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Alessandro Grattoni, PhD

Associate Professor of Nanomedicine, Institute for Academic Medicine
Associate Member, Research Institute
Chair, Department of Nanomedicine
Houston Methodist


Dr. Alessandro Grattoni obtained his bachelors and masters degrees in Mechanical Engineering at the Politecnico of Torino, Turin, Italy in 2005. During his masters degree thesis, he studied the osmotic pressure of non-ideal solutions though nanoporous membranes. This work produced two publications and two patents. A few months after starting graduate school in Biomedical Engineering at Politecnico of Torino in 2006, Alessandro Grattoni joined Dr. Mauro Ferrari’s research team as a visiting student in the Department of Nanomedicine and Biomedical Engineering at the University of Texas Health Science Center at Houston. In this new context, he engaged in the study of transport phenomena in silicon nanofluidic devices for drug delivery.

At the beginning of 2007, he began directing one of the four research platforms, the nanochannel Delivery System (nDS) project. Since then he has coordinated the work of his colleagues in the development and validation of nanochannel membranes for long-term administration of therapeutics from implantable capsules. His research focuses on the experimental and phenomenological analysis of concentration-driven transport in nanoconfinement tools and mathematical models of the nanofluidic system. Additionally he analyzes electrokinetic transport in nanochannels for the purpose of modulating the release of therapeutics from reservoirs. In collaboration with NanoMedical Systems Inc. of Austin, TX, Dr. Grattoni is working to translate innovations in nDS technology to clinical applications.

In April 2009 he was awarded the Heinlein Trust Microgravity Award to support diffusion experiments in microgravity conditions on-board the SpaceX Dragon spacecraft in early 2011. In May 2009 he completed his Ph.D. studies with fifteen peer-reviewed publications and five patent applications. In October 2010, he became an Assistant Member of The Methodist Hospital Research Institute and an Interim Co-Chair of the Nanomedicine Program.

Description of Research

Dr. Grattoni's research focuses on the development and clinical translation of implantable nanofluidic technologies for drug delivery, molecular sieving and cell transplantation. Silicon-based nanochannel membranes are developed for the controlled delivery of therapeutics by exploiting nanoscale physics, achieving a constant or tunable sustained release of molecules for extended periods of time. Dr. Grattoni’s research relates to the experimental and theoretical analysis of molecular transport at the nanoscale and the in vivo investigation of long term, sustained delivery of therapeutics. Dr. Grattoni's research has received the support of NASA and State of Texas Emerging Technology Funds, as well as from NanoMedical Systems, Inc.

Areas Of Expertise

Nanomedicine Nanofluidics Drug Delivery Silicon Technologies Implantable Devices Space Medicine
Education & Training

, Politecnico di Torino
, The University of Texas Health Science Center

Sustained zero-order delivery of GC-1 from a nanochannel membrane device alleviates metabolic syndrome
Filgueira, CS, Nicolov, E, Hood, RL, Ballerini, A, Garcia-Huidobro, J, Lin, JZ, Fraga, D, Webb, P, Sabek, O, Gaber, AO, Phillips, KJ & Grattoni, A 2016, International Journal of Obesity. DOI:

The Emerging Role of Nanotechnology in Cell and Organ Transplantation
Tasciotti, E, Cabrera, FJ, Evangelopoulos, M, Martinez, JO, Thekkedath, UR, Kloc Stepkowska, M, Ghobrial, RM, Li, XC, Grattoni, A & Ferrari, M 2016, Transplantation. DOI:

Three-dimensional printed polymeric system to encapsulate human mesenchymal stem cells differentiated into islet-like insulin-producing aggregates for diabetes treatment
Sabek, OM, Farina, M, Fraga, DW, Afshar, S, Ballerini, A, Filgueira, CS, Thekkedath, UR, Grattoni, A & Gaber, AO 2016, Journal of Tissue Engineering, vol 7, pp. 2041731416638198. DOI:

The Nanochannel Delivery System for Constant Testosterone Replacement Therapy
Ferrati, S, Nicolov, E, Zabre, E, Geninatti, T, Shirkey, BA, Hudson, L, Hosali, S, Crawley, M, Khera, M, Palapattu, G & Grattoni, A 2015, Journal of Sexual Medicine, vol 12, no. 6, pp. 1375-1380. DOI:

Leveraging electrokinetics for the active control of dendritic fullerene-1 release across a nanochannel membrane
Bruno, G, Geninatti, T, Hood, RL, Fine, D, Scorrano, G, Schmulen, J, Hosali, S, Ferrari, M & Grattoni, A 2015, Nanoscale, vol 7, no. 12, pp. 5240-5248. DOI:

Impedance characterization, degradation, and in vitro biocompatibility for platinum electrodes on BioMEMS
Geninatti, T, Bruno, G, Barile, B, Hood, RL, Farina, M, Schmulen, J, Canavese, G & Grattoni, A 2015, Biomedical Microdevices, vol 17, no. 1, pp. 24. DOI:

Delivering Enhanced Testosterone Replacement Therapy through Nanochannels
Ferrati, S, Nicolov, E, Bansal, S, Zabre, E, Geninatti, T, Ziemys, A, Hudson, L, Ferrari, M, Goodall, R, Khera, M, Palapattu, G & Grattoni, A 2015, Advanced Healthcare Materials, vol 4, no. 3, pp. 446-451. DOI:

Docetaxel/2-hydroxypropyl ß -cyclodextrin inclusion complex increases docetaxel solubility and release from a nanochannel drug delivery system
Ferrati, S, Nicolov, E, Bansal, S, Hosali, S, Landis, M & Grattoni, A 2015, Current Drug Targets, vol 16, no. 14, pp. 1645-1649.

Sustained administration of hormones exploiting nanoconfined diffusion through nanochannel membranes
Geninatti, T, Lyle Hood, R, Bruno, G, Jain, P, Nicolov, E, Ziemys, A & Grattoni, A 2015, Materials, vol 8, no. 8, pp. 5276-5288. DOI:

Functional validation of an implantable medical dosing device by MRI at 3T
Anderson, JR, Ferrati, S, Karmonik, C & Grattoni, A 2014, . in 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014., 6944091, Institute of Electrical and Electronics Engineers Inc. pp. 2346-2347, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014, Chicago, United States, 26-30 August. DOI:

Robotic UV-Vis apparatus for long-term characterization of drug release from nanochannels
Geninatti, T, Small, E & Grattoni, A 2014, Measurement Science and Technology, vol 25, no. 2, 027003. DOI:

Sustained zero-order release of intact ultra-stable drug-loaded liposomes from an implantable nanochannel delivery system
Celia, C, Ferrati, S, Bansal, S, van de Ven, AL, Ruozi, B, Zabre, E, Hosali, S, Paolino, D, Sarpietro, MG, Fine, D, Fresta, M, Ferrari, M & Grattoni, A 2014, Advanced Healthcare Materials, vol 3, no. 2, pp. 230-238. DOI:

Functional validation of an implantable medical dosing device by MRI at 3T
Anderson, JR, Ferrati, S, Karmonik, C & Grattoni, A 2014, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, vol 2014, pp. 2346-2347. DOI:

Leveraging nanochannels for universal, zero-order drug delivery in vivo
Ferrati, S, Fine, D, You, J, De Rosa, E, Hudson, L, Zabre, E, Hosali, S, Zhang, L, Hickman, C, Sunder Bansal, S, Cordero-Reyes, AM, Geninatti, T, Sih, J, Goodall, R, Palapattu, G, Kloc, M, Ghobrial, RM, Ferrari, M & Grattoni, A 2013, Journal of Controlled Release, vol 172, no. 3, pp. 1011-1019. DOI:

Characterization of a nanogland for the autotransplantation of human pancreatic islets
Sabek, OM, Ferrati, S, Fraga, DW, Sih, J, Zabre, EV, Fine, DH, Ferrari, M, Gaber, AO & Grattoni, A 2013, Lab on a Chip - Miniaturisation for Chemistry and Biology, vol 13, no. 18, pp. 3675-3688. DOI:

Scaling and crossovers in molecular transport in nano-fluidic systems
Pimpinelli, A, Ferrari, M & Grattoni, A 2013, Applied Physics Letters, vol 103, no. 11, 113104. DOI:

Validated RP-HPLC method for the simultaneous analysis of gemcitabine and LY-364947 in liposomal formulations
Bansal, SS, Celia, C, Ferrati, S, Zabre, E, Ferrari, M, Palapattu, G & Grattoni, A 2013, Current Drug Targets, vol 14, no. 9, pp. 1061-1069. DOI:

Differential scanning calorimetry as a tool to investigate the transfer of anticancer drugs to biomembrane model
Sarpietro, MG, Accolla, ML, Celia, C, Grattoni, A, Castelli, F, Fresta, M, Ferrari, M & Paolino, D 2013, Current Drug Targets, vol 14, no. 9, pp. 1053-1060. DOI:

Silicon Micro- and Nanofabrication for Medicine
Fine, D, Grattoni, A, Goodall, R, Bansal, SS, Chiappini, C, Hosali, S, van de Ven, AL, Srinivasan, S, Liu, X, Godin, B, Brousseau, L, Yazdi, IK, Fernandez-Moure, J, Tasciotti, E, Wu, HJ, Hu, Y, Klemm, S & Ferrari, M 2013, Advanced Healthcare Materials, vol 2, no. 5, pp. 632-666. DOI:

Erratum: Characterization of nanochannel delivery membrane systems for the sustained release of resveratrol and atorvastatin: New perspectives on promoting heart health (Analytical and Bioanalytical Chemistry DOI 10.1007/s00216-012- 6484-7)
Sih, J, Bansal, SS, Filippini, S, Ferrati, S, Raghuwansi, K, Zabre, E, Nicolov, E, Fine, D, Ferrari, M, Palapattu, G & Grattoni, A 2013, Analytical and Bioanalytical Chemistry, vol 405, no. 5. DOI: