E. Brian Butler, MD

Jim and Joan Harrell Chair in Radiation Oncology, Department of Radiation Oncology
Professor of Radiation Oncology, Institute for Academic Medicine
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


After completing his postdoctoral training in 1987, Dr. Butler returned to the Wilford Hall USAF Medical Center in San Antonio, Texas where he became both the Chief of Radiation Oncology and the Chief of Brachytherapy. He also joined the faculty at The University of Texas Health Science Center at San Antonio as a Clinical Assistant Professor that same year. Dr. Butler would later join the Baylor College of Medicine where he would eventually become a full professor and the Chief of Radiation Oncology for both the medical school and the VA Hospital. He became the Medical Director of Radiation Oncology at Methodist in 1991, and received his faculty appointment at the Weill Medical School in 2006.

Description of Research

Dr. Butler’s research centers on preclinical and clinical studies that combine radiation therapy and gene therapy for the treatment of prostate cancer. In recent years, he has extended these successful studies to other cancers, notably pancreatic cancer. His research interests also include three-dimensional reconstruction of body organs to assist in better localization of radiation therapy.

Areas Of Expertise

Prostate cancer Pancreatic cancer Radiation therapy Gene therapy Computer visualization techniques
Education & Training

Residency , Stanford School of Medicine
MD , Georgetown University

Radiation therapy utilization and outcomes for older women with breast cancer: Impact of molecular subtype and tumor grade
Haque, W, Kee Yuan, DM, Verma, V, Butler, EB, Teh, BS, Wiederhold, L & Hatch, S 2017, Breast, vol 35, pp. 34-41. DOI:

The utility of positron emission tomography/computed tomography in target delineation for stereotactic body radiotherapy for liver metastasis from primary gastric cancer: An illustrative case report and literature review
Lewis, GD, Chiang, SB, Butler, EB & Teh, BS 2017, Journal of Gastrointestinal Oncology, vol 8, no. 3, pp. E39-E42. DOI:

Patterns of care and outcomes of multi-agent versus single-agent chemotherapy as part of multimodal management of low grade glioma
Haque, W, Verma, V, Butler, EB & Teh, BS 2017, Journal of Neuro-Oncology. DOI:

Trends in the use of implantable accelerated partial breast irradiation for ductal carcinoma in situ: Implications of the recent amendments to the American Society for Radiation Oncology consensus guidelines
Haque, W, Verma, V, Haque, A, Butler, EB & Teh, BS 2017, Brachytherapy, vol 16, no. 2, pp. 402-408. DOI:

Early outcomes of uveal melanoma treated with intraoperative ultrasound guided brachytherapy using custom built plaques
Tann, AW, Teh, BS, Scarboro, SB, Lewis, GD, Bretana, ME, Croft, PC, Raizen, Y, Butler, EB, Kim, RS, Chevez-Barrios, P & Schefler, AC 2017, Practical Radiation Oncology. DOI:

Trends in cardiac mortality in women with ductal carcinoma in situ
Haque, W, Verma, V, Haque, A, Butler, EB & Teh, BS 2017, Breast Cancer Research and Treatment, vol 161, no. 2, pp. 345-351. DOI:

Nanochannel implants for minimally-invasive insertion and intratumoral delivery
Hood, RL, Bruno, G, Jain, P, Anderson, J, Wolfe, T, Quini, C, Schmulen, J, Li, XC, Butler, EB, Krishnan, S & Grattoni, A 2016, Journal of Biomedical Nanotechnology, vol 12, no. 10, pp. 1907-1915. DOI:

Addition of chemotherapy to definitive radiotherapy for IB1 and IIA1 cervical cancer: Analysis of the National Cancer Data Base
Haque, W, Verma, V, Fakhreddine, M, Hatch, S, Butler, EB & Teh, BS 2016, Gynecologic Oncology. DOI:

Pluripotent stem cells and DNA damage response to ionizing radiations
Mujoo, K , Butler, EB, Pandita, RK, Hunt, CR & Pandita, TK 2016, Radiation Research, vol 186, no. 1, pp. 17-26. DOI:

Changes in treatment patterns and impact of radiotherapy for early stage diffuse large B cell lymphoma after Rituximab: A population-based analysis
Haque, W, Dabaja, B, Tann, A, Khan, M, Szeja, S, Butler, EB & Teh, BS 2016, Radiotherapy and Oncology. DOI:

Clinical outcomes, toxicity, and cosmesis in breast cancer patients with close skin spacing treated with accelerated partial breast irradiation (APBI) using multi-lumen/catheter applicators
Akhtari, M, Abboud, M, Szeja, S, Pino, R, Lewis, GD, Bass, BL, Miltenburg, DM, Butler, EB & Teh, BS 2016, Journal of Contemporary Brachytherapy, vol 8, no. 6, pp. 497-504. DOI:

Long-term outcome of a phase II trial using immunomodulatory in situ gene therapy in combination with intensity-modulated radiotherapy with or without hormonal therapy in the treatment of prostate cancer
Teh, B, Ishiyama, H, Mai, WY, Thompson, TC & Butler, EB 2015, Journal of Radiation Oncology, vol 4, pp. 377-386. DOI:

Combining radiotherapy and immunotherapy for prostate cancer: two decades of research from preclinical to clinical trials
Huang, Y, Chen, W, Teh, B & Butler, EB 2015, Journal of Radiation Oncology, vol 4, pp. 365-375. DOI:

Radiotherapy and Abscopal Effect: Insight From the Past, Present and Future
Chen, AC, Butler, EB, Lo, SS & Teh, B 2015, Journal of Radiation Oncology, vol 4, pp. 321-330. DOI:

Comparison of supine and prone craniospinal irradiation in children with medulloblastoma
Verma, J, Mazloom, A, Teh, BS, South, M, Butler, EB & Paulino, AC 2015, Practical Radiation Oncology, vol 5, no. 2, pp. 93-98. DOI:

A Perspective on Chromosomal Double Strand Break Markers in Mammalian Cells
Wang, H, Adhikari, S, Butler, EB, Pandita, TK, Mitra, S & Hegde, ML 2015, Jacobs Journal of Radiation Oncology, vol 1, no. 1:003..

The Role of Combined Radiation and Immunotherapy in Breast Cancer Treatment
Farach, A, Farach-Carson, M, Butler, EB, Chang, JC & Teh, B 2015, Journal of Radiation Oncology, vol 347, pp. 347-354.

Dosimetric considerations and early clinical experience of accelerated partial breast irradiation using multi-lumen applicators in the setting of breast augmentation
Akhtari, M, Pino, R, Scarboro, SB, Bass, BL, Miltenburg, DM, Butler, EB & Teh, BS 2015, Journal of Contemporary Brachytherapy, vol 7, no. 6, pp. 423-429. DOI:

Three-dimensional sinus imaging as an adjunct to two-dimensional imaging to accelerate education and improve spatial orientation
Yao, WC, Regone, RM, Huyhn, N, Butler, EB & Takashima, M 2014, Laryngoscope, vol 124, no. 3, pp. 596-601. DOI:

Combined therapeutic effects of adenoviral vector-mediated GLIPR1 gene therapy and radiotherapy in prostate and bladder cancer models
Fujita, T, Satoh, T, Timme, TL, Hirayama, T, Zhu, JX, Kusaka, N, Naruishi, K, Yang, G, Goltsov, A, Wang, J, Vlachaki, MT, Teh, BS, Brian Butler, E & Thompson, TC 2014, Urologic Oncology: Seminars and Original Investigations, vol 32, no. 2, pp. 92-100. DOI: