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Arturas Ziemys, PhD

Assistant Professor in Nanomedicine, Institute for Academic Medicine
Assistant Member, Research Institute
Houston Methodist


aziemys@houstonmethodist.org
Biography

Dr. Ziemys earned his Ph.D. in Molecular Biophysics from the Vytautas Magnus University in 2002. He held a faculty appointment at Vytautas Magnus University and the position of staff scientist at the Institute of Biochemistry. Dr. Ziemys earned two awards from the Lithuanian Academy of Sciences during this period of time. The main focus of his research was biocatalysis using experimental and computational methods. He left for postdoctoral training at the Ohio State University in 2005, where he studied protein structure under ambient and extreme conditions. Dr. Ziemys continued his training at the University of Texas Health Science Center from 2009 to 2010, focusing on biophysical aspects of nanofluidics and drug delivery. While at the University of Texas Health Science Center he was awarded a postdoctoral fellowship, and worked on a research project that won a national competition to be performed in space.

Description of Research

Dr. Ziemys's research program focuses on nanofluidics, drug delivery, drug design, and interface phenomena for biomedical applications. His current research aims are the development of therapeutic agent mass transport and zero-order drug delivery mechanisms.

Areas Of Expertise

Diffusion Drug development Nanofluidics Particulate materials Model systems
Education & Training

Postdoctoral Fellowship , The Ohio State University
Postdoctoral Fellowship , The University of Texas Health Science Center
MS , Vytautas Magnus University
PhD , Vytautas Magnus University/Institute of Biochemistry
Publications

Computational analysis of drug transport in tumor microenvironment as a critical compartment for nanotherapeutic pharmacokinetics
Ziemys, A, Klemm, S, Milosevic, M, Yokoi, K, Ferrari, M & Kojic, M 2016, Drug Delivery, vol 23, no. 7, pp. 2524-2531. DOI:

A MODEL FOR DRUG TRANSPORT IN TUMOR
Kojic, M, Simic, V, Ferrari, M, Koay, EJ & Ziemys, A 2016, . in ECCOMAS Congress 2016, Crete Island, Greece, 5-10 June.

The protein kinase promiscuities in the cancer-preventive mechanisms of NSAIDs
Norvaisas, P, Chan, D, Yokoi, K, Dave, B & Ziemys, A 2016, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), vol 25, no. 1, pp. 77-84. DOI:

Reduced cationic nanoparticle cytotoxicity based on serum masking of surface potential
McConnell, KI, Shamsudeen, S, Meraz, IM, Mahadevan, TS, Ziemys, A, Rees, P, Summers, HD & Serda, RE 2016, Journal of Biomedical Nanotechnology, vol 12, no. 1, pp. 154-164. DOI:

Computational models for convective and diffusive drug transport in capillaries and tissue
Kojic, M, Milosevic, M, Isailovic, V, Simic, V, Ferrari, M & Ziemys, A 2015, . in 2015 IEEE 15th International Conference on Bioinformatics and Bioengineering, BIBE 2015., 7367633, IEEE, 15th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2015, Belgrade, Serbia, 2-4 November. DOI:

Liposomal doxorubicin extravasation controlled by phenotype-specific transport properties of tumor microenvironment and vascular barrier
Yokoi, K, Chan, D, Kojic, M, Milosevic, M, Engler, D, Matsunami, R, Tanei, T, Saito, Y, Ferrari, M & Ziemys, A 2015, Journal of Controlled Release, vol 217, pp. 293-299. DOI:

Capillary collagen as the physical transport barrier in drug delivery to tumor microenvironment
Ziemys, A , Yokoi, K & Kojic, M 2015, Tissue barriers, vol 3, no. 3, pp. e1037418. DOI:

Physicochemical properties affect the synthesis, controlled delivery, degradation and pharmacokinetics of inorganic nanoporous materials
Yazdi, IK, Ziemys, A, Evangelopoulos, M, Martinez, JO, Kojic, M & Tasciotti, E 2015, Nanomedicine, vol 10, no. 19, pp. 3057-3075. DOI:

A multi-scale FE model for convective-diffusive drug transport within tumor and large vascular networks
Kojic, M, Milosevic, M, Kojic, N, Starosolski, Z, Ghaghada, K, Serda, R, Annapragada, A, Ferrari, M & Ziemys, A 2015, Computer Methods in Applied Mechanics and Engineering, vol 294, pp. 100-122. DOI:

Mass partitioning effects in diffusion transport
Kojic, M, Milosevic, M, Wu, S, Blanco, E, Ferrari, M & Ziemys, A 2015, Physical Chemistry Chemical Physics, vol 17, no. 32, pp. 20630-20635. DOI:

Coupling fluid and solid domains in modeling drug transport within tumor
Kojic, M, Milosevic, M, Simic, V, Ziemys, A & Ferrari, M 2015, . in COUPLED PROBLEMS 2015 - Proceedings of the 6th International Conference on Coupled Problems in Science and Engineering. International Center for Numerical Methods in Engineering, pp. 583-592, 6th International Conference on Computational Methods for Coupled Problems in Science and Engineering, COUPLED PROBLEMS 2015, Venice, Italy, 18-20 May.

Delivering Enhanced Testosterone Replacement Therapy through Nanochannels
Ferrati, S, Nicolov, E, Bansal, S, Zabre, E, Geninatti, T, Ziemys, A, Hudson, L, Ferrari, M, Goodall, R, Khera, M, Palapattu, G & Grattoni, A 2015, Advanced Healthcare Materials, vol 4, no. 3, pp. 446-451. DOI:

Sustained administration of hormones exploiting nanoconfined diffusion through nanochannel membranes
Geninatti, T, Lyle Hood, R, Bruno, G, Jain, P, Nicolov, E, Ziemys, A & Grattoni, A 2015, Materials, vol 8, no. 8, pp. 5276-5288. DOI:

Capillary-wall collagen as a biophysical marker of nanotherapeutic permeability into the tumor microenvironment
Yokoi, K , Kojic, M, Milosevic, M, Tanei, T, Ferrari, M & Ziemys, A 2014, Cancer Research, vol 74, no. 16, pp. 4239-4246. DOI:

Polymer nanoparticles encased in a cyclodextrin complex shell for potential site- and sequence-specific drug release
Ruiz-Esparza, GU, Wu, S, Segura-Ibarra, V, Cara, FE, Evans, KW, Milosevic, M, Ziemys, A, Kojic, M, Meric-Bernstam, F, Ferrari, M & Blanco, E 2014, Advanced Functional Materials, vol 24, no. 30, pp. 4753-4761. DOI:

A multiscale MD-FE model of diffusion in composite media with internal surface interaction based on numerical homogenization procedure
Kojic, M, Milosevic, M, Kojic, N, Kim, K, Ferrari, M & Ziemys, A 2014, Computer Methods in Applied Mechanics and Engineering, vol 269, pp. 123-138. DOI:

A computational study of trajectories of micro- and nano-particles with different shapes in flow through small channels
Isailovic, V, Kojic, M, Milosevic, M, Filipovic, N, Kojic, N, Ziemys, A & Ferrari, M 2014, Journal of the Serbian Society for Computational Mechanics, vol 8, no. 2, pp. 14-28.

Transport in nanoconfinement and within blood vessel wall
Ziemys, A, Filipovic, N, Ferrari, M & Kojic, M 2014, . in Computational Surgery and Dual Training: Computing, Robotics and Imaging. Springer New York, pp. 273-288. DOI:

The role of payload hydrophobicity in nanotherapeutic pharmacokinetics
Norvaisas, P & Ziemys, A 2014, Journal of Pharmaceutical Sciences, vol 103, no. 7, pp. 2147-2156. DOI:

Engineering multi-stage nanovectors for controlled degradation andtunable release kinetics
Martinez, JO, Chiappini, C, Ziemys, A, Faust, AM, Kojic, M, Liu, X, Ferrari, M & Tasciotti, E 2013, Biomaterials, vol 34, no. 33, pp. 8469-8477. DOI: