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George Taffet, MD

Adjunct Professor of Medicine, Institute for Academic Medicine
Houston Methodist
Weill Cornell Medical College

Education & Training

, Baylor College of Medicine
, Brown University Program in Medicine

Unrecognized Cognitive Impairment and Its Effect on Heart Failure Readmissions of Elderly Adults
Agarwal, KS, Kazim, R, Xu, J, Borson, S & Taffet, GE 2016, Journal of the American Geriatrics Society, vol 64, no. 11, pp. 2296-2301. DOI:

Left atrial volume and pulmonary artery diameter are noninvasive measures of age-related diastolic dysfunction in mice
Medrano, G, Hermosillo-Rodriguez, J, Pham, T, Granillo, A, Hartley, CJ, Reddy, A, Osuna, PM, Entman, ML & Taffet, GE 2016, Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol 71, no. 9, pp. 1141-1150. DOI:

Measures of healthspan as indices of aging in Mice-A recommendation
Richardson, A, Fischer, KE, Speakman, JR, De Cabo, R, Mitchell, SJ, Peterson, CA, Rabinovitch, P, Chiao, YA, Taffet, G, Miller, RA, Rentería, RC, Bower, J, Ingram, DK, Ladiges, WC, Ikeno, Y, Sierra, F & Austad, SN 2016, Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol 71, no. 4, pp. 427-430. DOI:

TNF/Ang-II synergy is obligate for fibroinflammatory pathology, but not for changes in cardiorenal function
Mayr, M, Duerrschmid, C, Medrano, G, Taffet, GE, Wang, Y, Entman, ML & Haudek, SB 2016, Physiological Reports, vol 4, no. 8, e12765. DOI:

Plasma Levels of Endothelial Microparticles Bearing Monomeric C-reactive Protein are Increased in Peripheral Artery Disease
Crawford, JR, Trial, J, Nambi, V, Hoogeveen, RC, Taffet, GE & Entman, ML 2016, Journal of Cardiovascular Translational Research, pp. 1-10. DOI:

PHD2/3-dependent hydroxylation tunes cardiac response to ß-adrenergic stress via phospholamban
Xie, L, Pi, X, Townley-Tilson, WHD, Li, N, Wehrens, XHT, Entman, ML, Taffet, GE, Mishra, A, Peng, J, Schisler, JC, Meissner, G & Patterson, C 2015, Journal of Clinical Investigation, vol 125, no. 7, pp. 2759-2771. DOI:

Heart failure with preserved ejection fraction in the elderly: Scope of the problem
Upadhya, B, Taffet, GE, Cheng, CP & Kitzman, DW 2015, Journal of Molecular and Cellular Cardiology, vol 83, pp. 73-87. DOI:

Cardiovascular physiology in the older adults
Dai, X, Hummel, SL, Salazar, JB, Taffet, GE, Zieman, S & Schwartz, JB 2015, Journal of Geriatric Cardiology, vol 12, no. 3, pp. 196-201. DOI:

Substance P receptor antagonism: A potential novel treatment option for viral-myocarditis
Robinson, P, Taffet, GE, Engineer, N, Khumbatta, M, Firozgary, B, Reynolds, C, Pham, T, Bulsara, T & Firozgary, G 2015, BioMed Research International, vol 2015, 645153. DOI:

High-Sensitivity troponin t and cardiovascular events in systolic blood pressure categories atherosclerosis risk in communities study
Pokharel, Y, Sun, W, De Lemos, JA, Taffet, GE, Virani, SS, Ndumele, CE, Mosley, TH, Hoogeveen, RC, Coresh, J, Wright, JD, Heiss, G, Boerwinkle, EA, Bozkurt, B, Solomon, SD, Ballantyne, CM & Nambi, V 2015, Hypertension, vol 65, no. 1, pp. 78-84. DOI:

Hypernatremia in the geriatric population
Shah, MK, Workeneh, B & Taffet, GE 2014, Clinical Interventions in Aging, vol 9, pp. 1987-1992. DOI:

Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: Interplay with cerebral blood flow
Li, H, Guo, Q, Inoue, T, Polito, VA, Tabuchi, K, Hammer, RE, Pautler, RG, Taffet, GE & Zheng, H 2014, Molecular Neurodegeneration, vol 9, no. 1, 28. DOI:

Young Little mice express a premature cardiovascular aging phenotype
Reddy, AK, Hartley, CJ, Pham, TT, Darlington, G, Entman, ML & Taffet, GE 2014, Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol 69 A, no. 2, pp. 152-159. DOI:

Adverse fibrosis in the aging heart depends on signaling between myeloid and mesenchymal cells; role of inflammatory fibroblasts
Cieslik, KA, Trial, J, Crawford, JR, Taffet, GE & Entman, ML 2014, Journal of Molecular and Cellular Cardiology, vol 70, pp. 56-63. DOI:

Considerations for managing chronic obstructive pulmonary disease in the elderly
Taffet, GE, Donohue, JF & Altman, PR 2013, Clinical Interventions in Aging, vol 9, pp. 23-30. DOI:

AICAR-dependent AMPK activation improves scar formation in the aged heart in a murine model of reperfused myocardial infarction
Cieslik, KA, Taffet, GE, Crawford, JR, Trial, J, Mejia Osuna, P & Entman, ML 2013, Journal of Molecular and Cellular Cardiology, vol 63, pp. 26-36. DOI:

microRNA-22 Promotes Heart Failure through Coordinate Suppression of PPAR/ERR-Nuclear Hormone Receptor Transcription
Gurha, P, Wang, T, Larimore, AH, Sassi, Y, Abreu-Goodger, C, Ramirez, MO, Reddy, AK, Engelhardt, S, Taffet, GE, Wehrens, XHT, Entman, ML & Rodriguez, A 2013, PLoS ONE, vol 8, no. 9, e75882. DOI:

Application of speckle-tracking in the evaluation of carotid artery function in subjects with hypertension and diabetes
Yang, EY, Brunner, G, Dokainish, H, Hartley, CJ, Taffet, G, Lakkis, N, Taylor, AA, Misra, A, McCulloch, ML, Morrisett, JD, Virani, SS, Ballantyne, CM, Nagueh, SF & Nambi, V 2013, Journal of the American Society of Echocardiography, vol 26, no. 8. DOI:

Incidence of cholinesterase inhibitor therapy initiation among hospitalized patients
Swan, JT, Wagle, KC, Thompson-Moore, N & Taffet, GE 2013, Journal of Hospital Medicine, vol 8, no. 6, pp. 304-308. DOI:

Initiation of cholinesterase inhibitors in an inpatient setting
Wagle, KC, Rowan, PJ, Poon, OYI, Kunik, ME, Taffet, GE & Braun, UK 2013, American Journal of Alzheimers Disease and other Dementias, vol 28, no. 4, pp. 377-383. DOI: