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David Corry, MD

Full Affiliate Member, Research Institute
Houston Methodist


After completion of his postdoctoral training, Dr. Corry joined the faculty at the University of California at San Francisco as an Assistant Adjunct Professor of Medicine. He accepted an appointment at the Baylor College of Medicine in Houston, Texas in 1999 as an Assistant Professor in the Department of Medicine. Dr. Corry would later become a full professor of medicine and immunology there, as well as the Nancy Chang, Ph.D. Professor for the Biology of Inflammation Center, also at Baylor.

Description of Research

Dr. Corry’s research is focused on immune mechanisms of lung disease. His past research projects have included defining critical roles played by CD4+ T cells in lung inflammation and describing the distinct contributions of cytokines IL-4 and IL-13 in the immunopathogenesis of experimental allergic airway disease. Dr. Corry has also made fundamental discoveries on the role of integrins in T cell function and the role of innate immunity in controlling allergic lung disease, focusing specifically on the roles of exogenous proteinases and fungi as allergens and airway epithelial derived cytokines and proteinases such as IL-25 and matrix metalloproteinase 7. Additional major areas of research are microRNAs and the control of immunity and development of nanoparticulate vaccines.

Areas Of Expertise

Immunology Asthma T cells Proteinases microRNA

Preferential uptake of antioxidant carbon nanoparticles by T lymphocytes for immunomodulation
Huq, R, Samuel, ELG, Sikkema, WKA, Nilewski, LG, Lee, T, Tanner, MR, Khan, FS, Porter, PC, Tajhya, RB, Patel, RS, Inoue, T, Pautler, RG, Corry, DB, Tour, JM & Beeton, C 2016, Scientific Reports, vol 6, 33808. DOI:

Cell mediated immune responses following revaccination with an influenza A/H5N1 vaccine
Mbawuike, IN, Atmar, RL, Patel, SM, Corry, DB, Winokur, PL, Brady, RC, Chen, WH, Edwards, KM, Creech, CB, Walter, EB, Frey, SE, Belshe, RB, Goll, JB, Hill, H & Keitel, WA 2016, Vaccine, vol 34, no. 4, pp. 547-554. DOI:

Allergen-encoded signals that control allergic responses
Tung, HY, Landers, C, Li, E, Porter, P, Kheradmand, F & Corry, DB 2016, Current Opinion in Allergy and Clinical Immunology, vol 16, no. 1, pp. 51-58. DOI:

IL-37 Is a Novel Proangiogenic Factor of Developmental and Pathological Angiogenesis
Yang, T, Lin, Q, Zhao, M, Hu, Y, Yu, Y, Jin, J, Zhou, H, Hu, X, Wei, R, Zhang, X, Yang, X, Liu, G, Lu, P, Xu, G, Yang, J, Corry, DB, Su, SB, Liu, S & Liu, X 2015, Arteriosclerosis, Thrombosis, and Vascular Biology, vol 35, no. 12, pp. 2638-2646. DOI:

Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity
Mandal, PK, Morlacchi, P, Knight, JM, Link, TM, Lee, GR, Nurieva, R, Singh, D, Dhanik, A, Kavraki, L, Corry, DB, Ladbury, JE & McMurray, JS 2015, Journal of Medicinal Chemistry, vol 58, no. 22, pp. 8970-8984. DOI:

Clinical and immunological factors in emphysema progression: Five-year prospective longitudinal exacerbation study of chronic obstructive pulmonary disease (LES-COPD)
Bhavani, S, Tsai, CL, Perusich, S, Hesselbacher, S, Coxson, H, Pandit, L, Corry, DB & Kheradmand, F 2015, American Journal of Respiratory and Critical Care Medicine, vol 192, no. 10, pp. 1171-1178. DOI:

Long-acting beta agonists enhance allergic airway disease
Knight, JM, Mak, G, Shaw, J, Porter, P, McDermott, C, Roberts, L, You, R, Yuan, X, Millien, VO, Qian, Y, Song, LZ, Frazier, V, Kim, C, Kim, JJ, Bond, RA, Milner, JD, Zhang, Y, Mandal, PK, Luong, A, Kheradmand, F, McMurray, JS & Corry, DB 2015, PLoS ONE, vol 10, no. 11, e0142212. DOI:

Loss of peripheral tolerance in emphysema phenotypes, exacerbations, and disease progression
Bhavani, S, Yuan, X, You, R, Shan, M, Corry, D & Kheradmand, F 2015, Annals of the American Thoracic Society, vol 12, pp. S164-S168. DOI:

The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote TH17 cell-dependent emphysema
Lu, W, You, R, Yuan, X, Yang, T, Samuel, ELG, Marcano, DC, Sikkema, WKA, M. Tour, J, Rodriguez, A, Kheradmand, F & Corry, DB 2015, Nature Immunology, vol 16, no. 11, pp. 1185-1194. DOI:

Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema
You, R, Lu, W, Shan, M, Berlin, JM, Samuel, ELG, Marcano, DC, Sun, Z, Sikkema, WKA, Yuan, X, Song, L, Hendrix, AY, Tour, JM, Corry, DB & Kheradmand, F 2015, eLife, vol 4, no. OCTOBER2015, e09623. DOI:

Activation of C3a receptor is required in cigarette smoke-mediated emphysema
Yuan, X, Shan, M, You, R, Frazier, MV, Hong, MJ, Wetsel, RA, Drouin, S, Seryshev, A, Song, LZ, Cornwell, L, Rossen, RD, Corry, DB & Kheradmand, F 2015, Mucosal Immunology, vol 8, no. 4, pp. 874-885. DOI:

Porous Silicon Microparticle Potentiates Anti-Tumor Immunity by Enhancing Cross-Presentation and Inducing Type I Interferon Response
Xia, X, Mai, J, Xu, R, Perez, JET, Guevara, ML, Shen, Q, Mu, C, Tung, HY, Corry, DB, Evans, SE, Liu, X, Ferrari, M, Zhang, Z, Li, XC, Wang, RF & Shen, H 2015, Cell Reports, vol 11, no. 6, pp. 957-966. DOI:

IL-13 stimulates proliferation and expression of mucin and immunomodulatory genes in cultured conjunctival goblet cells
Henriksson, JT, Coursey, TG, Corry, DB, De Paiva, CS & Pflugfelder, SC 2015, Investigative Ophthalmology and Visual Science, vol 56, no. 8, pp. 4186-4197. DOI:

Leukotriene enhanced allergic lung inflammation through induction of chemokine production
Shin, K, Hwang, JJ, Kwon, BI, Kheradmand, F, Corry, DB & Lee, SH 2014, Clinical and Experimental Medicine, vol 15, no. 3, pp. 233-244. DOI:

Essential role for autophagy in the maintenance of immunological memory against influenza infection.
Chen, M, Hong, MJ, Sun, H, Wang, L, Shi, X, Gilbert, BE, Corry, DB, Kheradmand, F & Wang, J 2014, Nature Medicine, vol 20, no. 5, pp. 503-510. DOI:

Agonistic induction of PPAR? reverses cigarette smoke-induced emphysema
Shan, M, You, R, Yuan, X, Frazier, MV, Porter, P, Seryshev, A, Hong, JS, Song, LZ, Zhang, Y, Hilsenbeck, S, Whitehead, L, Zarinkamar, N, Perusich, S, Corry, DB & Kheradmand, F 2014, Journal of Clinical Investigation, vol 124, no. 3, pp. 1371-1381. DOI:

Airway fibrinogenolysis and the initiation of allergic inflammation
Millien, VO, Lu, W, Mak, G, Yuan, X, Knight, JM, Porter, P, Kheradmand, F & Corry, DB 2014, Annals of the American Thoracic Society, vol 11, pp. S277-S283. DOI:

Airway surface mycosis in chronic TH2-associated airway disease
Porter, PC, Lim, DJ, Maskatia, ZK, Mak, G, Tsai, CL, Citardi, MJ, Fakhri, S, Shaw, JL, Fothergil, A, Kheradmand, F, Corry, DB & Luong, A 2014, Journal of Allergy and Clinical Immunology, vol 134, no. 2. DOI:

CD11a polymorphisms regulate TH2 cell homing and T H2-related disease
Knight, JM, Lee, SH, Roberts, L, Smith, CW, Weiss, ST, Kheradmand, F & Corry, DB 2014, Journal of Allergy and Clinical Immunology, vol 133, no. 1. DOI:

Blocking Kv1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma
Koshy, S, Huq, R, Tanner, MR, Atik, MA, Porter, PC, Khan, FS, Pennington, MW, Hanania, NA, Corry, DB & Beeton, C 2014, Journal of Biological Chemistry, vol 289, no. 18, pp. 12623-12632. DOI: