Christopher Leveque, MD

Assistant Professor of Clinical Pathology and Genomic Medicine, Institute for Academic Medicine
Houston Methodist
Weill Cornell Medical College


Dr. Leveque received his medical degree from the Louisiana State University School of Medicine in New Orleans in 1981. He then completed a residency in pathology and a fellowship in transfusion medicine at The University of Texas Medical Branch in Galveston, Texas. Dr. Leveque remained at UTMB as the director of the Blood Bank until 1990 when he joined the faculty at the Baylor College of Medicine in Houston, Texas, as an assistant professor in the Department of Pathology. He joined the Department of Pathology and Genomic Medicine at Houston Methodist in 2004, where he is currently medical director of the blood bank and director of the Blood Banking/Transfusion Medicine Fellowship Program.

Description of Research

Dr. Leveque is a clinical pathologist with subspecialty certification in transfusion medicine. His current responsibilities include direction of the Houston Methodist donor center with fixed and mobile sites, an apheresis center, and a transfusion service that provides for active cardiovascular surgery, transplant, and oncology service lines. Dr. Leveque's research interests are focused on outcomes studies that assess strategies to reduce bleeding and initiate healing in injury and surgery, thereby reducing the demand for blood products. His current studies specifically evaluate the use of various drugs and growth factors including basic pancreatic trypsin inhibitors (BPTIs) and platelet-rich plasma (PRP).

Education & Training

, University of Texas Medical Branch
, LSU School of Medicine in New Orleans

Pre-clinical efficacy of combined therapy with novel ß-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cells
Fiskus, W, Sharma, S, Saha, S, Shah, B, Devaraj, SGT, Sun, B, Horrigan, S, Leveque, C, Zu, Y, Iyer, S & Bhalla, KN 2015, Leukemia, vol 29, no. 6, pp. 1267-1278. DOI:

BET protein antagonist JQ1 is synergistically lethal with FLT3 Tyrosine Kinase Inhibitor (TKI) and overcomes resistance to FLT3-TKI in AML cells expressing FLT-ITD
Fiskus, W, Sharma, S, Qi, J, Shah, B, Devaraj, SGT, Leveque, C, Portier, BP, Iyer, S, Bradner, JE & Bhalla, KN 2014, Molecular Cancer Therapeutics, vol 13, no. 10, pp. 2315-2327. DOI:

Donor body mass index is an important factor that affects peripheral blood progenitor cell yield in healthy donors after mobilization with granulocyte-colony-stimulating factor
Chen, J, Burns, KM, Babic, A, Carrum, G, Kennedy, M, Segura, FJ, Garcia, S, Potts, S & Leveque, C 2014, Transfusion, vol 54, no. 1, pp. 203-210. DOI:

Establishing a culture of blood management through education: A quality initiative study of postoperative blood use in CABG patients at methodist debakey heart & Vascular Center
Masud, F, Larson-Pollock, K, Leveque, C & Vykoukal, D 2011, American Journal of Medical Quality, vol 26, no. 5, pp. 349-356. DOI:

Therapeutic plasma exchange a potential strategy for patients with advanced heart failure
Torre-Amione, G, Orrego, CM, Khalil, N, Kottner-Assad, C, Leveque, C, Celis, R, Youker, KA & Estep, JD 2010, Journal of Clinical Apheresis, vol 25, no. 6, pp. 323-330. DOI:

Corneal nerve regeneration in neurotrophic keratopathy following autologous plasma therapy
Rao, K, Leveque, C & Pflugfelder, SC 2010, British Journal of Ophthalmology, vol 94, no. 5, pp. 584-591. DOI:

Retrograde cerebral perfusion during profound hypothermia and circulatory arrest in pigs
Safi, HJ, Iliopoulos, DC, Gopinath, SP, Hess, KR, Asimacopoulos, PJ, Bartoli, S, Raskin, SA, Shaibani, AT, Leveque, CM & Yawn, DH 1995, The Annals of Thoracic Surgery, vol 59, no. 5, pp. 1107-1112. DOI:

Limiting homologous blood exposure
Leveque, CM & Yawn, DH 1992, Clinics in Laboratory Medicine, vol 12, no. 4, pp. 771-785.

Evaluation of a case-based course in transfusion medicine for third-year medical students
Petrusa, ER, Patten, ED, Markus, JF & Leveque, CM 1991, Laboratory Medicine, vol 22, no. 7, pp. 475-476.

Fatal disseminated cryptococcosis following intraocular involvement
Schulman, JA, Leveque, C, Coats, M, Lawrence, L & Barber, JC 1988, British Journal of Ophthalmology, vol 72, no. 3, pp. 171-175. DOI:

Pulmonary calcification in long-term hemodialysis: A mimic of pulmonary thromboembolism
Haque, AK, Rubin, SA & Leveque, CM 1984, American Journal of Nephrology, vol 4, no. 2, pp. 109-113.