David Chiu, MD

Elizabeth Blanton Wareing Chair in the Eddy Scurlock Stroke Center, Stanley H. Appel Department of Neurology
Professor of Clinical Neurology, Institute for Academic Medicine
Associate Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

David Chiu, M.D. is medical director of the Houston Methodist Eddy Scurlock Stroke Center in Houston and neurologist at the Houston Methodist Neurological Institute. He serves on the board of directors for the American Heart Association and is an active member of the American Academy of Neurology, American Heart Association Stroke Council, Texas Medical Association and Harris County Medical Association. He is also a reviewer for Stroke and Journal of Neurology, Neurosurgery and Psychiatry.

Dr. Chiu is professor of clinical neurology at the Weill Medical College of Cornell University He received his M.D. from Yale University School of Medicine. He completed his residency in neurology at the University of California at San Francisco and his fellowship in cerebrovascular disease at University of Texas at Houston School of Medicine.

Description of Research

Dr. Chiu has an active clinical practice that benefits from extensive translational research. His research interests lie in extending the time and quality of life for stroke patients, acute stroke treatment, and stroke prevention in those who have experienced TIA and stroke.

Education & Training

Clinical Fellowship , University of Texas Medical School at Houston
Residency , University of California San Francisco, School of Medicine
Internship , University of California San Francisco, School of Medicine
MD , Yale School of Medicine
Publications

Safety and efficacy of multipotent adult progenitor cells in acute ischaemic stroke (MASTERS): A randomised, double-blind, placebo-controlled, phase 2 trial
Hess, DC, Wechsler, LR, Clark, WM, Savitz, SI, Ford, GA, Chiu, D, Yavagal, DR, Uchino, K, Liebeskind, DS, Auchus, AP, Sen, S, Sila, CA, Vest, JD & Mays, RW 2017, The Lancet Neurology. DOI: 10.1016/S1474-4422(17)30046-7

Aspiration Thrombectomy after Intravenous Alteplase Versus Intravenous Alteplase Alone
Mocco, J, Zaidat, OO, Von Kummer, R, Yoo, AJ, Gupta, R, Lopes, D, Frei, D, Shownkeen, H, Budzik, R, Ajani, ZA, Grossman, A, Altschul, D, McDougall, C, Blake, L, Fitzsimmons, BF, Yavagal, D, Terry, J, Farkas, J, Lee, SK, Baxter, B, Wiesmann, M, Knauth, M, Heck, D, Hussain, S, Chiu, D, Alexander, MJ, Malisch, T, Kirmani, J, Miskolczi, L & Khatri, P 2016, Stroke, vol 47, no. 9, pp. 2331-2338. DOI: 10.1161/STROKEAHA.116.013372

Enrollment volume effect on risk factor control and outcomes in the SAMMPRIS trial
Chiu, D , Klucznik, RP, Turan, TN, Lynn, MJ, McCane, CD, Katz, LB, Nizam, A, Derdeyn, CP, Fiorella, D, Lane, BF, Montgomery, J, Janis, S & Chimowitz, MI 2015, Neurology, vol 85, no. 24, pp. 2090-2097. DOI: 10.1212/WNL.0000000000002191

Quantifying cerebrovascular reactivity and identifying regions at risk from cerebrovascular steal with arterial spin labeling
Fung, SH, Diaz, O, Klucznik, RP, Zhang, Y, Britz, GW, Volpi, J, Thomas, AP & Chiu, D 2015, Interventional Neuroradiology, vol 21S1.

Management of vascular risk factors in the carotid revascularization endarterectomy versus stenting trial (CREST)
Meschia, JF, Voeks, JH, Leimgruber, PP, Mantese, VA, Timaran, CH, Chiu, D, Demaerschalk, BM, Howard, VJ, Hughes, SE, Longbottom, M, Howard, AG & Brott, TG 2014, Journal of the American Heart Association, vol 3, no. 6, 001180. DOI: 10.1161/JAHA.114.001180

Transcranial laser therapy in acute stroke treatment: Results of neurothera effectiveness and safety trial 3, a phase III clinical end point device trial
Hacke, W, Schellinger, PD, Albers, GW, Bornstein, NM, Dahlof, BL, Fulton, R, Kasner, SE, Shuaib, A, Richieri, SP, Dilly, SG, Zivin, J, Lees, KR, Zivin, JA, Broderick, J, Ivanova, A, Johnston, K, Norrving, B, Albars, G, Alexandrov, A, Brown, D, Capone, P, Chiu, D, Clark, W, Cochran, J, Deredyn, C, Devlin, T, Hickling, W, Howell, G, Huang, D, Hussain, S, Mallenbaum, S, Moonis, M, Nash, M, Rymer, M, Taylor, R, Tremwel, M, Buck, B, Perez, J, Gerloff, C, Greiwing, B, Grond, M, Hamman, G, Haarmeiter, T, Jander, S, Köhrmann, M, Ritter, M, Schallinger, P, Schneider, D, Sobesky, J, Steiner, T, Steinmetz, H, Veltkamp, R, Weimar, C, Gruber, F, Andersson, B, Welin, L, Leys, D, Tatlisumak, T, Luft, A, Lyrer, P, Michel, P, Molina, C & Segura, T 2014, Stroke, vol 45, no. 11, pp. 3187-3193. DOI: 10.1161/STROKEAHA.114.005795

Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): The final results of a randomised trial
Derdeyn, CP, Chimowitz, MI, Lynn, MJ, Fiorella, D, Turan, TN, Janis, LS, Montgomery, J, Nizam, A, Lane, BF, Lutsep, HL, Barnwell, SL, Waters, MF, Hoh, BL, Hourihane, JM, Levy, EI, Alexandrov, AV, Harrigan, MR, Chiu, D, Klucznik, RP, Clark, JM, McDougall, CG, Johnson, MD, Pride, GL, Lynch, JR, Zaidat, OO, Rumboldt, Z & Cloft, HJ 2014, The Lancet, vol 383, no. 9914, pp. 333-341. DOI: 10.1016/S0140-6736(13)62038-3

Detailed analysis of periprocedural strokes in patients undergoing intracranial stenting in stenting and aggressive medical management for preventing recurrent stroke in intracranial stenosis (SAMMPRIS)
Fiorella, D, Derdeyn, CP, Lynn, MJ, Barnwell, SL, Hoh, BL, Levy, EI, Harrigan, MR, Klucznik, RP, McDougall, CG, Pride, GL, Zaidat, OO, Lutsep, HL, Waters, MF, Hourihane, JM, Alexandrov, AV, Chiu, D, Clark, JM, Johnson, MD, Torbey, MT, Rumboldt, Z, Cloft, HJ, Turan, TN, Lane, BF, Janis, LS & Chimowitz, MI 2012, Stroke, vol 43, no. 10, pp. 2682-2688. DOI: 10.1161/STROKEAHA.112.661173

Restenosis after carotid artery stenting and endarterectomy: A secondary analysis of CREST, a randomised controlled trial
Lal, BK, Beach, KW, Roubin, GS, Lutsep, HL, Moore, WS, Malas, MB, Chiu, D, Gonzales, NR, Burke, JL, Rinaldi, M, Elmore, JR, Weaver, FA, Narins, CR, Foster, M, Hodgson, KJ, Shepard, AD, Meschia, JF, Bergelin, RO, Voeks, JH, Howard, G & Brott, TG 2012, The Lancet Neurology, vol 11, no. 9, pp. 755-763. DOI: 10.1016/S1474-4422(12)70159-X

Stenting versus aggressive medical therapy for intracranial arterial stenosis
Chimowitz, MI, Lynn, MJ, Derdeyn, CP, Turan, TN, Fiorella, D, Lane, BF, Janis, LS, Lutsep, HL, Barnwell, SL, Waters, MF, Hoh, BL, Hourihane, JM, Levy, EI, Alexandrov, AV, Harrigan, MR, Chiu, D, Klucznik, RP, Clark, JM, McDougall, CG, Johnson, MD, Pride, GL, Torbey, MT, Zaidat, OO, Rumboldt, Z & Cloft, HJ 2011, New England Journal of Medicine, vol 365, no. 11, pp. 993-1003. DOI: 10.1056/NEJMoa1105335

Safety of stenting and endarterectomy by symptomatic status in the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST)
Silver, FL, Mackey, A, Clark, WM, Brooks, W, Timaran, CH, Chiu, D, Goldstein, LB, Meschia, JF, Ferguson, RD, Moore, WS, Howard, G & Brott, TG 2011, Stroke, vol 42, no. 3, pp. 675-680. DOI: 10.1161/STROKEAHA.110.610212

Vascular Disease
Chiu, D 2010, . in Neurology Secrets. Elsevier, pp. 269-282. DOI: 10.1016/B978-0-323-05712-7.00017-9

The carotid revascularization endarterectomy versus stenting trial (CREST): Stenting versus carotid endarterectomy for carotid disease
Mantese, VA, Timaran, CH, Chiu, D, Begg, RJ & Brott, TG 2010, Stroke, vol 41, no. 10 SUPPL. 1. DOI: 10.1161/STROKEAHA.110.595330

Comparison of Outcomes after Intracerebral Hemorrhage and Ischemic Stroke
Chiu, D , Peterson, L, Elkind, MSV, Rosand, J, Gerber, LM & Silverstein, MD 2010, Journal of Stroke and Cerebrovascular Diseases, vol 19, no. 3, pp. 225-229. DOI: 10.1016/j.jstrokecerebrovasdis.2009.06.002

Comprehensive stroke center quality metrics
Censullo, J & Chiu, D 2008, Critical Pathways in Cardiology, vol 7, no. 3, pp. 178-184. DOI: 10.1097/HPC.0b013e3181821936

Effect of the glycine antagonist gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI substudy
Warach, S, Kaufman, D, Chiu, D, Devlin, T, Luby, M, Rashid, A, Clayton, L, Kaste, M, Lees, KR, Sacco, R & Fisher, M 2006, Cerebrovascular Diseases, vol 21, no. 1-2, pp. 106-111. DOI: 10.1159/000090208

Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice: The multicenter rt-PA acute stroke survey
Tanne, D, Kasner, SE, Demchuk, AM, Koren-Morag, N, Hanson, S, Grond, M, Levine, SR, Hamilton, SA, Hanson, SK, Grond, M, Grotta, JC, Morgenstern, L, Krieger, D, Kasner, SE, Villar, C, Chiu, D, Wein, T, Hickenbottom, S, Felberg, R, Demchuk, AM, Buchan, AM, Demchuk, AM, Barber, P, Newcommon, N, Bates, VE, Vereczkey-Porter, K, Kasner, SE, Chalela, JC, McGarvey, ML, Wang, DZ, DeCampo, J, Wechsler, LR, Binder, JR, Book, D, Tanne, D, Daley, S, Gorman, MJ, Mitsias, P, Lewandowski, CA, Levine, SR, Frey, JL, Jahnke, H, Zweifler, R, Koscicki, N, Cruz-Flores, S, Verro, P, Tiejen, G, Lee, JM, Lowenkopf, T, Worrall, BB, Johnston, KC, Fayad, P, Boiser, J, Giancarlo, T, Schuster, A, Becker, KJ, Karanjia, PN, Shuaib, A, Kochanski, P, Scott, P, Wehner, S, Dayno, JM, Bell, R, Benesch, C, Coplin, WM, Chaturvedi, S, Dulli, D, Kalafut, MA, Kidwell, CS, Saver, JL, Tanne, D, Daley, S, Salowich-Palm, L, Schultz, LR, DOlhaberriague, L & Levine, SR 2002, Circulation, vol 105, no. 14, pp. 1679-1685. DOI: 10.1161/01.CIR.0000012747.53592.6A

Safety of intra-arterial thrombolysis in the postoperative period
Chalela, JA, Katzan, I, Liebeskind, DS, Rasmussen, P, Zaidat, O, Suarez, JI, Chiu, D, Klucznick, RP, Jauch, E, Cucchiara, BL, Saver, J & Kasner, SE 2001, Stroke, vol 32, no. 6, pp. 1365-1368.

Agreement and variability in the interpretation of early CT changes in stroke patients qualifying for intravenous rtPA therapy
Grotta, JC, Chiu, D, Lu, M, Patel, S, Levine, SR, Tilley, BC, Brott, TG, Haley, EC, Lyden, PD, Kothari, R, Frankel, M, Lewandowski, CA, Libman, R, Kwiatkowski, T, Broderick, JP, Marler, JR, Corrigan, J, Huff, S, Mitsias, P, Talati, S & Tanne, D 1999, Stroke, vol 30, no. 8, pp. 1528-1533.

Ischemic strokes arriving too late for tPA are an ideal and ethical control group for continuing studies of tPA efficacy [2] (multiple letters)
Robinson, L & Chiu, D 1998, Stroke, vol 29, no. 7, pp. 1476-1477.