Eugene C. Lai, MD, PhD

Robert W. Hervey Chair for Parkinson's Research and Treatment, Stanley H. Appel Department of Neurology
Professor of Neurology and Neuroscience, Institute for Academic Medicine
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Eugene C. Lai is a clinician-scientist who has a special interest in the causes and treatments of neurodegenerative diseases, such as Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, and other related disorders. Dr. Lai has expertise in the assessment of motor function and quality of life. He is the principal investigator or co-investigator of many clinical research studies. His work has appeared in more than one hundred scientific publications and book chapters, and has lectured widely on topics in neurodegenerative diseases.

Description of Research

Dr. Lai's research interests are in the causes and treatments of neurodegenerative diseases and the assessment of motor function and quality of life of patients with movement disorders and dementias.

Areas Of Expertise

Neurodegenerative disease Motor function assessment Movement disorders Dementia Quality of life
Education & Training

, Baylor College of Medicine
Publications

Post-stroke dyskinesias
Nakawah, MO & Lai, EC 2016, Neuropsychiatric Disease and Treatment, vol 12, pp. 2885-2893. DOI:

Teaching Video Neuro Images: P/Q-type voltage-gated calcium channel-associated paraneoplastic elliptical nystagmus
Mistry, EA, Lee, AG & Lai, EC 2016, Neurology, vol 87, no. 10, pp. e109. DOI:

Teaching Video NeuroImages: P/Q-type voltage-gated calcium channel-associated paraneoplastic elliptical nystagmus
Mistry, EA, Lee, AG & Lai, EC 2016, Neurology, vol 87, no. 10, pp. e109. DOI:

Cognition in individuals at risk for Parkinson's: Parkinson associated risk syndrome (PARS) study findings
Chahine, LM, Weintraub, D, Hawkins, KA, Siderowf, A, Eberly, S, Oakes, D, Seibyl, J, Stern, MB, Marek, K, Jennings, D, Russell, D, Fiocco, A, Sethi, K, Jackson, P, Frank, S, Thomas, CA, James, RC, Simuni, T, Borushko, E, Stern, M, Rick, J, Hauser, R, Khavarian, L, Richard, I, Deeley, C, Liang, GS, Infeld, L, Adler, CH, Duffy, AK, Saunders-Pullman, R, Evatt, ML, McMurray, B, Lai, E, Johnson, S, DeBakey, ME, Subramanian, I, Gratiano, A, Chung, K, Lobb, B & OConner, S 2016, Movement Disorders, vol 31, no. 1, pp. 86-94. DOI:

Differential effects of deep brain stimulation target on motor subtypes in Parkinson's disease
Katz, M, Luciano, MS, Carlson, K, Luo, P, Marks, WJ, Larson, PS, Starr, PA, Follett, KA, Weaver, FM, Stern, MB, Reda, DJ, Ostrem, JL, CSP 468 study group & Lai, E 2015, Annals of Neurology, vol 77, no. 4, pp. 710-9. DOI:

Neuropsychological changes following deep brain stimulation surgery for Parkinson's disease: Comparisons of treatment at pallidal and subthalamic targets versus best medical therapy
Rothlind, JC, York, MK, Carlson, K, Luo, P, Marks, WJ, Weaver, FM, Stern, M, Follett, K, Reda, D, Ippolito, D, Stoner, G, Barnett, T, Bukowski, K, DeNicolo, R, Hur, K, Jimenez, J, Motyka, J, Simon, T, Thakkar, B, Woolson, R, Fye, C, Gagne, W, Harris, C, Heemskerk, J, Moy, C, Sheehy, P, OLeary, T, Huang, GD, Fiore, L, Hall, R, Stroupe, K, Burchiel, K, Koller, W, Pahwa, R, Sagher, O, Bakay, R, Chappell, R, Hart, R, Holloway, R, McCabe, G, Schenkman, M, Taha, J, Buckelew, J, Garin, M, Matzek, S, Smith, D, Bronstein, J, Duda, J, Hogarth, P, Holloway, K, Horn, S, Lai, EC, Samii, A, Atassi, F, Bello, C, Bunting-Perry, L, Conn, T, Cugley, A, Eubank, N, Fincher, L, Franks, R, Harris, T, Haselman, M, Heath, S, Hirsch, M, Janovsky, V, Lanier, E, Lloyd, M, Loehner, S, OConnor, S, Ordonez, L, Maccarone, H, Massey-Makhoul, K, Matthews, M, Meyn, E, Mimura, K, Morrow, W, Searles, T, Valotta, J, Vasthare, U, Volz, M, Ward, C, Warker, R, Watson, H, Willson, P, Baron, M, Brodsky, M, Calabrese, V, Campbell, G, Colcher, A, Farag, E, Henry, E, Hou, JG, Kang, G, Kleiner-Fisman, G, Kraakevik, J, Nutt, J, Ostrem, J, Sarwar, A, Subramanian, I, Vanek, Z, Baltuch, G, Salles, AD, Eller, J, Larson, P, Simpson, R, Starr, P, Carne, W, Erikson, T, Kreutzer, J, Mendez, M, Moberg, P, Ragland, J, Seel, R, Soety, E, Storzbach, D, Troster, A & Jaggi, J 2014, Journal of Neurology, Neurosurgery and Psychiatry. DOI:

Comparing clinical features of young onset, middle onset and late onset Parkinson's disease
Mehanna, R, Moore, S, Hou, JG, Sarwar, AI & Lai, EC 2014, Parkinsonism and Related Disorders, vol 20, no. 5, pp. 530-534. DOI:

Deep brain stimulation in Parkinson's disease
Mehanna, R & Lai, EC 2013, Translational Neurodegeneration, vol 2, no. 1, 22. DOI:

Effect of subthalamic nucleus or globus pallidus interna stimulation on oculomotor function in patients with parkinson's disease
Fridley, J, Adams, G, Sun, P, York, M, Atassi, F, Lai, E, Simpson, R, Viswanathan, A & Yoshor, D 2013, Stereotactic and Functional Neurosurgery, vol 91, no. 2, pp. 113-121. DOI:

Erratum: Cognitive rehabilitation for executive dysfunction in parkinson's disease: Application and current directions (Parkinson's Disease)
Calleo, J, Burrows, C, Levin, H, Marsh, L, Lai, E & York, MK 2012, Parkinsons Disease. DOI:

Two different 18F-FDG brain PET metabolic patterns in autoimmune limbic encephalitis
Fisher, RE, Patel, NR, Lai, EC & Schulz, PE 2012, Clinical Nuclear Medicine, vol 37, no. 9. DOI:

An exploratory study of activity in veterans with Parkinson's disease
Trail, M, Petersen, NJ, Nelson, N & Lai, EC 2012, Journal of Neurology, vol 259, no. 8, pp. 1686-1693. DOI:

Randomized trial of deep brain stimulation for Parkinson disease: Thirty-six-month outcomes
Weaver, FM, Follett, KA, Stern, M, Luo, P, Harris, CL, Hur, K, Marks, WJ, Rothlind, J, Sagher, O, Moy, C, Pahwa, R, Burchiel, K, Hogarth, P, Lai, EC, Duda, JE, Holloway, K, Samii, A, Horn, S, Bronstein, JM, Stoner, G, Starr, PA, Simpson, R, Baltuch, G, De Salles, A, Huang, GD & Reda, DJ 2012, Neurology, vol 79, no. 1, pp. 55-65. DOI:

The relation of falls to fatigue, depression and daytime sleepiness in Parkinson's disease
Bryant, MS, Rintala, DH, Hou, JG, Rivas, SP, Fernandez, AL, Lai, EC & Protas, EJ 2012, European Neurology, vol 67, no. 6, pp. 326-330. DOI:

Assessment of appropriate medication administration for hospitalized patients with Parkinson's disease
Hou, JG, Wu, LJ, Moore, S, Ward, C, York, M, Atassi, F, Fincher, L, Nelson, N, Sarwar, A & Lai, EC 2012, Parkinsonism and Related Disorders, vol 18, no. 4, pp. 377-381. DOI:

Impaired olfaction and other prodromal features in the Parkinson At-Risk Syndrome study
Siderowf, A, Jennings, D, Eberly, S, Oakes, D, Hawkins, KA, Ascherio, A, Stern, MB, Marek, K, Russell, D, Fiocco, A, Cotto, C, Sethi, K, Jackson, P, Frank, S, Hohler, A, Thomas, CA, James, RC, Simuni, T, Borushko, E, Stern, M, Rick, J, Hauser, R, Khavarian, L, McClain, T, Richard, I, Deely, C, Liang, GS, Reys, L, Adler, CH, Duffy, AK, Saunders-Pullman, R, Evatt, ML, McGinn, L, Lai, E, Johnson, S, Atassi, F, DeBakey, ME, Subramanian, I, Gratiano, A, Chung, K, Lobb, B, OConner, S, Albelo, MR, Cioffi, C, Gadoury, A, Howard, B, Iannucci, V, Lasch, S, Mendick, S, Miles, D, Miles, K, Virden, E & Wisniewski, G 2012, Movement Disorders, vol 27, no. 3, pp. 406-412. DOI:

Cognitive rehabilitation for executive dysfunction in Parkinson's disease: Application and current directions
Calleo, J, Burrows, C, Levin, H, Marsh, L, Lai, E & York, MK 2012, Parkinsons Disease. DOI:

Effects of levodopa on forward and backward gait patterns in persons with Parkinson's disease
Bryant, MS, Rintala, DH, Hou, JG, Lai, EC & Protas, EJ 2011, NeuroRehabilitation, vol 29, no. 3, pp. 247-252. DOI:

Gait variability in Parkinson's disease: Influence of walking speed and dopaminergic treatment
Bryant, MS, Rintala, DH, Hou, JG, Charness, AL, Fernandez, AL, Collins, RL, Baker, J, Lai, EC & Protas, EJ 2011, Neurological Research, vol 33, no. 9, pp. 959-964. DOI:

Brain Stem Disease
Lai, EC 2010, . in Neurology Secrets. Elsevier, pp. 141-156. DOI: