Zheng Yin

Zheng Yin, PhD

Assistant Professor of Computational Biology and Mathematics in Radiology, Academic Institute
Assistant Member & Director, Biomedical Informatics Service Core, Research Institute
Houston Methodist
Weill Cornell Medical College


ZYin@houstonmethodist.org
Publications

Identification of a targetable JAK-STAT enriched androgen receptor and androgen receptor splice variant positive triple-negative breast cancer subtype
Asemota, S, Effah, W, Young, KL, Holt, J, Cripe, L, Ponnusamy, S, Thiyagarajan, T, Hwang, DJ, He, Y, Mcnamara, K, Johnson, D, Wang, Y, Grimes, B, Khosrosereshki, Y, Hollingsworth, TJ, Fleming, MD, Pritchard, FE, Hendrix, A, Khan, F, Fan, M, Makowski, L, Yin, Z, Sasano, H, Hayes, DN, Pfeffer, LM, Miller, DD & Narayanan, R 2023, , Cell Reports, vol. 42, no. 12, 113461. https://doi.org/10.1016/j.celrep.2023.113461

Continuous Expression of Interferon Regulatory Factor 4 Sustains CD8+ T Cell Immunity against Tumor
Yu, A, Fu, J, Yin, Z, Yan, H, Xiao, X, Zou, D, Zhang, X, Zu, X, Li, XC & Chen, W 2023, , Research, vol. 6, 0271. https://doi.org/10.34133/research.0271

A prognostic matrix code defines functional glioblastoma phenotypes and niches
Vishnoi, M, Dereli, Z, Yin, Z, Kong, EK, Kinali, M, Thapa, K, Babur, O, Yun, K, Abdelfattah, N, Li, X, Bozorgui, B, Rostomily, RC & Korkut, A 2023, , bioRxiv. https://doi.org/10.1101/2023.06.06.543903

G1 or Bust? “Mother” Knows Best: Stress Activated Kinases in Mother Cells Promotes ERK-mediated Proliferation during G1 of Daughter Cells in BRAF Driven Melanomas
Wong, ST, Yin, Z & Wang, L 2023, , Cancer Systems Biology Consortium (CSBS), Aurora, United States, 3/16/23 - 3/17/23.

Inhibiting androgen receptor splice variants with cysteineselective irreversible covalent inhibitors to treat prostate cancer
Thiyagarajan, T, Ponnusamy, S, Hwang, DJ, He, Y, Asemota, S, Young, KL, Johnson, DL, Bocharova, V, Zhou, W, Jain, AK, Petricoin, EF, Yin, Z, Pfeffer, LM, Miller, DD & Narayanan, R 2023, , Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 1, 120 (1) e2211832120, pp. e2211832120. https://doi.org/10.1073/pnas.2211832120

Inhibiting androgen receptor splice variants with cysteineselective irreversible covalent inhibitors to treat prostate cancer
Thiyagarajan, T, Ponnusamy, S, Hwang, DJ, He, Y, Asemota, S, Young, KL, Johnson, DL, Bocharova, V, Zhou, W, Jain, AK, Petricoin, EF, Yin, Z, Pfeffer, LM, Miller, DD & Narayanan, R 2023, , Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 1, e2211832120. https://doi.org/10.1073/pnas.2211832120

Mitochondria-targeted atovaquone promotes anti-lung cancer immunity by reshaping tumor microenvironment and enhancing energy metabolism of anti-tumor immune cells
Xiong, D, Yin, Z, Huang, M, Wang, Y, Hardy, M, Kalyanaraman, B, Wong, ST & You, M 2023, , Cancer communications (London, England). https://doi.org/10.1002/cac2.12500

TP-0184 inhibits FLT3/ACVR1 to overcome FLT3 inhibitor resistance and hinder AML growth synergistically with venetoclax
Tyagi, A, Jaggupilli, A, Ly, S, Yuan, B, El-Dana, F, Hegde, VL, Anand, V, Kumar, B, Puppala, M, Yin, Z, Wong, STC, Mollard, A, Vankayalapati, H, Foulks, JM, Warner, SL, Daver, N, Borthakur, G & Battula, VL 2023, , Leukemia. https://doi.org/10.1038/s41375-023-02086-6

Mitochondria-targeted atovaquone promotes anti-lung cancer immunity by reshaping tumor microenvironment and enhancing energy metabolism of anti-tumor immune cells
Xiong, D, Yin, Z, Huang, M, Wang, Y, Hardy, M, Kalyanaraman, B, Wong, ST & You, M 2023, , Cancer Communications. https://doi.org/10.1002/cac2.12500

An AI-driven clinical care pathway to reduce 30-day readmission for chronic obstructive pulmonary disease (COPD) patients
Wang, L, Li, G, Ezeana, CF, Ogunti, R, Puppala, M, He, T, Yu, X, Wong, SSY, Yin, Z, Roberts, AW, Nezamabadi, A, Xu, P, Frost, A, Jackson, RE & Wong, STC 2022, , Scientific Reports, vol. 12, no. 1, 20633. https://doi.org/10.1038/s41598-022-22434-3

An AI-driven clinical care pathway to reduce 30-day readmission for chronic obstructive pulmonary disease (COPD) patients
Wang, L, Li, G, Ezeana, CF, Ogunti, R, Puppala, M, He, T, Yu, X, Wong, SSY, Yin, Z, Roberts, AW, Nezamabadi, A, Xu, P, Frost, A, Jackson, RE & Wong, STC 2022, , Scientific Reports, vol. 12, no. 1, 20633, pp. 20633. https://doi.org/10.1038/s41598-022-22434-3, https://doi.org/10.1038/s41598-022-22434-3

Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer’s disease
Faridar, A, Vasquez, M, Thome, AD, Yin, Z, Xuan, H, Wang, JH, Wen, S, Li, X, Thonhoff, JR, Zhao, W, Zhao, H, Beers, DR, Wong, STC, Masdeu, JC & Appel, SH 2022, , Acta Neuropathologica Communications, vol. 10, no. 1, 144. https://doi.org/10.1186/s40478-022-01447-z

Ryanodine receptor 1-mediated Ca2+ signaling and mitochondrial reprogramming modulate uterine serous cancer malignant phenotypes
Zhang, L, Au-Yeung, CL, Huang, C, Yeung, TL, Ferri-Borgogno, S, Lawson, BC, Kwan, SY, Yin, Z, Wong, ST, Thomas, V, Lu, KH, Yip, KP, Sham, JSK & Mok, SC 2022, , Journal of Experimental and Clinical Cancer Research, vol. 41, no. 1, 242, pp. 242. https://doi.org/10.1186/s13046-022-02419-w

Converging multi-modality datasets to build efficient drug repositioning pipelines against Alzheimer’s disease and related dementias
Yin, Z & Wong, STC 2022, , Medical Review, vol. 2, no. 1, pp. 110-113. https://doi.org/10.1515/mr-2021-0017

Risk factors and machine learning model for predicting hospitalization outcomes in geriatric patients with dementia
Wang, X, Ezeana, CF, Wang, L, Puppala, M, Huang, Y-S, He, Y, Yu, X, Yin, Z, Zhao, H, Lai, EC & Wong, STC 2022, , Alzheimers and Dementia: Translational Research and Clinical Interventions, vol. 8, no. 1, e12351, pp. e12351. https://doi.org/10.1002/trc2.12351

Risk factors and machine learning model for predicting hospitalization outcomes in geriatric patients with dementia
Wang, X, Ezeana, CF, Wang, L, Puppala, M, Huang, YS, He, Y, Yu, X, Yin, Z, Zhao, H, Lai, EC & Wong, STC 2022, , Alzheimers and Dementia: Translational Research and Clinical Interventions, vol. 8, no. 1, e12351. https://doi.org/10.1002/trc2.12351

Artificial Intelligence Unifies Knowledge and Actions in Drug Repositioning
Yin, Z & Wong, ST 2021, , Emerging topics in life sciences, vol. 5, no. 6, Emerg Top Life Sci (2021) ETLS20210223, pp. 803-813. https://doi.org/10.1042/ETLS20210223

Artificial intelligence unifies knowledge and actions in drug repositioning
Yin, Z & Wong, STC 2021, , Emerging Topics in Life Sciences, vol. 5, no. 6, pp. 803-813. https://doi.org/10.1042/ETLS20210223

Converging Multi-Modality Datasets to Build Efficient Drug Repositioning Pipelines against Alzheimer's Disease and Related Dementias
Yin, Z & Wong, ST 2021, , Medical Review.

Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
Li, Z, Liu, H, He, J, Wang, Z, Yin, Z, You, G, Wang, Z, Davis, RE, Lin, P, Bergsagel, PL, Manasanch, EE, Wong, STC, Esnaola, NF, Chang, JC, Orlowski, RZ, Yi, Q & Yang, J 2021, , Cell Metabolism, vol. 33, no. 1, pp. 78-93.e7. https://doi.org/10.1016/j.cmet.2020.12.011

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