alzheimers treatment
Mancuso, J, Chen, Y, Zhao, Z, Li, X, Xue, Z & Wong, STC 2013, . in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8565, 85655M, Photonic Therapeutics and Diagnostics IX, San Francisco, CA, United States, 2-7 February. DOI:

In vivo optical activation of astrocytes as a potential therapeutic strategy for neurodegenerative diseases
Chen, Y, Mancuso, J, Zhao, Z, Li, X, Xue, Z & Wong, STC 2013, . in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8565, 85655K, Photonic Therapeutics and Diagnostics IX, San Francisco, CA, United States, 2-7 February. DOI:

Distribution of RGS9-2 in neurons of the mouse striatum
Mancuso, JJ, Qian, Y, Long, C, Wu, GY & Wensel, TG 2010, Journal of Neurochemistry, vol 112, no. 3, pp. 651-661. DOI:

Optogenetic probing of functional brain circuitry
Mancuso, JJ, Kim, J, Lee, S, Tsuda, S, Chow, NBH & Augustine, GJ 2010, Experimental Physiology, vol 96, no. 1, pp. 26-33. DOI:

Multiphoton adaptation of a commercial low-cost confocal microscope for live tissue imaging
Mancuso, JJ, Larson, AM, Wensel, TG & Saggau, P 2009, Journal of Biomedical Optics, vol 14, no. 3, 034048. DOI: