Anisha A. Gupte, Ph.D.
B.S. University of Mumbai (Lifesciences- Biochemistry, Valedictorian)
Postdoctoral Research Fellow with Dr. Willa Hsueh, Diabetes Research Center, The Methodist Hospital Research Institute, Houston, USA.
The goal of Dr. Gupte's research is to define the mechanisms underlying the development of liver complications in diabetes. Specifically, she investigates the role of nuclear receptors PPARgamma, PPARdelta and TR beta in non-alcoholic steatohepatitis. Dr. Gupte is also interested in understanding the relationship between estrogen signaling and insulin resistance. One of her areas of expertise is development and standardization of mitochondrial function assessment tools.
Gupte, A.A., J.Z. Liu, Y. Ren, L.J. Minze, J.R. Wiles, A.R. Collins, C.J. Lyon, D. Pratico, M.J. Finegold, S.T. Wong, P. Webb, J.D. Baxter, D.D. Moore and W.A. Hsueh. Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male LDL receptor knockout mice. Hepatology. In press.
Geiger P.C. and A.A. Gupte. The protective effects of heat shock proteins on skeletal muscle insulin sensitivity. Review. Exercise and Sport Sciences Reviews. In press.
Smittkamp S., H. Spalding, J. Brown, A.A. Gupte, J. Chen, H. Nishimune, P.C. Geiger and J.A. Stanford. Measures of bulbar and spinal motor function, muscle innervation, and mitochondrial function in ALS rats. Behavioural Brain Res. 2010 Jul 29; 211(1):48-57.
Gupte A.A., J.K. Morris, H. Zhang, G.L. Bomhoff, P.C. Geiger and J.A. Stanford. Age-related changes in Heat Shock Protein expression in the brain. Neuroscience Lett. 2010 Mar 19;472(2):90-3.
Gupte A.A., G.L. Bomhoff, J. K. Morris, B. K. Gorres and P.C. Geiger. Lipoic acid increases heat shock protein expression and inhibits stress kinase activation to improve insulin signaling in skeletal muscle from high fat-fed rats. J Appl Physiol. 2009 Apr; 106(4):1425-34.
Gupte A.A., G.L. Bomhoff, R.H. Swerdlow and P.C. Geiger. Heat treatment improves insulin-stimulated glucose uptake and mitochondrial function in skeletal muscle from rats fed a high fat diet. Diabetes. 2009 Mar;58(3):567-78.
Morris, J.K., H. Zhang, A.A. Gupte, G.L. Bomhoff, P.C. Geiger and J.A. Stanford. Measures of insulin resistance in 6-hydroxydopamine model of Parkinson's disease. Brain Research. (2008 Nov): 1240:185-95.
Gupte A.A., G.L. Bomhoff, and P.C. Geiger. Age-related differences in skeletal muscle insulin signaling: the role of stress kinases and heat shock proteins. J Appl Physiol. (2008 Sep); 105(3):839-48.
Gupte A., S. Mora. Activation of the Cbl insulin signaling pathway in cardiac muscle; Dysregulation in obesity and diabetes. Biochem Biophys Res Comm. (2006 Apr); 342:751-757.