David B. Corry, M.D.
Senior Affiliate Member
Internal Medicine Residency, Duke University Medical Center, Durham, NC
After completion of his postdoctoral training, Dr. Corry joined the faculty at the University of California at San Francisco as an Assistant Adjunct Professor of Medicine. He accepted an appointment at the Baylor College of Medicine in Houston, Texas in 1999 as an Assistant Professor in the Department of Medicine. Dr. Corry would later become a full professor of medicine and immunology there, as well as the Nancy Chang, Ph.D. Professor for the Biology of Inflammation Center, also at Baylor.
Dr. Corry’s research is focused on immune mechanisms of lung disease. His past research projects have included defining critical roles played by CD4+ T cells in lung inflammation and describing the distinct contributions of cytokines IL-4 and IL-13 in the immunopathogenesis of experimental allergic airway disease. Dr. Corry has also made fundamental discoveries on the role of integrins in T cell function and the role of innate immunity in controlling allergic lung disease, focusing specifically on the roles of exogenous proteinases and fungi as allergens and airway epithelial derived cytokines and proteinases such as IL-25 and matrix metalloproteinase 7. Additional major areas of research are microRNAs and the control of immunity and development of nanoparticulate vaccines.
Immunology, asthma, T cells, proteinases, microRNA
Porter P, Polikepahad S, Qian Y, Knight JM, Lu W, Tai WMT, Roberts L, Ongeri V, Yang T, Seryshev A, Abramson S, Delclos GL, Kheradmand F, Corry DB. Respiratory Tract Allergic Disease and Atopy: Experimental Evidence for A Fungal Infectious Etiology. Med. Mycol. (2010 Aug 31). (Epub ahead of print)
Tai, W, Roberts L, Seryshev A, Gubatan JM, Bland CS, Zabriskie R, Kulkarni S, Soong L, Mbawuike I, Gilbert B, Kheradmand F, and Corry DB. Multi-Strain Influenza Protection Induced by a Nanoparticulate Mucosal Immunotherapeutic. Mucosal Immunol. (2010 Aug 24). (Epub ahead of print)
Polikepahad S, Knight JM, Naghavi AO, Oplt T, Creighton CJ, Shaw CA, Benham AL, Kim J, Soibam B, Zhu H, Harris RA, Coarfa C, Zariff A, Milosavljevic A, Batts LM, Kheradmand F, Gunaratne PH, Corry DB. Pro-Inflammatory Role For Let-7 MicroRNAs In Experimental Asthma. J Biol Chem. 285(39):30139-49 (2010).
Singh M, Porter P, Lee S-H, Ohno A, Atmar R, Greenberg S, Bandi V, Gern J, Amineva S, Skern T, Smithwick P, Perusich S, Barrows N, Corry DB, Kheradmand F. Human Rhinovirus Proteinase 2A Induces Th1 and Th2 Immunity in COPD. J Allergy Clin Immunol. 125: 1369-1378 (2010).
Kheradmand F, Shan M, Corry DB. Smoking gun: mature dendritic cells in human lung provide clues to chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 180:1166-7 (2009).
Corry DB, Kheradmand F. Toward a comprehensive understanding of allergic lung disease. Trans Am Clin Climatol Assoc. 120:33-48 (2009).
Porter P, Susarla SC, Polikepahad S, Qian Y, Hampton J, Kiss A, Vaidya S, Sur S, Ongeri V, Yang T, Delclos GL, Abramson S, Kheradmand F, Corry DB. Link between allergic asthma and airway mucosal infection suggested by proteinase-secreting household fungi. Mucosal Immunol. 2:504-517 (2009).
Ko KW, Corry DB, Brayton CF, Paul A, Chan L. Extravascular inflammation does not increase atherosclerosis in apoE-deficient mice. Biochi Biophys Res Commun. 384:93-99 (2009).
Vargas-Inchaustegui DA, Tai W, Xin L, Hogg AE, Corry DB, Soong L. Distinct roles for MyD88 and Toll-like receptor 2 during Leishmania braziliensis infection in mice. Infect Immun. 77:2948-2956 (2009).
Shan M, Cheng H-F, Song L-Z, Roberts L, Green L, Hacken-Bitar J, Huh J, Bakaeen F, Coxson HO, Storness-bliss C, Lee S-H, Corry DB and Kheradmand F. Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema. Science Transl Med. 1132-1140 (2009).