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Dan Gombos, MD

Associate Affiliate Member, Research Institute
Houston Methodist


After completing his postdoctoral training in London, UK, Dr. Gombos returned to The University of
Texas M.D. Anderson Cancer Center (MDACC) in Houston, Texas as an Assistant Professor in 2001. He also joined the faculty at The University of Texas Medical Branch in Galveston, Texas in 2005 as a Clinical Assistant Professor of Ophthalmology and Visual Sciences. Dr. Gombos became an Associate Professor at MDACC in 2007, and a Clinical Associate Professor at The University of Texas Medical Branch in 2008. At MDACC, he is currently developing a comprehensive program for the management of patients with intra and periocular tumors. The program will also include special services for children with intraocular retinoblastoma. Dr. Gombos was also a founding physician in the Retinoblastoma Center of Houston, a collaborative effort between The Methodist Hospital, Baylor College of Medicine, Texas Children's Hospital, and MDACC that provides a comprehensive treatment program for retinoblastoma patients and conducts groundbreaking research to improve diagnostic methods and treatment and public awareness campaigns to promote early detection.

Description of Research

Dr. Gombos' research involves clinical trials that use proton beam radiation therapy or gene transfer therapy for pediatric refractory retinoblastoma.

Areas Of Expertise

Retinoblastoma Intraocular tumors Radiation therapy Gene transfer

Systemic neoadjuvant chemotherapy for Group B intraocular retinoblastoma (ARET0331): A report from the Children's Oncology Group
Friedman, DL, Krailo, M, Villaluna, D, Gombos, D, Langholz, B, Jubran, R, Shields, C, Murphree, L, OBrien, J, Kessel, S, Rodriguez-Galindo, C, Chintagumpala, M & Meadows, AT 2017, Pediatric Blood and Cancer, vol 64, no. 7, e26394. DOI:

Vitreous Seeds in Retinoblastoma. Clinicopathologic Classification and Correlation
Amram, AL, Rico, G, Kim, JW, Chintagumpala, M, Herzog, CE, Gombos, DS & Chévez-Barrios, P 2017, Ophthalmology. DOI:

Late Presentation of Retinoblastoma in a Teen with Aicardi Syndrome
Akinfenwa, PY, Chévez-Barrios, P, Harper, CA & Gombos, DS 2016, Ocular Oncology and Pathology, vol 2, no. 3, pp. 181-4. DOI:

Intensive chemoimmunotherapy and bilateral globe irradiation as initial therapy for primary intraocular lymphoma
Cheah, CY, Milgrom, S, Chihara, D, Gombos, DS, Pinnix, CC, Dabaja, BS & Fowler, NH 2016, Neuro-Oncology, vol 18, no. 4, pp. 575-581. DOI:

Acute and late toxicity of bilateral orbital irradiation in the management of primary intraocular lymphoma
Milgrom, SA, Cheah, CY, Pinnix, CC, Smith, GL, Dabaja, BS, Horace, P, Chevez-Barrios, P, Fowler, NH & Gombos, DS 2016, Leukemia and Lymphoma, pp. 1-7. DOI:

Uveal melanoma: From diagnosis to treatment and the science in between
Chattopadhyay, C, Kim, DW, Gombos, DS, Oba, J, Qin, Y, Williams, MD, Esmaeli, B, Grimm, EA, Wargo, JA, Woodman, SE & Patel, SP 2016, Cancer. DOI:

Expression of angiogenic factors in invasive retinoblastoma tumors is associated with increase in tumor cells expressing stem cell marker sox2
Garcia, JR, Gombos, DS, Prospero, CM, Ganapathy, A, Penland, RL & Chévez-Barrios, P 2015, Archives of Pathology and Laboratory Medicine, vol 139, no. 12, pp. 1531-1538. DOI:

Conjunctival melanoma - Clinical pearls now, hope for the future
Gombos, DS 2015, JAMA ophthalmology, vol 133, no. 11, pp. 1303-1304. DOI:

Diagnostic Ophthalmic Ultrasound for Radiologists
Kendall, CJ, Prager, TC, Cheng, H, Gombos, D, Tang, RA & Schiffman, JS 2015, Neuroimaging Clinics of North America, vol 25, no. 3, pp. 327-365. DOI:

A choice of radionuclide: Comparative outcomes and toxicity of ruthenium-106 and iodine-125 in the definitive treatment of uveal melanoma
Takiar, V, Voong, KR, Gombos, DS, Mourtada, F, Rechner, LA, Lawyer, AA, Morrison, WH, Garden, AS & Beadle, BM 2015, Practical Radiation Oncology, vol 5, no. 3, pp. e169-e176. DOI:

Sinonasal melanoma arising from conjunctival primary acquired melanosis
Shehata, M, Gombos, D, Bishop, J & Zafereo, ME 2015, BMJ Case Reports, vol 2015. DOI:

Children’s Oncology Group (COG) Trials for Retinoblastoma
Gombos, DS, Meadows, AT, Chintagumpala, M, Dunkel, IJ, Friedman, D, Stoner, JA, Jubran, R & Villablanca, JG 2015, . in Clinical Ophthalmic Oncology: Retinoblastoma, Second Edition. Springer Berlin Heidelberg, pp. 215-223. DOI:

Adjunctive treatment strategies for high-risk ocular melanoma
Patel, SP & Gombos, DS 2014, . in Ocular Melanoma: Advances in Diagnostic and Therapeutic Strategies. Future Medicine Ltd. pp. 160-167. DOI:

Survival outcomes of primary intraocular lymphoma: A single-institution experience
Kim, MM, Dabaja, BS, Medeiros, J, Kim, S, Allen, P, Chevez-Barrios, P, Gombos, DS & Fowler, N 2014, American Journal of Clinical Oncology: Cancer Clinical Trials. DOI:

Principles of cryotherapy
Gombos, DS 2014, . in Clinical Ophthalmic Oncology: Basic Principles and Diagnostic Techniques, Second Edition. Springer Berlin Heidelberg, pp. 77-82. DOI:

Disease control and toxicity outcomes using ruthenium eye plaque brachytherapy in the treatment of uveal melanoma
Takiar, V, Gombos, DS, Mourtada, F, Rechner, LA, Lawyer, AA, Morrison, WH, Garden, AS & Beadle, BM 2014, Practical Radiation Oncology, vol 4, no. 4. DOI:

Retinoblastoma and the RB1 Cancer Syndrome
Murphree, AL, Clark, RD, Randolph, LM, Sachdeva, UM, Gombos, DS & OBrien, JM 2013, . in Emery and Rimoins Principles and Practice of Medical Genetics. Elsevier, pp. 1-27. DOI:

Tumors in infants and children
Kavanagh, MC, OBrien, JM, Aaberg, TM, Hubbard, GB & Gombos, DS 2013, . in Pediatric Retina: Second Edition. Wolters Kluwer Health.

OBrien, JM & Gombos, DS 2013, . in Pediatric Retina: Second Edition. Wolters Kluwer Health.

Incidence, prevalence and epidemiology
Garza, R & Gombos, DS 2013, . in Retinoblastoma: Clinical Advances and Emerging Treatment Strategies. Future Medicine Ltd. pp. 19-23. DOI: