Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Steven Shen


Steven Shen, MD, Ph.D.

Steven Shen, MD, Ph.D.

Associate Medical Director, Surgical Pathology
Medical Director, Immunohistochemistry
Department of Pathology and Genomic Medicine
Methodist Physician Organization
Assistant Member
Houston Methodist Research Institute 
Professor of Pathology and Laboratory Medicine
Weill Cornell Medical College of Cornell University

6565 Fannin Street, Suite M227
Houston, TX 77030
Phone: 713-441-6987
Fax: 713-793-1603


Dr. Shen received his M.D. and M.S. from Tongji Medical University, Wuhan, People's Republic of China in 1987. After receiving his Ph.D. from the Graduate School of Biomedical Sciences at The University of Texas Health Science Center at Houston in 1994, he received two years of postdoctoral training at the National Institutes of Health. From 1997 to 2001, he received his residency training in anatomical and clinical pathology at Pennsylvania State University/Hershey Medical Center, followed by a one-year fellowship in surgical pathology at The University of Texas M.D. Anderson Cancer Center in Houston, Texas. He joined Baylor College of Medicine and Houston Methodist Hospital as an assistant professor in 2002, and became an assistant professor of pathology and laboratory medicine at the Weill Cornell Medical College of Cornell University in 2004. He was promoted to associate professor there in 2008, and to professor in 2013.

Dr. Shen is a general surgical pathologist with subspecialty interest in genitourinary pathology. His research activities focus on identifying morphologic and molecular abnormalities of neoplasm, and correlating these with diagnosis, prognosis, and in some instances, future treatment. He is actively involved in independent and collaborative research using conventional histomorphologic techniques, immunohistochemical methods, tissue microarray, and new molecular approaches to study cancers of the kidney, urinary bladder, and prostate.

Representative Recent Publications

  • Piña-Oviedo S, Shen SS, Truong LD, Ayala AG, Ro JY. Flat pattern of nephrogenic adenoma: previously unrecognized pattern unveiled using PAX2 and PAX8 immunohistochemistry. Mod Pathol. 2013 Jun;26(6):792-8.
  • Kassi M, Polsani V, Shen S, Chang SM. A Rare Case of Cardiac Hemangioma Causing Ventricular Fibrillation. J Am Coll Cardiol. 2013 Jun 3. [Epub ahead of print]
  • Crumley S, Ge Y, Zhou H, Shen SS, Ro JY. Interstitial cystitis: another IgG4-related inflammatory disease? Ann Diagn Pathol. 2013 May 31. [Epub ahead of print]
  • Ozcan A, de la Roza G, Ro JY, Shen SS, Truong LD. PAX2 and PAX8 expression in primary and metastatic renal tumors: a comprehensive comparison. Arch Pathol Lab Med. 2012 Dec;136(12):1541-51.
  • Gulmann C, Paner GP, Parakh RS, Hansel DE, Shen SS, Ro JY, Annaiah C, Lopez-Beltran A, Rao P, Arora K, Cho Y, Herrera-Hernandez L, Alsabeh R, Amin MB. Immunohistochemical profile to distinguish urothelial from squamous differentiation in carcinomas of urothelial tract. Hum Pathol. 2013 Feb;44(2):164-72.
  • Ordóñez NG, Shen SS, Zenali M, Deavers MT. Melan A (A103) is not a Marker of Mesothelioma. Appl Immunohistochem Mol Morphol. 2013 Mar;21(2):184-7.
  • Shen SS, Truong LD, Ro JY, Ayala AG. Use of frozen section in genitourinary pathology. Pathology. 2012 Aug;44(5):427-33.
  • Yaziji H, Eisen R, Wick M, Swanson P, Badve S, Cartun R, Haas T, Marolt M, Hicks D, Martin A, Barry T, Alsabeh R, Taylor J, Fulton R, Goldsmith J, Shen S, Taylor C. Immunohistochemistry Cocktails Are Here to Stay: Center of Medicare and Medicaid Services Should Revise Its New Reimbursement Policy. Appl Immunohistochem Mol Morphol. 2012 Jul;20(4):331-333.
  • McQuitty E, Ro JY, Truong LD, Shen SS, Zhai Q, Ayala AG. Lymphovascular invasion in micropapillary urothelial carcinoma: a study of 22 cases. Arch Pathol Lab Med. 2012 Jun;136(6):635-9.
  • Shen SS, Truong LD, Scarpelli M, Lopez-Beltran A. Role of immunohistochemistry in diagnosing renal neoplasms: when is it really useful? Arch Pathol Lab Med. 2012 Apr;136(4):410-7.
  • Turner BM, Cagle PT, Sainz IM, Fukuoka J, Shen SS, Jagirdar J. Napsin A, a new marker for lung adenocarcinoma, is complementary and more sensitive and specific than thyroid transcription factor 1 in the differential diagnosis of primary pulmonary carcinoma: evaluation of 1674 cases by tissue microarray. Arch Pathol Lab Med. 2012 Feb;136(2):163-71.
  • Guo CC, Shen SS, Si Q, Dancer J, Stanton ML, Tamboli P, Ro JY, Czerniak BA. Necrosis assessment in renal carcinoma - reply. Hum Pathol. 2012 Jan;43(1):151-2.
  • Ozcan A, Liles N, Coffey D, Shen SS, Truong LD. PAX2 and PAX8 Expression in Primary and Metastatic Müllerian Epithelial Tumors: A Comprehensive Comparison. Am J Surg Pathol. 2011 Dec;35(12):1837-47.
  • Kosarac O, Zhai QJ, Shen S, Takei H, Ro JY, Ayala AG. Minimal or no residual prostatic adenocarcinoma on radical prostatectomy: a 5-year experience with "vanishing carcinoma phenomenon". Arch Pathol Lab Med. 2011 Nov;135(11):1466-70.
  • Williamson SR, Zhang S, Yao JL, Huang J, Lopez-Beltran A, Shen S, Osunkoya AO, MacLennan GT, Montironi R, Cheng L. ERG-TMPRSS2 rearrangement is shared by concurrent prostatic adenocarcinoma and prostatic small cell carcinoma and absent in small cell carcinoma of the urinary bladder: evidence supporting monoclonal origin. Mod Pathol. 2011 Aug;24(8):1120-7.
  • Yang Y, Li F, Gao L, Wang Z, Thrall MJ, Shen SS, Wong KK, Wong ST. Differential diagnosis of breast cancer using quantitative, label-free and molecular vibrational imaging. Biomed Opt Express. 2011 Aug 1;2(8):2160-74.
  • Kum JB, Grignon DJ, Wang M, Zhou M, Montironi R, Shen SS, Zhang S, Lopez-Beltran A, Eble JN, Cheng L. Mixed epithelial and stromal tumors of the kidney: evidence for a single cell of origin with capacity for epithelial and stromal differentiation. Am J Surg Pathol. 2011 Aug;35(8):1114-22.
  • Si Q, Dancer J, Stanton ML, Tamboli P, Ro JY, Czerniak BA, Shen SS, Guo CC. Small cell carcinoma of the kidney: a clinicopathologic study of 14 cases. Hum Pathol. 2011 Jul 4. [Epub ahead of print]
  • Paner GP, McKenney JK, Barkan GA, Yao JL, Frankel WL, Sebo TJ, Shen SS, Jimenez RE. Immunohistochemical analysis in a morphologic spectrum of urachal epithelial neoplasms: diagnostic implications and pitfalls. Am J Surg Pathol. 2011 Jun;35(6):787-98.
  • Kim SA, Lee SR, Huh J, Shen SS, Ro JY. IgG4-associated inflammatory pseudotumor of ureter: clinicopathologic and immunohistochemical study of 3 cases. Hum Pathol. 2011 Aug;42(8):1178-84.
  • Ozcan A, Shen SS, Hamilton C, Anjana K, Coffey D, Krishnan B, Truong LD. PAX 8 expression in non-neoplastic tissues, primary tumors, and metastatic tumors: a comprehensive immunohistochemical study. Mod Pathol. 2011 Jun;24(6):751-64.
  • Truong LD, Shen SS. Immunohistochemical diagnosis of renal neoplasms. Arch Pathol Lab Med. 2011 Jan;135(1):92-109. Review.
  • Raparia K, Zhai QJ, Schwartz MR, Shen SS, Ayala AG, Ro JY. Muscularis mucosae versus muscularis propria in gallbladder, cystic duct, and common bile duct: smoothelin and desmin immunohistochemical study. Ann Diagn Pathol. 2010 Dec;14(6):408-12.
  • Yang Q, Wang H, Cho HY, Jung SJ, Kim KR, Ro JY, Shen SS. Carcinoma of müllerian origin presenting as colorectal cancer: a clinicopathologic study of 13 Cases. Ann Diagn Pathol. 2011 Feb;15(1):12-8.
  • Sangoi AR, Beck AH, Amin MB, Cheng L, Epstein JI, Hansel DE, Iczkowski KA, Lopez-Beltran A, Oliva E, Paner GP, Reuter VE, Ro JY, Shah RB, Shen SS, Tamboli P, McKenney JK. Interobserver reproducibility in the diagnosis of invasive micropapillary carcinoma of the urinary tract among urologic pathologists. Am J Surg Pathol. 2010 Sep;34(9):1367-76.
  • Fang X, Gupta N, Shen SS, Tamboli P, Charnsangavej C, Rashid A, Wang H. Intraluminal polypoid metastasis of renal cell carcinoma in gallbladder mimicking gallbladder polyp. Arch Pathol Lab Med. 2010 Jul;134(7):1003-9.
  • Ozcan A, Zhai Q, Javed R, Shen SS, Coffey D, Krishnan B, Truong LD. PAX-2 is a helpful marker for diagnosing metastatic renal cell carcinoma: comparison with the renal cell carcinoma marker antigen and kidney-specific cadherin. Arch Pathol Lab Med. 2010 Aug;134(8):1121-9.
  • Sangoi AR, Beck AH, Amin MB, Cheng L, Epstein JI, Hansel DE, Iczkowski KA, Lopez-Beltran A, Oliva E, Paner GP, Reuter VE, Ro JY, Shah RB, Shen SS, Tamboli P, McKenney JK. Interobserver reproducibility in the diagnosis of invasive micropapillary carcinoma of the urinary tract among urologic pathologists. Am J Surg Pathol. 2010 Sep;34(9):1367-76.
  • Paner GP, Brown JG, Lapetino S, Nese N, Gupta R, Shen SS, Hansel DE, Amin MB. Diagnostic use of antibody to smoothelin in the recognition of muscularis propria in transurethral resection of urinary bladder tumor (TURBT) specimens. Am J Surg Pathol. 2010 Jun;34(6):792-9.
    Rivera AL, Takei H, Zhai J, Shen SS, Ro JY, and Powell SZ. Useful immunhistochemical markers in differentiating hemangioblastoma versus metastatic renal cell carcinoma. Neuropathology. 2010 Dec;30(6):580-5.
  • Nazeer T, Kee K H, Ro JY, Jennings TA, Ross J, Mian BM, Shen SS, Suh JH, Lee MJ, and Ayala AG. Intraprostatic adipose tissue: a study of 427 whole mount radical prostatectomy specimens. Hum Pathol. 2009;40:538-541.
  • Zhou M, Yang X, Lopez JI, Shah RB, Hes O, Shen SS, Li R, Yang Y, Lin F, Sercia L, Magi-Galluzzi C, Tubbs R. Renal tubulocystic carcinoma is closely related to papillary renal cell carcinoma: implication for pathologic classification. Am J Surg Pathol 2009;33:1840-1849.