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David W. Bernard, MD, PhD

Associate Professor of Pathology and Genomic Medicine, Institute for Academic Medicine
Associate Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College

Dr. Bernard received his MD and PhD (biochemistry) degrees from the Medical College of Pennsylvania in Philadelphia. After completing a clinical pathology residency and a clinical chemistry fellowship at the Hospital of the University of Pennsylvania, he became an assistant professor in the Departments of Pathology and Biochemistry at the MCP-Hahnemann School of Medicine at the Allegheny University of Health Sciences. From 1998 until 2004, Dr. Bernard was an Assistant Professor in the Department of Pathology at the Baylor College of Medicine in Houston, Texas. He left Baylor in 2004 to join the Methodist Hospital Department of Pathology and Genomic Medicine. He has many roles within the Department including Medical Director of Clinical Pathology, Referral Testing, Laboratory Medicine Information Technology, and Point-of-Care Testing.

Description of Research

Dr. Bernard’s current research focuses on improved utilization and effectiveness of clinical testing and information technology for identification and treatment of hospitalized patients. Active interests also include how to effectively use clinical information technology to reduce medical errors and improve patient safety.

Areas Of Expertise

Information technology Clinical decision support Medical errors
Education & Training

, University of Pennsylvania Health System
, University of Pennsylvania Hospital
, Medical College of Pennsylvania

A new ever-evolving paradigm
Cagle, PT , Olsen, RJ, Portier, BP, Takei, H & Bernard, DW 2015, Archives of Pathology and Laboratory Medicine, vol 139, no. 4, pp. 446-447. DOI:

The presence of anti-HLA donor-specific antibodies in lung allograft recipients does not correlate with C4d immunofluorescence in transbronchial biopsy specimens
Roberts, JA, Barrios, R, Cagle, PT, Ge, Y, Takei, H, Haque, AK, Burns, KM, Land, GA, Dilioglou, S & Bernard, DW 2014, Archives of Pathology and Laboratory Medicine, vol 138, no. 8, pp. 1053-1058. DOI:

Analytical performance of QMS everolimus assay on ortho vitros 5,1 FS fusion analyzer: Measuring everolimus trough levels for solid organ transplant recipients
Shu, I, Wright, AM, Chandler, WL, Bernard, DW & Wang, P 2014, Therapeutic Drug Monitoring, vol 36, no. 2, pp. 264-268. DOI:

In utero drugs of abuse exposure testing for newborn twins
Wang, P, Molina, CP, Maldonado, JE & Bernard, DW 2010, Journal of Clinical Pathology, vol 63, no. 3, pp. 259-261. DOI:

Detection of the JAK2V617F mutation in myeloproliferative disorders by melting curve analysis using the lightcycler system
Olsen, RJ, Tang, Z, Farkas, DH, Bernard, DW, Zu, Y, Chang, CC & Chang, JCC 2006, Archives of Pathology and Laboratory Medicine, vol 130, no. 7, pp. 997-1003.

Herbal remedies: Effects on clinical laboratory tests
Dasgupta, A & Bernard, DW 2006, Archives of Pathology and Laboratory Medicine, vol 130, no. 4, pp. 521-528.

Immunoglobulin G(?) [IgG(?)] and IgG(?) paraproteinemia in a child with aids and response to highly active antiretroviral therapy
Seeborg, FO, Gay, H, Schmiege, LM, Bernard, D & Shearer, WT 2005, Clinical and Diagnostic Laboratory Immunology, vol 12, no. 11, pp. 1331-1333. DOI:

Variation in prostate specific antigen results from 2 different assay platforms: Clinical impact on 2,304 patients undergoing prostate cancer screening
Link, RE, Shariat, SF, Nguyen, CV, Farr, A, Weinberg, AD, Morton, RA, Richardson, B, Bernard, D & Slawin, KM 2004, Journal of Urology, vol 171, no. 6 I, pp. 2234-2238. DOI:

Early postoperative peripheral blood reverse transcription PCR assay for prostate-specific antigen is associated with prostate cancer progression in patients undergoing radical prostatectomy
Shariat, SF, Kattan, MW, Song, W, Bernard, D, Gottenger, E, Wheeler, TM & Slawin, KM 2003, Cancer Research, vol 63, no. 18, pp. 5874-5878.

Hormone sensitive lipase mRNA in both monocyte and macrophage forms of the human THP-1 cell line
Johnson, WJ, Jang, SY & Bernard, DW 2000, Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, vol 126, no. 4, pp. 543-552. DOI:

FGF receptor availability regulates skeletal myogenesis
Scata, KA, Bernard, DW, Fox, J & Swain, JL 1999, Experimental Cell Research, vol 250, no. 1, pp. 10-21. DOI:

Cholesteryl ester hydrolysis in J774 macrophages occurs in the cytoplasm and lysosomes
Avart, SJ, Bernard, DW, Gray Jerome, W & Glick, JM 1999, Journal of Lipid Research, vol 40, no. 3, pp. 405-414.

Monitoring heparin therapy: APTT results from partial- vs full-draw tubes
Siegel, JE, Bernard, DW, Swami, VK & Sazama, K 1998, American Journal of Clinical Pathology, vol 110, no. 2, pp. 184-187.

cAMP selectively promotes the efflux of cholesterol derived from cholesteryl ester hydrolysis in J774 foam cells
Rodriguez, A, Bernard, DW, Rothblat, GH & Glick, JM 1996, Endocrinology and Metabolism, vol 3, no. 4, pp. 243-252.

Nighttime dosing assures postdistribution sampling for therapeutic drug monitoring of digoxin
Bernard, DW, Bowman, RL, Grimm, FA, Wolf, BA, Simson, MB & Shaw, LM 1996, Clinical Chemistry, vol 42, no. 1, pp. 45-49.

cAMP stimulates cholesteryl ester clearance to high density lipoproteins in J774 macrophages
Bernard, DW, Rodriguez, A, Rothblat, GH & Glick, JM 1991, Journal of Biological Chemistry, vol 266, no. 2, pp. 710-716.

Inhibitors of neutral cholesteryl ester hydrolase
Harrison, EH, Bernard, DW, Scholm, P, Quinn, DM, Rothblat, GH & Glick, JM 1990, Journal of Lipid Research, vol 31, no. 12, pp. 2187-2193.

Influence of high density lipoprotein on esterified cholesterol stores in macrophages and hepatoma cells
Bernard, DW, Rodriguez, A, Rothblat, GH & Glick, JM 1990, Arteriosclerosis, Thrombosis, and Vascular Biology, vol 10, no. 1, pp. 135-144.

Potential problems in the use of commercial preparations of radiolabeled cholesterol
Mahlberg, FH, Rodriguez-Oquendo, A, Bernard, DW, Glick, JM & Rothblat, GH 1990, Atherosclerosis, vol 84, no. 2-3, pp. 95-100.