The mission of the Center for the Rational Design of Multifunctional Nanoconstructs is to develop mathematical tools, microfluidic-based assays and small animal imaging systems for studying and optimizing the performance of intravascularly injectable nanoconstructs. Multifunctional nanoconstructs are nanoscale vehicles, loaded with therapeutic and contrast agents, that are rationally designed to preferentially accumulate at disease sites, where they can release or activate their therapeutic payload. The Center is focused on the delivery of therapeutics for cancer (brain, breast, ovarian and pancreatic tumors), and cardiovascular and metabolic diseases. In addition the Center develops multimodal imaging agents that combining MR and nuclear imaging capabilities, and optimizes nanoconstructs for the thermal ablation of diseased tissue.
Paolo Decuzzi, Ph.D, Director,
Center for the Rational Design of Multifunctional Nanoconstructs
Dr. Decuzzi earned his M.Sc. degree in Mechanical Engineering from the Politecnico di Bari, one of the three Politecnical Schools in Italy, and his Ph.D. degree in Mechanical Engineering from the University of Naples - Federico II. His Ph.D. course was developed in collaboration with the Department of Theoretical and Applied Mechanics at the University of Michigan - Ann Arbor, where he worked on the multiscale modeling of adhesion and friction as a visiting scientist. He became Assistant Professor of Mechanical Engineering at the Politecnico di Bari (IT) in 2003, and Associate Professor of Biomedical and Mechanical Engineering at the School of Medicine of the University of Magna Graecia (IT) in 2005.