Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Chunying Yang, Ph.D.

Chunying Yang, Ph.D.

Chunying Yang, Ph.D

Chunying Yang, Ph.D.

Instructor

Radiation Oncology
The Methodist Hospital Research Institute
Cornell University

Phone: 713-441-4656
Fax: 713-790-3755
E-mail: cyang@houstonmethodist.org


Education

B.S.   Shandong Agriculture University, Shandong, China (Genetics)
M.S.   Shandong Agriculture University, Shandong, China (Molecular Biology and Genetics)
Ph.D.   Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China (Genetics, Developmental and Molecular Biology)

Postdoctoral Training

Postdoctoral Fellow, Department of Biochemistry and Molecular Biology, Southern Research Institute, Birmingham, Alabama.
Postdoctoral Fellow, Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama.

 

Biography

Dr. Yang received her Ph.D at Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China in 2006. After 3-year postdoctoral training in University of Alabama at Birmingham and Southern Research Institute, she joined the Methodist Hospital Research Institute in 2009. She is a member of the American Association for Cancer Research. She has published several high impact papers in prestigious journals including Nature, Molecular Cell etc.

Description of Research

Dr. Yang´s research focuses on identifying basic mechanisms involved in maintaining genome stability and understanding their relationship to tumor. Particularly, she is elucidating the crosstalk between DNA damage response and mitosis. She is also interested in high throughput screening for small molecules on protein-protein interactions.

Major Areas of Research

DNA damage response, DNA repair, Mitosis, ATM, drug discovery

Recent Publications

Chunying Yang, Mike Lee, Jianwei Hao, Xiaoli Cui, Xiaojing Guo, Caroline Smal, Françoise Bontemps, Shumei Ma, Xiaodong Liu, David Engler, William B. Parker, and Bo Xu. Deoxycytidine kinase regulates the G2/M checkpoint through interaction with Cyclin-dependent kinase 1 in response to DNA damage. Nuclear Acids Research 2012, Oct 40 (19): 9621-9632.

Mianen Sun, Xiaojing Guo, Xiaolong Qian, Haibo Wang, Chunying Yang, Kathryn L. Brinkman, Monica Serrano-Gonzalez, Richard S. Jope, Binhua Zhou, David A. Engler, Ming Zhan, Stephen T.C. Wong, Li Fu, and Bo Xu. Activation of the ATM-Snail pathway promotes breast cancer metastasis. Journal of Molecular Cell Biology 2012, Oct 4(5):304-15.

Chunying Yang, Haibo Wang, Yiran Xu, Kathryn L. Brinkman, Hiromichi Ishiyama, Stephen T.C. Wong and Bo Xu. The kinetochore protein Bub1 participates in the DNA damage response. DNA Repair 2012, Feb 1: 11 (2): 185-191.

Xiaonan Sun*, Chunying Yang*, Hai Liu, Wang Qi, Shi-Xiu Wu, Xia Li, Tian Xie, Kathryn L. Brinkman, Bo Xu and Shu Zheng. Identification and Characterization of a Small Inhibitory Peptide that can Target DNA-PKcs Autophosphorylation and Increase Tumor Radiosensitivity. International Journal of Radiation Oncology, Biology, Physics. 2012, May 17: 1-8 (*these authors contributed equally to this work).

Jinping Liu, Shukun Luo, Hongchang Zhao, Ji Liao, Jing Li, Chunying Yang, Bo Xu, David F Stern, Xingzhi Xu and Keqiong Ye. Structural mechanism of the phosphorylation-dependent dimerization of MDC1 forkhead-associated domain. Nucleic Acids Research 2012, 1-15.

Chunying Yang, Xi Tang, Xiaojing Guo, Yohei Niikura, Katsumi Kitagawa, Kemi Cui, Stephen T.C. Wong, Li Fu, and Bo Xu. Aurora-B mediated ATM Serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint. Molecular Cell 2011, 44: 597-608 (Selected by Faculty 1000, Top 5 Read paper, Highlighted as Preview Paper in Molecular Cell).

Chunzhi Zhang, Chunsheng Kang, Ping Wang, Yongzhen Cao, Zhonghong Lv, Shizhu Yu, Guangxiu Wang, Anling Zhang, Zhifan Jia, Lei Han, Chunying Yang, Hiromichi Ishiyama, Bin Teh, Bo Xu, and Peiyu Pu. MicroRNA-221-222 regulates radiation sensitivity by targeting the PTEN pathway. International Journal of Radiation Oncology, Biology, Physics. 2011, 80 (1): 240-248.

Heui-Yun Joo, Amada Jones, Chunying Yang, Ling Zhai, Archer D Smith IV, Zhuo Zhang, Mahesh B Chandrasekharan, Zu-wen Sun, Matthew Renfrow, Yanming Wang, Chenbei Chang, and Hengbin Wang. Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46. The Journal of Biological Chemistry 2011, 286 (9): 7190-7201.

Heui-Yun Joo, Ling Zhai, Chunying Yang, Shuyi Nie, Hediye Erdjument-Bromage, Paul Tempst, Chenbei Chang and Hengbin Wang. Regulation of cell cycle progression and gene expression by H2A deubiquitination. Nature 2007, 449:1068-1072.

Xiu-fen Song*, Chunying Yang*, Jie Liu and Wei-Cai Yang. RPA, a Class II ARFGAP protein, activates ARF1 and U5 and plays a role in root hair development in Arabidopsis thaliana. Plant Physiology 2006, 141(3): 966-976 (*these authors contributed equally to this work).