RESEARCH & clinical trials
The Center for Neuroregeneration at Houston Methodist is developing emerging approaches to modify and harness the fate of neural stem cells to increase cellular repair after spinal cord and brain injury.
Director: Philip J. Horner, PhD
The Cerebrovascular Research Laboratory studies brain microcirculation in normal and pathological conditions. The brain is critically dependent on a continuous and adequate blood supply for normal functioning, so such catastrophic events like stroke or subarachnoid hemorrhage not only damage the brain, but they lead to abnormalities of cerebrovascular circulation which may aggravate the consequences of the perpetrating event. The ultimate goal of our studies is to develop new therapeutic approaches for the treatment of various neurological disturbances related to cerebrovascular circulation.
Gavin W. Britz, MBBCh, MPH, MBA, FAANS
Eugene V. Golanov, MD, PhD
The long-term goals of Dr. Baskin’s laboratory are to elucidate the DNA mechanisms in various types of neurological disease and to develop novel diagnostics and treatments for primary brain tumors and autistic spectrum disorder. Dr. Baskin has recently developed methodologies to quantify the levels of different types of DNA damage and of labeled antibody staining in the field of fluorescence microscopy, using a new type of labeled tissue phantoms.
Principal Investigator: David Baskin, MD, FAANS, FACS
As part of the Translational Imaging Core at Houston Methodist, the scientists of the Magnetic Resonance Imaging Facility are ready to assist you with your clinical and preclinical imaging needs by offering services to help you design experiments, acquire complex images and perform clinical translational research studies. We use a state-of-the-art 70 cm wide-bore 3.0 Tesla whole body MRI scanner that is in immediate proximity to the positron emission tomography or single-photon emission computed tomography (PET/SPECT) facility, making it simple to facilitate high-throughput multi-modality imaging. The scanner software we use includes magnetic resonance spectroscopy, diffusion tensor imaging and cardiac imaging sequences.
Principal Investigator: Christof Karmonik, PhD
Medical Director: Steve H. Fung, MD
Using the tools of human neuroimaging, including MRI, PET and EEG, the Neuroimaging Lab aims to clarify the neurobiology and improve the treatment of the following disorders causing cognitive impairment: Alzheimer’s, frontotemporal dementia, genetic underpinning of regional involvement patterns, neuroimaging correlates of social cognition, traumatic brain injury, amyloid and tau imaging in acute and chronic concussion, timing and brain localization of tau deposition in patients with repeated head trauma and schizophrenia.
Joseph C. Masdeu, MD, PhD
Belen Pascual, PhD
The Speech and Language Center of the Department of Neurology conducts basic neurophysiological studies in the songbird zebra finch, and functional magnetic resonance imaging (fMRI) and brain magnetic stimulation studies in humans. The songbird research pertains to the neurobiology of vocal learning and animal models of speech-motor disorders.
Santosh A. Helekar, MD, PhD
David B. Rosenfield, MD
Research in the Peggy and Gary Edwards ALS Laboratory focuses on developing new insights into degenerative neurologic diseases, with a primary emphasis on Amyotrophic Lateral Sclerosis (ALS). More specifically, the importance of immune/inflammatory alterations, as well as increased intracellular calcium and free-radical stress in ALS, Parkinson’s disease and Alzheimer’s disease.
Director: Stanley H. Appel, MD
The Houston Institute for Neuropsychological Knowledge (THINK) laboratory, studies the neurobiological basis of human behavior using neuropsychological, neuroimaging e.g., functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), neurophysiological, and sensory psychophysical methods to better understand the impact of disease on the brain.
Principal Investigator: Mario F. Dulay Jr., PhD
The scientists and technicians of the Translational Imaging Core at Houston Methodist provide the research community with access to advanced high-performance imaging for preclinical and clinical investigative studies. We provide magnetic resonance imaging, positron emission tomography with an on-site cyclotron and a PET imaging clinic and a preclinical imaging clinic to perform multimodality imaging studies on preclinical study models.