Dale J. Hamilton, MD

Elaine and Marvy A. Finger Distinguished Chair for Translational Research in Metabolic Disorders & Professor of Clinical Medicine, Institute for Academic Medicine
Full Clinical Member, Research Institute
Director, Center for Bioenergetics
Houston Methodist
Weill Cornell Medical College


Dr. Hamilton’s professional career tract has provided the expertise, leadership, and experience to direct the Center for Bioenergetics at Houston Methodist Research Institute. His education was in cellular molecular biology and medicine, and post-graduate training in medicine and endocrinology, as well as laboratory research. His early professional career combined clinical practice and graduate medical education. The transition to translational research began in 2002 when he formed collaborations with colleagues involving clinical treatment trials and orthotopic human islet transplantation. By 2006 his research focus had narrowed to translational issues related to mitochondrial substrate oxidation and energy transfer in failing organ systems such as the human heart.

Description of Research

In 2013, Dr. Hamilton established a bioenergetic research initiative at Houston Methodist Research Institute with the objective of identifying mechanisms of altered energy transduction in disease states, especially those involving high energy tissues. Early and ongoing investigations focus on myocardial energetics in the failing heart. Evolving projects now include the mechanistic study of energy strategies in neoplasia and bioenergetic changes associated with estrogen deficiency. A recent novel but growing project addresses the challenge of transferring functional mitochondria into energy altered tissue such as the failing cardiomyocyte or growing neoplastic cell. The investigative methods include the use of pre-clinical models, tissue cultures and human tissue for analysis. Oxygen consumption, respiratory coupling and glycolytic energy transfer using genomics, metabolomic and proteomic methods are also studied. The team includes basic science specialists in biochemistry and cell biology as well as clinical investigators in cardiology, endocrinology and cardiothoracic surgery. These results have been communicated to the local and national scientific community; positive feedback on these results has strengthened the lab’s ability to design a realistic research plan.

Areas Of Expertise

Bioenergetics & Molecular Medicine Diabetes Endocrine disorders Diabetic complications
Education & Training

Clinical Fellowship , Baylor College of Medicine
Residency , Baylor College of Medicine
MD , Saint Louis University

Mitochondrial Function in Non-ischemic Heart Failure
Gupte, AA & Hamilton, DJ 2017, . in G Santulli (ed.), Mitochondrial Dynamics in Cardiovascular Medicine. vol. 982, Advances in Experimental Medicine and Biology, no. 1, Springer International Publishing.

Exercise Intolerance In Heart Failure With Preserved Ejection Fraction
Gupte, AA & Hamilton, DJ 2016, Houston Methodist DeBakey Cardiovascular Journal, vol 12, no. 2, pp. 105-9. DOI:

Estrogen receptor alpha activation enhances mitochondrial function and systemic metabolism in high fat-fed ovariectomized mice.
Hamilton, DJ, Minze, LJ, Cao, TN, Lyon, CJ, Geiger, PC, Hsueh, WA & Gupte, AA 2016, Physiological Reports, vol 4, no. 17, pp. e12913.

Molecular Imaging and Precision Medicine
Gupte, AA & Hamilton, DJ 2016, Cardiology, vol 133, no. 3, pp. 178-180. DOI:

Combination of angiotensin II and l-NG-nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure
Hamilton, DJ, Zhang, A, Li, S, Cao, TN, Smith, JA, Vedula, I, Cordero-Reyes, AM, Youker, KA, Torre-Amione, G & Gupte, AA 2016, American Journal of Physiology - Heart and Circulatory Physiology, vol 310, no. 6, pp. H667-H680. DOI:

Full expression of cardiomyopathy is partly dependent on B-cells: A pathway that involves cytokine activation, immunoglobulin deposition, and activation of apoptosis
Cordero-Reyes, AM, Youker, KA, Trevino, AR, Celis, R, Hamilton, DJ, Flores-Arredondo, JH, Orrego, CM, Bhimaraj, A, Estep, JD & Torre-Amione, G 2016, Journal of the American Heart Association, vol 5, no. 1, pp. 1-12. DOI:

Exercise intolerance and training in heart failure with preserved ejection fraction.
Gupte, AA & Hamilton, DJ 2015, Houston Methodist DeBakey Cardiovascular Journal.

Differential mitochondrial function in remodeled right and non-remodeled left ventricles in pulmonary hypertension.
Gupte, AA, Cordero-Reyes, AM, Youker, K, Matsunami, RK, Engler, DA, Loebe, M, Ashrith, G, Torre, G & Hamilton, DJ 2015, Journal of Cardiac Failure, pp. Epub.

A PKM2 signature in the failing heart
Rees, ML, Subramaniam, J, Li, Y, Hamilton, DJ, Frazier, OH & Taegtmeyer, H 2015, Biochemical and Biophysical Research Communications, vol 459, no. 3, pp. 430-436. DOI:

Hypertensive Emergency Following Embolization of a Large Adrenal Myelolipoma_Adrenal Medullary Infarction, Pheochromocytoma or Acute Sympathetic Discharge?
Ansari, M, Dela Garza, M, Deavers, M, Balogh, J, Rosenberg, WR, Hai, S, Ruppe, M & Hamilton, DJ 2015, AACE Clinical Case Reports, vol 1, no. 4, pp. e216-e220. DOI:

Estrogen: An emerging regulator of insulin action and mitochondrial function
Gupte, AA , Pownall, HJ & Hamilton, DJ 2015, Journal of Diabetes Research, vol 2015, 916585. DOI:

Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway in obesity-induced adipose inflammation
Yin, Z , Deng, T , Peterson, LE, Yu, R, Lin, J, Hamilton, DJ, Reardon, PR, Sherman, V, Winnier, GE, Zhan, M, Lyon, CJ, Wong, STC & Hsueh, WA 2014, Molecular and Cellular Endocrinology, vol 394, no. 1-2, pp. 80-87. DOI:

Freshly isolated mitochondria from failing human hearts exhibit preserved respiratory function
Cordero-Reyes, AM, Gupte, AA, Youker, KA, Loebe, M, Hsueh, WA, Torre-Amione, G, Taegtmeyer, H & Hamilton, DJ 2014, Journal of Molecular and Cellular Cardiology, vol 68, pp. 98-105. DOI:

Mechanical unloading promotes myocardial energy recovery in human heart failure
Gupte, AA , Hamilton, DJ, Cordero-Reyes, AM, Youker, KA, Yin, Z, Estep, JD, Stevens, RD, Wenner, B, Ilkayeva, O, Loebe, M, Peterson, LE, Lyon, CJ, Wong, STC, Newgard, CB, Torre-Amione, G, Taegtmeyer, H & Hsueh, WA 2014, Circulation: Cardiovascular Genetics, vol 7, no. 3, pp. 266-276. DOI:

High-fat feeding-induced hyperinsulinemia increases cardiac glucose uptake and mitochondrial function despite peripheral insulin resistance
Gupte, AA, Minze, LJ, Reyes, M, Ren, Y, Wang, X, Brunner, G, Ghosn, M, Cordero-Reyes, AM, Ding, K, Pratico, D, Morrisett, J, Shi, ZZ, Hamilton, DJ, Lyon, CJ & Hsueh, WA 2013, Endocrinology, vol 154, no. 8, pp. 2650-2662. DOI:

Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation
Deng, T, Lyon, CJ, Minze, LJ, Lin, J, Zou, J, Liu, JZ, Ren, Y, Yin, Z, Hamilton, DJ, Reardon, PR, Sherman, V, Wang, HY, Phillips, KJ, Webb, P, Wong, STC, Wang, RF & Hsueh, WA 2013, Cell Metabolism, vol 17, no. 3, pp. 411-422. DOI:

Mechanisms of disease: is mitochondrial function altered in heart failure?
Hamilton, DJ 2013, Houston Methodist DeBakey Cardiovascular Journal, vol 9, no. 1, pp. 44-48.

Molecular, cellular, and functional characterization of myocardial regions in hypertrophic cardiomyopathy
Cordero-Reyes, AM, Youker, K, Hamilton, DJ, Torre-Amione, G, Marian, AJ & Nagueh, SF 2012, Circulation: Cardiovascular Imaging, vol 5, no. 3, pp. 419-422. DOI:

Hürthle cell carcinoma of the thyroid presenting as thyrotoxicosis
Karanchi, H, Hamilton, DJ & Robbins, RJ 2012, Endocrine Practice, vol 18, no. 1. DOI:

Glucose management, heart failure and transplantation.
Hamilton, DJ, Hendricks, SJ, Ihaza, E & Rollins, JL 2009, Houston Methodist DeBakey Cardiovascular Journal, vol 5, no. 3, pp. 12-15.