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Anna Tampieri, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Biography

Dr. Tampieri's research focus is materials science with special attention to inorganic chemistry applications in ceramic materials and bio-hybrid composites. Early in her career from 1986 to 1995, Dr. Tampieri coordinated research collaborations for the development of High-Tc Ceramic Superconductors.

Beginning in 1995, Dr. Tampieri created a new research group dedicated to the development of biomaterials and biotechnology for regenerative medicine. Her research team combines a high degree of technical specialization with broad interdisciplinary expertise that supports a large number of national and international research projects.

Dr. Tampieri's research is internationally recognized for contributions to global health. Her research on osteochondral substitutes was named one of the most important contributions to human healthcare in 2008 by the Literature Awareness System (UK). The commercial development of this innovation by Dr. Tampieri, resulted in a CE marked osteochondral scaffold product, which has been adopted for orthopaedic surgical practice in Europe as the first step toward a completely biologic prosthesis.

The Dr. Tampieri's approach to research is to tackle new and complex problems from a technological perspective. TIME magazine named her research project From Wood to Bone one of 50 most important inventions of 2009. This innovation received worldwide media attention including interviews, articles in specialized and popular magazines, and international TV and radio appearances. The BBC, Sidney Broadcasting News, The Discovery Channel, and Reuter Television have reported on Dr. Tampieri's research initiatives.

Description of Research

Dr. Tampieri's research program focuses on synthesis methodologies, forming methods, sintering processes, and the relationships between microstructural properties and material performance.

Specific initiatives include development of:
-highly porous bioactive bone scaffolds endowed with intrinsic magnetic properties
-biomorphic ceramics with hierarchically organized morphology, derived from the transformation of native ligneous structures for load-bearing applications
-ceramic pastes/cements, designed to exhibit high interconnected porosity and mechanical strength
-bio-hybrid composites based on natural polymers and mineralized with nanostructured biomimetic apatites following biologically inspired processes
-bio-hybrid scaffolds exhibiting mineralization gradients, obtained through interpenetration of bio-hybrid composites for the selective regeneration of bone and osteo-cartilaginous tissues
-organomorphic transformations to obtain three-dimensional polymeric scaffolds that reproduce the morphology and functionality of stromal/vascular systems
-innovative filters for nanoparticles
-recycling technology for nanopowders to reduce environmental toxicity
-intelligent drug delivery systems using nanoparticles driven by magnetic signals

Areas Of Expertise

Biologically inspired processes Bioactive nano-powders Bio-hybrid composites Scaffold for bone and cartilage regeneration Drug delivery
Education & Training

, Government Industrial Research Institute, Nagoya
, Industria Farmitalia-Carlo Erba-Montedison
, National Institute for Inorganic Materials, Tsukuba
, USDA, San Francisco, CA
, University of Bologna
, University of Trento
Publications

Sr-substituted bone cements direct mesenchymal stem cells, osteoblasts and osteoclasts fate
Montesi, M, Panseri, S, Dapporto, M, Tampieri, A & Sprio, S 2017, PLoS ONE, vol 12, no. 2, e0172100. DOI:

In situ mechanical and molecular investigations of collagen/apatite biomimetic composites combining Raman spectroscopy and stress-strain analysis
Chatzipanagis, K, Baumann, CG, Sandri, M, Sprio, S, Tampieri, A & Kröger, R 2016, Acta Biomaterialia, vol 46, pp. 278-285. DOI:

Biomimetic mineralization of recombinant collagen type I derived protein to obtain hybrid matrices for bone regeneration
Ramírez-Rodríguez, GB, Delgado-López, JM, Iafisco, M, Montesi, M, Sandri, M, Sprio, S & Tampieri, A 2016, Journal of Structural Biology, vol 196, no. 2, pp. 138-146. DOI:

Osteointegration in cranial bone reconstruction: A goal to achieve
Sprio, S, Fricia, M, Maddalena, GF, Nataloni, A & Tampieri, A 2016, Journal of Applied Biomaterials and Functional Materials, vol 14, no. 4, pp. e470-e476. DOI:

Novel osteointegrative sr-substituted apatitic cements enriched with Alginate
Sprio, S, Dapporto, M, Montesi, M, Panseri, S, Lattanzi, W, Pola, E, Logroscino, G & Tampieri, A 2016, Materials, vol 9, no. 9, pp. 1-17. DOI:

A novel route for the synthesis of macroporous bioceramics for bone regeneration
Dapporto, M, Sprio, S, Fabbi, C, Figallo, E & Tampieri, A 2016, Journal of the European Ceramic Society, vol 36, no. 9, pp. 2383-2388. DOI:

Development of innovative hybrid and intrinsically magnetic nanobeads as a drug delivery system
Campodoni, E, Adamiano, A, Dozio, SM, Panseri, S, Montesi, M, Sprio, S, Tampieri, A & Sandri, M 2016, Nanomedicine, vol 11, no. 16, pp. 2119-2130. DOI:

Investigation of different cross-linking approaches on 3D gelatin scaffolds for tissue engineering application: A comparative analysis
Shankar, KG, Gostynska, N, Montesi, M, Panseri, S, Sprio, S, Kon, E, Marcacci, M, Tampieri, A & Sandri, M 2017, International Journal of Biological Macromolecules, vol 95, pp. 1199-1209. DOI:

Magnetic labelling of mesenchymal stem cells with iron-doped hydroxyapatite nanoparticles as tool for cell therapy
Panseri, S, Montesi, M, Sandri, M, Iafisco, M, Adamiano, A, Ghetti, M, Cenacchi, G & Tampieri, A 2016, Journal of Biomedical Nanotechnology, vol 12, no. 5, pp. 909-921. DOI:

Surface morphology, tribological properties and in vitro biocompatibility of nanostructured zirconia thin films
Bianchi, M, Gambardella, A, Berni, M, Panseri, S, Montesi, M, Lopomo, N, Tampieri, A, Marcacci, M & Russo, A 2016, Journal of Materials Science: Materials in Electronics, vol 27, no. 5, 96. DOI:

Bioinspired negatively charged calcium phosphate nanocarriers for cardiac delivery of MicroRNAs
Di Mauro, V, Iafisco, M, Salvarani, N, Vacchiano, M, Carullo, P, Ramírez-Rodríguez, GB, Patrício, T, Tampieri, A, Miragoli, M & Catalucci, D 2016, Nanomedicine, vol 11, no. 8, pp. 891-906. DOI:

Bio-inspired regenerative medicine: Materials, processes and clinical applications
Sprio, S & Tampieri, A 2016, . Pan Stanford Publishing Pte. Ltd. DOI:

New biomimetic strategies for regeneration of load-bearing bones
Sprio, S, Ruffini, A, Dapporto, M & Tampieri, A 2016, . in A Tampieri & S Sprio (eds), Bio-Inspired Regenerative Medicine: Materials, Processes and Clinical Applications. Pan Stanford Publishing Pte. Ltd. pp. 85-117. DOI:

Bioartificial endocrine organs: At the cutting edge of translational research in endocrinology
Toni, R, Bassi, E, Barbaro, F, Zini, N, Zamparelli, A, Alfieri, M, Dallatana, D, Mosca, S, Della Casa, C, Gnocchi, C, Lippi, G, Spaletta, G, Bassoli, E, Denti, L, Gatto, A, Ricci, F, Tazzari, PL, Parrilli, A, Fini, M, Sandri, M, Sprio, S & Tampieri, A 2016, . in Bio-Inspired Regenerative Medicine: Materials, Processes and Clinical Applications. Pan Stanford Publishing Pte. Ltd. pp. 357-387. DOI:

Preface
Sprio, S & Tampieri, A 2016, . in Bio-Inspired Regenerative Medicine: Materials, Processes and Clinical Applications. Pan Stanford Publishing Pte. Ltd. pp. xiii. DOI:

Biologically inspired nanomaterials and nanobiomagnetism: A synergy among new emerging concepts in regenerative medicine
Tampieri, A, Sandri, M, Panseri, S, Adamiano, A, Montesi, M & Sprio, S 2016, . in Bio-Inspired Regenerative Medicine: Materials, Processes and Clinical Applications. Pan Stanford Publishing Pte. Ltd. pp. 1-20. DOI:

Magnetic forces and magnetized biomaterials provide dynamic flux information during bone regeneration
Russo, A, Bianchi, M, Sartori, M, Parrilli, A, Panseri, S, Ortolani, A, Sandri, M, Boi, M, Salter, DM, Maltarello, MC, Giavaresi, G, Fini, M, Dediu, V, Tampieri, A & Marcacci, M 2016, Journal of Materials Science: Materials in Electronics, vol 27, no. 3, 51, pp. 1-13. DOI:

Tissue Engineering: Biomimetic Concealing of PLGA Microspheres in a 3D Scaffold to Prevent Macrophage Uptake (Small 11/2016)
Minardi, S, Corradetti, B, Taraballi, F, Sandri, M, Martinez, JO, Powell, ST, Tampieri, A, Weiner, BK & Tasciotti, E 2016, Small (Weinheim an der Bergstrasse, Germany), vol 12, no. 11, pp. 1394. DOI:

Biomimetic Concealing of PLGA Microspheres in a 3D Scaffold to Prevent Macrophage Uptake
Minardi, S, Corradetti, B, Taraballi, F, Sandri, M, Martinez, JO, Powell, ST, Tampieri, A, Weiner, BK & Tasciotti, E 2016, Small (Weinheim an der Bergstrasse, Germany), vol 12, no. 11, pp. 1479-88. DOI:

Needle-like ion-doped hydroxyapatite crystals influence osteogenic properties of PCL composite scaffolds
Guarino, V, Veronesi, F, Marrese, M, Giavaresi, G, Ronca, A, Sandri, M, Tampieri, A, Fini, M & Ambrosio, L 2016, Biomedical Materials (Bristol), vol 11, no. 1, 015018. DOI: