E. Brian Butler, MD

Jim and Joan Harrell Distinguished Professor in Radiation Oncology, Department of Radiation Oncology
Professor of Radiation Oncology, Institute for Academic Medicine
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


After completing his postdoctoral training in 1987, Dr. Butler returned to the Wilford Hall USAF Medical Center in San Antonio, Texas where he became both the Chief of Radiation Oncology and the Chief of Brachytherapy. He also joined the faculty at The University of Texas Health Science Center at San Antonio as a Clinical Assistant Professor that same year. Dr. Butler would later join the Baylor College of Medicine where he would eventually become a full professor and the Chief of Radiation Oncology for both the medical school and the VA Hospital. He became the Medical Director of Radiation Oncology at Methodist in 1991, and received his faculty appointment at the Weill Medical School in 2006.

Description of Research

Dr. Butler’s research centers on preclinical and clinical studies that combine radiation therapy and gene therapy for the treatment of prostate cancer. In recent years, he has extended these successful studies to other cancers, notably pancreatic cancer. His research interests also include three-dimensional reconstruction of body organs to assist in better localization of radiation therapy.

Areas Of Expertise

Prostate cancer Pancreatic cancer Radiation therapy Gene therapy Computer visualization techniques
Education & Training

, Stanford School of Medicine
, Georgetown University

Pluripotent stem cells and DNA damage response to ionizing radiations
Mujoo, K , Butler, EB, Pandita, RK, Hunt, CR & Pandita, TK 2016, Radiation Research, vol 186, no. 1, pp. 17-26. DOI:

Changes in treatment patterns and impact of radiotherapy for early stage diffuse large B cell lymphoma after Rituximab: A population-based analysis
Haque, W, Dabaja, B, Tann, A, Khan, M, Szeja, S, Butler, EB & Teh, BS 2016, Radiotherapy and Oncology. DOI:

Long-term outcome of a phase II trial using immunomodulatory in situ gene therapy in combination with intensity-modulated radiotherapy with or without hormonal therapy in the treatment of prostate cancer
Teh, B, Ishiyama, H, Mai, WY, Thompson, TC & Butler, EB 2015, Journal of Radiation Oncology, vol 4, pp. 377-386. DOI:

Combining radiotherapy and immunotherapy for prostate cancer: two decades of research from preclinical to clinical trials
Huang, Y, Chen, W, Teh, B & Butler, EB 2015, Journal of Radiation Oncology, vol 4, pp. 365-375. DOI:

Radiotherapy and Abscopal Effect: Insight From the Past, Present and Future
Chen, AC, Butler, EB, Lo, SS & Teh, B 2015, Journal of Radiation Oncology, vol 4, pp. 321-330. DOI:

Comparison of supine and prone craniospinal irradiation in children with medulloblastoma
Verma, J, Mazloom, A, Teh, BS, South, M, Butler, EB & Paulino, AC 2015, Practical Radiation Oncology, vol 5, no. 2, pp. 93-98. DOI:

A Perspective on Chromosomal Double Strand Break Markers in Mammalian Cells
Wang, H, Adhikari, S, Butler, EB, Pandita, TK, Mitra, S & Hegde, ML 2015, Jacobs Journal of Radiation Oncology, vol 1, no. 1:003..

The Role of Combined Radiation and Immunotherapy in Breast Cancer Treatment
Farach, A, Farach-Carson, M, Butler, EB, Chang, JC & Teh, B 2015, Journal of Radiation Oncology, vol 347, pp. 347-354.

Dosimetric considerations and early clinical experience of accelerated partial breast irradiation using multi-lumen applicators in the setting of breast augmentation
Akhtari, M, Pino, R, Scarboro, SB, Bass, BL, Miltenburg, DM, Butler, EB & Teh, BS 2015, Journal of Contemporary Brachytherapy, vol 7, no. 6, pp. 423-429. DOI:

Three-dimensional sinus imaging as an adjunct to two-dimensional imaging to accelerate education and improve spatial orientation
Yao, WC, Regone, RM, Huyhn, N, Butler, EB & Takashima, M 2014, Laryngoscope, vol 124, no. 3, pp. 596-601. DOI:

Combined therapeutic effects of adenoviral vector-mediated GLIPR1 gene therapy and radiotherapy in prostate and bladder cancer models
Fujita, T, Satoh, T, Timme, TL, Hirayama, T, Zhu, JX, Kusaka, N, Naruishi, K, Yang, G, Goltsov, A, Wang, J, Vlachaki, MT, Teh, BS, Brian Butler, E & Thompson, TC 2014, Urologic Oncology: Seminars and Original Investigations, vol 32, no. 2, pp. 92-100. DOI:

Computer assisted management of disease and surgery: Plato’s cave: A multidimensional, image-guided radiation therapy cross reality platform with advanced surgical planning, simulation, and visualization techniques using (native) dicom patient image studies
Butler, EB, Sovelius, PE & Huynh, N 2014, . in Computational Surgery and Dual Training: Computing, Robotics and Imaging. Springer New York, pp. 27-36. DOI:

Is there an increase in genitourinary toxicity in patients treated with transurethral resection of the prostate and radiotherapy? A systematic review.
Ishiyama, H, Hirayama, T, Jhaveri, P, Satoh, T, Paulino, AC, Xu, B, Butler, EB & Teh, BS 2014, American journal of clinical oncology, vol 37, no. 3, pp. 297-304. DOI:

Management of predictable pain using fentanyl pectin nasal spray in patients undergoing radiotherapy
Bell, BC & Butler, EB 2013, Journal of Pain Research, vol 6, pp. 843-848. DOI:

Intraprostatic distribution and long-term follow-up after AdV-tk immunotherapy as neoadjuvant to surgery in patients with prostate cancer
Rojas-Martínez, A, Manzanera, AG, Sukin, SW, Esteban-María, J, González-Guerrero, JF, Gomez-Guerra, L, Garza-Guajardo, R, Flores-Gutiérrez, JP, Elizondo Riojas, G, Delgado-Enciso, I, Ortiz-López, R, Aguilar, LK, Butler, EB, Barrera-Saldaña, HA & Aguilar-Cordova, E 2013, Cancer Gene Therapy, vol 20, no. 11, pp. 642-649. DOI:

External radiation treatment of malignant liver disease: A critical review
Blanco, AI, Teh, BS, Dawson, LA, Pino, R, Paulino, AC & Butler, EB 2013, Journal of Radiation Oncology, vol 2, no. 3, pp. 249-262. DOI:

Salvage intensity modulated radiotherapy using endorectal balloon after radical prostatectomy: Clinical outcomes
Ishiyama, H, Teh, BS, Blanco, AI, Paulino, AC, Mai, WY, Caillouet, J, Xu, B & Butler, EB 2013, International Journal of Urology, vol 20, no. 12, pp. 1178-1183. DOI:

Identification and characterization of a small inhibitory peptide that can target DNA-PKcs autophosphorylation and increase tumor radiosensitivity
Sun, X, Yang, C, Liu, H, Wang, Q, Wu, SX, Li, X, Xie, T, Brinkman, KL, Teh, BS, Butler, EB, Xu, B & Zheng, S 2012, International Journal of Radiation Oncology Biology Physics, vol 84, no. 5, pp. 1212-1219. DOI:

Stereotactic body radiation therapy for medically inoperable early-stage lung cancer patients
Abboud, M, Teh, BS, Blackmon, SH, Kim, M, Blanco, AI, Lee, DY, Santacruz, JF, Paulino, A, Butler, EB, Mayr, NA, Huang, Z & Lo, SS 2012, Clinical Pulmonary Medicine, vol 19, no. 6, pp. 289-294. DOI:

Long-term Outcomes and Prognostic Factors of Re-irradiation for Locally Recurrent Nasopharyngeal Carcinoma using Intensity-modulated Radiotherapy
Han, F, Zhao, C, Huang, SM, Lu, LX, Huang, Y, Deng, XW, Mai, WY, Teh, BS, Butler, EB & Lu, TX 2012, Clinical Oncology, vol 24, no. 8, pp. 569-576. DOI: