Bryan Michael-Paul Spann, DO, PhD

Assistant Professor of Clinical Neurology, Institute for Academic Medicine
Houston Methodist
Weill Cornell Medical College


Education & Training

, USC-RANCHO LOS AMIGOS, Downey, CA
, The Cleveland Clinic Foundation
, Detroit Medical Center/Wayne State University
, Michigan State University
Publications

Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis
Iturria-Medina, Y, Sotero, RC, Toussaint, PJ, Mateos-Pérez, JM, Evans, AC, Weiner, MW, Aisen, P, Petersen, R, Jack, CR, Jagust, W, Trojanowki, JQ, Toga, AW, Beckett, L, Green, RC, Saykin, AJ, Morris, J, Shaw, LM, Khachaturian, Z, Sorensen, G, Kuller, L, Raichle, M, Paul, S, Davies, P, Fillit, H, Hefti, F, Holtzman, D, Mesulam, MM, Potter, W, Snyder, P, Schwartz, A, Montine, T, Thomas, RG, Donohue, M, Walter, S, Gessert, D, Sather, T, Jiminez, G, Harvey, D, Bernstein, M, Fox, N, Thompson, P, Schuff, N, Borowski, B, Gunter, J, Senjem, M, Vemuri, P, Jones, D, Kantarci, K, Ward, C, Koeppe, RA, Foster, N, Reiman, EM, Chen, K, Mathis, C, Landau, S, Cairns, NJ, Householder, E, Taylor-Reinwald, L, Lee, V, Korecka, M, Figurski, M, Crawford, K, Neu, S, Foroud, TM, Potkin, S, Shen, L, Faber, K, Kim, S, Nho, K, Thal, L, Buckholtz, N, Albert, M, Frank, R, Hsiao, J, Kaye, J, Quinn, J, Lind, B, Carter, R, Dolen, S, Schneider, LS, Pawluczyk, S, Beccera, M, Teodoro, L, Spann, BM, Brewer, J, Vanderswag, H, Fleisher, A, Heidebrink, JL, Lord, JL, Mason, SS, Albers, CS, Knopman, D, Johnson, K, Doody, RS, Villanueva-Meyer, J, Chowdhury, M, Rountree, S, Dang, M, Stern, Y, Honig, LS, Bell, KL, Ances, B, Carroll, M, Leon, S, Mintun, MA, Schneider, S, Oliver, A, Marson, D, Griffith, R, Clark, D, Geldmacher, D, Brockington, J, Roberson, E, Grossman, H, Mitsis, E, De Toledo-Morrell, L, Shah, RC, Duara, R, Varon, D, Greig, MT, Roberts, P, Albert, M, Onyike, C, DAgostino, D, Kielb, S, Galvin, JE, Cerbone, B, Michel, CA, Rusinek, H, De Leon, MJ, Glodzik, L, De Santi, S, Doraiswamy, PM, Petrella, JR, Wong, TZ, Arnold, SE, Karlawish, JH, Wolk, D, Smith, CD, Jicha, G, Hardy, P, Sinha, P, Oates, E, Conrad, G, Lopez, OL, Oakley, M, Simpson, DM, Porsteinsson, AP, Goldstein, BS, Martin, K, Makino, KM, Ismail, MS, Brand, C, Mulnard, RA, Thai, G, Mc-Adams-Ortiz, C, Womack, K, Mathews, D, Quiceno, M, Diaz-Arrastia, R, King, R, Weiner, M, Martin-Cook, K, DeVous, M, Levey, AI, Lah, JJ, Cellar, JS, Burns, JM, Anderson, HS, Swerdlow, RH, Apostolova, L, Tingus, K, Woo, E, Silverman, DHS, Lu, PH, Bartzokis, G, Graff-Radford, NR, Parfitt, F, Kendall, T, Johnson, H, Farlow, MR, Hake, A, Matthews, BR, Herring, S, Hunt, C, Van Dyck, CH, Carson, RE, MacAvoy, MG, Chertkow, H, Bergman, H, Hosein, C, Black, S, Stefanovic, B, Caldwell, C, Hsiung, GYR, Feldman, H, Mudge, B, Assaly, M, Kertesz, A, Rogers, J, Bernick, C, Munic, D, Kerwin, D, Mesulam, MM, Lipowski, K, Wu, CK, Johnson, N, Sadowsky, C, Martinez, W, Villena, T, Turner, RS, Johnson, K, Reynolds, B, Sperling, RA, Johnson, KA, Marshall, G, Frey, M, Lane, B, Rosen, A, Tinklenberg, J, Sabbagh, MN, Belden, CM, Jacobson, SA, Sirrel, SA, Kowall, N, Killiany, R, Budson, AE, Norbash, A, Johnson, PL, Allard, J, Lerner, A, Ogrocki, P, Hudson, L, Fletcher, E, Carmichael, O, Olichney, J, DeCarli, C, Kittur, S, Borrie, M, Lee, TY, Bartha, R, Johnson, S, Asthana, S, Carlsson, CM, Potkin, SG, Preda, A, Nguyen, D, Tariot, P, Reeder, S, Bates, V, Capote, H, Rainka, M, Scharre, DW, Kataki, M, Adeli, A, Zimmerman, EA, Celmins, D, Brown, AD, Pearlson, GD, Blank, K, Anderson, K, Santulli, RB, Kitzmiller, TJ, Schwartz, ES, Sink, KM, Williamson, JD, Garg, P, Watkins, F, Ott, BR, Querfurth, H, Tremont, G, Salloway, S, Malloy, P, Correia, S, Rosen, HJ, Miller, BL, Mintzer, J, Spicer, K, Bachman, D, Finger, E, Pasternak, S, Rachinsky, I, Drost, D, Pomara, N, Hernando, R, Sarrael, A, Schultz, SK, Ponto, LLB, Shim, H, Smith, KE, Relkin, N, Chaing, G, Raudin, L, Smith, A, Fargher, K, Raj, BA, Neylan, T, Grafman, J, Davis, M, Morrison, R, Hayes, J, Finley, S, Friedl, K, Fleischman, D, Arfanakis, K, James, O, Massoglia, D, Fruehling, JJ, Harding, S, Peskind, ER, Petrie, EC, Li, G, Yesavage, JA, Taylor, JL & Furst, AJ 2016, Nature Communications, vol 7, 11934. DOI:

Association between anticholinergic medication use and cognition, brain metabolism, and brain atrophy in cognitively normal older adults
Risacher, SL, McDonald, BC, Tallman, EF, West, JD, Farlow, MR, Unverzagt, FW, Gao, S, Boustani, M, Crane, PK, Petersen, RC, Jack, CR, Jagust, WJ, Aisen, PS, Weiner, MW, Saykin, AJ, Trojanowki, JQ, Toga, AW, Beckett, L, Green, RC, Morris, J, Shaw, LM, Khachaturian, Z, Sorensen, G, Carrillo, M, Kuller, L, Raichle, M, Paul, S, Davies, P, Fillit, H, Hefti, F, Holtzman, D, Mesulam, MM, Potter, W, Snyder, PJ, Schwartz, A, Montine, T, Thomas, RG, Donohue, M, Walter, S, Gessert, D, Sather, T, Jiminez, G, Balasubramanian, AB, Mason, J, Sim, I, Harvey, D, Bernstein, M, Fox, N, Thompson, P, Schuff, N, DeCarli, C, Borowski, B, Gunter, J, Senjem, M, Vemuri, P, Jones, D, Kantarci, K, Ward, C, Koeppe, RA, Foster, N, Reiman, EM, Chen, K, Mathis, C, Landau, S, Cairns, NJ, Householder, E, Taylor-Reinwald, L, Lee, V, Korecka, M, Figurski, M, Crawford, K, Neu, S, Foroud, TM, Potkin, SG, Shen, L, Faber, K, Kim, S, Nho, K, Thal, L, Thal, L, Buckholtz, N, Albert, M, Frank, R, Hsiao, J, Kaye, J, Quinn, J, Silbert, L, Lind, B, Carter, R, Dolen, S, Schneider, LS, Pawluczyk, S, Beccera, M, Teodoro, L, Spann, BM, Brewer, J, Vanderswag, H, Fleisher, A, Heidebrink, JL, Lord, JL, Mason, SS, Albers, CS, Knopman, D, Johnson, K, Doody, RS, Villanueva-Meyer, J, Chowdhury, M, Rountree, S, Dang, M, Stern, Y, Honig, LS, Bell, KL, Ances, B, Carroll, M, Creech, ML, Franklin, E, Mintun, MA, Schneider, S, Oliver, A, Marson, D, Griffith, R, Clark, D, Geldmacher, D, Brockington, J, Roberson, E, Love, MN, Grossman, H, Mitsis, E, Shah, RC, De Toledo-Morrell, L, Duara, R, Varon, D, Greig, MT, Roberts, P, Onyike, C, DAgostino, D, Kielb, S, Galvin, JE, Cerbone, B, Michel, CA, Pogorelec, DM, Rusinek, H, De Leon, MJ, Glodzik, L, De Santi, S, Murali Doraiswamy, P, Petrella, JR, Borges-Neto, S, Wong, TZ, Coleman, E, Arnold, SE, Karlawish, JH, Wolk, D, Clark, CM, Smith, CD, Jicha, G, Hardy, P, Sinha, P, Oates, E, Conrad, G, Lopez, OL, Oakley, MA, Simpson, DM, Porsteinsson, AP, Goldstein, BS, Martin, K, Makino, KM, Saleem Ismail, M, Brand, C, Mulnard, RA, Thai, G, McAdams-Ortiz, C, Womack, K, Mathews, D, Quiceno, M, Levey, AI, Lah, JJ, Cellar, JS, Burns, JM, Swerdlow, RH, Brooks, WM, Apostolova, L, Tingus, K, Woo, E, Silverman, DHS, Lu, PH, Bartzokis, G, Graff-Radford, NR, Parfitt, F, Kendall, T, Johnson, H, Hake, AM, Matthews, BR, Brosch, JR, Herring, S, Hunt, C, Van Dyck, CH, Carson, RE, MacAvoy, MG, Varma, P, Chertkow, H, Bergman, H, Hosein, C, Black, S, Stefanovic, B, Caldwell, C, Hsiung, GYR, Feldman, H, Mudge, B, Assaly, M, Finger, E, Pasternack, S, Rachisky, I, Trost, D, Kertesz, A, Bernick, C, Munic, D, Lipowski, K, Weintraub, S, Bonakdarpour, B, Kerwin, D, Wu, CK, Johnson, N, Sadowsky, C, Villena, T, Turner, RS, Johnson, K, Reynolds, B, Sperling, RA, Johnson, KA, Marshall, G, Yesavage, J, Taylor, JL, Lane, B, Rosen, A, Tinklenberg, J, Sabbagh, MN, Belden, CM, Jacobson, SA, Sirrel, SA, Kowall, N, Killiany, R, Budson, AE, Norbash, A, Johnson, PL, Obisesan, TO, Wolday, S, Allard, J, Lerner, A, Ogrocki, P, Tatsuoka, C, Fatica, P, Fletcher, E, Maillard, P, Olichney, J, Carmichael, O, Kittur, S, Borrie, M, Lee, TY, Bartha, R, Johnson, S, Asthana, S, Carlsson, CM, Preda, A, Nguyen, D, Tariot, P, Burke, A, Trncic, N, Reeder, S, Bates, V, Capote, H, Rainka, M, Scharre, DW, Kataki, M, Adeli, A, Zimmerman, EA, Celmins, D, Brown, AD, Pearlson, GD, Blank, K, Anderson, K, Flashman, LA, Seltzer, M, Hynes, ML, Santulli, RB, Sink, KM, Gordineer, L, Williamson, JD, Garg, P, Watkins, F, Ott, BR, Querfurth, H, Tremont, G, Salloway, S, Malloy, P, Correia, S, Rosen, HJ, Miller, BL, Perry, D, Mintzer, J, Spicer, K, Bachman, D, Pasternak, S, Rachinsky, I, Rogers, J, Drost, D, Pomara, N, Hernando, R, Sarrael, A, Schultz, SK, Boles Ponto, LL, Shim, H, Smith, KE, Relkin, N, Chaing, G, Lin, M, Ravdin, L, Smith, A, Ashok Raj, B, Fargher, K, Neylan, T, Grafman, J, Davis, M, Morrison, R, Hayes, J, Finley, S, Friedl, K, Fleischman, D, Arfanakis, K, Doraiswamy, PM, James, O, Goldstei, B, Martin, KS, Massoglia, D, Brawman-Mintzer, O, Martinez, W, Ros, H, Behan, K, Sirrel, SA, Johnson, SC, Fruehling, JJ, Harding, S, Peskind, ER, Petrie, EC, Li, G, Yesavage, JA, Furst, AJ & Chao, S 2016, JAMA Neurology, vol 73, no. 6, pp. 721-732. DOI:

Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE
Ayton, S, Faux, NG, Bush, AI, Weiner, MW, Aisen, P, Petersen, R, Jack, CR, Jagust, W, Trojanowki, JQ, Toga, AW, Beckett, L, Green, RC, Saykin, AJ, Morris, J, Shaw, LM, Khachaturian, Z, Sorensen, G, Kuller, L, Raichle, M, Paul, S, Davies, P, Fillit, H, Hefti, F, Holtzman, D, Mesulam, MM, Potter, W, Snyder, P, Schwartz, A, Montine, T, Thomas, RG, Donohue, M, Walter, S, Gessert, D, Sather, T, Jiminez, G, Harvey, D, Bernstein, M, Fox, N, Thompson, P, Schuff, N, Borowski, B, Gunter, J, Senjem, M, Vemuri, P, Jones, D, Kantarci, K, Ward, C, Koeppe, RA, Foster, N, Reiman, EM, Chen, K, Mathis, C, Landau, S, Cairns, NJ, Householder, E, Taylor-Reinwald, L, Lee, V, Korecka, M, Figurski, M, Crawford, K, Neu, S, Foroud, TM, Potkin, S, Shen, L, Faber, K, Kim, S, Nho, K, Thal, L, Buckholtz, N, Albert, M, Frank, R, Hsiao, J, Kaye, J, Quinn, J, Lind, B, Carter, R, Dolen, S, Schneider, LS, Pawluczyk, S, Beccera, M, Teodoro, L, Spann, BM, Brewer, J, Vanderswag, H, Fleisher, A, Heidebrink, JL, Lord, JL, Mason, SS, Albers, CS, Knopman, D, Johnson, K, Doody, RS, Villanueva-Meyer, J, Chowdhury, M, Rountree, S, Dang, M, Stern, Y, Honig, LS, Bell, KL, Ances, B, Carroll, M, Leon, S, Mintun, MA, Schneider, S, Oliver, A, Marson, D, Griffith, R, Clark, D, Geldmacher, D, Brockington, J, Roberson, E, Grossman, H, Mitsis, E, De Toledo-Morrell, L, Shah, RC, Duara, R, Varon, D, Greig, MT, Roberts, P, Albert, M, Onyike, C, DAgostino, D, Kielb, S, Galvin, JE, Cerbone, B, Michel, CA, Rusinek, H, De Leon, MJ, Glodzik, L, De Santi, S, Doraiswamy, PM, Petrella, JR, Wong, TZ, Arnold, SE, Karlawish, JH, Wolk, D, Smith, CD, Jicha, G, Hardy, P, Sinha, P, Oates, E, Conrad, G, Lopez, OL, Oakley, MA, Simpson, DM, Porsteinsson, AP, Goldstein, BS, Martin, K, Makino, KM, Ismail, MS, Brand, C, Mulnard, RA, Thai, G, Mc-Adams-Ortiz, C, Womack, K, Mathews, D, Quiceno, M, Diaz-Arrastia, R, King, R, Weiner, M, Martin-Cook, K, DeVous, M, Levey, AI, Lah, JJ, Cellar, JS, Burns, JM, Anderson, HS, Swerdlow, RH, Apostolova, L, Tingus, K, Woo, E, Silverman, DHS, Lu, PH, Bartzokis, G, Graff-Radford, NR, Parfitt, F, Kendall, T, Johnson, H, Farlow, MR, Hake, AM, Matthews, BR, Herring, S, Hunt, C, Van Dyck, CH, Carson, RE, MacAvoy, MG, Chertkow, H, Bergman, H, Hosein, C, Black, S, Stefanovic, B, Caldwell, C, Hsiung, GYR, Feldman, H, Mudge, B, Assaly, M, Kertesz, A, Rogers, J, Bernick, C, Munic, D, Kerwin, D, Mesulam, MM, Lipowski, K, Wu, CK, Johnson, N, Sadowsky, C, Martinez, W, Villena, T, Turner, RS, Johnson, K, Reynolds, B, Sperling, RA, Johnson, KA, Marshall, G, Frey, M, Lane, B, Rosen, A, Tinklenberg, J, Sabbagh, MN, Belden, CM, Jacobson, SA, Sirrel, SA, Kowall, N, Killiany, R, Budson, AE, Norbash, A, Johnson, PL, Allard, J, Lerner, A, Ogrocki, P, Hudson, L, Fletcher, E, Carmichael, O, Olichney, J, DeCarli, C, Kittur, S, Borrie, M, Lee, TY, Bartha, R, Johnson, S, Asthana, S, Carlsson, CM, Potkin, SG, Preda, A, Nguyen, D, Tariot, P, Reeder, S, Bates, V, Capote, H, Rainka, M, Scharre, DW, Kataki, M, Adeli, A, Zimmerman, EA, Celmins, D, Brown, AD, Pearlson, GD, Blank, K, Anderson, K, Santulli, RB, Kitzmiller, TJ, Schwartz, ES, Sink, KM, Williamson, JD, Garg, P, Watkins, F, Ott, BR, Querfurth, H, Tremont, G, Salloway, S, Malloy, P, Correia, S, Rosen, HJ, Miller, BL, Mintzer, J, Spicer, K, Bachman, D, Finger, E, Pasternak, S, Rachinsky, I, Drost, D, Pomara, N, Hernando, R, Sarrael, A, Schultz, SK, Boles Ponto, LL, Shim, H, Smith, KE, Relkin, N, Chaing, G, Raudin, L, Smith, A, Fargher, K, Raj, BA, Neylan, T, Grafman, J, Davis, M, Morrison, R, Hayes, J, Finley, S, Friedl, K, Fleischman, D, Arfanakis, K, James, O, Massoglia, D, Fruehling, JJ, Harding, S, Peskind, ER, Petrie, EC, Li, G, Yesavage, JA, Taylor, JL & Furst, AJ 2015, Nature Communications, vol 6, 6760. DOI:

Donepezil treatment in ethnically diverse patients with alzheimer disease
Tinklenberg, JR, Kraemer, HC, Yaffe, K, OHara, R, Ringman, JM, Ashford, JW, Yesavage, JA, Taylor, JL, Reed, B, Vieira, K, Mungas, D, DeCarli, C, LaGrande, J, Bloom, T, Sanchez, R, Cotman, C, Dick, RM, Sirivong, S, Hoang, D, Mobley, S, Ringman, J, Cummings, J, Suarez, J, Metz, K, Hwang, S, Ramirez, A, Galasko, D, Salmon, D, Sundsmo, M, Booth, A, Miller, B, Yaffe, K, Johnson, J, Kramer, J, Gearhart, R, Barton, C, Hesse, J, Alving, L, Hewett, L, Conley, P, Sherriffs, A, Segal-Gidan, F, Chui, H, Smith, B, Ireland, A, Lyness, S, Schneider, L, Dagerman, K, Danner, J, Pawluczyk, S, Spann, B, Davies, H, Luu, P, Miller, T, Newkirk, L, Reed, B, Vieira, K, Yesavage, J, Gere, E, Joseph, S, OHara, R, Wakabayashi, E, Yaffe, K, Barton, C, Sayegh, P, Fox, P, Tyrrell, D, Ross, L & Tang, P 2015, American Journal of Geriatric Psychiatry, vol 23, no. 4, pp. 384-390. DOI:

Accuracy and reliability of ASL perfusion in evaluating neurodegenerative disease: voxel-wise and cortical-regional comparison with 18F-FDG PET
Fung, SH , Karmonik, C , Dulay, M , Pascual, MB, Lee, D, Chiang, S, Fisher, RE, Grossman, R, Spann, BM-P & Roman, GC 2014, International Society of Magnetic Resonance in Medicine, Milan, Italy, 5/10/14 - 5/16/14, .

Striatal hypodensities, not white matter hypodensities on CT, Are Associated with Late-Onset Depression in Alzheimer's Disease
Brommelhoff, JA, Spann, BM, Go, JL, MacK, WJ & Gatz, M 2011, Journal of Aging Research, vol 2011, 187219. DOI:

Transcriptome analysis of synaptoneurosomes identifies neuroplasticity genes overexpressed in incipient Alzheimer's disease
Williams, C, Shai, RM, Wu, Y, Hsu, YH, Sitzer, T, Spann, B, McCleary, C, Mo, Y & Miller, CA 2009, PLoS ONE, vol 4, no. 3, e4936. DOI:

Cholinergic and non-cholinergic neurons in the rat pedunculopontine tegmental nucleus
Spann, BM & Grofova, I 1992, Anatomy and Embryology, vol 186, no. 3, pp. 215-227. DOI:

Nigropedunculopontine projection in the rat: An anterograde tracing study with phaseolus vulgaris-leucoagglutinin (PHA-L)
Spann, BM & Grofova, I 1991, Journal of Comparative Neurology, vol 311, no. 3, pp. 375-388.

Origin of ascending and spinal pathways from the nucleus tegmenti pedunculopontinus in the rat
Spann, BM & Grofova, I 1989, Journal of Comparative Neurology, vol 283, no. 1, pp. 13-27.