Guillermo Torre, MD, PhD

Professor of Cardiology, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Torre-Amione received his first academic appointment in 1995 as a Clinical Instructor at the Baylor College of Medicine in Houston, Texas. He became an Assistant Professor there one year later, the same year he became the Medical Director for the Cardiac Transplant Service at Houston Methodist DeBakey Heart and Vascular Center. Dr.Torre-Amione joined the Houston Methodist Specialty Physician Group and Weill Medical College in 2005.

Description of Research

Dr. Torre-Amione is the director of the Heart Failure Research Laboratory at Houston Methodist, and conducts research examining the mechanisms of immune activation and inflammation as it relates to myocardial dysfunction in the areas of heart failure and cardiac transplantation. The doctor and his colleagues have conducted numerous studies that suggest novel immune modulatory therapies for the treatment of heart failure and transplant patients. Dr. Torre-Amione led the first two FDA-approved trials of Celacade with impressive results, and a Phase III trial is underway. Other studies underway in the Heart Failure Research Laboratory are investigating additional immune response pathways that contribute to the progression of heart failure, including the role of heat shock proteins and cardiac mast cells.

Areas Of Expertise

Heart failure Cardiac transplant Immune activation Inflammation Heat shock proteins Cardiac mast cells
Education & Training

Clinical Fellowship , Baylor College of Medicine
Residency , Baylor College of Medicine
Postdoctoral Fellowship , Baylor College of Medicine
MD , Facultad De Medicina - Instituto Tech.
PhD , University of Chicago
Publications

Risk Stratification of Patients With Current Generation Continuous-Flow Left Ventricular Assist Devices Being Bridged to Heart Transplantation
Guha, A, Nguyen, D, Cruz-Solbes, AS, Amione-Guerra, J, Schutt, RC, Bhimaraj, A, Trachtenberg, BH, Park, MH, Graviss, EA, Gaber, OO, Montane, E, Torre-Amione, G & Estep, JD 2017, ASAIO Journal. DOI: 10.1097/MAT.0000000000000635

Prevalence of in-hospital nonsteroidal antiinflammatory drug exposure in patients with a primary diagnosis of heart failure
Alvarez, PA, Putney, D, Ogunti, R, Puppala, M, Ganduglia, C, Torre-Amione, G, Schutt, R, Wong, STC & Estep, JD 2017, Cardiovascular Therapeutics, vol 35, no. 3. DOI: 10.1111/1755-5922.12256

Measurement of troponin and natriuretic peptides shortly after admission in patients with heart failure—does it add useful prognostic information? An analysis of the Value of Endothelin Receptor Inhibition with Tezosentan in Acute heart failure Studies (VERITAS)
Cleland, JGF, Teerlink, JR, Davison, BA, Shoaib, A, Metra, M, Senger, S, Milo, O, Cotter, G, Bourge, RC, Parker, JD, Jondeau, G, Krum, H, OConnor, CM, Torre-Amione, G, van Veldhuisen, DJ, McMurray, JJV & for the VERITAS Investigators 2017, European Journal of Heart Failure, vol 19, no. 6, pp. 739-747. DOI: 10.1002/ejhf.786

Rapamycin nanoparticles localize in diseased lung vasculature and prevent pulmonary arterial hypertension
Segura-Ibarra, V, Amione-Guerra, J, Cruz-Solbes, AS, Cara, FE, Iruegas-Nunez, DA, Wu, S, Youker, KA, Bhimaraj, A, Torre-Amione, G, Ferrari, M, Karmouty-Quintana, H, Guha, A & Blanco, E 2017, International Journal of Pharmaceutics, vol 524, no. 1-2, pp. 257-267. DOI: 10.1016/j.ijpharm.2017.03.069

Silica nanoparticles induce cardiotoxicity interfering with energetic status and Ca2+ handling in adult rat cardiomyocytes
Guerrero-Beltrán, CE, Bernal-Ramírez, J, Lozano, O, Oropeza-Almazán, Y, Castillo, EC, Garza, JR, García, N, Vela, J, García-García, A, Ortega, E, Torre-Amione, G, Ornelas-Soto, N & García-Rivas, G 2017, American Journal of Physiology - Heart and Circulatory Physiology, vol 312, no. 4, pp. H645-H661. DOI: 10.1152/ajpheart.00564.2016

Small Interfering RNA Targeting Mitochondrial Calcium Uniporter Improves Cardiomyocyte Cell Viability in Hypoxia/Reoxygenation Injury by Reducing Calcium Overload
Oropeza-Almazán, Y, Vázquez-Garza, E, Chapoy-Villanueva, H, Torre-Amione, G & García-Rivas, G 2017, Oxidative Medicine and Cellular Longevity, vol 2017, 5750897. DOI: 10.1155/2017/5750897

Role of Adaptive Immunity in the Development and Progression of Heart Failure: New Evidence
Sánchez-Trujillo, L, Vázquez-Garza, E, Castillo, EC, García-Rivas, G & Torre-Amione, G 2017, Archives of Medical Research, vol 48, no. 1, pp. 1-11. DOI: 10.1016/j.arcmed.2016.12.008

The Obesity Paradox in End Stage Heart Failure: Does LVAD Resolve the Paradox?
Cruz-Solbes, AS, Nguyen, DT, Trachtenberg, B, Bhimaraj, A, Torre-Amione, G, Graviss, EA, Estep, JD & Guha, A 2017, Journal of Cardiac Failure, vol 23, no. 8, pp. S17. DOI: 10.1016/j.cardfail.2017.07.058

Systolic blood pressure reduction during the first 24h in acute heart failure admission: Friend or foe?
Cotter, G, Metra, M, Davison, BA, Jondeau, G, Cleland, JGF, Bourge, RC, Milo, O, OConnor, CM, Parker, JD, Torre-Amione, G, van Veldhuisen, DJ, Kobrin, I, Rainisio, M, Senger, S, Edwards, C, Mcmurray, JJV & Teerlink, JR 2017, European Journal of Heart Failure. DOI: 10.1002/ejhf.889

Impact of Cytomegalovirus on Survival after Heart Transplant: Analysis of 20,000 Patients from the UNOS Registry Data
Ashrith, G, Daoud, A, Teeter, LD, Amione-Guerra, J, Cordero-Reyes, AM, Graviss, E, Trachtenberg, BH, Bhimaraj, A, Gaber, A, Scheinin, S, Torre-Amione, G & Estep, JD 2016, Journal of Heart and Lung Transplantation, vol 35, no. 4, pp. S60. DOI: 10.1016/j.healun.2016.01.165

Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1a/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1a and Regulates Responsive Cardiac Angiogenesis
Yue, X, Lin, X, Yang, T, Yang, X, Yi, X, Jiang, X, Li, X, Li, T, Guo, J, Dai, Y, Shi, J, Wei, L, Youker, KA, Torre-Amione, G, Yu, Y, Andrade, KC & Chang, J 2016, Hypertension, vol 67, no. 3, pp. 597-605. DOI: 10.1161/HYPERTENSIONAHA.115.06412

A specifically designed nanoconstruct associates, internalizes, traffics in cardiovascular cells, and accumulates in failing myocardium: A new strategy for heart failure diagnostics and therapeutics
Ruiz-Esparza, GU, Segura-Ibarra, V, Cordero-Reyes, AM, Youker, KA, Serda, RE, Cruz-Solbes, AS, Amione-Guerra, J, Yokoi, K, Kirui, DK, Cara, FE, Paez-Mayorga, J, Flores-Arredondo, JH, Guerrero-Beltrán, CE, Garcia-Rivas, G, Ferrari, M, Blanco, E & Torre-Amione, G 2016, European Journal of Heart Failure, vol 18, no. 2, pp. 169-178. DOI: 10.1002/ejhf.463

Combination of angiotensin II and l-NG-nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure
Hamilton, DJ, Zhang, A, Li, S, Cao, TN, Smith, JA, Vedula, I, Cordero-Reyes, AM, Youker, KA, Torre-Amione, G & Gupte, AA 2016, American Journal of Physiology - Heart and Circulatory Physiology, vol 310, no. 6, pp. H667-H680. DOI: 10.1152/ajpheart.00746.2015

Full expression of cardiomyopathy is partly dependent on B-cells: A pathway that involves cytokine activation, immunoglobulin deposition, and activation of apoptosis
Cordero-Reyes, AM, Youker, KA, Trevino, AR, Celis, R, Hamilton, DJ, Flores-Arredondo, JH, Orrego, CM, Bhimaraj, A, Estep, JD & Torre-Amione, G 2016, Journal of the American Heart Association, vol 5, no. 1, pp. 1-12. DOI: 10.1161/JAHA.115.002484

Impact of pre-operative coronary artery disease on cardiovascular events following lung transplantation
Chaikriangkrai, K, Jyothula, S, Jhun, HY, Estep, J, Loebe, M, Scheinin, S & Torre-Amione, G 2016, Journal of Heart and Lung Transplantation, vol 35, no. 1, pp. 115-121. DOI: 10.1016/j.healun.2015.08.009

Standardized extracts from black bean coats (Phaseolus vulgaris L.) prevent adverse cardiac remodeling in a murine model of non-ischemic cardiomyopathy
García-Rivas, G, Youker, KA, Orrego, C, Flores-Arredondo, J, Guerrero-Beltrán, CE, Cordero-Reyes, A, Gutiérrez-Uribe, JA, García, M, Serna-Saldivar, SO & Torre-Amione, G 2015, RSC Advances, vol 5, no. 110, pp. 90858-90865. DOI: 10.1039/c5ra07715j

Differential mitochondrial function in remodeled right and non-remodeled left ventricles in pulmonary hypertension.
Gupte, AA, Cordero-Reyes, AM, Youker, K, Matsunami, RK, Engler, DA, Loebe, M, Ashrith, G, Torre, G & Hamilton, DJ 2015, Journal of Cardiac Failure, pp. Epub.

Acute heart failure in the elderly: Differences in clinical characteristics, outcomes, and prognostic factors in the Veritas study
Metra, M, Cotter, G, El-Khorazaty, J, Davison, BA, Milo, O, Carubelli, V, Bourge, RC, Cleland, JG, Jondeau, G, Krum, H, OConnor, CM, Parker, JD, Torre-Amione, G, Van Veldhuisen, DJ, Rainisio, M, Kobrin, I, McMurray, JJ & Teerlink, JR 2015, Journal of Cardiac Failure, vol 21, no. 3, pp. 179-188. DOI: 10.1016/j.cardfail.2014.12.012

Persistent blood stream infection in patients supported with a continuous-flow left ventricular assist device is associated with an increased risk of cerebrovascular accidents
Trachtenberg, BH, Cordero-Reyes, AM, Aldeiri, M, Alvarez, P, Bhimaraj, A, Ashrith, G, Elias, B, Suarez, EE, Bruckner, B, Loebe, M, Harris, RL, Zhang, JY, Torre-Amione, G & Estep, JD 2015, Journal of Cardiac Failure, vol 21, no. 2, pp. 119-125. DOI: 10.1016/j.cardfail.2014.10.019

Impaired oxidative metabolism and calcium mishandling underlie cardiac dysfunction in a rat model of post-acute isoproterenol-induced cardiomyopathy
Willis, BC, Salazar-Cantú, A, Silva-Platas, C, Fernández-Sada, E, Villegas, CA, Rios-Argaiz, E, González-Serrano, P, Sánchez, LA, Guerrero-Beltrán, CE, García, N, Torre-Amione, G, García-Rivas, GJ & Altamirano, J 2015, American Journal of Physiology - Heart and Circulatory Physiology, vol 308, no. 5, pp. H467-H477. DOI: 10.1152/ajpheart.00734.2013