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Anna Tampieri, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Dr. Tampieri's research focus is materials science with special attention to inorganic chemistry applications in ceramic materials and bio-hybrid composites. Early in her career from 1986 to 1995, Dr. Tampieri coordinated research collaborations for the development of High-Tc Ceramic Superconductors.

Beginning in 1995, Dr. Tampieri created a new research group dedicated to the development of biomaterials and biotechnology for regenerative medicine. Her research team combines a high degree of technical specialization with broad interdisciplinary expertise that supports a large number of national and international research projects.

Dr. Tampieri's research is internationally recognized for contributions to global health. Her research on osteochondral substitutes was named one of the most important contributions to human healthcare in 2008 by the Literature Awareness System (UK). The commercial development of this innovation by Dr. Tampieri, resulted in a CE marked osteochondral scaffold product, which has been adopted for orthopaedic surgical practice in Europe as the first step toward a completely biologic prosthesis.

The Dr. Tampieri's approach to research is to tackle new and complex problems from a technological perspective. TIME magazine named her research project From Wood to Bone one of 50 most important inventions of 2009. This innovation received worldwide media attention including interviews, articles in specialized and popular magazines, and international TV and radio appearances. The BBC, Sidney Broadcasting News, The Discovery Channel, and Reuter Television have reported on Dr. Tampieri's research initiatives.

Description of Research

Dr. Tampieri's research program focuses on synthesis methodologies, forming methods, sintering processes, and the relationships between microstructural properties and material performance.

Specific initiatives include development of:
-highly porous bioactive bone scaffolds endowed with intrinsic magnetic properties
-biomorphic ceramics with hierarchically organized morphology, derived from the transformation of native ligneous structures for load-bearing applications
-ceramic pastes/cements, designed to exhibit high interconnected porosity and mechanical strength
-bio-hybrid composites based on natural polymers and mineralized with nanostructured biomimetic apatites following biologically inspired processes
-bio-hybrid scaffolds exhibiting mineralization gradients, obtained through interpenetration of bio-hybrid composites for the selective regeneration of bone and osteo-cartilaginous tissues
-organomorphic transformations to obtain three-dimensional polymeric scaffolds that reproduce the morphology and functionality of stromal/vascular systems
-innovative filters for nanoparticles
-recycling technology for nanopowders to reduce environmental toxicity
-intelligent drug delivery systems using nanoparticles driven by magnetic signals

Areas Of Expertise

Biologically inspired processes Bioactive nano-powders Bio-hybrid composites Scaffold for bone and cartilage regeneration Drug delivery
Education & Training

Postdoctoral Fellowship , Government Industrial Research Institute, Nagoya
Postdoctoral Fellowship , Industria Farmitalia-Carlo Erba-Montedison
Postdoctoral Fellowship , National Institute for Inorganic Materials, Tsukuba
Postdoctoral Fellowship , USDA, San Francisco, CA
PhD , University of Bologna
MSc , University of Bologna
Research Fellowship , University of Bologna
Research Fellowship , University of Trento

On the surface effects of citrates on nano-apatites: Evidence of a decreased hydrophilicity
Ivanchenko, P, Delgado-López, JM, Iafisco, M, Gómez-Morales, J, Tampieri, A, Martra, G & Sakhno, Y 2017, Scientific Reports, vol 7, no. 1, 8901. DOI: 10.1038/s41598-017-09376-x

3D porous collagen scaffolds reinforced by glycation with ribose for tissue engineering application
Gostynska, N, Shankar Krishnakumar, G, Campodoni, E, Panseri, S, Montesi, M, Sprio, S, Kon, E, Marcacci, M, Tampieri, A & Sandri, M 2017, Biomedical Materials (Bristol), vol 12, no. 5, 055002. DOI: 10.1088/1748-605X/aa7694

New bioactive bone-like microspheres with intrinsic magnetic properties obtained by bio-inspired mineralisation process
Fernandes Patrício, TM, Panseri, S, Sandri, M, Tampieri, A & Sprio, S 2017, Materials Science and Engineering C, vol 77, pp. 613-623. DOI: 10.1016/j.msec.2017.03.258

Ribose mediated crosslinking of collagen-hydroxyapatite hybrid scaffolds for bone tissue regeneration using biomimetic strategies
Krishnakumar, GS, Gostynska, N, Campodoni, E, Dapporto, M, Montesi, M, Panseri, S, Tampieri, A, Kon, E, Marcacci, M, Sprio, S & Sandri, M 2017, Materials Science and Engineering C, vol 77, pp. 594-605. DOI: 10.1016/j.msec.2017.03.255

Polyester fibers can be rendered calcium phosphate-binding by surface functionalization with bisphosphonate groups
Polini, A, Petre, DG, Iafisco, M, de Lacerda Schickert, S, Tampieri, A, van den Beucken, J & Leeuwenburgh, SCG 2017, Journal of Biomedical Materials Research - Part A, vol 105, no. 8, pp. 2335-2342. DOI: 10.1002/jbm.a.36077

Strontium doped calcium phosphate coatings on poly(etheretherketone) (PEEK) by pulsed electron deposition
Bianchi, M, Degli Esposti, L, Ballardini, A, Liscio, F, Berni, M, Gambardella, A, Leeuwenburgh, SCG, Sprio, S, Tampieri, A & Iafisco, M 2017, Surface and Coatings Technology, vol 319, pp. 191-199. DOI: 10.1016/j.surfcoat.2017.04.012

Fe-Doping-Induced Magnetism in Nano-Hydroxyapatites
Iannotti, V, Adamiano, A, Ausanio, G, Lanotte, L, Aquilanti, G, Coey, JMD, Lantieri, M, Spina, G, Fittipaldi, M, Margaris, G, Trohidou, K, Sprio, S, Montesi, M, Panseri, S, Sandri, M, Iafisco, M & Tampieri, A 2017, Inorganic Chemistry, vol 56, no. 8, pp. 4446-4458. DOI: 10.1021/acs.inorgchem.6b03143

Investigation of different cross-linking approaches on 3D gelatin scaffolds for tissue engineering application: A comparative analysis
Shankar, KG, Gostynska, N, Montesi, M, Panseri, S, Sprio, S, Kon, E, Marcacci, M, Tampieri, A & Sandri, M 2017, International Journal of Biological Macromolecules, vol 95, pp. 1199-1209. DOI: 10.1016/j.ijbiomac.2016.11.010

Sr-substituted bone cements direct mesenchymal stem cells, osteoblasts and osteoclasts fate
Montesi, M, Panseri, S, Dapporto, M, Tampieri, A & Sprio, S 2017, PLoS ONE, vol 12, no. 2, e0172100. DOI: 10.1371/journal.pone.0172100

Tethering of Gly-Arg-Gly-Asp-Ser-Pro-Lys Peptides on Mg-Doped Hydroxyapatite
Pistone, A, Iannazzo, D, Espro, C, Galvagno, S, Tampieri, A, Montesi, M, Panseri, S & Sandri, M 2017, Engineering, vol 3, no. 1, pp. 55-59. DOI: 10.1016/J.ENG.2017.01.007

Silibinin-conjugated graphene nanoplatform: Synthesis, characterization and biological evaluation
Neri, G, Micale, N, Scala, A, Fazio, E, Mazzaglia, A, Mineo, PG, Montesi, M, Panseri, S, Tampieri, A, Grassi, G & Piperno, A 2017, FlatChem, vol 1, pp. 34-41. DOI: 10.1016/j.flatc.2016.10.002

Luminescent calcium phosphate bioceramics doped with europium derived from fish industry byproducts
Piccirillo, C, Adamiano, A, Tobaldi, DM, Montalti, M, Manzi, J, Castro, PML, Panseri, S, Montesi, M, Sprio, S, Tampieri, A & Iafisco, M 2017, Journal of the American Ceramic Society. DOI: 10.1111/jace.14884

A new bioinspired collagen-hydroxyapatite bone graft substitute in adult scoliosis surgery: Results at 3-year follow-up
Giorgi, P, Capitani, D, Sprio, S, Sandri, M, Tampieri, A, Canella, V, Nataloni, A & Schirò, GR 2017, Journal of Applied Biomaterials and Functional Materials, vol 15, no. 3, pp. e262-e270. DOI: 10.5301/jabfm.5000366

Evaluation of different crosslinking agents on hybrid biomimetic collagen-hydroxyapatite composites for regenerative medicine
Krishnakumar, GS, Gostynska, N, Dapporto, M, Campodoni, E, Montesi, M, Panseri, S, Tampieri, A, Kon, E, Marcacci, M, Sprio, S & Sandri, M 2017, International Journal of Biological Macromolecules. DOI: 10.1016/j.ijbiomac.2017.08.076

Biomineralization of a titanium-modified hydroxyapatite semiconductor on conductive wool fibers
Adamiano, A, Sangiorgi, N, Sprio, S, Ruffini, A, Sandri, M, Sanson, A, Gras, P, Grossin, D, Francès, C, Chatzipanagis, K, Bilton, M, Marzec, B, Varesano, A, Meldrum, F, Kröger, R & Tampieri, A 2017, Journal of Materials Chemistry B, vol 5, no. 36, pp. 7608-7621. DOI: 10.1039/c7tb00211d

New hydroxyapatite nanophases with enhanced osteogenic and anti-bacterial activity
Ballardini, A, Montesi, M, Panseri, S, Vandini, A, Balboni, PG, Tampieri, A & Sprio, S 2017, Journal of Biomedical Materials Research - Part A. DOI: 10.1002/jbm.a.36249

In situ mechanical and molecular investigations of collagen/apatite biomimetic composites combining Raman spectroscopy and stress-strain analysis
Chatzipanagis, K, Baumann, CG, Sandri, M, Sprio, S, Tampieri, A & Kröger, R 2016, Acta Biomaterialia, vol 46, pp. 278-285. DOI: 10.1016/j.actbio.2016.09.028

Biomimetic mineralization of recombinant collagen type I derived protein to obtain hybrid matrices for bone regeneration
Ramírez-Rodríguez, GB, Delgado-López, JM, Iafisco, M, Montesi, M, Sandri, M, Sprio, S & Tampieri, A 2016, Journal of Structural Biology, vol 196, no. 2, pp. 138-146. DOI: 10.1016/j.jsb.2016.06.025

Osteointegration in cranial bone reconstruction: A goal to achieve
Sprio, S, Fricia, M, Maddalena, GF, Nataloni, A & Tampieri, A 2016, Journal of Applied Biomaterials and Functional Materials, vol 14, no. 4, pp. e470-e476. DOI: 10.5301/jabfm.5000293

Novel osteointegrative sr-substituted apatitic cements enriched with Alginate
Sprio, S, Dapporto, M, Montesi, M, Panseri, S, Lattanzi, W, Pola, E, Logroscino, G & Tampieri, A 2016, Materials, vol 9, no. 9, pp. 1-17. DOI: 10.3390/ma9090763