A. Osama Gaber, MD, FACS

J.C. Walter Jr. Presidential Distinguished Chair & Director, J.C. Walter Jr. Transplant Center
Professor of Surgery, Institute for Academic Medicine
Full Member, Research Institute
Program Director, Transplant Surgery Residency, Department of Surgery
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Gaber received his first academic appointment in 1987, as an Assistant Professor in the Department of Surgery at the University of Tennessee in Memphis. He became an Associate Professor there in 1991, and received his full professorship and was named to the Baptist Memorial Health Care Foundation chair of excellence in transplantation in 1994. While at the University of Tennessee, Dr. Gaber also held professorships in the Departments of Pharmacy and in the College of Nursing. He was also the Medical Director for the University of Tennessee Bowld Hospital, and the Methodist University Transplant Institute.

Dr. Gaber is a prolific researcher and has authored over 270 scientific papers, as well as more than 340 abstracts and numerous book chapters,and his research has been funded by numerous grants from the National Institutes of Health, the Juvenile Diabetes Research Foundation, and several national and local foundations. Dr. Gaber assumed his positions at the Houston Methodist Hospital and Research Institute in Houston in 2006.

Description of Research

While also conducting transplant immunotherapy research for liver and kidney whole organ transplants and allografts, the main focus of Dr. Gaber´s research is in the transplantation of islets to alleviate diabetic complications. He and his collaborators have developed the protocol for long term islet culture and described the clinical transplantation of islets through the intestinal veins. Dr. Gaber´s current studies center on the testing of gene therapy and other approaches to test for islet viability and assist the transplanted islets to develop a sustaining blood supply and resist rejection by the recipient´s immune system.

Areas Of Expertise

Transplant immunotherapy Islet cells Cell isolation protocols Kidney transplant Pancreas transplant Liver transplant Diabetes Kidney disorders
Education & Training

Clinical Fellowship, University of Chicago
Residency, Boston University Medical Center
Internship, Washington Hospital Center
MD, Ain Shams University School of Medicine
Publications

Belatacept conversion in an HIV-positive kidney transplant recipient following anti-thymocyte globulin induction
Kuten, SA, Patel, SJ, Baru, A, Gaber, AO, Crutchley, RD, Ramanathan, V & Knight, RJ 2017, Transplant Infectious Disease, vol 19, no. 5, e12748. DOI: 10.1111/tid.12748

Treatment of Refractory Gastrointestinal Bleeding in Patients With Portal Hypertension: A Case Series and Treatment Algorithm
Balogh, J, Gordon-Burroughs, S, Schwarz, P, Galati, J, McFadden, RA, Cusick, M, Snyder, MJ, Bailey, HR, Weiner, M, Wong, A, Ochoa, RA, Saharia, A, Gaber, AO & Ghobrial, RM 2017, Transplantation Proceedings, vol 49, no. 8, pp. 1864-1869. DOI: 10.1016/j.transproceed.2017.06.022

Risk Stratification of Patients With Current Generation Continuous-Flow Left Ventricular Assist Devices Being Bridged to Heart Transplantation
Guha, A, Nguyen, D, Cruz-Solbes, AS, Amione-Guerra, J, Schutt, RC, Bhimaraj, A, Trachtenberg, BH, Park, MH, Graviss, EA, Gaber, AO, Montane, E, Torre-Amione, G & Estep, JD 2017, ASAIO Journal. DOI: 10.1097/MAT.0000000000000635

Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism
Mukherjee, A, Morales-Scheihing, D, Salvadores, N, Moreno-Gonzalez, I, Gonzalez, C, Taylor-Presse, K, Mendez, N, Shahnawaz, M, Gaber, AO, Sabek, OM, Fraga, DW & Soto, C 2017, The Journal of experimental medicine. DOI: 10.1084/jem.20161134

Optimal cut points of plasma and urine neutrophil gelatinase-associated lipocalin for the prediction of acute kidney injury among critically ill adults: Retrospective determination and clinical validation of a prospective multicentre study
Tecson, KM, Erhardtsen, E, Eriksen, PM, Gaber, AO, Germain, M, Golestaneh, L, De Los Angeles Lavoria, M, Moore, LW & McCullough, PA 2017, BMJ Open, vol 7, no. 7, e016028. DOI: 10.1136/bmjopen-2017-016028

Early clearance vs persistence of de novo donor-specific antibodies following lung transplantation
Islam, AK, Sinha, N, DeVos, JM, Kaleekal, TS, Jyothula, SS, Teeter, LD, Nguyen, DTM, Eagar, TN, Moore, LW, Puppala, M, Wong, STC, Knight, RJ, Frost, AE, Graviss, EA & Osama Gaber, A 2017, Clinical Transplantation. DOI: 10.1111/ctr.13028

The incremental cost of Incompatible Living Donor Kidney Transplant: A National Cohort Analysis
Axelrod, D, Lentine, KL, Schnitzler, MA, Luo, X, Xiao, H, Orandi, BJ, Massie, A, Garonzik-Wang, J, Stegall, MD, Jordan, SC, Oberholzer, J, Dunn, TB, Ratner, LE, Kapur, S, Pelletier, RP, Roberts, JP, Melcher, ML, Singh, P, Sudan, DL, Posner, MP, El-Amm, JM, Shapiro, R, Cooper, M, Lipkowitz, GS, Rees, MA, Marsh, CL, Sankari, BR, Gerber, DA, Nelson, PW, Wellen, J, Bozorgzadeh, A, Gaber, AO, Montgomery, RA & Segev, DL 2017, American Journal of Transplantation. DOI: 10.1111/ajt.14392

Incidence and Factors Associated with De Novo DSA After BK Viremia in Renal Transplant Recipients
Patel, SJ, Kuten, SA, Knight, RJ, Graviss, EA, Nguyen, DTM & Gaber, AO 2017, . in Clinical Transplants 2016. Terasaki Research Institute, Los Angeles, California, pp. 103-109.

Neurogenic Orthostatic Hypotension: An Iatrogenic Complication of Successful Pancreas Transplantation?
Kuten, SA, Simpson, EP, Gaber, AO, Nguyen, DTM, Graviss, EA, Patel, S & Knight, RJ 2017, .

The Incidence and Outcomes of Fever of Unknown Origin After Pancreas Transplantation
Klasek, R, Kuten, SA, Patel, S, Nguyen, DT, Graviss, EA, Gaber, AO & Knight, RJ 2017, American Journal of Transplantation, vol 17, no. suppl 3, 17 (suppl 3).

Risk Analysis of Patients with Proven Coronary Artery Disease Undergoing Liver Transplant
Balogh, J, Lunsford, KE, Nguyen, DTM, Graviss, EA, Cercio, O, Mobley, CM, Saharia, A, Burroughs, SG, Gaber, AO & Ghobrial, RM 2017, American Journal of Transplantation, vol 17, no. suppl 3.

Optimizing Survival Outcomes for Advanced Age Patients Undergoing Liver Transplant
Balogh, J, Lunsford, KE, Nguyen, DTM, Graviss, EA, Saharia, A, Mobley, CM, Burroughs, SG, Cercio, O, Victor, JD, Monsour, Jr. HP, Gaber, AO & Ghobrial, RM 2017, 2017 American Transplant Congress, 4/30/17, .

The Lung Transplant Risk Model - A Nationally Validated Tool for Pre-Transplant Risk Assessment
Chan, EY, Nguyen, DT, Sinha, N, Kaleekal, TS, Goodarzi, A, Youssef, JG, Bruckner, BA, Suarez, EE, Scheinin, SA, Graviss, EA & Gaber, AO 2017, pp. S114-S115. DOI: 10.1016/j.healun.2017.01.293

Frontiers in Organ Failure and Transplant Management
Estep, JD & Gaber, AO 2017, Methodist DeBakey cardiovascular journal, vol 12, no. 4 Suppl, pp. 1. DOI: 10.14797/mdcj-12-4s1-1

Evaluation of Carotid Ultrasonography Screening Among Kidney Transplant Candidates: A Single-Center, Retrospective Study
Rossitter, CW, Vigo, RB, Gaber, AO, Swan, JT & Suki, WN 2017, Transplantation Direct, vol 3, no. 3, pp. e135. DOI: 10.1097/TXD.0000000000000649

Serum undercarboxylated osteocalcin correlates with hemoglobin A1c in children with recently diagnosed pediatric diabetes
Redondo, MJ, Shirkey, BA, Fraga, DW, Gaber, AO & Sabek, OM 2017, Pediatric Diabetes, vol 18, no. 8, pp. 869-873. DOI: 10.1111/pedi.12501

The detrimental impact of persistent vs an isolated occurrence of de novo donor-specific antibodies on intermediate-term renal transplant outcomes
Loucks-DeVos, JM, Eagar, TN, Gaber, AO, Patel, SJ, Teeter, LD, Graviss, EA & Knight, RJ 2017, Clinical Transplantation, vol 31, no. 8. DOI: 10.1111/ctr.13025

3D Printed Vascularized Device for Subcutaneous Transplantation of Human Islets
Farina, M, Ballerini, A, Fraga, DW, Nicolov, E, Hogan, M, Demarchi, D, Scaglione, F, Sabek, OM, Horner, P, Thekkedath, U, Gaber, OA & Grattoni, A 2017, Biotechnology Journal. DOI: 10.1002/biot.201700169

Hospital readmissions following HLA-incompatible live donor kidney transplantation: A multi-center study
Orandi, BJ, Luo, X, King, EA, Garonzik-Wang, JM, Bae, S, Montgomery, RA, Stegall, MD, Jordan, SC, Oberholzer, J, Dunn, TB, Ratner, LE, Kapur, S, Pelletier, RP, Roberts, JP, Melcher, ML, Singh, P, Sudan, DL, Posner, MP, El-Amm, JM, Shapiro, R, Cooper, M, Lipkowitz, GS, Rees, MA, Marsh, CL, Sankari, BR, Gerber, DA, Nelson, PW, Wellen, J, Bozorgzadeh, A, Osama Gaber, A & Segev, DL 2017, American Journal of Transplantation. DOI: 10.1111/ajt.14472

Sustained zero-order delivery of GC-1 from a nanochannel membrane device alleviates metabolic syndrome
Filgueira, CS, Nicolov, E, Hood, RL, Ballerini, A, Garcia-Huidobro, J, Lin, JZ, Fraga, D, Webb, P, Sabek, O, Gaber, AO, Phillips, KJ & Grattoni, A 2016, International Journal of Obesity. DOI: 10.1038/ijo.2016.129