Timothy B. Boone, MD, PhD

Professor of Urology, Academic Institute
Chief Education Officer, Academic Institute
Full Member, Research Institute
Craig C. Brown and Suzanne H. Smith Centennial Chair in Medical Education, Houston Methodist
Weill Cornell Medical College


Biography

Dr. Timothy B. Boone is Director of Education for the Houston Methodist Academic Institute, and a member of the Neurological Institute at Houston Methodist Hospital. He is Professor of Urology at Weill Cornell Medical College and holds appointments as Professor of Urology at Texas A&M College of Medicine and Baylor College of Medicine where he is a Clinical Professor of Urology. In 2014, Dr. Boone was appointed Associate Dean, Texas A&M University College of Medicine at the Houston campus.

Dr. Boone earned his Master of Science in physiology and Ph.D. in neuroscience at the University of Texas Graduate School of Biomedical Sciences at Houston. He completed his M.D./Ph.D. at the University of Texas Medical School at Houston and urology residency training at the University of Texas Southwestern Medical School in Dallas. In 1991 he joined the faculty in the Department of Urology at UT Southwestern for two years and then moved to Baylor College of Medicine where he joined the Scott Department of Urology. In 2000 Dr. Boone was named Professor and Chair of the Scott Department of Urology where he served until 2008. For over 20 years he actively participated in the care of spinal cord injured veterans with neurogenic bladder dysfunction at the VA Spinal Cord Injury Unit in Dallas and in Houston.

Boone specializes in the treatment of patients with incontinence following prostatectomy, women with complex voiding disorders, and bladder problems related to neurologic disease including spinal cord injury, stroke, multiple sclerosis, and Parkinson's disease. He maintains active participation in research, focusing on mechanisms of sensory control and dysfunction in the bladder and urethra that are related to spinal cord injury, diabetes or obstruction. Dr. Boone is the primary investigator for the Neuroregeneration and Bladder Sensory Science Laboratory at the Houston Methodist Research Institute.

Throughout his career Dr. Boone has written over 200 publications and given hundreds of lectures regionally and nationally while serving as a visiting professor for many departments of urology. He is a member of the American Association of Genitourinary Surgeons, Clinical Society of GU Surgeons, American Urological Association, Texas Urological Society, Society for Neuroscience, Society for Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction, and the AOA Honor Medical Society. He serves as consultant reviewer for several scientific journals including Neurourology and Urodynamics, Journal of Urology, British Journal of Urology, Urology, Spinal Cord, and the New England Journal of Medicine. He is on the editorial board of Nature Reviews in Urology. Dr. Boone was elected as a Trustee to the American Board of Urology in 2006 and served as President of the American Board of Urology from 2011 - 2012.

Description of Research

Incontinence, Neurourology, Neurogenic Bladder, Urinary Diversion and Urinary Reconstruction

Areas Of Expertise

Incontinence Neurourology Neurogenic Bladder Regenerative Medicine Urinary Diversion and Urinary Reconstruction
Education & Training

Residency, University of Texas Southwestern Medical Center
PhD, University of Texas Graduate School of Biomedical Science - Houston
Internship, University of Texas Health Science Center at Houston
MD, University of Texas Health Science Center at Houston
Publications

Is the Brainstem Activation Different Between Healthy Young Male and Female Volunteers at Initiation of Voiding? A High Definition 7-Tesla Magnetic Resonance Imaging Study
Schott, B, Choksi, D, Tran, K, Karmonik, C, Salazar, B, Boone, T & Khavari, R 2023, , International Neurourology Journal, vol. 27, no. 3, pp. 174-181. https://doi.org/10.5213/inj.2346104.052

Classification of multiple sclerosis women with voiding dysfunction using machine learning: Is functional connectivity or structural connectivity a better predictor?
Tran, K, Salazar, BH, Boone, TB, Khavari, R & Karmonik, C 2023, , BJUI Compass, vol. 4, no. 3, pp. 277-284. https://doi.org/10.1002/bco2.217

Noninvasive, Individualized Cortical Modulation Using Transcranial Rotating Permanent Magnet Stimulator for Voiding Dysfunction in Women with Multiple Sclerosis: A Pilot Trial
Khavari, R, Tran, K, Helekar, SA, Shi, Z, Karmonik, C, Rajab, H, John, B, Jalali, A & Boone, T 2022, , Journal of Urology, vol. 207, no. 3, pp. 657-667. https://doi.org/10.1097/JU.0000000000002297

Preliminary Analysis of Brain Footprints in Multiple Sclerosis Females With Detrusor Sphincter Dyssynergia: A Concurrent Urodynamic and Functional Magnetic Resonance Imaging Study
Tran, K, Hubbard, L, Karmonik, C, Boone, TB & Khavari, R 2022, , International Neurourology Journal, vol. 26, no. Suppl 1, pp. S38-S46. https://doi.org/10.5213/inj.2142012.006

Prospective Evaluation of Intradetrusor Injections of OnabotulinumtoxinA in Adults With Spinal Dysraphism
Mackay, A, Sosland, R, Tran, K, Stewart, J, Boone, T & Khavari, R 2022, , Urology, vol. 161, pp. 146-152. https://doi.org/10.1016/j.urology.2021.09.045

Alterations in brain activation patterns in women with functional defecatory disorder: A novel fMRI rectal balloon expulsion study
Neshatian, L, Karmonik, C, Khavari, R, Shi, Z, Elias, S, Boone, T & Quigley, EMM 2022, , Neurogastroenterology and Motility, vol. 34, no. 12, e14389. https://doi.org/10.1111/nmo.14389

Altered bladder-related brain network in multiple sclerosis women with voiding dysfunction
Shi, Z, Karmonik, C, Soltes, A, Tran, K, Lincoln, JA, Boone, T & Khavari, R 2022, , Neurourology and Urodynamics, vol. 41, no. 7, pp. 1612-1619. https://doi.org/10.1002/nau.25008

Therapeutic effects of non-invasive, individualized, transcranial neuromodulation treatment for voiding dysfunction in multiple sclerosis patients: study protocol for a pilot clinical trial
Tran, K, Shi, Z, Karmonik, C, John, B, Rajab, H, Helekar, SA, Boone, T & Khavari, R 2021, , Pilot and Feasibility Studies, vol. 7, no. 1, 83. https://doi.org/10.1186/s40814-021-00825-z

The AUA/SUFU Guideline on Adult Neurogenic Lower Urinary Tract Dysfunction: Treatment and Follow-up
Ginsberg, DA, Boone, TB, Cameron, AP, Gousse, A, Kaufman, MR, Keays, E, Kennelly, MJ, Lemack, GE, Rovner, ES, Souter, LH, Yang, CC & Kraus, SR 2021, , Journal of Urology, vol. 206, no. 5, pp. 1106-1113. https://doi.org/10.1097/JU.0000000000002239

The AUA/SUFU Guideline on Adult Neurogenic Lower Urinary Tract Dysfunction: Diagnosis and Evaluation
Ginsberg, DA, Boone, TB, Cameron, AP, Gousse, A, Kaufman, MR, Keays, E, Kennelly, MJ, Lemack, GE, Rovner, ES, Souter, LH, Yang, CC & Kraus, SR 2021, , Journal of Urology, vol. 206, no. 5, pp. 1097-1105. https://doi.org/10.1097/JU.0000000000002235

Editorial Comment
Boone, TB 2021, , Journal of Urology, vol. 206, no. 5, pp. 1256. https://doi.org/10.1097/JU.0000000000001954.01

Noninvasive, Individualized Cortical Modulation Using Transcranial Rotating Permanent Magnet Stimulator for Voiding Dysfunction in Women with Multiple Sclerosis: A Pilot Trial
Khavari, R, Tran, K, Helekar, SA, Shi, Z, Karmonik, C, Rajab, H, John, B, Jalali, A & Boone, T 2022, , The Journal of urology, vol. 207, no. 3, pp. 657-668. https://doi.org/10.1097/JU.0000000000002297

Dissecting the role of radical cystectomy and urinary diversion in post-operative complications: an analysis using the American College of Surgeons national surgical quality improvement program database
Anaissie, J, Dursun, F, Wallis, CJD, Klaassen, Z, Taylor, J, Obando-Perez, C, Xu, J, Boone, T, Khavari, R & Satkunasivam, R 2021, , International Braz J Urol, vol. 47, no. 5, pp. 1006-1019. https://doi.org/10.1590/S1677-5538.IBJU.2020.1098

EDITORIAL COMMENT
Boone, TB 2021, , Urology, vol. 153, pp. 350. https://doi.org/10.1016/j.urology.2020.11.078

High spatial correlation in brain connectivity between micturition and resting states within bladder-related networks using 7 T MRI in multiple sclerosis women with voiding dysfunction
Shi, Z, Tran, K, Karmonik, C, Boone, T & Khavari, R 2021, , World Journal of Urology, vol. 39, no. 9, pp. 3525-3531. https://doi.org/10.1007/s00345-021-03599-4

Low interrater reliability of videourodynamic diagnosis of detrusor external sphincter dyssynergia
Miller, BD, Tallman, CT, Boone, TB & Khavari, R 2021, , Female Pelvic Medicine and Reconstructive Surgery, vol. 27, no. 5, pp. 297-299. https://doi.org/10.1097/SPV.0000000000000754

Voiding dysfunction in old male rats associated with enlarged prostate and irregular afferent-triggered reflex responses
Zhang, C, Li, X, Boone, TB, Cruz, Y, Zhang, Y & Munoz, A 2020, , International Neurourology Journal, vol. 24, no. 3, pp. 258-269. https://doi.org/10.5213/inj.2040114.057

Refractory bladder dysfunction: A multi-institutional experience with intravesical botulinum toxin-a injection in adult patients who underwent previous augmentation cystoplasty
Martinez, L, Tubre, R, Roberts, R, Boone, TB, Griebling, TL, Padmanabhan, P & Khavari, R 2020, , Turkish Journal of Urology, vol. 46, no. 4, pp. 309-313. https://doi.org/10.5152/tud.2020.19259

Are White Matter Tract Integrities Different in Multiple Sclerosis Women With Voiding Dysfunction?
Tran, K, Karmonik, C, Boone, TB & Khavari, R 2021, , Female pelvic medicine & reconstructive surgery, vol. 27, no. 1, pp. e101-e105. https://doi.org/10.1097/SPV.0000000000000830

Editorial Comment
Sosland, R & Boone, T 2020, , The Journal of urology, vol. 203, no. 4, pp. 791. https://doi.org/10.1097/JU.0000000000000618.02