Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Meng Zhong

Meng Zhong, M.S.

Meng Zhong, M.S.

Meng Zhong, M.S.

Research Associate I
The Methodist Hospital Research Institute

E-mail: mzhong@houstonmethodist.org
Phone: 713-441-3044
Fax:


Education

B.S.   Pharmacy, Shandong Medical University, China
M.S.   Medicinal Chemistry, Shandong Medical University, China
 

 

Biography

Meng Zhong joined our group in December, 2010 and he is involved several research areas including in vitro and in vivo evaluation of biological functions of nanoparticles, peptides and new formulations of chemo agents; microRNA expression on Epithelial-Mesenchymal Transition (EMT) in human bladder cancer;  delivery of non-coding RNAs (siRNAs) in bladder cancer cells using near infrared irradiated gold nanoparticles; conducted experiments on molecular nature of ion channels in sensory cells of the inner ear of mutant mouse and mechanism underlying NOS-2 inhibition by infection of mice with spiralis larvae.

Description of Research

  • Cytotoxicity of drug loaded nanoparticles and emulsion; cell surface binding, internalization of nanoparticles.
  • Cell proliferation by nanoparticles in vitro & in vivo.
  • Drug resistance
  • The characterization of cancer cell heterogeneity

Major Areas of Research

Cell Imaging, nanomedicine,  drug-delivery, in vitro & in vivo evaluation  of nanoparticles/drugs.

Recent Publications

Zhao J, Song S, Zhong M, and Li C. Dual-Modal Tumor Imaging via Long-Circulating Biodegradable Core-Cross-Linked Polymeric Micelles. ACS Macro Letters. 2012, 1, 150 -153.

You J, Zhang R, Zhang G, Zhong M, Liu Y, Van Pelt CS, Liang D, Wei W, Sood AK, Li C. Photothermal-chemotherapy with doxorubicin-loaded hollow gold nanospheres: A platform for near-infrared light-trigged drug release. J Control Release. 2011 Oct 28.

Melancon MP, Lu W, Zhong M, Zhou M, Liang G, Elliott AM, Hazle JD, Myers JN, Li C, Stafford RJ. Biomaterials. 2011 Oct; 32(30):7600-8.

Adam L, Zhong M, Choi W, Nicoloso M, Calin G, McConkey D, Bar-Eli M, and Dinney C.  miR-200c Expression Regulates Epithelial to Mesenchymal Transition in Bladder Cancer Cells and Reverses Resistance to EGFR Therapy.  Clinic Cancer Research. 2009;15(16):5060.

Rostro BC, Bickford LR, Payne CM, Day ES, Adam L, Zhong M, Colin P, Dinney N, Drezek RA, West JL, Hafner JH. Stabilization and Targeting of Surfactant-Synthesized Gold Nanorods.  Nanotechnology. 2009;20(43):434005.

Wooltorton J, Gaboyard S, Hurley K, Price S, Garcia J, Zhong M, Lysakowski A, Eatock RA.  Developmental changes in two voltage-dependent sodium currents in vestibular hair cells. The Journal of Neurophysiology. 2007; 97(2):1684-704.

Hurley KM, Price SD, Zhong M, Lysakowski A, Eatock RA. M-like K+ currents in type I hair cells and calyx afferent endings of the developing rat utricle. The Journal of Neuroscience. 2006;26(40):10253.

Bian K, Zhong M, Harari Y, Lai M, Weisbrodt N, Murad F. Helminth regulation 4R_/stat6 signaling: mechanism underlying NOS-2 inhibition by trichinella spiralis. Proc Natl Acad Sci USA. 2005;102(11), 3936.

Bian K, Harari Y, Zhong M, Lai M, Castro G, Weisbrodt N and Murad F. Down-regulation of inducible nitric-oxide synthase (NOS-2) during parasite-induced gut inflammation: a path to identify a selective NOC-2 inhibitor. Mol Pharmacol. 2001;59(4):939.