David Huston, MD

Full Affiliate Member, Research Institute
Houston Methodist


After completing his subspecialty training at the National Institutes of Health in 1980, Dr. Huston joined the faculty at the Baylor College of Medicine in Houston, Texas. While at Baylor, he became a full Professor of Medicine and Immunology, and held numerous leadership positions including the Cullen Chair of Immunology, the chief of the Immunology, Allergy, and Rheumatology Section, and director of the Immunology, Allergy, and Rheumatology Service at Houston Methodist Hospital. Dr. Huston also directed several training programs including the Allergy and Immunology Fellowship Training Program, the Clinical and Laboratory Immunology Fellowship Training Program, the Rheumatology Fellowship Training Program, the Translational Biology and Molecular Medicine Training Program in the Graduate School of Biomedical Sciences, and the Howard Hughes Medical Research Institute Grad into Med Program. He assumed his current positions at the Texas A&M Health Science Center in 2008. Dr. Huston serves on the American Board of Internal Medicine and the American Board of Allergy and Immunology, is a member of the American Association of Physicians, and consistently recognized as among the Best Doctors in America.

Description of Research

Dr. Huston’s research centers on the study of various mechanisms of allergic inflammation, utilizing basic science, pre-clinical, and clinical studies. He has been the principal investigator on several NIH grants, including an 11-year R01 from the National Institutes of Allergy and Infectious Diseases that defined the functional structure of Interleukin-5. Dr. Huston’s current studies investigate the role of human thymic stromal lymphopoietin in the development and maintenance of the Th2 immune response that dominates the allergic phenotype. Additional studies investigate the mechanisms of immune regulation in autoimmune and immune deficiency disorders.

Areas Of Expertise

Immunology Inflammation Allergy Immunodeficiency Cytokines

Evidence-based evaluation for allergies to avoid inappropriate testing, diagnosis, and treatment
Huston, DP & Cox, LS 2014, JAMA Internal Medicine, vol 174, no. 8, pp. 1223-1224. DOI:

Emerging role of human basophil biology in health and disease
Cromheecke, JL, Nguyen, KT & Huston, DP 2014, Current Allergy and Asthma Reports, vol 14, no. 1, 408. DOI:

Therapeutic strategies for harnessing human eosinophils in allergic inflammation, hypereosinophilic disorders, and cancer
Amini-Vaughan, ZJ, Martinez-Moczygemba, M & Huston, DP 2012, Current Allergy and Asthma Reports, vol 12, no. 5, pp. 402-412. DOI:

Defects in interleukin-17 immunity in the pathogenesis of chronic mucocutaneous candidiasis
Huston, DP 2011, Current Allergy and Asthma Reports, vol 11, no. 5, pp. 342-344. DOI:

A novel subset of CD4+ TH2 memory/ effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma
Wang, YH, Voo, KS, Liu, B, Chen, CY, Uygungil, B, Spoede, W, Bernstein, JA, Huston, DP & Liu, YJ 2010, Journal of Experimental Medicine, vol 207, no. 11, pp. 2479-2491. DOI:

Defective B-cell response to toll-like receptor-9 ligands in common variable immunodeficiency
Patel, JY, Singh, SK & Huston, DP 2010, Current Allergy and Asthma Reports, vol 10, no. 5, pp. 303-305. DOI:

Immune dysregulation in the pathogenesis of pulmonary alveolar proteinosis
Martinez-Moczygemba, M & Huston, DP 2010, Current Allergy and Asthma Reports, vol 10, no. 5, pp. 320-325. DOI:

T-regulatory cells in common variable immunodeficiency: Comments
Komarla, A, Patel, JY & Huston, DP 2009, Current Allergy and Asthma Reports, vol 9, no. 5, pp. 335-336. DOI:

Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRa gene in the X chromosome pseudoautosomal region 1
Martinez-Moczygemba, M, Doan, ML, Elidemir, O, Fan, LL, Cheung, SW, Lei, JT, Moore, JP, Tavana, G, Lewis, LR, Zhu, Y, Muzny, DM, Gibbs, RA & Huston, DP 2008, Journal of Experimental Medicine, vol 205, no. 12, pp. 2711-2716. DOI:

Immune dysfunction in autoimmune pulmonary alveolar proteinosis
Singh, SK, Galicia, DG & Huston, DP 2007, Current Allergy and Asthma Reports, vol 7, no. 5, pp. 319-322. DOI:

IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells
Wang, YH, Angkasekwinai, P, Lu, N, Voo, KS, Arima, K, Hanabuchi, S, Hippe, A, Corrigan, CJ, Dong, C, Homey, B, Yao, Z, Ying, S, Huston, DP & Liu, YJ 2007, Journal of Experimental Medicine, vol 204, no. 8, pp. 1837-1847. DOI:

JAK kinases control IL-5 receptor ubiquitination, degradation, and internalization
Martinez-Moczygemba, M, Huston, DP & Lei, JT 2007, Journal of Leukocyte Biology, vol 81, no. 4, pp. 1137-1148. DOI:

Update in allergy and immunology
Huston, DP 2006, Annals of Internal Medicine, vol 145, no. 6, pp. 454-458.

Thymic stromal lymphopoietin: A potential therapeutic target for allergy and asthma
Huston, DP & Liu, YJ 2006, Current Allergy and Asthma Reports, vol 6, no. 5, pp. 372-376. DOI:

Fostering interdisciplinary immunology
Huston, DP, Utz, PJ & Fathman, CG 2005, Clinical Immunology, vol 115, no. 1 SPEC. ISS. pp. 1-2. DOI:

CXCL13 neutralization reduces the severity of collagen-induced arthritis
Zheng, B, Ozen, Z, Zhang, X, De Silva, S, Marinova, E, Guo, L, Wansley, D, Huston, DP, West, MR & Han, S 2005, Arthritis and Rheumatism, vol 52, no. 2, pp. 620-626. DOI:

Reduction of the incidence and severity of collagen-induced arthritis by constitutive Nur77 expression in the T cell lineage
De Silva, S, Han, S, Zhang, X, Huston, DP, Winoto, A & Zheng, B 2005, Arthritis and Rheumatism, vol 52, no. 1, pp. 333-338. DOI:

Increased noncanonical splicing of autoantigen transcripts provides the structural basis for expression of untolerized epitopes
Ng, B, Yang, F, Huston, DP, Yan, Y, Yang, Y, Xiong, Z, Peterson, LE, Wang, H & Yang, XF 2004, Journal of Allergy and Clinical Immunology, vol 114, no. 6, pp. 1463-1470. DOI:

Biology of common ß receptor-signaling cytokines: IL-3, IL-5, and GM-CSF
Martinez-Moczygemba, M & Huston, DP 2003, Journal of Allergy and Clinical Immunology, vol 112, no. 4, pp. 653-666. DOI:

Urticarial vasculitis
Venzor, J, Lee, WL & Huston, DP 2002, Clinical Reviews in Allergy and Immunology, vol 23, no. 2, pp. 201-216. DOI: