Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Louis C. Brousseau III Ph.D.

Louis C. Brousseau, III, Ph.D. 

Louis C. Brousseau, III, Ph.D.

Louis C. Brousseau, III, Ph.D.

Assistant Member
Department of Nanomedicine
Houston Methodist Research Institute

E-mail: lbrousseau@houstonmethodist.org
Phone: 512-470-5031


Education

B.A.   Transylvania University (Chemistry)
B.A.   Transylvania University (International Affairs)
Ph.D.   University of Texas at Austin (Chemistry)

Postdoctoral Training

 

Biography

Dr. Brousseau earned his Ph.D. in Chemistry from the University of Texas at Austin in 1996, which was followed by research appointments at Arizona State University and North Carolina State University. From 2000-2010, Dr. Brousseau worked in industry developing fabrication processes for nanoscale electronic sensors and bio-detectors. During this time he was awarded over $2.25-million in competitive funding from the National Cancer Institute, Department of Defense, NASA, and the Texas Emerging Technology Fund. He has seven US and five international patents, as well as over 20 peer-reviewed publications. He is frequently invited to national and international conferences to speak on biosensors, nanotechnology development, and commercialization.

Description of Research

Dr. Brousseau's research program focuses on two themes:

  • Rationally designed nanomaterials for biomedical applications such as drug delivery and biomolecular harvesting
  • Nanoelectronic sensors for advanced diagnostics

Working with other researchers at HMRI, he is developing molecular coatings for selective harvesting of low molecular weight proteomic biomarkers for cancer, including phosphorylated and glycosylated peptides that have very low abundance and are often masked by other proteins in patient samples. By engineering specific functionality within the pores of mesoporous solid films, these LMWP signatures can be captured and enriched for analysis. Similarly, nanopore engineering enables selective targeting and release of drugs from ingestible and injectible microparticles for improved dosing and control of therapeutics. The integration of nanoscale sensors with molecularly-selective interfaces will cause a sea-change in biomedical research as well as point-of-care diagnosis of cancer and other diseases. Such devices demonstrate superior specificity and sensitivity to conventional fluorescent staining methods, yet will be as simple to use as FLASH memory thumb-drives. With advanced diagnostic tests available readily at the patient's side, medicine is expected to become more efficient and less costly. In addition, when combined with the selective film technologies described above, biomarker research will accelerate and advance more quickly to the clinic.

Major Areas of Research

Single molecules, nanodevices, sensors, diagnostics, surface engineering

Recent Publications

Hu Y, Peng Y, Brousseau L, Bouamrani A, Liu X, Ferrari M. Nanotexture Optimization by Oxygen Plasma of Mesoporous Silica Thin Film for Enrichment of Low Molecular Weight Peptides Captured from Human Serum. Sci China Chem. 2010 Nov 1;53(11):2257-2264. PMID: 21179395

Serda RE, Mack A, van de Ven AL, Ferrati S, Dunner K Jr, Godin B, Chiappini C, Landry M, Brousseau L, Liu X, Bean AJ, Ferrari M. Logic-embedded vectors for intracellular partitioning, endosomal escape, and exocytosis of nanoparticles. Small. 2010 Dec 6;6(23):2691-700. doi: 10.1002/smll.201000727. PMID: 20957619

Brousseau LC 3rd. Label-free "digital detection" of single-molecule DNA hybridization with a single electron transistor. J Am Chem Soc. 2006 Sep 6;128(35):11346-7.PMID: 16939245

McConnell WP, Novak JP, Brousseau LC, Feldheim Dl. Electronic and Optical Properties of Chemically Modified Metal Nanoparticles and Coupled Nanoparticle Arrays. J Phys Chem B. 2000;104:8925. DOI: 10.1021/jp000926t

Wu M, O'Neill SA, Brousseau LC, McConnell W, Shultz DA, Feldheim DL, Linderman R. Synthesis of Nanometer-sized Hollow Polymer Capsules from Alkanethiol-coated Gold Particles. Chem Comm. 2000;775. DOI: 10.1039/B001019G

Novak JP, Brousseau LC, Vance FW, Lemon BI, Johnson RC, Hupp JT, Feldheim DL. Nonlinear Optical Properties of Molecularly Bridged Gold Nanoparticle Arrays. J Am Chem Soc. 2000; 122:12029 - 12030.