Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Projects & Cores

Projects & Cores

The CTO articulates into three tightly integrated projects, under the unifying theme of the quest for a deeper understanding of the multi-scale differentials in transport properties that accompany and in several ways define the evolution of malignancies. These differentials manifest themselves with the emergence or the modulation of pathology-associated biophysical and biological barriers to transport. The operational corollary to the unifying basic science theme of this proposed CTO is the quest for innovative, physical science-based methodologies that afford the exploitation of these differentials for improved diagnostics and treatment of cancer.

Project 1Directed transport physics and multi-scale therapy of colon cancer liver metastasis
Project Leaders: Mauro Ferrari Ph.D., Biana Godin Vilentchouk, Ph.D. and Kenji Yokoi, M.D., Ph.D.

Project 2Non-invasive radio-frequency field induced thermal destruction of malignant cells in human hepatocellular cancer. 
Project Leaders: Steven Curley, M.D. and Lon Wilson, Ph.D.

Project 3Genomic correlates of mass transport differentials. 
Project Leader: Neal Copeland, Ph.D., Nancy Jenkins, Ph.D., Haifa Shen, Ph.D.
Investigators: Eugene Koay, M.D., Ph.D. and Karen Mann, Ph.D.

Cores: Each of the Three projects are supported by the following cores.

  • Core 1BioMathematics Core. Core Leaders: Vittorio Cristini, Ph.D. and Paolo Decuzzi, Ph.D.
  • Core 2: Advanced Intravital Microscopy Core. Core Leader: Seok H. (Andy) Yun, Ph.D.
  • Core 3: Orthotopic Tumor Models.  Core Leaders: Kenji Yokoi, M.D., Ph.D. 


CTO Flow Chart