Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Melissa D. Pagel Ph.D.

 

Melissa D. Pagel, Ph.D.

Postdoctoral Fellow
The Methodist Hospital Research Institute

E-mail: mdpagel@houstonmethodist.org                                              
Phone: 713-441-7106

Education

Ph.D.   University of Houston, Houston, TX (Biology)

Postdoctoral Training

Postdoctoral Fellowship, Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, TX

Biography

Dr. Pagel received her Ph.D. in Biology from the University of Houston in 2010. Her dissertation studied the mutagenesis and electrophysiology of the properties of the Vibrio cholerae porins OmpU and OmpT.  Dr. Pagel joined the Center for Molecular and Translational Human Infectious Diseases Research in 2010 to study under the mentorship of Dr. James Musser.   

Description of Research

Dr. Pagel is investigating the genetic basis of drug resistance in group A Streptococcus at the molecular level.

Major Areas of Research

Group A Streptococcus, vibrio cholerae, gene expression, drug resistance

Recent Publications

Pagel M, Delcour AH. Effects of conjugated and unconjugated bile acids on the activity of the Vibrio cholerae porin OmpT. Mol Membr Biol. 2011 Jan;28(1):69-78.

Lauman B, Pagel M, Delcour AH. Altered pore properties and kinetic changes in mutants of the Vibrio cholerae porin OmpU. Mol Membr Biol. 2008 Sep;25(6-7):498-505.

Pagel M, Simonet V, Li J, Lallemand M, Lauman B, Delcour AH. Phenotypic characterization of pore mutants of the Vibrio cholerae porin OmpU. J Bacteriol. 2007 Dec;189(23):8593-600.