The CTO articulates into three tightly integrated projects, under the unifying theme of the quest for a deeper understanding of the multi-scale differentials in transport properties that accompany and in several ways define the evolution of malignancies. These differentials manifest themselves with the emergence or the modulation of pathology-associated biophysical and biological barriers to transport. The operational corollary to the unifying basic science theme of this proposed CTO is the quest for innovative, physical science-based methodologies that afford the exploitation of these differentials for improved diagnostics and treatment of cancer.
Project 1: Directed transport physics and multi-scale therapy of colon cancer liver metastasis
Project Leaders: Mauro Ferrari Ph.D., Kenji Yokoi, M.D., Ph.D., Biana Godin Vilentchouk, Ph.D.
Project 2: Non-invasive radio-frequency field induced thermal destruction of malignant cells in human hepatocellular cancer.
Project Leaders: Steven Curley, M.D., Renata Pasqualini, Ph.D., Lon Wilson, Ph.D.
Project 3: Genomic correlates of mass transport differentials.
Project Leader: Neal Copeland, Ph.D., Nancy Jenkins, Ph.D., Haifa Shen, Ph.D.
Cores: Each of the Three projects are supported by the following cores.