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Biana Godin , MScPharm, PhD

Assistant Professor of Nanomedicine, Institute for Academic Medicine
Assistant Member, Research Institute
Houston Methodist


Research Lab


Phone:
713.441.7329


bgodin@houstonmethodist.org
Biography

Dr. Biana Godin earned her Ph.D. in Pharmaceutical Sciences from the Hebrew University of Jerusalem in 2006. During her Ph.D. studies, Dr. Godin focused on designing a non-invasive treatment for the hard-to-treat skin deep infections and on nasal delivery of proteins. She was recruited as a Postdoctoral trainee in the field of Cancer Nanotechnology to the University of Texas Health Sciences Center. Her postdoctoral research focused on injectable multistage nanovectors (MSVs) for cancer treatment and imaging. Her work provided insightful understanding of the interactions of MSVs with immune cells in vivo and in vitro, biocompatibility of MSV, effect of geometry and targeting moieties on MSV biodistribution, and evaluation of MSV systems as near-infra red and MRI imaging agents. During the three years of her postdoctoral research, Dr. Godin published numerous book chapters, and peer-reviewed articles and reviews in top journals including Nature Nanotechnology and Cancer Research. She also received awards for her work at international conferences. In October 2010, Dr. Godin joined the Department of Nanomedicine at the Research Institute. 

Research in Dr. Godin's lab, largely funded by federal and foundation grants, focuses on developing physiologically relevant in vitro and in vivo disease models and exploiting physical and biological mechanisms to improve currently available therapeutic options in oncology and obstetrics. Dr. Godin considers herself a translational scientist on the interception of biological and physical sciences, with the ultimate goal of bringing advanced and safe therapies and the techniques to personalize therapies into the clinic to benefit patients.

Dr. Godin has more than 200 scientific publications, received multiple federal and foundation-based grants and participated in multiple national and international grant review panels. 

Description of Research

Dr. Godin's research focuses primarily on the following areas:

-Targeting liver metastasis with advanced nanocarriers

-Novel strategies to target tumor microenvironment

-Employing principles of nanomedicine in Ob/Gyn

-Advanced disease models

The main objective of these studies is to provide innovative approaches to treatment and diagnosis of cancer and Ob/Gyn disorders. 

Areas Of Expertise

Nanomedicine Cancer Physical sciences in oncology Nanocarrier biocompatibility Biodistribution Ob/Gyn Nano-therapeutics targeting
Education & Training

, The Hebrew University of Jerusalem
, University of Texas Health Science Center
Publications

Generation of an in vitro 3D PDAC stroma rich spheroid model
Ware, MJ, Keshishian, V, Law, JJ, Ho, JC, Favela, CA, Rees, P, Smith, B, Mohammad, S, Hwang, RF, Rajapakshe, K, Coarfa, C, Huang, S, Edwards, DP, Corr, SJ, Godin, B & Curley, SA 2016, Biomaterials, vol 108, pp. 129-142. DOI:

Uterus-targeted liposomes for preterm labor management: Studies in pregnant mice
Refuerzo, JS, Leonard, F, Bulayeva, N, Gorenstein, D, Chiossi, G, Ontiveros, A, Longo, M & Godin, B 2016, Scientific Reports, vol 6, 34710. DOI:

Multiscale benchmarking of drug delivery vectors
Summers, HD, Ware, MJ, Majithia, R, Meissner, KE, Godin, B & Rees, P 2016, Nanomedicine: Nanotechnology, Biology, and Medicine, vol 12, no. 7, pp. 1843-1851. DOI:

Enhanced performance of macrophage-encapsulated nanoparticle albumin-bound-paclitaxel in hypo-perfused cancer lesions
Leonard, F, Curtis, LT, Yesantharao, P, Tanei, T, Alexander, JF, Wu, M, Lowengrub, J, Liu, X, Ferrari, M, Yokoi, K, Frieboes, HB & Godin, B 2016, Nanoscale, vol 8, no. 25, pp. 12544-12552. DOI:

Generation of homogenous three-dimensional pancreatic cancer cell spheroids using an improved hanging drop technique
Ware, MJ, Colbert, K, Keshishian, V, Ho, J, Corr, SJ, Curley, SA & Godin, B 2016, Tissue Engineering - Part C: Methods, vol 22, no. 4, pp. 312-321. DOI:

Redirecting transport of nanoparticle albumin-bound paclitaxel to macrophages enhances therapeutic efficacy against liver metastases
Tanei, T, Leonard, F, Liu, X, Alexander, JF, Saito, Y, Ferrari, M, Godin, B & Yokoi, K 2016, Cancer Research, vol 76, no. 2, pp. 429-439.

10: Targeted liposomes direct the delivery of indomethacin to the uterus enhancing its tocolytic efficacy to reduce uterine contractions and preterm birth rate: 36th Annual Meeting of the Society for Maternal Fetal MedicineThe Pregnancy Meeting36th Annual Meeting of the Society for Maternal Fetal Medicine
Refuerzo, J, Leonard, F, Ontiveros, AE, Buleyeva, N, Godin, B & Longo, M 2016, American Journal of Obstetrics and Gynecology, vol 214, no. 1, Supplement, pp. S8-S9. DOI:

Ethosomes: Enhanced delivery of drugs to and across the skin
Ainbinder, D, Godin, B & Touitou, E 2016, . in Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Nanocarriers. Springer Berlin Heidelberg, pp. 61-75. DOI:

3D In Vitro Model for Breast Cancer Research Using Magnetic Levitation and Bioprinting Method
Leonard, F & Godin, B 2016, . in J Cao (ed.), Breast Cancer: Methods and Protocols. vol. 1406, Methods in Molecular Biology, vol. 1406, Springer, pp. 239-251. DOI:

Cubical Shape Enhances the Interaction of Layer-by-Layer Polymeric Particles with Breast Cancer Cells
Alexander, JF, Kozlovskaya, V, Chen, J, Kuncewicz, T, Kharlampieva, E & Godin, B 2015, Advanced Healthcare Materials, vol 4, no. 17, pp. 2657-2666. DOI:

Dermal and Transdermal Delivery
Godin, B & Touitou, E 2015, . in B Bhushan (ed.), Encyclopedia of Nanotechnology. Springer Netherlands, pp. 1.

Tuning Geometry of the Therapeutic Nanovectors and Thioaptamer Targeting: A Dual Approach to Improve Anti-Tuberculosis Treatment.
Leonard, F, Ha, NP, Alexander, JF, Gorenstein, DG, Graviss, E & Godin, B 2015, 2015 Biomedical Engineering Society - Annual Meeting, Tampa, United States, 10/7/15 - 10/10/15, .

Tunneling nanotubes as a conduit for drug resistance transfer.
Ware, MJ, Keshishian, V, Corr, SJ, Godin, B & Curley, SA 2015, 2015 Biomedical Engineering Society - Annual Meeting, Tampa, United States, 10/7/15 - 10/10/15, .

Tuning Geometry of the Therapeutic Nanovectors and Thioaptamer Targeting: A Dual Approach to Improve Anti-Tuberculosis Treatment.
Leonard, F, Ha, NP, Alexander, JF, Gorenstein, DG, Graviss, E & Godin, B 2015, 2015 Biomedical Engineering Society - Annual Meeting, Tampa, United States, 10/7/15 - 10/10/15, .

Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles
Ramishetti, S, Kedmi, R, Goldsmith, M, Leonard, F, Sprague, AG, Godin, B, Gozin, M, Cullis, PR, Dykxhoorn, DM & Peer, D 2015, ACS Nano, vol 9, no. 7, pp. 6706-6716. DOI:

Radiofrequency treatment alters cancer cell phenotype
Ware, MJ, Tinger, S, Colbert, KL, Corr, SJ, Rees, P, Koshkina, N, Curley, S, Summers, HD & Godin, B 2015, Scientific reports, vol 5, 12083. DOI:

Enhanced therapeutic efficacy of a combination of gemcitabine and albumin-bound paclitaxel in multistage nanovectors in pancreatic ductal adenocarcinoma: Evaluation of transport phenomena
Borsoi, C, Yokoi, K, Leonard, F, Ferrari, M & Godin, B 2015, American Association for Cancer Research Annual Meeting 2015, United States, 4/18/15 - 4/22/15, .

Liposomes: A nanoscale drug carrying system to prevent indomethacin passage to the fetus in a pregnant mouse model
Refuerzo, JS, Alexander, JF, Leonard, F, Leon, M, Longo, M & Godin, B 2015, American Journal of Obstetrics and Gynecology, vol 212, no. 4. DOI:

Liposomes: a nanoscale drug carrying system to prevent indomethacin passage to the fetus in a pregnant mouse model.
Refuerzo, JS, Alexander, JF, Leonard, F, Leon, M, Longo, M & Godin, B 2015, 35th Annual Meeting of the Society for Maternal-Fetal Medicine — The Pregnancy Meeting, United Kingdom, 2/2/15 - 2/7/15, .

Journal Cover Image: Cubical Shape Enhances the Interaction of Layer-by-Layer Polymeric Particles with Breast Cancer Cells
Alexander, JF, Kozlovskaya, V, Chen, J, Kuncewicz, T, Kharlampieva, E & Godin, B, , 2015, Design, Wiley-VCH. DOI: