The NCI Center for Modeling Cancer Development (CMCD) focuses on the analysis of cancer as a complex biological system. This center is part of the National Cancer Institute’s (NCI) Integrative Cancer Biology Program (ICBP), which is a cornerstone in the development and implementation of computational models of processes relevant to cancer prevention, diagnostics, and therapeutics. The integration of experimental biology with computational biology will result in new insights in the cancer biology of and new approaches to the effective treatments of cancer. This center brings clinical and basic cancer researchers together with researchers from mathematics, physics, information technology, imaging sciences, and computer science to work on key challenges in cancer biology. The center is led by Houston Methodist Research Institute with three partnering leading biomedical institutions across the country, including Baylor College of Medicine, Weill Cornell Medical College of Cornell University, and The University of New Mexico.