Adriana E. Rosato, Ph.D.
Department of Pathology and Genomic Medicine
Houston Methodist Hospital
Houston Methodist Research Institute
6565 Fannin Street, Suite R6-113
Houston, Texas 77030
Dr. Rosato received her Ph.D. in microbiology from the University of Paris, XI, in Paris, France in 1997. She then completed a postdoctoral fellowship in microbiology and infectious diseases at the University of Southern California and Children’s Hospital Los Angeles and, later, at Virginia Commonwealth University in Richmond, Virginia where she was the recipient of a prestigious National Research Service Award from the National Institutes of Health. After completing her postdoctoral training, Dr. Rosato remained at Virginia Commonwealth as an assistant professor in the Department of Internal Medicine, Division of Infectious Diseases. She earned numerous honors while there including the Faculty Award for Distinguished Research, and three Faculty Awards from the American Society of Microbiology for mentoring minority trainees. Dr. Rosato joined the Department of Pathology and Genomic Medicine at Houston Methodist Hospital, and the Center for Molecular and Translational Human Infectious Diseases Research at Houston Methodist Research Institute in 2010.
Dr. Rosato conducts translational research focusing on multidrug-resistant bacterial pathogens. Specifically, her studies aim to identify the molecular genetic causes of drug resistance in a clinically important pathogen, methicillin-resistant S. aureus (MRSA). Her research goals are to use the techniques of molecular biology to understand the genetic basis of antimicrobial resistance and resistance gene spread among staphylococci. Additional goals are to apply molecular biology technology to the study of the epidemiology of nosocomial staphylococcal infections, as well as test novel methods to prevent disease transmission in the clinical setting.
Representative Recent Publications
- Plata KB, Riosa S, Singh CR, Rosato RR, Rosato AE. Targeting of PBP1 by ß-lactams Determines recA/SOS Response Activation in Heterogeneous MRSA Clinical Strains. PLoS One. 2013 Apr 23;8(4):e61083.
- Mehta S, Singh C, Plata KB, Chanda PK, Paul A, Riosa S, Rosato RR, Rosato AE. ß-lactams increase the antibacterial activity of daptomycin against clinical MRSA strains and prevent selection of DAP-resistant derivatives. Antimicrob Agents Chemother. 2012 Dec;56(12):6192-200.
- Bearman GM, Rosato A, Elam K, Sanogo K, Stevens MP, Sessler CN, Wenzel RP. A crossover trial of antimicrobial scrubs to reduce methicillin-resistant Staphylococcus aureus burden on healthcare worker apparel. Infect Control Hosp Epidemiol. 2012 Mar;33(3):268-75.
- Ciustea M, Mootien S, Rosato AE, Perez O, Cirillo P, Yeung KR, Ledizet M, Cynamon MH, Aristoff PA, Koski RA, Kaplan PA, Anthony KG. Thiadiazolidinones: a new class of alanine racemase inhibitors with antimicrobial activity against methicillin-resistant Staphylococcus aureus. Biochem Pharmacol. 2012 Feb1;83(3):368-77.
Mehta S, Cuirolo AX, Plata KB, Riosa S, Silverman JA, Rubio A, Rosato RR, Rosato AE. VraSR two-component regulatory system contributes to mprF-mediated decreased susceptibility to daptomycin in in vivo-selected clinical strains of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2012 Jan;56(1):92-102.
- Plata KB, Rosato RR, Rosato AE. Fate of Mutation Rate Depends on agr Locus Expression during Oxacillin-Mediated Heterogeneous-Homogeneous Selection in Methicillin-Resistant Staphylococcus aureus Clinical Strains. Antimicrob Agents Chemother. 2011 Jul;55(7):3176-86.
- Bearman G, Rosato AE, Duane TM, Elam K, Sanogo K, Haner C, Kazlova V, Edmond MB. Trial of universal gloving with emollient-impregnated gloves to promote skin health and prevent the transmission of multidrug-resistant organisms in a surgical intensive care unit. Infect Control Hosp Epidemiol. 2010 May;31(5):491-7.
- Bearman GM, Rosato AE, Assanasen S, Kleiner EA, Elam K, Haner C, Wenzel RP. Nasal carriage of inducible dormant and community-associated methicillin-resistant Staphylococcus aureus in an ambulatory population of predominantly university students. Int J Infect Dis. 2010 Sep;14 Suppl 3:e18-24.
- Plata K, Rosato AE, Wegrzyn G. Staphylococcus aureus as an infectious agent: overview of biochemistry and molecular genetics of its pathogenicity. Acta Biochim Pol. 2009;56(4):597-612.
- Higgins PG, Rosato AE, Seifert H, Archer GL, Wisplinghoff H. Differential expression of ccrA in methicillin-resistant Staphylococcus aureus strains carrying staphylococcal cassette chromosome mec type II and IVa elements. Antimicrob Agents Chemother. 2009 Oct;53(10):4556-8.
- Cuirolo A, Plata K, Rosato AE. Development of homogeneous expression of resistance in methicillin-resistant Staphylococcus aureus clinical strains is functionally associated with a beta-lactam-mediated SOS response. J Antimicrob Chemother. 2009 Jul;64(1):37-45.
- Forbes BA, Bombicino K, Plata K, Cuirolo A, Webber D, Bender CL, Rosato AE. Unusual form of oxacillin resistance in methicillin-resistant Staphylococcus aureus clinical strains. Diagn Microbiol Infect Dis. 2008 Aug;61(4):387-95.
- Goldstein F, Perutka J, Cuirolo A, Plata K, Faccone D, Morris J, Sournia A, Kitzis MD, Ly A, Archer G, Rosato AE. Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain. Antimicrob Agents Chemother. 2007 Jul;51(7):2514-22.
- Rosato AE, Tallent SM, Edmond MB, Bearman GM. Susceptibility of coagulase-negative staphylococcal nosocomial bloodstream isolates to the chlorhexidine/silver sulfadiazine-impregnated central venous catheter. Am J Infect Control. 2004 Dec;32(8):486-8.
- Wisplinghoff H, Rosato AE, Enright MC, Noto M, Craig W, Archer GL. Related clones containing SCCmec type IV predominate among clinically significant Staphylococcus epidermidis isolates. Antimicrob Agents Chemother. 2003 Nov;47(11):3574-9.
- Rosato AE, Craig WA, Archer GL. Quantitation of mecA transcription in oxacillin-resistant Staphylococcus aureus clinical isolates. J Bacteriol. 2003 Jun;185(11):3446-52.