Guillermo Torre, MD, PhD

Professor of Cardiology, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. Torre-Amione received his first academic appointment in 1995 as a Clinical Instructor at the Baylor College of Medicine in Houston, Texas. He became an Assistant Professor there one year later, the same year he became the Medical Director for the Cardiac Transplant Service at Houston Methodist DeBakey Heart and Vascular Center. Dr.Torre-Amione joined the Houston Methodist Specialty Physician Group and Weill Medical College in 2005.

Description of Research

Dr. Torre-Amione is the director of the Heart Failure Research Laboratory at Houston Methodist, and conducts research examining the mechanisms of immune activation and inflammation as it relates to myocardial dysfunction in the areas of heart failure and cardiac transplantation. The doctor and his colleagues have conducted numerous studies that suggest novel immune modulatory therapies for the treatment of heart failure and transplant patients. Dr. Torre-Amione led the first two FDA-approved trials of Celacade with impressive results, and a Phase III trial is underway. Other studies underway in the Heart Failure Research Laboratory are investigating additional immune response pathways that contribute to the progression of heart failure, including the role of heat shock proteins and cardiac mast cells.

Areas Of Expertise

Heart failure Cardiac transplant Immune activation Inflammation Heat shock proteins Cardiac mast cells
Education & Training

, Baylor College of Medicine
, Facultad De Medicina - Instituto Tech.
, University of Chicago

Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1a/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1a and Regulates Responsive Cardiac Angiogenesis
Yue, X, Lin, X, Yang, T, Yang, X, Yi, X, Jiang, X, Li, X, Li, T, Guo, J, Dai, Y, Shi, J, Wei, L, Youker, KA, Torre-Amione, G, Yu, Y, Andrade, KC & Chang, J 2016, Hypertension, vol 67, no. 3, pp. 597-605. DOI:

A specifically designed nanoconstruct associates, internalizes, traffics in cardiovascular cells, and accumulates in failing myocardium: A new strategy for heart failure diagnostics and therapeutics
Ruiz-Esparza, GU, Segura-Ibarra, V, Cordero-Reyes, AM, Youker, KA, Serda, RE, Cruz-Solbes, AS, Amione-Guerra, J, Yokoi, K, Kirui, DK, Cara, FE, Paez-Mayorga, J, Flores-Arredondo, JH, Guerrero-Beltrán, CE, Garcia-Rivas, G, Ferrari, M, Blanco, E & Torre-Amione, G 2016, European Journal of Heart Failure, vol 18, no. 2, pp. 169-178. DOI:

Combination of Angiotensin II and L-NG-Nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure
Hamilton, DJ, Zhang, A, Li, S, Cao, TN, Smith, JA, Vedula, I, Cordero-Reyes, AM, Youker, KA, Torre-Amione, G & Gupte, AA 2016, American Journal of Physiology - Heart and Circulatory Physiology, pp. ajpheart.00746.2015.

Combination of angiotensin II and l-NG-nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure
Hamilton, DJ, Zhang, A, Li, S, Cao, TN, Smith, JA, Vedula, I, Cordero-Reyes, AM, Youker, KA, Torre-Amione, G & Gupte, AA 2016, American Journal of Physiology - Heart and Circulatory Physiology, vol 310, no. 6, pp. H667-H680. DOI:

Full Expression of Cardiomyopathy Is Partly Dependent on B-Cells: A Pathway That Involves Cytokine Activation, Immunoglobulin Deposition, and Activation of Apoptosis
Cordero-Reyes, AM, Youker, KA, Trevino, AR, Celis, R, Hamilton, DJ, Flores-Arredondo, JH, Orrego, CM, Bhimaraj, A, Estep, JD & Torre-Amione, G 2016, Journal of the American Heart Association, vol 5, no. 1. DOI:

Impact of pre-operative coronary artery disease on cardiovascular events following lung transplantation
Chaikriangkrai, K, Jyothula, S, Jhun, HY, Estep, J, Loebe, M, Scheinin, S & Torre-Amione, G 2016, Journal of Heart and Lung Transplantation, vol 35, no. 1, pp. 115-121. DOI:

Standardized extracts from black bean coats (Phaseolus vulgaris L.) prevent adverse cardiac remodeling in a murine model of non-ischemic cardiomyopathy
García-Rivas, G, Youker, KA, Orrego, C, Flores-Arredondo, J, Guerrero-Beltrán, CE, Cordero-Reyes, A, Gutiérrez-Uribe, JA, García, M, Serna-Saldivar, SO & Torre-Amione, G 2015, RSC Advances, vol 5, no. 110, pp. 90858-90865. DOI:

Differential mitochondrial function in remodeled right and non-remodeled left ventricles in pulmonary hypertension.
Gupte, AA, Cordero-Reyes, AM, Youker, K, Matsunami, RK, Engler, DA, Loebe, M, Ashrith, G, Torre, G & Hamilton, DJ 2015, Journal of Cardiac Failure, pp. Epub.

Echocardiographic Predictors of combined Pre and Post Capillary Pulmonary Hypertension (PH) in a Population of Systolic Heart Failure with WHO Group II Pulmonary Hypertension
Guha Ashrith, Nadia Fida, Andrea Cordero-Reyes, Javier Amione-Guerra, Zahoor Khan, Bhimaraj, A, Trachtenberg, B, Torre, G, Nagueh, S & Estep, J 2015, American College of Cardiology (ACC) 2015 , San Diego, United States, 3/14/15 - 3/16/15, .

Acute heart failure in the elderly: Differences in clinical characteristics, outcomes, and prognostic factors in the Veritas study
Metra, M, Cotter, G, El-Khorazaty, J, Davison, BA, Milo, O, Carubelli, V, Bourge, RC, Cleland, JG, Jondeau, G, Krum, H, OConnor, CM, Parker, JD, Torre-Amione, G, Van Veldhuisen, DJ, Rainisio, M, Kobrin, I, McMurray, JJ & Teerlink, JR 2015, Journal of Cardiac Failure, vol 21, no. 3, pp. 179-188. DOI:

Persistent blood stream infection in patients supported with a continuous-flow left ventricular assist device is associated with an increased risk of cerebrovascular accidents
Trachtenberg, BH, Cordero-Reyes, AM, Aldeiri, M, Alvarez, P, Bhimaraj, A, Ashrith, G, Elias, B, Suarez, EE, Bruckner, B, Loebe, M, Harris, RL, Zhang, JY, Torre-Amione, G & Estep, JD 2015, Journal of Cardiac Failure, vol 21, no. 2, pp. 119-125. DOI:

Cardiac mitochondrial function in a non-ischemic mouse model of heart failure.
Gupte, AA, Cao, TN, Li, S, Zhang, A, Cordero-Reyes, AM, Youker, K, Torre, G & Hamilton, DJ 2015, Keystone symposia: Mitochondria, Metabolism and Heart Failure (J5), Santa Fe, United States, 1/27/15 - 2/1/15, .

Impaired oxidative metabolism and calcium mishandling underlie cardiac dysfunction in a rat model of post-acute isoproterenol-induced cardiomyopathy
Willis, BC, Salazar-Cantú, A, Silva-Platas, C, Fernández-Sada, E, Villegas, CA, Rios-Argaiz, E, González-Serrano, P, Sánchez, LA, Guerrero-Beltrán, CE, García, N, Torre-Amione, G, García-Rivas, GJ & Altamirano, J 2015, American Journal of Physiology - Heart and Circulatory Physiology, vol 308, no. 5, pp. H467-H477. DOI:

Isolation and chemical identification of lipid derivatives from avocado (Persea americana) pulp with antiplatelet and antithrombotic activities
Rodriguez-Sanchez, DG, Flores-García, M, Silva-Platas, C, Rizzo, S, Torre-Amione, G, De La Peña-Diaz, A, Hernández-Brenes, C & García-Rivas, G 2015, Food and Function, vol 6, no. 1, pp. 193-203. DOI:

High proportion of patients with end-stage heart failure regardless of aetiology demonstrates anti-cardiac antibody deposition in failing myocardium: Humoral activation, a potential contributor of disease progression
Youker, KA, Assad-Kottner, C, Cordero-Reyes, AM, Trevino, AR, Flores-Arredondo, JH, Barrios, R, Fernandez-Sada, E, Estep, JD, Bhimaraj, A & Torre-Amione, G 2014, European Heart Journal, vol 35, no. 16, pp. 1061-1068. DOI:

Freshly isolated mitochondria from failing human hearts exhibit preserved respiratory function
Cordero-Reyes, AM, Gupte, AA, Youker, KA, Loebe, M, Hsueh, WA, Torre-Amione, G, Taegtmeyer, H & Hamilton, DJ 2014, Journal of Molecular and Cellular Cardiology, vol 68, pp. 98-105. DOI:

Molecular and cellular correlates of cardiac function in end-stage DCM: A study using speckle tracking echocardiography
Cordero-Reyes, AM, Youker, K, Estep, JD, Torre-Amione, G & Nagueh, SF 2014, JACC: Cardiovascular Imaging, vol 7, no. 5, pp. 441-452. DOI:

Effects of spironolactone treatment in elderly women with heart failure and preserved left ventricular ejection fraction
Kurrelmeyer, KM, Ashton, Y, Xu, JS, Nagueh, SF, Torre-Amione, G & Deswal, A 2014, Journal of Cardiac Failure, vol 20, no. 8, pp. 560-568. DOI:

Atrial arrhythmias after lung transplant: Underlying mechanisms, risk factors, and prognosis
Orrego, CM, Cordero-Reyes, AM, Estep, JD, Seethamraju, H, Scheinin, S, Loebe, M & Torre-Amione, G 2014, Journal of Heart and Lung Transplantation, vol 33, no. 7, pp. 734-740. DOI:

Mechanical unloading promotes myocardial energy recovery in human heart failure
Gupte, AA , Hamilton, DJ, Cordero-Reyes, AM, Youker, KA, Yin, Z, Estep, JD, Stevens, RD, Wenner, B, Ilkayeva, O, Loebe, M, Peterson, LE, Lyon, CJ, Wong, STC, Newgard, CB, Torre-Amione, G, Taegtmeyer, H & Hsueh, WA 2014, Circulation: Cardiovascular Genetics, vol 7, no. 3, pp. 266-276. DOI: