Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Biana Godin Vilentchouk Ph.D.

Biana Godin Vilentchouk, Ph.D., M.Sc.Pharm


Assistant Member 
Department of Nanomedicine
Houston Methodist Research Institute

Adjunct Assistant Professor
The University of Texas Graduate School of Biomedical Sciences at Houston
Adjunct Assistant Professor
University of Houston, Department of Electrical and Computer Engineering

E-mail:  bgodin@houstonmethodist.org
Phone: 713-441-7329
Fax: 713-441-7438


Education

B.Pharm.

The Hebrew University of Jerusalem, Israel 

M.Sc.Pharm.

The Hebrew University of Jerusalem, Israel 

Ph.D.

The Hebrew University of Jerusalem, Israel (Pharmaceutical Sciences)

Postdoctoral Training

The Hebrew University if Jerusalem, Israel (Pharmaceutics)

University of Texas Health Science Center at Houston, TX (Nanomedicine)

Biography

Dr. Biana Godin Vilentchouk earned her Ph.D. in Pharmaceutical Sciences from the Hebrew University of Jerusalem in 2006. During her Ph.D. studies, Dr. Godin Vilentchouk focused on designing a non-invasive treatment for the hard-to-treat skin deep infections and on nasal delivery of proteins. She was recruited as a Postdoctoral trainee in the field of Cancer Nanotechnology to the research team of Dr. Mauro Ferrari at the University of Texas Health Sciences Center. Her postdoctoral research focused on injectable multistage nanovectors (MSVs) for cancer treatment and imaging. Her work provided insightful understanding of the interactions of MSVs with immune cells in vivo and in vitro, biocompatibility of MSV, effect of geometry and targeting moieties on MSV biodistribution, and evaluation of MSV systems as near-infra red and MRI imaging agents. During the three years of her postdoctoral research, Dr. Godin Vilentchouk published numerous book chapters, and peer-reviewed articles and reviews in top journals including Nature Nanotechnology and Cancer Research. She also received awards for her work at international conferences. In October 2010, Dr. Biana Godin Vilentchouk joined the Department of Nanomedicine at the Research Institute.

Description of Research

Dr. Godin Vilentchouk's research focuses primarily on the following four areas:

  • Targeting liver metastasis with advanced nanocarriers
  • Physical sciences in oncology
  • Novel strategies to target tumor microenvironment
  • Nanovectors for improved treatment of infectious diseases

The main objective of these studies is to provide innovative approaches to cancer treatment and diagnosis. Dr. Godin Vilentchouk is one of the key team members on two multicenter multi-investigator NIH National Cancer Institute grants: Physical Science in Oncology and Center for Cancer Nanotechnology Excellence. She is a PI on TATRC/DoD seed-grant and two NIH pilot projects. Dr. Godin Vilentchouk's research interests also include nanomedicine applications in cardiology and infectious diseases.

Major Areas of Research

Nanomedicine, cancer, physical sciences in oncology, nanocarrier biocompatibility, biodistribution

Recent Publications

Kozlovskaya V, Baggett J, Godin B, Liu X, Kharlampieva E. Hydrogen-bonded Multilayers of Silk Fibroin: From Coatings to Cell-mimicking Shaped Microcontainers. ACS Macroletters, 2012 Feb 24;2012(1):384-387, PMID: 22432092, PMCID: PMC3306187 http://www.ncbi.nlm.nih.gov/pubmed/22432092

Yokoi K#, Godin B #, Oborn CJ, Alexander JF, Liu X, Ferrari M, Fidler IJ. Porous silicon nanocarriers for dual targeting tumor associated endothelial cells and macrophages in stroma of orthotopic human pancreatic cancers. Can Lett, 2012  (#equal contribution), PMID: 23000514.

Jaganathan H and Godin B, Biocompatibility assessment of Si and SiO-based nano- and micro-particles. Adv Drug Del Rev, 2012, invited, doi:10.1016/j.addr.2012.05.008. http://www.ncbi.nlm.nih.gov/pubmed/22634160

      *Cover story

Godin B, Chiappini C., Srinivasan S, Alexander JF, Yokoi K., Ferrari M, Decuzzi P, Liu X. Discoidal NanoPorous Silicon Particles: fabrication, in vitro characterization and biodistribution in breast cancer bearing mice. Adv. Func. Mater., 2012, 22: 4225-4235. http://www.ncbi.nlm.nih.gov/pubmed/23227000

      *Cover story

Ketharnath D, Leiming PX, Pande R, Srimeenakshi S, Godin B#, Wosik J#, A method to calculate specific absorption rate of nanoparticles in colloidal suspension by using different configurations of conservative and magnetically-induced electric fields. App Phys Let, 2012, 101, 083118. Appl Phys Lett. 2012 Aug 20;101(8):83118. Epub 2012 Aug 24.PMID: 22991480 http://www.ncbi.nlm.nih.gov/pubmed/22991480

The PS-OC Cell-Line Project Team and the PS-OC Network (NCI), A physical sciences network characterization of nonmalignant and metastatic cells. Scientific Reports (NPG), 2013,    3, Article number: 1449, doi:10.1038/srep01449. Contributing team members from MHRI:  Godin B, Srinivasan S, Alexander JF, Ferrari M. PMID: 23618955 http://www.ncbi.nlm.nih.gov/pubmed/23618955

Fine D, Grattoni A, Goodall R, Bansal SS, Chiappini C, Hosali S, van de Ven AL, Srinivasan S, Liu X, Godin B, Brousseau L 3rd, Yazdi IK, Fernandez-Moure J, Tasciotti E, Wu HJ, Hu Y, Klemm S, Ferrari M. Silicon Micro- and Nanofabrication for Medicine, Adv Healthc Mater. 2013; 2:632-66. doi: 10.1002/adhm.201200214. Epub 2013 Apr 15.     *Cover story

Wang Z, Fine D, Wu HJ, Schumulen J, Godin B., Zhang J.X., Liu X. Ciliary micro-pillar arrays in a microfluidic device for harvesting of lipid vesicles. Lab Chip, 2013,13, 2879-2882; DOI: 10.1039/C3LC41343H PMID: 23743667

Wosik J, Pande R, Xie L, Ketharnath D, Srinivasan S, Godin B. Protein adsorption enhanced radio-frequency heating of silica nanoparticles. Appl. Phys. Lett. 2013; 103, 043706, http://dx.doi.org/10.1063/1.4816668. PMID: 23964135

Srinivasan S, Alexander JF, Driessen WH, Ananta JS, Ye H, Liu X, Arap W, Pasqualini R, Ferrari M, Godin B. Bacteriophage Associated Silicon Particles: Design and Characterization of a Novel Theranostic Vector with Improved Payload Carrying Potential, 2013, J Mat Chem B, in press.

Yokoi K, Tanei T, Godin B, van de Ven AL, Hanibuchi M, Matsunoki A, Alexander J, Ferrari F. Serum biomarkers for personalization of nanotherapeutics-based therapy in different tumor and organ microenvironments. Can Lett, 2013, accepted.   

Ananta JS*, Godin B*, Sethi R, Moriggi L, Liu X, Serda RE, Krishnamurthy R, Muthupillai R, Helm L, Ferrari M, Wilson LJ, Decuzzi P. Geometrical confinement of Gd-based agents in nanoporous particles enhances T1 contrast. Nat Nanotechnol. 2010 Nov;5(11):815-21. PMID: 20972435; *equal contribution

Tasciotti E*, Godin B*, Martinez JO, Chiappini C, Bhavane R, Liu X, Ferrari M. A near-infrared imaging method for the in-vivo assessment of the biodistribution of porous silicon particles. Mol Imaging, 2011, 10(1):56-68. PMID: 21303615; *equal contribution

Refuerzo JS*, Godin B*, Bishop K, Srinivasan S, Shah S, Ramin SM, Ferrari M. Size of the nanovectors determines the transplacental passage in pregnancy: study in rats. 2011 Apr 7. [Epub ahead of print], PMID: 21481834; *equal contribution.

Godin B, Gu J, Serda RE, Bhavane R, Tasciotti E, Chiappini C, Liu X, Tanaka T, Decuzzi P, Ferrari M. Tailoring the degradation kinetics of mesoporous silicon structures through PEGylation. J Biomed Mater Res A. 2010 Sep 15;94(4):1236-43. PMID: 20694990

Serda RE, Mack A, van de Ven A, Ferrati S, Dunner K, Godin B, Chiappini C, Landry M, Brousseau L, Liu X, Bean AJ, Ferrari M. Logic-embedded vectors for intracellular partitioning, endosomal escape and exocytosis of nanoparticles. Small. 2010 Dec 6;6(23):2691-700. PMID: 20957619

Godin B, Driessen WH, Proneth B, Lee S-Y, Srinivasan S, Rumbaut R, Arap W, Pasqualini R, Ferrari M, Decuzzi P. An integrated approach for the rational design of nanovectors for biomedical imaging and therapy. Adv Genet. 2010;69:31-64. PMID: 20807601

Tanaka T, Mangala LS, Vivas-Mejia PE, Nieves-Alicea R, Mann AP, Mora E, Han H-D, Shahzad MMK, Liu X, Bhavane R, Gu J, Fakhoury JR, Chiappini C, Lu C, Matsuo K, Godin B, Stone RL, Nick AM, Lopez-Berestein G, Sood AK, Ferrari M. Sustained siRNA delivery by mesoporous silicon particles. Cancer Res. 2010 May 1;70(9):3687-96.PMID: 20430760

Godin B, Sakamoto JH, Serda RE, Grattoni A, Boumarini A, Ferrari M. Emerging applications of nanomedicine for therapy and diagnosis of cardiovascular diseases. Trends Pharmacol Sci. 2010 May;31(5):199-205. Epub 2010 Feb 19. PMID: 20172613

Tanaka T*, Godin B*, Bhavane R, Nieves RA, Gu J, Liu X, Chiappini C, Fakhoury J, Amra S, Ewing A, Li Q, Fidler IJ, Ferrari M. In vivo evaluation of safety of nanoporous silicon carriers following single and multiple dose intravenous administrations in mice. Int J Pharm. 2010 Dec 15;402(1-2):190-7. PMID: 20883755; *equal contribution

Serda RE, Mack A, Pulikkathara M, Zaske AM, Chiappini C, Fakhoury J, Webb D, Godin B, Conyers JL, Liu X, Bankson JA, Ferrari M. Cellular association and assembly of a multi-stage delivery system. Small. 2010 Jul 13. PMID: 20629053

Serda R, Godin B, Tasciotti E, Blanco E, Ferrari M. Multi-stage delivery nano-particle systems for therapeutic applications. Biochim Biophys Acta. 2010 May 21. PMID: 20493927

Sakamoto J, Van de Ven A, Godin B, Blanco E, Serda RE, Grattoni A, Ziemys A, Hu Y, Ranganathan S, De Rosa E, Martinez J, Smid CA, Buchanan RM, Lee SY, Srinivasan S, Meyn A, Tasciotti E, Liu X, Decuzzi P, Ferrari M. Enabling individualized therapy through nanotechnology. Pharmacol Res. 2010 Aug;62(2):57-89. PMID: 20045055