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Andrew Dannenberg, MD

Full Affiliate Member, Research Institute
Houston Methodist


Dr. Andrew Dannenberg is the Henry R. Erle, MD-Roberts Family Professor of Medicine at Weill Cornell Medical College.  He received his medical degree from Washington University in St. Louis and served as a medical resident and gastroenterology fellow at The New York Hospital-Cornell Medical Center. His research focuses on the mechanisms underlying the inflammation-cancer connection in multiple organs. Dr. Dannenberg has authored more than 150 scientific articles, and edited several books and journals. In 2011, he was awarded the American Association for Cancer Research-Prevent Cancer Foundation award for excellence in cancer prevention research. He is a member of the Association of American Physicians, the American Society for Clinical Investigation, and the American Association for Cancer Research. He previously chaired the Program Committee of the AACR "Frontiers in Cancer Prevention Research" meeting and serves on the editorial boards of several journals including Cancer Prevention Research and the Journal of Clinical Oncology. 

Description of Research

Dr. Dannenberg’s research is focused on the connection between chronic inflammation and cancer with an emphasis on prostaglandin (PG) biology. The long-term goal of this research is to develop evidence-based strategies to decrease inflammation and reduce the risk of developing cancer.

Human cancers, premalignant lesions and chronic inflammatory states (e.g. ulcerative colitis), are identified in which the expression of enzymes involved in PG biosynthesis (cyclooxygenase-2, COX-2), catabolism (15-hydroxyprostaglandin dehydrogenase) or transport (PGT) is deregulated. The signal transduction pathways that control the expression of these genes in normal and diseased tissues are then explored. In this way, the mechanisms by which PGs impact wound healing or stimulate the formation and progression of tumors are being defined.

As second major focus of the research program is hormone receptor-positive breast cancer, and a key signaling pathway by which PGE2 induces cytochrome P450 aromatase, the enzyme that catalyzes the synthesis of estrogens from androgens. Pharmacological and genetic studies are used to assess the impact of targeting specific molecules involved in PG synthesis on tumor formation and growth. The contribution of body mass and diet to changes in PG levels, inflammation and the expression of genes implicated in carcinogenesis is also being explored. Given the link between chronic colitis and colon cancer, a major goal is to identify PG-responsive genes that play key roles in colorectal mucosal homeostasis, and biomarkers that may reflect inflammation and cancer prognosis.

Areas Of Expertise

Cancer Breast Prostaglandin Inflammation

Celecoxib alters the intestinal microbiota and metabolome in association with reducing polyp burden
Montrose, DC, Zhou, XK, McNally, EM, Sue, E, Yantiss, RK, Gross, SS, Leve, ND, Karoly, ED, Suen, CS, Ling, L, Benezra, R, Pamer, EG & Dannenberg, AJ 2016, Cancer Prevention Research, vol 9, no. 9, pp. 721-731. DOI:

Hsp90 and PKM2 drive the expression of aromatase in Li-Fraumeni syndrome breast adipose stromal cells
Subbaramaiah, K, Brown, KA, Zahid, H, Balmus, G, Weiss, RS, Herbert, BS & Dannenberg, AJ 2016, Journal of Biological Chemistry, vol 291, no. 31, pp. 16011-16023. DOI:

Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation
Haka, AS, Barbosa-Lorenzi, VC, Lee, HJ, Falcone, DJ, Hudis, CA, Dannenberg, AJ & Maxfield, FR 2016, Journal of Lipid Research, vol 57, no. 6, pp. 980-992. DOI:

Elevated levels of urinary PGE-M are found in tobacco users and indicate a poor prognosis for oral squamous cell carcinoma patients
Kekatpure, VD, Bs, N, Wang, H, Zhou, XK, Kandasamy, C, Sunny, SP, Suresh, A, Milne, GL, Kuriakose, MA & Dannenberg, AJ 2016, Cancer Prevention Research, vol 9, no. 6, pp. 428-436. DOI:

Erratum: Sphingosine kinases are not required for inflammatory responses in macrophages (The Journal of Biological Chemistry 288 (2013) 2563-32573)
Xiong, Y, Jong Lee, H, Mariko, B, Lu, YC, Dannenberg, AJ, Haka, AS, Maxfield, FR, Camerer, E, Proia, RL & Hla, T 2016, Journal of Biological Chemistry, vol 291, no. 21, pp. 11465. DOI:

Systemic Correlates of White Adipose Tissue Inflammation in Early-Stage Breast Cancer
Iyengar, NM, Zhou, XK, Gucalp, A, Morris, PG, Howe, LR, Giri, DD, Morrow, M, Wang, H, Pollak, M, Jones, LW, Hudis, CA & Dannenberg, AJ 2016, Clinical Cancer Research, vol 22, no. 9, pp. 2283-2289. DOI:

Obesity-associated alterations in inflammation, epigenetics, and mammary tumor growth persist in formerly obese mice
Rossi, EL, De Angel, RE, Bowers, LW, Khatib, SA, Smith, LA, Van Buren, E, Bhardwaj, P, Giri, D, Estecio, MR, Troester, MA, Hair, BY, Kirk, EL, Gong, T, Shen, J, Dannenberg, AJ & Hursting, SD 2016, Cancer Prevention Research, vol 9, no. 5, pp. 339-348. DOI:

Noninvasive Detection of Inflammatory Changes in White Adipose Tissue by Label-Free Raman Spectroscopy
Haka, AS, Sue, E, Zhang, C, Bhardwaj, P, Sterling, J, Carpenter, C, Leonard, M, Manzoor, M, Walker, J, Aleman, JO, Gareau, D, Holt, PR, Breslow, JL, Zhou, XK, Giri, D, Morrow, M, Iyengar, N, Barman, I, Hudis, CA & Dannenberg, AJ 2016, Analytical Chemistry, vol 88, no. 4, pp. 2140-2148. DOI:

Targeting obesity-related adipose tissue dysfunction to prevent cancer development and progression
Gucalp, A, Iyengar, NM, Hudis, CA & Dannenberg, AJ 2016, Seminars in Oncology, vol 43, no. 1, pp. 154-160. DOI:

Transforming cancer prevention through precision medicine and immune-oncology
Kensler, TW, Spira, A, Garber, JE, Szabo, E, Lee, JJ, Dong, Z, Dannenberg, AJ, Hait, WN, Blackburn, E, Davidson, NE, Foti, M & Lippman, SM 2016, Cancer Prevention Research, vol 9, no. 1, pp. 2-10. DOI:

Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1
Rayes, TE, Catena, R, Lee, S, Stawowczyk, M, Joshi, N, Fischbach, C, Powell, CA, Dannenberg, AJ, Altorki, NK, Gao, D & Mittal, V 2015, Proceedings of the National Academy of Sciences of the United States of America, vol 112, no. 52, pp. 16000-16005. DOI:

Leptin and adiponectin modulate the self-renewal of normal human breast epithelial stem cells
Esper, RM, Dame, M, Mcclintock, S, Holt, PR, Dannenberg, AJ, S.wicha, M & Brenner, DE 2015, Cancer Prevention Research, vol 8, no. 12, pp. 1174-1183. DOI:

Id1 expression in endothelial cells of the colon is required for normal response to injury
Zhang, N, Subbaramaiah, K, Yantiss, RK, Zhou, XK, Chin, Y, Scherl, EJ, Bosworth, BP, Benezra, R & Dannenberg, AJ 2015, American Journal of Pathology, vol 185, no. 11, pp. 2983-2993. DOI:

Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis
Seo, BR, Bhardwaj, P, Choi, S, Gonzalez, J, Eguiluz, RCA, Wang, K, Mohanan, S, Morris, PG, Du, B, Zhou, XK, Vahdat, LT, Verma, A, Elemento, O, Hudis, CA, Williams, RM, Gourdon, D, Dannenberg, AJ & Fischbach, C 2015, Science Translational Medicine, vol 7, no. 301, 3010467. DOI:

Estrogen protects against obesity-induced mammary gland inflammation in mice
Bhardwaj, P, Du, B, Zhou, KX, Sue, E, Giri, D, Harbus, MD, Falcone, DJ, Hudis, CA, Subbaramaiah, K & Dannenberg, AJ 2015, Cancer Prevention Research, vol 8, no. 8, pp. 751-759. DOI:

Menopause is a determinant of breast adipose inflammation
Iyengar, NM, Morris, PG, Zhou, XK, Gucalp, A, Giri, D, Harbus, MD, Falcone, DJ, Krasne, MD, Vahdat, LT, Subbaramaiah, K, Morrow, M, Hudis, CA & Dannenberg, AJ 2015, Cancer Prevention Research, vol 8, no. 5, pp. 349-358. DOI:

Id1 deficiency protects against tumor formation in Apc<sup>Min/+</sup> Mice but not in a mouse model of colitis-associated colon cancer
Zhang, N, Subbaramaiah, K, Yantiss, RK, Zhou, XK, Chin, Y, Benezra, R & Dannenberg, AJ 2015, Cancer Prevention Research, vol 8, no. 4, pp. 303-311. DOI:

Obesity and cancer: Local and systemic mechanisms
Iyengar, NM, Hudis, CA & Dannenberg, AJ 2015, Annual Review of Medicine, vol 66, pp. 297-309. DOI:

Factors predicting outcome after salvage treatment for stage IV oral squamous cell carcinoma: Evidence of the potential importance of the cyclooxygenase-2-prostaglandin E2 pathway
Kekatpure, VD, Singh, M, Selvam, S, Shetkar, G, Hedne, NC, Trivedi, NP, Siddappa, G, Govindan, SV, Suresh, A, Rangarajan, B, Dannenberg, AJ & Kuriakose, MA 2015, Head and Neck, vol 37, no. 8, pp. 1142-1149. DOI:

Implications of obesity in breast cancer
Gucalp, A, Morris, PG, Hudis, CA & Dannenberg, AJ 2014, . in Diseases of the Breast: Fifth Edition. Wolters Kluwer Health Adis (ESP).