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Edward A. Graviss, PhD, MPH

Associate Professor of Pathology and Genomic Medicine, Institute for Academic Medicine
Associate Member, Research Institute
Houston Methodist

Research Lab

After receiving his doctoral degree in Epidemiology from The University of Texas Health Science Center at Houston, School of Public Health in 1993, Dr. Graviss joined the Michael DeBakey Houston VA Medical Center in Houston as an infectious disease epidemiologist, a position he still holds. He became a Research Instructor of Medicine at Baylor College of Medicine in 1994, and was later promoted to dual Associate Professorships there in the Departments of Pathology and Medicine in the section of Infectious Diseases, where he still holds adjunct positions. Dr. Graviss joined the Center for Molecular and Translational Human Infectious Diseases Research in the Houston Methodist Research Institute in 2008. Dr. Graviss holds several other joint adjunct positions including; Associate Professorships at the UT School of Public Health and the Division of the Health Sciences, the School of Biotechnology, and Health Tecnolóico de Monterrey, Monterrey, Mexico.


Description of Research

Dr. Graviss has extensive expertise in the study of the epidemiology and population-based surveillance of a variety of infectious agents including Mycobacterium tuberculosis. His recent studies focus on evaluation of the new Interferon Gamma Release Assays (IGRAs) in the diagnosis of latent tuberculosis infection.

Areas Of Expertise

Infectious agents Mycobacterium tuberculosis Latent tuberculosis
Education & Training

PhD , University of Texas Health Science Center
MPH , The University of Texas Health Science Center
MS , University of Texas San Antonio
BS , Texas Tech. University

Clinical and bacteriological characteristics associated with clustering of multidrug-resistant tuberculosis
J-Y Feng, J-Y, Jarlsberg, LG, Salcedo, K, Rose, J, Janes, M, Lin, S-YG, Osmond, DH, Jost, KC, Soehnlen, MK, Flood, J, Graviss, EA, Desmond, E, Moonan, PK, Nahid, P, Hopewell, PC & Kato-Maeda, M 2017, International Journal of Tuberculosis and Lung Disease, vol 5. DOI:

Quantification of circulating Mycobacterium tuberculosis antigen peptides allows rapid diagnosis of active disease and treatment monitoring
Liu, YC, Zhao, Z, Fan, J, Lyon, CJ, Wu, HJ, Nedelkov, D, Zelazny, AM, Olivier, KN, Cazares, LH, Holland, SM, Graviss, EA & Hu, Y 2017, Proceedings of the National Academy of Sciences of the United States of America, vol 114, no. 15, pp. 3969-3974. DOI:

Outcomes and costs of out-patient MDR-TB care in the USA
Marks, SM, Hirsch-Moverman, Y, Seaworth, B, Salcedo, K, Graviss, EA, Armstrong, L, Armitige, L, Flood, J & Mase, S 2017, International Journal of Tuberculosis and Lung Disease, vol 21, no. 4, pp. 477-478. DOI:

Longitudinal change in pulmonary arterial capacitance as an indicator of prognosis and response to therapy and in pulmonary arterial hypertension
Medrek, SK, Kloefkorn, C, Nguyen, DTM, Graviss, EA, Frost, AE & Safdar, Z 2017, Pulmonary circulation, vol 7, no. 1, pp. 2045893217698715. DOI:

Predictive value of serum bradykinin and desArg9-bradykinin levels for chemotherapeutic responses in active tuberculosis patients: A retrospective case series
Qian, X, Nguyen, DTM, Li, Y, Lyu, J, Graviss, E & Hu, TY 2016, Tuberculosis, vol 101, pp. S109-S118. DOI:

Texas Tuberculosis Research Symposium 2016: Research and clinical collaboration within the state of Texas towards elimination of TB
Graviss, EA & Actor, JK 2016, Tuberculosis, vol 101, pp. S1. DOI:

Comparing TSPOT assay results between an Elispot reader and manual counts
Agarwal, S, Nguyen, DT, Lew, JD, Teeter, LD, Yamal, JM, Restrepo, BI, Brown, EL, Dorman, SE & Graviss, EA 2016, Tuberculosis, vol Volume 101, Supplement, pp. S92–S98. DOI:

Differential positive TSPOT assay responses to ESAT-6 and CFP-10 in health care workers
Agarwal, S, Nguyen, DT, Lew, JD, Teeter, LD, Yamal, JM, Restrepo, BI, Brown, EL, Dorman, SE & Graviss, EA 2016, Tuberculosis, vol Volume 101, Supplement, pp. S83–S91. DOI:

Characterization of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone as a novel inhibitor of methionine aminopeptidases from Mycobacterium tuberculosis
John, SF, Aniemeke, E, Ha, NP, Chong, CR, Gu, P, Zhou, J, Zhang, Y, Graviss, EA, Liu, JO & Olaleye, OA 2016, Tuberculosis, vol 101, pp. S73-S77. DOI:

Screening for tuberculosis in neuro-ophthalmology
Little, LM, Graviss, EA, Foroozan, R & Lee, AG 2016, Expert Review of Ophthalmology, vol Vol. 11, no. 6, pp. 1-6. DOI:

Validation of genotype cluster investigations for Mycobacterium tuberculosis: application results for 44 clusters from four heterogeneous United States jurisdictions
Teeter, LD, Vempaty, P, Nguyen, DTM, Tapia, J, Sharnprapai, S, Ghosh, S, Kammerer, JS, Miramontes, R, Cronin, WA, Graviss, EA & Tuberculosis Epidemiologic Studies Consortium 2016, BMC Infectious Diseases, vol 16, no. 1, pp. 594. DOI:

Differentiating between live and dead Mycobacterium smegmatis using autofluorescence
Wong, C, Ha, NP, Pawlowski, ME, Graviss, EA & Tkaczyk, TS 2016, Tuberculosis, vol 101, no. Supplement, pp. S119-S123. DOI:

Schistosome Soluble Egg Antigen Decreases Mycobacterium tuberculosis-Specific CD4+ T-Cell Effector Function With Concomitant Arrest of Macrophage Phago-Lysosome Maturation
DiNardo, AR, Mace, EM, Lesteberg, K, Cirillo, JD, Mandalakas, AM, Graviss, EA, Orange, JS & Makedonas, G 2016, Journal of Infectious Diseases, vol 214, no. 3, pp. 479-88. DOI:

Effect of Chlorhexidine Bathing Every Other Day on Prevention of Hospital-Acquired Infections in the Surgical ICU: A Single-Center, Randomized Controlled Trial
Swan, JT , Ashton, CM, Bui, LN, Pham, VP, Shirkey, BA, Blackshear, JE, Bersamin, JB, Pomer, RML, Johnson, ML, Magtoto, AD, Butler, MO, Tran, SK, Sanchez, LR, Patel, JG, Ochoa, RA, Hai, SA, Denison, KI, Graviss, EA & Wray, NP 2016, Critical Care Medicine. DOI:

School-based study to identify and treat adolescent students at risk for tuberculosis infection
Hatzenbuehler, LA, Starke, JR, Graviss, EA, Smith, EOB & Cruz, AT 2016, Pediatric Infectious Disease Journal, vol 35, no. 7, pp. 733-738. DOI:

Heme oxygenase-1 regulates inflammation and mycobacterial survival in human macrophages during mycobacterium tuberculosis infection
Scharn, CR, Collins, AC, Nair, VR, Stamm, CE, Marciano, DK, Graviss, EA & Shiloh, MU 2016, Journal of Immunology, vol 196, no. 11, pp. 4641-4649. DOI:

Impact of Cytomegalovirus on Survival after Heart Transplant: Analysis of 20,000 Patients from the UNOS Registry Data
Ashrith, G, Daoud, A, Teeter, LD, Amione-Guerra, J, Cordero-Reyes, AM, Graviss, E, Trachtenberg, BH, Bhimaraj, A, Gaber, A, Scheinin, S, Torre-Amione, G & Estep, JD 2016, Journal of Heart and Lung Transplantation, vol 35, no. 4, pp. S60. DOI:

Characteristics and costs of multidrug-resistant tuberculosis inpatient care in the United States, 2005-2007
Marks, SM, Hirsch-Moverman, Y, Salcedo, K, Graviss, EA, Oh, P, Seaworth, B, Flood, J, Armstrong, L, Armitige, L & Mase, S 2016, International Journal of Tuberculosis and Lung Disease, vol 20, no. 4, pp. 435-441. DOI:

The Utility of Interferon-Gamma Release Assays (IGRAs) for the Diagnosis of Mycobacterium Tuberculosis (Mtb) in Hematopoietic Cell Transplant (HCT) Recipients
Kmeid, J, Shah, DP, El Chaer, F, Ariza-Heredia, EJ, Graviss, E, Mulanovich, VE & Chemaly, RF 2016, Biology of Blood and Marrow Transplantation, vol 22, no. 3, pp. S175. DOI:

Yield of chest radiograph in tuberculosis screening for HIV-infected persons at a district-level HIV clinic
Nguyen, DTM, Bang, ND, Hung, NQ, Beasley, RP, Hwang, LY & Graviss, EA 2016, International Journal of Tuberculosis and Lung Disease, vol 20, no. 2, pp. 211-217. DOI: