David R. Beers, Ph.D.
Associate Research Member, Houston Methodist Research Institute
Department of Neurology, Houston Methodist Hospital
6565 Fannin St. B5-031
Houston TX 77030
Dr. Beers is Director of the Neurology Transgenic Mouse Facility. His research focuses on the mechanisms underlying neuronal injury in neurodegenerative diseases, including amyotrophic lateral sclerosis, Alzheimer’s disease, and Parkinson’s disease.
PhD - University of Utah; SLC, UT
Postdoctorate - Gene Therapy, Neurodegeneration in ALS;
Baylor College of Medicine, Houston, TX
- Henkel JS, Beers DR, Zhao W, Wen S, Toennis KM, Appel JE, Appel SH. Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival. EMBO Molecular Medicine. 2013; 5:64-79.
- Zhao W, Beers DR, Liao B, Henkel JS, Appel SH. Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms. Neurobiol Dis. 2012; 48:418-428.
- Beers DR, Henkel JS, Zhao W, Wang J, Huang A, Wen S, Liao B, Appel SH. Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis. Brain. 2011; 134:1293-1314.
- Appel SH, Beers DR, Henkel JS. T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening? Trends Immunol. 2010; 31:7-17.
- Liao B, Zhao W, Beers DR, Henkel JS, Appel SH. Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS. Exp Neurol. 2012; 237:147-152.
- Kano O, Beers DR, Henkel JS, Appel SH. Peripheral nerve inflammation in ALS mice: cause or consequence. Neurology. 2012; 78:833-835.
- Vaknin I, Kunis G, Miller O, Butovsky O, Bukshpan S, Beers DR, Henkel JS, Yoles E, Appel SH, Schwartz M. Excess circulating alternatively activated myeloid (M2) cells accelerate ALS progression while inhibiting experimental autoimmune encephalomyelitis. PLoS One. 2011; 6:e26921.
- Appel SH, Zhao W, Beers DR, Henkel JS. The microglial-motoneuron dialogue in ALS. Acta Myol. 2011; 30:4-8.
- Beers DR, Zhao W, Liao B, Kano O, Wang J, Huang A, Appel SH, Henkel JS. Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice. Brain Behav Immun. 2011; 25:1025-1035.
- Zhao W, Beers DR, Henkel JS, Zhang W, Urushitani M, Julien J-P, Appel SH. Extracellular mutant SOD1 induces microglial-mediated motoneuron injury. Glia. 2010; 58:231-243.
- Henkel JS, Beers DR, Zhao W, and Appel SH. Microglia in ALS: the good, the bad, and the resting. J Neuroimmune Pharmacol. 2009; 4:389–398.