Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Magnus Hook Ph.D.

 

Magnus Höök, Ph.D.

Magnus Höök, Ph.D.

Senior Affiliate Member
The Methodist Hospital Research Institute
Director, Center for Infectious and Inflammatory Diseases
Texas A&M University Institute of Biosciences and Technology
Professor of Biochemistry and Biophysics
Texas A&M University

E-mail: mhook@ibt.tamhsc.edu
Phone: 713-677-7551

Education

B.S.   University of Uppsala, Uppsala, Sweden (Biochemistry)
Ph.D.   University of Uppsala, Uppsala, Sweden (Medical Chemistry)
 

Biography

Dr. Höök earned his Ph.D. in Medical Chemistry from the University of Uppsala in Uppsala, Sweden in 1974. He held faculty appointments at the Swedish University of Agricultural Sciences in Ultuna, Uppsala, Sweden and the University of Alabama at Birmingham in Birmingham, Alabama before joining the faculty at Texas A&M University in 1992. Dr. Höök also holds adjunct faculty appointments at The University of Texas Medical School at Houston, Baylor College of Medicine, and M.D. Anderson Cancer Center. In addition to directing the very active research efforts of the Center for Infectious and Inflammatory Diseases at the Institute of Biosciences and Technology, he has also been a member of 9 NIH study sections and review boards and chaired the Pathobiochemistry Study Section from 1986-1988. Dr. Höök is a founding member of the American Society of Matrix Biology and served as the Associate Editor of the Matrix Biology journal from 1994-2000.

Description of Research

Dr. Höök’s research focuses on the molecular analysis of host-pathogen interactions, especially as they pertain to pathogenic bacteria. Current research efforts aim to understand the structural function of extracellular matrix proteins and their corresponding adhesins and virulence factors.

Major Areas of Research

Infectious diseases, host-pathogen interactions, bacteria, extracellular matrix proteins, adhesins

Current Funding

NIH / CDC

Recent Publications

Barbu EM, Ganesh VK, Gurusiddappa S, Mackenzie RC, Foster TJ, Sudhof TC, Höök M. beta- Neurexin is a ligand for the Staphylococcus aureus MSCRAMM SdrC. PLoS Pathog. 2010 Jan 15;6(1):e1000726.

Geoghegan JA, Ganesh VK, Smeds E, Liang X, Höök M, Foster TJ. Molecular characterization of the interaction of staphylococcal microbial surface components recognizing adhesive matrix molecules (MSCRAMM) ClfA and Fbl with fibrinogen. J Biol Chem. 2010 Feb 26;285(9):6208-16.

Nuka S, Zhou W, Henry SP, Gendron CM, Schultz JB, Shinomura T, Johnson J, Wang Y, Keene DR, Ramírez-Solis R, Behringer RR, Young MF, Höök M. Phenotypic characterization of epiphycan-deficient and epiphycan/biglycan double-deficient mice. Osteoarthritis Cartilage. 2010 Jan;18(1):88-96.

Prabhakaran S, Liang X, Skare JT, Potts JR, Höök M. A novel fibronectin binding motif in MSCRAMMs targets F3 modules. PLoS One. 2009;4(4):e5412.

Sillanpää J, Nallapareddy SR, Houston J, Ganesh VK, Bourgogne A, Singh KV, Murray BE, Höök M. A family of fibrinogen-binding MSCRAMMs from Enterococcus faecalis. Microbiology. 2009Jul;155(Pt 7):2390-400.