Hematopathology

The Hematopathology Section is staffed by five board-certified hematopathologists and provides pathology diagnostic services to Houston Methodist Hospital (HMH) System and consultation services to outside patients. Our faculty are highly experienced in diagnosis of both benign and neoplastic hematolymphoid disorders, including blood, bone marrow, and lymphoid diseases. Clinical laboratories are equipped with state-of-the-art facilities and offering comprehensive ancillary analyses for precision diagnosis. With the volume and variety of clinical cases, excellent facilities and instrumentation, and phenomenal faculty, we provide unequaled opportunities for clinical training including an ACGME-accredited hematopathology fellowship program.

The flow cytometry laboratory performs clinical tests, including immunophenotyping of hematopoietic neoplasms, quantification of stem cells in harvests for transplant, T cell subset evaluation, DNA ploidy analysis, PNH-testing, and cell sorting. Multi-parametric (4- to 8-color) flow cytometry is routinely used for immunophenotyping most specimens, enabling evaluation of several markers even in limited specimens.

The clinical hematology laboratory conducts routine hematology testing and various body fluid testing and analysis. Complete blood counts (CBC) with differentials are performed with the state of the art Sysmex XN series of analyzers along with its automation line. Body fluid analysis includes automated urinalysis with the IRIS analyzer, cell counts for CSF, pleural fluid, and ascites, and joint fluid analyses for crystal evaluation and cell counts.

The hemoglobinopathy service diagnoses inherited blood disorders that result in abnormal structure or reduced synthesis of one or more of the globin chains in the hemoglobin molecules. Over 1,500 hemoglobinopathy tests per year are performed by using a variety of methodologies, including hemoglobin electrophoresis, high-performance liquid chromatography (HPLC), and sickle solubility testing.

The ACGME-accredited hematology pathology (hematopathology) fellowship program is a competitive fellowship that has trained excellent trainees from across the nation. The program provides broad training experience in both benign and malignant hematolymphoid disorders at HMH. Training also includes deep exposure to diagnostic technologies for hematolymphoid disorders. In addition, fellows also have opportunities to rotate at the MD Anderson Cancer Center, Baylor College of Medicine, and Texas Children's Hospital to practice under different clinical settings.