The Vascular Biology and Therapeutics Program focuses on the biology of the vessel wall and in vivo/in vitro cell signaling of vascular smooth muscle cells. The emphasis of the program is to understand the responses of the vessel wall to injury, flow and atherogenic environments. Using in vitro and in vivo models of flow disturbance, arterial injury and vein grafting, the program provides a suitable environment for translational research in key areas of vascular biology. A better understanding of the cell biology of the vessel wall should lead to improved patency rates after intervention or bypass. The program provides its researchers with the most modern techniques in molecular and cell biology and systems biology. The program integrates these disciplines with physiological, pharmacological, pathological and therapeutic approaches to address questions in clinically relevant questions in vessel wall biology.
The three current areas of research interest are:
NIH- NHLBI (HL086968) "Phospholipids, metabolic syndrome and response to injury."
Bakken AM, Protack CD, Roztocil E, Nicholl SM, Davies MG. Cell Migration In response to the Aminoterminal Fragment Of Urokinase Requires Epidermal Growth Factor Receptor Activation Through An ADAM-mediated Mechanism. J Vasc Surg 2009; 49:1296-1303. PMC2691776
Roztocil E, Nicholl SM, Davies MG. Mechanisms of sphingosine-1-phosphate-induced akt-dependent smooth muscle cell migration. Surgery 2009; 145:34-41. PMC2676383
Zou Y, Qi Y, Roztocil E, Nicholl SM, Lumsden AB, Davies MG. Patterns of gelatinase activation induced by injury in the murine femoral artery. J Surg Res 2009: 54(1):135-42. PMC2698815
Roztocil E, Nicholl SM, Davies MG. Insulin induced Epidermal Growth Factor Receptor transactivation in smooth muscle cells is ADAM-dependent. Surgery 2008; 144(2):245-51. PMC18656632
Roztocil E, Nicholl SM, Davies MG. Mechanisms of Kringle Fragment of Urokinase induced Vascular Smooth Muscle Cell Migration. J Surg Res 2007; 141: 83-90. PMC2048815
Zou Y, Qi Y, Roztocil E, Nicholl SM, Davies MG. Patterns of Kinase activation induced by injury in the murine femoral artery. J Surg Res 2007; 141: 332-340. PMC2048817
Roztocil E, Nicholl SM, Davies MG. S-1-P induced VSMC migration via activation of NAD(P)H oxidase requires G?12/13 protein mediated phospholipase C activation. J Vasc Surg 2007; 46: 1253-1259. PMC2607047
Nicholl SM, Roztocil E, Davies MG. Plasminogen Activator System and Vascular Disease. Curr Vasc Pharmacol 2006; 2006; 4(2):101-16.
Roztocil E, Nicholl SM, Galaria II, Davies MG. Plasmin induced smooth muscle cell proliferation requires epidermal growth factor activation. Surgery 2005; 138:180-6.
Galaria II, Nicholl SM, Roztocil E, Davies MG. Urokinase-induced smooth muscle cell migration requires both PI3K / akt and PI3K / ERK1/2 activation. J Surg Res 2005; 127: 46-52.
Nicholl SM, Roztocil E, Galaria II, Davies MG. Plasmin induces smooth muscle cell proliferation through G?i- and G?q- mediated pathways. J Surg Res 2005; 127: 39-45.
Tanski WJ, Nicholl S, Kim D, Roztocil E, Davies MG. Sphingosine-1-phosphate-induced smooth muscle cell migration involves the Mammalian Target of Rapamycin. J Vasc Surg 2005; 41:91-98.
Nicholl SM, Roztocil E, Davies MG. Differential MAPK activation controls urokinase-induced smooth cell responses: a role for the epidermal growth factor receptor. J Vasc Surg 2005; 41:672-81.
Tanski WJ, Fegley AJ, Roztocil E, Davies MG. Domain dependent actions of urokinase (sc-uPA) on smooth muscle cell response to injury. J Vasc Surg 2004; 39:214-22.
Galaria II, Fegley AJ, Nicholl SM, Roztocil E, Davies MG. Differential regulation of ERK1/2 and p38MAPK by components of the rho signaling pathway during sphingosine-1-phosphate-induced smooth muscle cell migration. J Surg Res 2004; 122: 173-179.
Tanski WJ, Roztocil E, Hernady E, Williams JP, Davies MG. Role of G?q in smooth muscle cell proliferation. J Vasc Surg 2004; 39: 639-644.
Fegley AJ, Tanski WJ, Roztocil E, Davies MG. Sphingosine-1-phosphate stimulates smooth muscle cell migration through G?i- and PI3-kinase-dependent p38MAPK activation. J Surg Res 2003; 113:32-41.
Tanski WJ, Roztocil E, Davies MG. Sphingosine-1-phosphate induces G?i coupled, PI3-kinase-dependent smooth muscle cell migration. J Surg Res 2002; 108: 98-106.