Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Christopher R. Singh Ph.D.

 

Christopher R. Singh, Ph.D.

Postdoctoral Fellow
The Methodist Hospital Research Institute

E-mail: crsingh@houstonmethodist.org   
Phone: 713-441-7118                                                    

Education

M.S. The University of Texas Health Science Center at Houston, Houston, TX (Biomedical Science)
Ph.D.   The University of Texas Health Science Center at Houston, Houston, TX (Molecular Pathology)

Postdoctoral Training

Postdoctoral Fellowship, Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, TX

Biography

Dr. Singh received his Ph.D. in Molecular Pathology from The University of Texas Health Science Center at Houston in 2011. He earned numerous honors and awards while at The University of Texas, including the L.D. Mehta Achievement Award and a Keystone Symposia NIAID Scholarship. Dr. Singh then joined the Center for Molecular and Translational Human Infectious Diseases Research at The Methodist Hospital Research Institute to study vaccine development under the supervision of Dr. Adriana Rosato.

Description of Research

Dr. Singh is investigating the genetic basis of drug resistance in Staphylococcus aureus at the molecular level.

Major Areas of Research

Methicillin-resistant Staphylococcus aureus (MRSA),gene expression, drug resistance

Recent Publications

Mehta S, Singh C, Plata KB, Chanda PK, Paul A, Riosa S, Rosato RR, Rosato AE. β-lactams increase the antibacterial activity of daptomycin against clinical MRSA strains and prevent selection of DAP-resistant derivatives. Antimicrob Agents Chemother. 2012 Sep 17. [Epub ahead of print]

Singh CR, Bakhru P, Khan A, Li QB, Jagannath C. Cutting Edge: Nicastrin and Related Components of γ-Secretase Generate a Peptide Epitope Facilitating Immune Recognition of Intracellular Mycobacteria, through MHC Class II-Dependent Priming of T Cells. J Immunol. 2011 Oct 28. [Epub ahead of print]

Li Q, Singh CR, Ma S, Price ND, Jagannath C. Label-free proteomics and systems biology analysis of mycobacterial phagosomes in dendritic cells and macrophages. J Proteome Res. 2011 May 6;10(5):2425-39.

Li Q, Jagannath C, Rao PK, Singh CR, Lostumbo G. Analysis of phagosomal proteomes: from latex-bead to bacterial phagosomes. Proteomics. 2010 Nov;10(22):4098-116.

Rao PK, Singh CR, Jagannath C, Li Q. A systems biology approach to study the phagosomal proteome modulated by mycobacterial infections. Int J Clin Exp Med. 2009 Sep 30;2(3):233-47.

Katti MK, Dai G, Armitige LY, Rivera Marrero C, Daniel S, Singh CR, Lindsey DR, Dhandayuthapani S, Hunter RL, Jagannath C. The Delta fbpA mutant derived from Mycobacterium tuberculosis H37Rv has an enhanced susceptibility to intracellular antimicrobial oxidative mechanisms, undergoes limited phagosome maturation and activates macrophages and dendritic cells. Cell Microbiol. 2008 Jun;10(6):1286-303.