Yuliang Zhao

Yuliang Zhao, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Biography

Dr. Yuliang Zhao earned his Ph.D. in Chemical Science from the Tokyo Metropolitan University in 1999. He held faculty appointments at the Chinese Academy of Sciences in Beijing before becoming a member of Houston Methodist Research Institute in 2011. Dr. Zhao also holds adjunct faculty appointments at Peking University (Beijing), the Medical School of Jilin University (Changchun), and Sichuan University (Chengdu).

As the the founder and Director of CAS Key Lab for Biomedical Effects of Nanomaterials & Nanosafety, he directs a research program that is developing a new generation of cancer chemotherapeutics using low-toxic nanoparticles. Dr. Zhao has also been a member of nine study sections and review boards in China and Europe. He is the founder and Director of Research Center for Cancer Nanotechnology at Tianjin Cancer Hospital in China. He has served as the Associate Editor and editorial board member of seven scientific research journals since 2006.

Description of Research

Dr. Zhao's research program focuses on nanotoxicology, cancer nanotechnology, and nanochemistry. He is developing molecular dynamics modeling for designing low-toxic nanosurfaces for cancer nanotechnology applications, and for lowering the toxicity of nanomaterials in living systems. A major aim of his research is to understand the mechanisms of nanotoxicity of engineered nanoparticles in vivo. In addition, a major research goal is to characterize the structure-function relationships between the tumor microenvironment (like extracellular matrices) and engineered nanoparticles that inhibit tumor growth and metastasis. Dr. Zhao's research team at CAS collaborates with Dr. Mauro Ferrari, Dr. Ye "Tony" Hu and other faculty members of the Department of Nanomedicine at the Research Institute in the research of cancer nanotechnology and nanotechnology based biomarker identification.

Areas Of Expertise

Nanotoxicology Cancer nanotechnology Chemistry Nanoscale molecular dynamics modeling
Education & Training

Postdoctoral Fellowship, Japan Society for the Promotion of Science, Tokyo Metropolitan University, Tokyo
PhD, Tokyo Metropolitan University
Publications

The dynamic role of platelets in cancer progression and their therapeutic implications
Li, S, Lu, Z, Wu, S, Chu, T, Li, B, Qi, F, Zhao, Y & Nie, G 2024, , Nature Reviews Cancer, vol. 24, no. 1, pp. 72-87. https://doi.org/10.1038/s41568-023-00639-6

Programming conformational cooperativity to regulate allosteric protein-oligonucleotide signal transduction
Liang, Y, Qie, Y, Yang, J, Wu, R, Cui, S, Zhao, Y, Anderson, GJ, Nie, G, Li, S & Zhang, C 2023, , Nature Communications, vol. 14, no. 1, 4898. https://doi.org/10.1038/s41467-023-40589-z

Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine
Guo, M, Cao, M, Sun, J, Chen, Z, Wang, X, Dai, L, Gao, GF, Zhao, Y, Wang, Y & Chen, C 2023, , Signal Transduction and Targeted Therapy, vol. 8, no. 1, 462. https://doi.org/10.1038/s41392-023-01718-8

STING and TLR9 agonists synergistically enhance the immunogenicity of SARS-CoV-2 subunit vaccine
Li, Y, Chen, Z, Lu, X, Sun, J, Guo, M, Zhou, H, Bai, R, Zhao, Y, Chen, C & Wang, Y 2023, , Nano Research, vol. 16, no. 12, pp. 13322-13334. https://doi.org/10.1007/s12274-023-6295-5

A special issue for the 20th anniversary of National Center for Nanoscience and Technology
Dai, Q, Nie, G, Tang, Z & Zhao, Y 2023, , Nano Research, vol. 16, no. 12, pp. 12881-12882. https://doi.org/10.1007/s12274-023-6377-4

Recent advances in nanoantibiotics against multidrug-resistant bacteria
Li, M, Liu, Y, Gong, Y, Yan, X, Wang, L, Zheng, W, Ai, H & Zhao, Y 2023, , Nanoscale Advances, vol. 5, no. 23, pp. 6278-6317. https://doi.org/10.1039/d3na00530e

Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2
Yang, PP, Ye, XW, Liu, MQ, Yang, JX, Feng, XL, Li, YJ, Zhang, K, Liang, HW, Yi, Y, Wang, L, Liu, YX, Yang, XL, Shi, ZL, Feng, LQ, Chen, L, Xue, Y, Pan-Hammarström, Q, Wang, H & Zhao, Y 2023, , Advanced Healthcare Materials, vol. 12, no. 24, 2300673. https://doi.org/10.1002/adhm.202300673

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He, H, Wu, S, Xin, J, Zhao, H, Wang, Y, Yan, D, Shan, L, Wang, X & Zhao, Y 2023, , Bulletin of Chinese Academy of Sciences, vol. 38, no. 9, pp. 1315-1324. https://doi.org/10.16418/j.issn.1000-3045.20230815001

Catalytic Signal Transduction Theory Enabled Virtual Screening of Nanomaterials for Medical Functions
Gao, XJ, Zhao, Y & Gao, X 2023, , Accounts of Chemical Research, vol. 56, no. 17, pp. 2366-2377. https://doi.org/10.1021/acs.accounts.3c00339

Enzyme and MicroRNA Dual-Regulated Photodynamic Molecular Beacons for Cell-Selective Amplification of Antitumor Efficacy
Feng, X, Li, L, Zhao, Y & Li, M 2023, , Nano Letters, vol. 23, no. 16, pp. 7743-7749. https://doi.org/10.1021/acs.nanolett.3c01814

Two-Dimensional Carbon Graphdiyne: Advances in Fundamental and Application Research
Zheng, X, Chen, S, Li, J, Wu, H, Zhang, C, Zhang, D, Chen, X, Gao, Y, He, F, Hui, L, Liu, H, Jiu, T, Wang, N, Li, G, Xu, J, Xue, Y, Huang, C, Chen, C, Guo, Y, Lu, TB, Wang, D, Mao, L, Zhang, J, Zhang, Y, Chi, L, Guo, W, Bu, XH, Zhang, H, Dai, L, Zhao, Y & Li, Y 2023, , ACS Nano, vol. 17, no. 15, pp. 14309-14346. https://doi.org/10.1021/acsnano.3c03849

Fabrication of AuPt heterostructured nanorings for enhanced synergistic radio-photothermal therapy
Luo, M, Zhu, X, Yang, H, Yan, L, Cai, R, Zhao, Y & Tan, W 2023, , Nano Today, vol. 51, 101919. https://doi.org/10.1016/j.nantod.2023.101919

Intelligent nanomaterials for cancer therapy: Recent progresses and future possibilities
Wang, J, Zhao, Y & Nie, G 2023, , Medical Review, vol. 3, no. 4, pp. 321-342. https://doi.org/10.1515/mr-2023-0028

Reprogramming Hypoxic Tumor-Associated Macrophages by Nanoglycoclusters for Boosted Cancer Immunotherapy
Zhao, YD, An, HW, Mamuti, M, Zeng, XZ, Zheng, R, Yang, J, Zhou, W, Liang, Y, Qin, G, Hou, DY, Liu, X, Wang, H, Zhao, Y & Fang, X 2023, , Advanced Materials, vol. 35, no. 24, 2211332. https://doi.org/10.1002/adma.202211332

Stereoselective coronas regulate the fate of chiral gold nanoparticles in vivo
Baimanov, D, Wang, L, Liu, K, Pan, M, Cai, R, Yuan, H, Huang, W, Yuan, Q, Zhou, Y, Chen, C & Zhao, Y 2023, , Nanoscale Horizons, vol. 8, no. 7, pp. 859-869. https://doi.org/10.1039/d3nh00124e

High-resolution discrimination of homologous and isomeric proteinogenic amino acids in nanopore sensors with ultrashort single-walled carbon nanotubes
Peng, W, Yan, S, Zhou, K, Wu, HC, Liu, L & Zhao, Y 2023, , Nature Communications, vol. 14, no. 1, 2662, pp. 2662. https://doi.org/10.1038/s41467-023-38399-4

Adhesive Ergothioneine Hyaluronate Gel Protects against Radiation Gastroenteritis by Alleviating Apoptosis, Inflammation, and Gut Microbiota Dysbiosis
Liu, Y, Wang, C, Liu, R, Zhao, M, Ding, X, Zhang, T, He, R, Zhu, S, Dong, X, Xie, J, Gu, Z & Zhao, Y 2023, , ACS Applied Materials and Interfaces, vol. 15, no. 16, pp. 19833-19846. https://doi.org/10.1021/acsami.2c23142

Untethered artificial muscles powered by wearable sweat-based energy generator
Chen, Y, Xue, Y, Liu, W, Li, S, Wang, X, Zhou, W, Zhang, G, Liu, K, Zhang, H, Zhao, Y, Chen, C & Liu, Y 2023, , Nano Today, vol. 49, 101765. https://doi.org/10.1016/j.nantod.2023.101765

A bispecific glycopeptide spatiotemporally regulates tumor microenvironment for inhibiting bladder cancer recurrence
An, HW, Hou, DY, Yang, J, Wang, ZQ, Wang, MD, Zheng, R, Zhang, NY, Hu, XJ, Wang, ZJ, Wang, L, Liu, D, Hao, JF, Xu, W, Zhao, Y & Wang, H 2023, , Science advances, vol. 9, no. 9, eabq8225, pp. eabq8225. https://doi.org/10.1126/sciadv.abq8225

Multifunctional Nanoprobe for 3D Nanoresolution Imaging of Intact Cell HER2 Protein with Hard X-ray Tomography
Zhang, C, Zhang, K, Cui, Y, Guo, Y, Wang, C, Xu, C, Yao, Q, Zhao, Y, Chen, C & Wang, Y 2023, , Analytical Chemistry, vol. 95, no. 4, pp. 2129-2133. https://doi.org/10.1021/acs.analchem.2c03699