Xuewu Liu

Xuewu Liu, PhD

Associate Professor of Nanomedicine, Academic Institute
Associate Member, Research Institute
Houston Methodist


Biography

Dr. Xuewu Liu got his Ph.D. in 2002, then undertook a  postdoctoral training at the Indiana Center for Biological Microscopy at IUPUI Indianapolis. In 2003, he joined Ohio State University as a senior research associate in nanomedicine. He was appointed assistant professor of nanomedicine and biomedical engineering at the University of Texas Health Science Center in Houston in 2006. In 2010, Dr. Liu joined to The Methodist Hospital Research Institute, to direct the nanoengineering core.

Dr. Xuewu Liu is a leading scientist in silicon nanotechnology. With over 20 years of experience in silicon microfabrication, nanomaterials, microfluidics, and cancer nanotechnology, Dr. Liu has been leading the effort in the research and development of silicon-based nanomedicine platforms, and coordinates a nanoengineering team to support biomedical research at the institute levels.  The nanomedicine platforms he developed include porous silicon nanovectors for drug delivery, multifunctional nanoparticles, nanochannel membranes for drug implants, nanostructure enhanced microfluidic devices, injectable nanoparticulate scavengers, and nanoporous assay for diagnostic biomarkers. Dr. Liu had published 150 peer-reviewed journal papers, and issued 10 US patents. He is intensively involved in the researches on targeted cancer therapy, in vitro and in vivo studies of particles-cells interaction, implanted drug delivery, microfluidic analysis of exosomes, and particulate cytokine scavengers for immune regulation. As the director of nanoengineering, he led the cleanroom microfabrication and the development of in-house nanofabrication capabilities in the Houston Methodist cGMP facility. His current active researches focus  on microfluidic study of platelet-mediated tumor metastasis, injectable cytokine scavenging for immune modulation, and microfluidic cell manipulation for the study of intracellular interaction at single cell level. 

Description of Research

Dr. Liu’s research focus is the development of silicon based nanotechnology platforms for prevention, diagnosis and treatment of human disease. His current interests include microfluidic study of platelet-mediated tumor metastasis, injectable cytokine scavenging for immune modulation, and microfluidic cell manipulation for the study of intracellular interaction at single cell level.

Areas Of Expertise

Silicon nanotechnology Drug delivery nanoparticles Theranostics Biological microfluidics
Education & Training

MS, Jilin University
Postdoctoral Associate, Heart and Lung Research Institute
Postdoctoral Associate, Indiana Center for Biological Microscopy, Indianapolis, IN
PhD, Kent State University
Patents

NANOCHANNELED DEVICE WITH ELECTRODES AND RELATED METHODS

Patent Number: EP3027264, Jun 08 2016


Nanochanneled device with electrodes and related methods

Patent Number: CN105530988, Apr 27 2016


NANOCHANNELED DEVICE AND RELATED METHODS

Patent Number: US2015246174, Sep 03 2015


NANOCHANNELED DEVICE WITH ELECTRODES AND RELATED METHODS

Patent Number: US2015088102, Mar 26 2015


NANOCHANNELED DEVICE WITH ELECTRODES AND RELATED METHODS

Patent Number: WO2015017777, Feb 05 2015


Publications

Modeling critical interaction for metastasis between circulating tumor cells (CTCs) and platelets adhered to the capillary wall
Milosevic, M, Simic, V, Nikolic, A, Shao, N, Kawamura Hashimoto, C, Godin, B, Leonard, F, Liu, X & Kojic, M 2023, , Computer Methods and Programs in Biomedicine, vol. 242, 107810. https://doi.org/10.1016/j.cmpb.2023.107810

Injectable Porous Silicon Nanoparticles as a Plasma Cytokine Scavenger for Potentiating Cytokine Storm Syndrome Treatment
Qi, R, Li, S, Li, F, Mai, J, Wang, Y, Zhu, G, Zhang, D, Li, Z, Shen, H, Shen, J & Liu, X 2023, , Advanced NanoBiomed Research, vol. 3, no. 10, 2300037. https://doi.org/10.1002/anbr.202300037

A Bidirectional Single-Cell Migration and Retrieval Chip for Quantitative Study of Dendritic Cell Migration
Shao, N, Zhou, Y, Yao, J, Zhang, P, Song, Y, Zhang, K, Han, X, Wang, B & Liu, X 2023, , Advanced Science, vol. 10, no. 8, 2204544, pp. e2204544. https://doi.org/10.1002/advs.202204544

Long-acting tunable release of amlodipine loaded PEG-PCL micelles for tailored treatment of chronic hypertension
Di Trani, N, Liu, HC, Qi, R, Viswanath, DI, Liu, X, Chua, CYX & Grattoni, A 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 37, 102417. https://doi.org/10.1016/j.nano.2021.102417

Platforms to test the temporospatial capabilities of carrier systems in delivering growth factors to benefit vascular bioengineering
Argueta, LB, Niles, JA, Sakamoto, J, Liu, X, Vega, SP, Frank, L, Paessler, M, Cortiella, J & Nichols, JE 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 36, 102419. https://doi.org/10.1016/j.nano.2021.102419

Silicon Carbide-Gated Nanofluidic Membrane for Active Control of Electrokinetic Ionic Transport
Silvestri, A, Di Trani, N, Canavese, G, Motto Ros, P, Iannucci, L, Grassini, S, Wang, Y, Liu, X, Demarchi, D & Grattoni, A 2021, , Membranes, vol. 11, no. 7. https://doi.org/10.3390/membranes11070535

Silicon carbide-gated nanofluidic membrane for active control of electrokinetic ionic transport
Silvestri, A, Di Trani, N, Canavese, G, Ros, PM, Iannucci, L, Grassini, S, Wang, Y, Liu, X, Demarchi, D & Grattoni, A 2021, , Membranes, vol. 11, no. 7, 535. https://doi.org/10.3390/membranes11070535, https://doi.org/10.3390/membranes11070535

Long-acting tunable release of amlodipine loaded PEG-PCL micelles for tailored treatment of chronic hypertension
Di Trani, N, Liu, HC, Qi, R, Viswanath, DI, Liu, X, Chua, CYX & Grattoni, A 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 37, 102417. https://doi.org/10.1016/j.nano.2021.102417

Synergistic Activation of Antitumor Immunity by a Particulate Therapeutic Vaccine
Mai, J, Li, Z, Xia, X, Zhang, J, Li, J, Liu, H, Shen, J, Ramirez, M, Li, F, Li, Z, Yokoi, K, Liu, X, Mittendorf, EA, Ferrari, M & Shen, H 2021, , Advanced Science, vol. 8, no. 12, 2100166. https://doi.org/10.1002/advs.202100166

Enhanced thermal effect of plasmonic nanostructures confined in discoidal porous silicon particles
Zhang, D, Wu, HJ, Zhou, X, Qi, R, Xu, L, Guo, Y & Liu, X 2020, , RSC Advances, vol. 10, no. 51, pp. 30840-30847. https://doi.org/10.1039/d0ra03379k

Silicon nanofluidic membrane for electrostatic control of drugs and analytes elution
Di Trani, N, Silvestri, A, Wang, Y, Demarchi, D, Liu, X & Grattoni, A 2020, , Pharmaceutics, vol. 12, no. 7, 679, pp. 1-16. https://doi.org/10.3390/pharmaceutics12070679

Liposome-embedding silicon microparticle for oxaliplatin delivery in tumor chemotherapy
Cevenini, A, Celia, C, Orrù, S, Sarnataro, D, Raia, M, Mollo, V, Locatelli, M, Imperlini, E, Peluso, N, Peltrini, R, De Rosa, E, Parodi, A, Del Vecchio, L, Di Marzio, L, Fresta, M, Netti, PA, Shen, H, Liu, X, Tasciotti, E & Salvatore, F 2020, , Pharmaceutics, vol. 12, no. 6, 559, pp. 1-28. https://doi.org/10.3390/pharmaceutics12060559

Sequential deconstruction of composite drug transport in metastatic breast cancer
Goel, S, Zhang, G, Dogra, P, Nizzero, S, Cristini, V, Wang, Z, Hu, Z, Li, Z, Liu, X, Shen, H & Ferrari, M 2020, , Science advances, vol. 6, no. 26, eaba4498, pp. eaba4498. https://doi.org/10.1126/sciadv.aba4498

Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery
Di Trani, N, Silvestri, A, Sizovs, A, Wang, Y, Erm, DR, Demarchi, D, Liu, X & Grattoni, A 2020, , Lab on a Chip, vol. 20, no. 9, pp. 1562-1576. https://doi.org/10.1039/d0lc00121j

Design and in vitro characterization of multistage silicon-PLGA budesonide particles for inflammatory bowel disease
Leonard, F, Srinivasan, S, Liu, X, Collnot, EM, Ferrari, M, Lehr, CM & Godin, B 2020, , European Journal of Pharmaceutics and Biopharmaceutics, vol. 151, pp. 61-72. https://doi.org/10.1016/j.ejpb.2020.03.020

Hollow Mesoporous Metal-Organic Framework Microdisks via a Solid Template-Based Approach and Post-Synthetic Wet-Chemical Etching for Protein Loading
Zhu, G, Cheng, L, Qi, R & Liu, X 2020, , ChemNanoMat, vol. 6, no. 4, pp. 589-597. https://doi.org/10.1002/cnma.202000061

Biocompatible PLGA-mesoporous silicon microspheres for the controlled release of bmp-2 for bone augmentation
Minardi, S, Fernandez-Moure, JS, Fan, D, Murphy, MB, Yazdi, IK, Liu, X, Weiner, BK & Tasciotti, E 2020, , Pharmaceutics, vol. 12, no. 2, 118. https://doi.org/10.3390/pharmaceutics12020118

Potentiating Antitumor Efficacy Through Radiation and Sustained Intratumoral Delivery of Anti-CD40 and Anti-PDL1
Liu, HC, Viswanath, DI, Pesaresi, F, Xu, Y, Zhang, L, Di Trani, N, Paez-Mayorga, J, Hernandez, N, Wang, Y, Erm, DR, Ho, J, Susnjar, A, Liu, X, Demaria, S, Chen, SH, Teh, BS, Butler, EB, Xuan Chua, CY & Grattoni, A 2021, , International Journal of Radiation Oncology Biology Physics, vol. 110, no. 2, pp. 492-506. https://doi.org/10.1016/j.ijrobp.2020.07.2326

Mesenchymal Stromal Cell-Mediated Treatment of Local and Systemic Inflammation through the Triggering of an Anti-Inflammatory Response
Martinez, JO, Evangelopoulos, M, Brozovich, AA, Bauza, G, Molinaro, R, Corbo, C, Liu, X, Taraballi, F & Tasciotti, E 2020, , Advanced Functional Materials, vol. 31, no. 3, 2002997. https://doi.org/10.1002/adfm.202002997

Investigation of parameters that determine Nano-DC vaccine transport
Zhang, J, Mai, J, Li, F, Shen, J, Zhang, G, Li, J, Hinkle, LE, Lin, D, Liu, X, Li, Z, Wang, RF, Mittendorf, EA, Ferrari, M & Shen, H 2019, , Biomedical Microdevices, vol. 21, no. 2, 39. https://doi.org/10.1007/s10544-019-0397-6