A. Osama Gaber, MD, FACS

J.C. Walter Jr. Presidential Distinguished Chair & Director, J.C. Walter Jr. Transplant Center
Professor of Surgery, Institute for Academic Medicine
Full Member, Research Institute
Program Director, Transplant Surgery Residency, Department of Surgery
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Gaber received his first academic appointment in 1987, as an Assistant Professor in the Department of Surgery at the University of Tennessee in Memphis. He became an Associate Professor there in 1991, and received his full professorship and was named to the Baptist Memorial Health Care Foundation chair of excellence in transplantation in 1994. While at the University of Tennessee, Dr. Gaber also held professorships in the Departments of Pharmacy and in the College of Nursing. He was also the Medical Director for the University of Tennessee Bowld Hospital, and the Methodist University Transplant Institute.

Dr. Gaber is a prolific researcher and has authored over 270 scientific papers, as well as more than 340 abstracts and numerous book chapters,and his research has been funded by numerous grants from the National Institutes of Health, the Juvenile Diabetes Research Foundation, and several national and local foundations. Dr. Gaber assumed his positions at the Houston Methodist Hospital and Research Institute in Houston in 2006.

Description of Research

While also conducting transplant immunotherapy research for liver and kidney whole organ transplants and allografts, the main focus of Dr. Gaber´s research is in the transplantation of islets to alleviate diabetic complications. He and his collaborators have developed the protocol for long term islet culture and described the clinical transplantation of islets through the intestinal veins. Dr. Gaber´s current studies center on the testing of gene therapy and other approaches to test for islet viability and assist the transplanted islets to develop a sustaining blood supply and resist rejection by the recipient´s immune system.

Areas Of Expertise

Transplant immunotherapy Islet cells Cell isolation protocols Kidney transplant Pancreas transplant Liver transplant Diabetes Kidney disorders
Education & Training

Clinical Fellowship , University of Chicago
Residency , Boston University Medical Center
Internship , Washington Hospital Center
MD , Ain Shams University School of Medicine
Publications

Early clearance vs persistence of de novo donor-specific antibodies following lung transplantation
Islam, AK, Sinha, N, DeVos, JM, Kaleekal, TS, Jyothula, SS, Teeter, LD, Nguyen, DTM, Eagar, TN, Moore, LW, Puppala, M, Wong, STC, Knight, RJ, Frost, AE, Graviss, EA & Osama Gaber, A 2017, Clinical Transplantation. DOI:

Incidence and Factors Associated with De Novo DSA After BK Viremia in Renal Transplant Recipients
Patel, SJ, Kuten, SA, Knight, RJ, Graviss, EA, Nguyen, DTM & Gaber, AO 2017, . in Clinical Transplants 2016. Terasaki Research Institute, Los Angeles, California, pp. 103-109.

Serum undercarboxylated osteocalcin correlates with hemoglobin A1c in children with recently diagnosed pediatric diabetes
Redondo, MJ, Shirkey, BA, Fraga, DW, Gaber, AO & Sabek, OM 2017, Pediatric Diabetes. DOI:

Sustained zero-order delivery of GC-1 from a nanochannel membrane device alleviates metabolic syndrome
Filgueira, CS, Nicolov, E, Hood, RL, Ballerini, A, Garcia-Huidobro, J, Lin, JZ, Fraga, D, Webb, P, Sabek, O, Gaber, AO, Phillips, KJ & Grattoni, A 2016, International Journal of Obesity. DOI:

Combination Drug Products for HIV—A Word of Caution for the Transplant Clinician
Patel, SJ, Kuten, SA, Musick, WL, Gaber, AO, Monsour, HP & Knight, R 2016, American Journal of Transplantation, vol 16, no. 8, pp. 2479-2482. DOI:

Terminal Complement Inhibitor Eculizumab in Adult Patients with Atypical Hemolytic Uremic Syndrome: A Single-Arm, Open-Label Trial
Fakhouri, F, Hourmant, M, Campistol, JM, Cataland, SR, Espinosa, M, Gaber, AO, Menne, J, Minetti, EE, Provôt, F, Rondeau, E, Ruggenenti, P, Weekers, LE, Ogawa, M, Bedrosian, CL & Legendre, CM 2016, American Journal of Kidney Diseases, vol 68, no. 1, pp. 84-93. DOI:

Simultaneous Scalp, Skull, Kidney, and Pancreas Transplant from a Single Donor
Selber, JC, Chang, EI, Clemens, MW, Gaber, L, Hanasono, MM, Klebuc, M, Skoracki, RJ, Trask, T, Yu, P & Gaber, AO 2016, Plastic and Reconstructive Surgery, vol 137, no. 6, pp. 1851-1861. DOI:

Three-dimensional printed polymeric system to encapsulate human mesenchymal stem cells differentiated into islet-like insulin-producing aggregates for diabetes treatment
Sabek, OM, Farina, M, Fraga, DW, Afshar, S, Ballerini, A, Filgueira, CS, Thekkedath, UR, Grattoni, A & Gaber, AO 2016, Journal of Tissue Engineering, vol 7, pp. 2041731416638198. DOI:

Impact of Cytomegalovirus on Survival after Heart Transplant: Analysis of 20,000 Patients from the UNOS Registry Data
Ashrith, G, Daoud, A, Teeter, LD, Amione-Guerra, J, Cordero-Reyes, AM, Graviss, E, Trachtenberg, BH, Bhimaraj, A, Gaber, A, Scheinin, S, Torre-Amione, G & Estep, JD 2016, Journal of Heart and Lung Transplantation, vol 35, no. 4, pp. S60. DOI:

Survival benefit with kidney transplants from HLA-incompatible live donors
Orandi, BJ, Luo, X, Massie, AB, Garonzik-Wang, JM, Lonze, BE, Ahmed, R, Van Arendonk, KJ, Stegall, MD, Jordan, SC, Oberholzer, J, Dunn, TB, Ratner, LE, Kapur, S, Pelletier, RP, Roberts, JP, Melcher, ML, Singh, P, Sudan, DL, Posner, MP, El-Amm, JM, Shapiro, R, Cooper, M, Lipkowitz, GS, Rees, MA, Marsh, CL, Sankari, BR, Gerber, DA, Nelson, PW, Wellen, J, Bozorgzadeh, A, Gaber, AO, Montgomery, RA & Segev, DL 2016, New England Journal of Medicine, vol 374, no. 10, pp. 940-950. DOI:

Disparate rates of acute rejection and donor-specific antibodies among high-immunologic risk renal transplant subgroups receiving antithymocyte globulin induction
Patel, SJ, Suki, WN, Loucks-DeVos, J, Graviss, EA, Nguyen, DT, Knight, RJ, Kuten, SA, Moore, LW, Teeter, LD, Gaber, LW & Gaber, AO 2016, Transplant International, vol 29, no. 8, pp. 897-908. DOI:

Poor immune reconstitution is associated with symptomatic BK polyomavirus viruria in allogeneic stem cell transplant recipients
Abudayyeh, A, Hamdi, A, Abdelrahim, M, Lin, H, Page, VD, Rondon, G, Andersson, BS, Afrough, A, Martinez, CS, Tarrand, JJ, Kontoyiannis, DP, Marin, D, Gaber, AO, Oran, B, Chemaly, RF, Ahmed, S, Abudayyeh, I, Olson, A, Jones, R, Popat, U, Champlin, RE, Shpall, EJ & Rezvani, K 2016, Transplant Infectious Disease. DOI:

Intermediate-Term Outcomes of Dual Adult versus Single-Kidney Transplantation: Evolution of a Surgical Technique
Islam, AK, Knight, RJ, Mayer, WA, Hollander, AB, Patel, S, Teeter, LD, Graviss, EA, Saharia, A, Podder, H, Asham, EH & Gaber, AO 2016, The Journal of Heart Transplantation, vol 2016, pp. 2586761. DOI:

A Double-Blind, Double-Dummy, Flexible-Design Randomized Multicenter Trial: Early Safety of Single- Versus Divided-Dose Rabbit Anti-Thymocyte Globulin Induction in Renal Transplantation
Stevens, RB, Wrenshall, LE, Miles, CD, Farney, AC, Jie, T, Sandoz, JP, Rigley, TH & Osama Gaber, A 2016, American Journal of Transplantation, vol 16, no. 6, pp. 1858-1867. DOI:

Symptomatic BK Virus Infection Is Associated With Kidney Function Decline and Poor Overall Survival in Allogeneic Hematopoietic Stem Cell Recipients
Abudayyeh, A, Hamdi, A, Lin, H, Abdelrahim, M, Rondon, G, Andersson, BS, Afrough, A, Martinez, CS, Tarrand, JJ, Kontoyiannis, DP, Marin, D, Gaber, AO, Salahudeen, A, Oran, B, Chemaly, RF, Olson, A, Jones, R, Popat, U, Champlin, RE, Shpall, EJ, Winkelmayer, WC & Rezvani, K 2016, American Journal of Transplantation. DOI:

Efficacy and cost-effectiveness of voriconazole prophylaxis for prevention of invasive aspergillosis in high-risk liver transplant recipients
Balogh, J, Gordon Burroughs, S, Boktour, M, Patel, S, Saharia, A, Ochoa, RA, McFadden, R, Victor, DW, Ankoma-Sey, V, Galati, J, Monsour, HP, Fainstein, V, Li, XC, Grimes, KA, Gaber, AO, Aloia, T & Ghobrial, RM 2016, Liver Transplantation, vol 22, no. 2, pp. 163-170. DOI:

Adverse outcomes of tacrolimus withdrawal in immune-quiescent kidney transplant recipients
Hricik, DE, Formica, RN, Nickerson, P, Rush, D, Fairchild, RL, Poggio, ED, Gibson, IW, Wiebe, C, Tinckam, K, Bunnapradist, S, Samaniego-Picota, M, Brennan, DC, Schröppel, B, Gaber, O, Armstrong, B, Ikle, D, Diop, H, Bridges, ND & Heeger, PS 2015, Journal of the American Society of Nephrology, vol 26, no. 12, pp. 3114-3122. DOI:

Osteocalcin effect on human ß-cells mass and function
Sabek, OM, Nishimoto, SK, Fraga, D, Tejpal, N, Ricordi, C & Gaber, AO 2015, Endocrinology, vol 156, no. 9, pp. 3137-3146. DOI:

Association of dietary phosphate and serum phosphorus concentration by levels of kidney function
Moore, LW, Nolte, JV, Gaber, AO & Suki, WN 2015, American Journal of Clinical Nutrition, vol 102, no. 2, pp. 444-453. DOI:

Post-Transplant Length of Stay and Discharge Disposition Is Impacted By Pre-Transplant Location But Not Transplant Survival
Victor, III, DW, Monsour, Jr. HP, Boktour, MR, Gordon Burroughs, S, Saharia, A, McFadden, R, Ankoma-Sey, V, Egwim, C, Galati, J, Mobley, CM, Gaber, AO & Ghobrial, RM.